Correspondence. Selim UZUNOĞLU. Date of Birth 05 October 1962

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1 Curriculum Curriculum Vitae Vitae for for Faculty Faculty Members Members Name Title Selim UZUNOĞLU Prof. Dr. Medical Biology Date of Birth 05 October 1962 Place of Birth Fields of Study Phone GSM Yenipazar-AYDIN Molecular Cell Biology of Cancer. Cytotoxicity. Apoptosis. Genetic and memetic substrates of temperament and personality. Molecular genetics of emotions. Analysis of thinking, emotion and behavior as interaction interfaces of gene and meme. Emergenetics based personality maps. Integrative Medicine Correspondence 90 (236) extension 419 VOIP :

2 Undergraduate Masters degree Specialty/Doctorate Subspecialty Education BS in Biology Education, Ege University, TURKIYE MSc in Medical Biology, Health Science Institute, Dokuz Eylul University, TURKIYE PhD in Medical Biology, Health Science Institute Dokuz Eylul University, TURKIYE Academic Titles Assistant Professor of Biology, Faculty of Science and Letters, Celal Bayar University Associate Professor Professor Discipline of Medical Biology in Health Sciences. of Medical Biology School of Medicine, Celal Bayar University Administrative Duties Vice President of of Computing Rectorate of Celal Bayar University Vice President of Biology of Biology, Faculty of Science and Letters, Celal Bayar University President of Molecular Biology Division of Biology, Faculty of Science and Letters, Celal Bayar University Vice President of Biology of Biology, Faculty of Science and Letters, Celal Bayar University Central Research Laboratory Setup Celal Bayar University, Muradiye Campus

3 Manager of Center for Applied Natural Sciences Applications and Research Celal Bayar University Project Coordinator 2011 K numbered project titled Central Research Laboratory Setup funded by Ministry of Development. Celal Bayar University Head of of Medical Biology Faculty of Medicine, Celal Bayar University. January Memberships and Affiliations - Association of Medical Biology and Genetics - Turkish Biochemical Society - National Geographic Society - Molecular Cancer Research Society - European Association for Cancer Research SELECTED PUBLICATIONS 3 INTERNATIONAL PUBLICATIONS 1. Atmaca H, Bozkurt E, Uzunoglu S, Uslu R, Karaca B. A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett Jun 20;221(2): Karaca B, Atmaca H, Bozkurt E, Kisim A, Uzunoglu S, Karabulut B, Sezgin C, Sanli UA, Uslu R Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells. Mol Biol Rep Jun;40(6): Bozkurt E, Atmaca H, Kisim A, Uzunoglu S, Uslu R, Karaca B. Effects of Thymus serpyllum Extract on Cell Proliferation, Apoptosis and Epigenetic Events in Human Breast Cancer Cells. Nutrition and Cancer, (8),

4 4. Cirak Y, Varol U, Atmaca H, Kisim A, Sezgin C, Karabulut B, Uzunoglu S, Uslu R, Karaca B. Zoledronic acid in combination with serine/threonine phosphatase inhibitors induces enhanced cytotoxicity and apoptosis in hormone-refractory prostate cancer cell lines by decreasing the activities of PP1 and PP2A. BJU Int Dec;110(11 Pt C):E Kisim A, Atmaca H, Cakar B, Karabulut B, Sezgin C, Uzunoğlu S, Uslu R, Karaca B. Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels. J of Cancer Res and Clin Oncol, 138(7): , Selim UZUNOĞLU, Burçak KARACA, Harika ATMACA, Aslı KISIM, Bülent KARABULUT, Rüçhan USLU. Targeting Bcl-2 Protein to Enhance Chemosensitivity of Hormone Refractory Prostate Cancer Cell Line, DU-145 by a Synergistic Combination of Docetaxel and Gossypol. Turkiye Klinikleri J Med Sci 2011;31(4): Karabulut B, Karaca B, Atmaca H, Kisim A, Uzunoglu S, Sezgin C, Uslu R. Regulation of apoptosisrelated molecules by synergistic combination of all-trans retinoic acid and zoledronic acid in hormone-refractory prostate cancer cell lines. Mol Biol Rep Jan;38(1): Karabulut B, Karaca B, Varol U, Muslu U, Cakar B, Atmaca H, Kisim A, Uzunoglu S, Uslu R. Enhancing cytotoxic and apoptotic effect in OVCAR-3 and MDAH-2774 cells with all-trans retinoic acid and zoledronic acid: a paradigm of synergistic molecular targeting treatment for ovarian cancer. J Exp Clin Cancer Res Jul 30;29: Uzunoglu S, Karaca B, Atmaca H, Kisim A, Sezgin C, Karabulut B, Uslu R. Comparison of XTT and Alamar blue assays in the assessment of the viability of various human cancer cell lines by AT-101 (-/- gossypol). Toxicol Mech Methods Oct;20(8): Kucukzeybek Y, Gorumlu G, Cengiz E, Karabulut B, Sezgin C, Atmaca H, Sanlı UA, Uzunoglu S, Uslu R. Apoptosis-mediated cytotoxic effects of ibandronic acid on hormone- and drug refractory prostate cancer cells and human breast cancer cells. The Journal of International Medical Research, 38: , Ozlem Akagunduz, Burcak Karaca, Harika Atmaca, Selim Uzunoglu, Bulent Karabulut, Ulus Ali

