CURRICULUM VITAE. 7. Language skills: Indicate competence on a scale of 1 to 5 (1-excellent; 5-basic)

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1 CURRICULUM VITAE 1. Family name: COSGUN 2. First name: ERDAL 3. Date of birth: Nationality: Turkish 5. Civil status: Married 6. Education : Institution Degree(s) or Diploma(s) obtained: Ph. Degree in Hacettepe University, Faculty of Medicine, Department of Biostatistics (Ankara-TURKEY) BS Degree in Hacettepe University, Faculty of Science, Department of Statistics (Ankara-TURKEY) 7. Language skills: Indicate competence on a scale of 1 to 5 (1-excellent; 5-basic) Language Reading Speaking Writing Turkish English Have Academicals English score (IELTS-Academic): 7.0- Sept Membership of professional bodies: Association of Turkish Biostatisticians Society for Design and Process Science as a Next Generation Leadership International Biometric Society International Educational Data Mining Society 9. Other skills: Hacettepe University Hospital, Management of Clinical Databases Experience on providing training courses; Data Mining, Biostatistics and Bioinformatics. 10. Present position: Hacettepe University Faculty of Medicine, Department of Biostatistics, Asst.Prof. 11. Years within the firm: 6 years

2 12. Key qualifications: Extensive experience on Biostatistical Analysis Expert on Data Mining Analysis (Medicine, Veterinary, Genetics) Extensive Experience in Cost-benefit Analysis Experience on Statistical Software (R, IBM-SPSS, STATISTICA & Data Mining, SPSS Modeller-Data Mining, MATLAB, PLINK, SAS, NCSS, S-PLUS) Experience on Health Care Systems Expert on Prediction, Clustering, Classification Analysis Expert on Bioinformatics Experience in statistical analysis for epidemiological studies. Experience in preparation and implementation on disease surveys. 13. Specific experience in the region: Country Date from Date to Turkey Professional experience

3 Date Location Company Position Description 2007 Turkey Ankara Hacettepe University Research Assistant Work on Faculty of Medicine Department of Biostatistics. Have the role and responsibility as in the following; Instructor of lectures below: BIS 785- Data Mining BIS 786- Machine Learning BIS 761- Introduction to Bioinformatics BIS 771- Introduction to R Software BIS 785- Statistical Genetics BIS 755- Introduction to Linux OS for Bioinformatics Analysis Within this period I will advise different thesis and university project about Bioinformatics. June Turkey Ankara Rgenetik Ar- GE Bioinformatic Co. Ltd. Hacettepe Technopolis, No:2/9,Ankara,Turkey General Manager I am a co-founder and General Manager of company. Company provides services on analyze bioinformatics, biostatistics data. Overall project management, institutional researches, project planning, need assessment, impact assessment, qualitative/quantitative surveys. My role in this company is: *Analyze data which come from different fields (medicine, veterinary, social sciences) * Create prediction algorithms for future projections * Cost-benefit analysis Feb Sept 2010 Turkey Ankara USA Alabama- Birmingham Research Scholar I was a research scholar at University of Alabama at Birmingham, Department of Biostatistics, Section on Statistical Genetic. In this period I analyzed department databases with Machine Learning-Data Mining methods in two different projects. My advisor is Dr.David Allison who is the famous researcher in USA. I published my predictive algorithm for Warfarin on famous journal, Bioinformatics. Agu Oct 2011 USA Groton Pfizer Inc. Statistical Analyst I was a statistical analyst in Pfizer R&D center in Groton. They supported my visit and paid all my expenses. I responsible to analyze genetic and clinical data. We have created a bioinformatics analysis manual for Pfizer. They are still use this manual in their clinical trials. Jan July 2011 USA Texas, Commerce Texas A&M at Commerce Data Miner Work on Faculty of Engineering, Department of Computer Engineering as a dataminer. I have responsibilities on finding and analyzing different data sets with Data Mining method. My advisor in this university is Prof.Sang Suh who is the head of department.

4 15. Other relevant information a) Projects