5 Sanli, Ayfer Haydaroglu, Ruchan Uslu. Radiosensitization of Hormone-Refractory Prostate Cancer Cells by Gossypol Treatment. Journal of BUON, 2010 Oct-Dec;15(4): Duygu Unuvar Purcu, Burcak Karaca, Murat Kapkac, Necmettin Ozdemir, Selim Uzunoglu, Ruchan Uslu. High-Resolution Melting Analysis for Screening of Turkish Germline Mutations in BRCA1 and BRCA2. International Journal of Hematology and Oncology, 20(4): , Cengiz E, Karaca B, Kucukzeybek Y, Gorumlu G, Gul MK, Erten C, Atmaca H, Uzunoglu S, Karabulut B, Sanli UA, Uslu R. Overcoming drug resistance in hormone- and drug-refractory prostate cancer cell line, PC-3 by docetaxel and gossypol combination. Mol Biol Rep Mar;37(3): Serbetcioglu B, Mutlu B, Kirkim G, Uzunoglu S. Results of factorial Validity and Reliability of the International Outcome Inventory for Hearing Aids in Turkish. Int. Adv. Otol. 2009;(1) Atmaca H, Gorumlu G, Karaca B, Degirmenci M, Tunali D, Cirak Y, Purcu DU, Uzunoglu S, Karabulut B, Sanli UA, Uslu R. Combined gossypol and zoledronic acid treatment results in synergistic induction of cell death and regulates angiogenic molecules in ovarian cancer cells. Eur Cytokine Netw Sep;20(3): Çelik A., Abalı Y., Edgünlü G., Uzunoğlu S., Tirtom V.N. İnsan Saçında Bulunan (Manisa İlinin Üç Farklı Yerleşim Bölgesinde) Bazı Ağır Metallerin ICP-OES Yöntemi ile Tayini. Ekoloji 19, 73, 71-75, Karaca B, Atmaca H, Uzunoglu S, Karabulut B, Sanli UA, Uslu R. Enhancement of taxane-induced cytotoxicity and apoptosis by gossypol in human breast cancer cell line MCF-7. J BUON Jul- Sep;14(3): Sanli UA, Gorumlu G, Erten C, Gul MK, Cengiz E, Kucukzeybek Y, Karaca B, Atmaca H, Uzunoglu S, Karabulut B, Uslu R. Targeting apoptosis in the hormone- and drug-resistant prostate cancer cell line, DU-145, by gossypol/zoledronic acid combination. Cell Biol Int Nov;33(11): Erten C, Karaca B, Kucukzeybek Y, Gorumlu G, Cengiz E, Gul MK, Atmaca H, Uzunoglu S, Karabulut B, Sanli UA, Uslu R. Regulation of growth factors in hormone- and drug-resistant prostate cancer cells by synergistic combination of docetaxel and octreotide. BJU Int Jul;104(1):

6 20. Karabulut B, Erten C, Gul MK, Cengiz E, Karaca B, Kucukzeybek Y, Gorumlu G, Atmaca H, Uzunoglu S, Sanli UA, Baran Y, Uslu R. Docetaxel/zoledronic acid combination triggers apoptosis synergistically through downregulating antiapoptotic Bcl-2 protein level in hormone-refractory prostate cancer cells. Cell Biol Int Feb;33(2): Karaca B, Kucukzeybek Y, Gorumlu G, Erten C, Gul MK, Cengiz E, Atmaca H, Uzunoglu S, Sanli UA, Karabulut B, Uslu R. Profiling of angiogenic cytokines produced by hormone- and drugrefractory prostate cancer cell lines, PC-3 and DU-145 before and after treatment with gossypol. Eur Cytokine Netw Dec;19(4): Kucukzeybek Y, Gul MK, Cengiz E, Erten C, Karaca B, Gorumlu G, Atmaca H, Uzunoglu S, Karabulut B, Sanli UA, Uslu R. Enhancement of docetaxel-induced cytotoxicity and apoptosis by all-trans retinoic acid (ATRA) through downregulation of survivin (BIRC5), MCL-1 and LTbeta-R in hormone- and drug resistant prostate cancer cell line, DU-145. J Exp Clin Cancer Res Sep 12;27: Uzunoglu S, Acar H, Okudan N, Gokbel H, Mevlitoglu I, Sari F: Evaluation of the association between null genotypes of glutathione-s-transferases and Behcet's disease. Arch Dermatol Res. 297(7): , Aydin HH, Selvi N, Saydam G, Tobu M, Uzunoglu S, Uslu R, Buyukkececi F, Omay SB: Upregulation of serine/threonine protein phosphatase type 2A regulatory subunits during methylprednisolone-induced differentiation of leukaemic HL-60 cells. Clin Lab Haematol. 22(5): , Uzunoglu S, Uslu R, Tobu M, Saydam G, Terzioglu E, Buyukkececi F, Omay SB: Augmentation of methylprednisolone-induced differentiation of myeloid leukemia cells by serine/threonine protein phosphatase inhibitors. Leuk Res. 23(5): , NATIONAL PUBLICATIONS 1. Bozkurt E, Atmaca H, Uzunoglu S. Glioblastoma Tümörlerinde Çoklu İlaç Direnci. Genel Tıp Dergisi, 23: , Kısım A, Uzunoğlu S. Hormesis: Toksik Ajanların Düşük Dozlarına Uyum Sağlamada Öncül Fenomen. Adli Tıp Dergisi. 26(3): , 2012.

7 3. Kısım A, Karaca B, Atmaca H, Purcu D.U, Uzunoğlu S, Uslu R. Türk Meme Kanseri Hastalarında Kanserli ve Normal Meme Dokusu Örneklerinde FGFR2 Gen Polimorfizminin Belirlenmesi. Meme Sağlığı Dergisi, 7(1): , Asbagh AL, Deniz A, Uzunoğlu S, Uslu FR: Translational Perspective of Mathematical Models Used in The Assessment Of Cellular Synergy in Cytotoxicity Assays. C.B.Ü. Fen Bilimleri Dergisi. 4 (1) : , Korkmaz N, Uzunoğlu, S: Astım Hastalarında Serum Nitrik Oksit Düzeyleri. Genel Tıp Dergisi. Cilt 16, Sayı 2, 65-69, Uzunoğlu, S : Çevreyi Korumada Yeni Bir Konsept:Ekolojik Ego. Ekoloji. 15: 58:33-37, Uzunoğlu, S : Eniseler GA. Kişiliğin Biyolojisi. C.B.Ü. Fen Bilimleri Dergisi,1:1, 81-90, Töbü M, Çağırgan S, Tombuloğlu M, Saydam G, Uzunoğlu S, Büyükkeçeci F, Omay SB : A Retrospective Analysis of Some Myelodysplastic Syndromes in Aegean Region of Turkey, Turkish Journal of Haematology. 16:2, 73-78, Uzunoğlu, S : Çevre Eğitiminin Amaçları, Uğraşı Alanları Ve Sorunları. Ekoloji.21:7-12, Uzunoğlu, S : Çevrenin Korunmasında Bireyin Rolü. Ekoloji. 14, 29-31, Uzunoğlu, S : Çevre Problemlerine Farklı Bir Bakış. Ekoloji. 12, 4-7, Uzunoğlu S, Terzioğlu, O: Değişik antibiyotiklerin Üropatojenik Escherichia coli suşlarının logaritmik büyümesi üzerine çeşitli antibiyotiklerin etkileri. Kükem Dergisi. 9:2: 1-8, 1986.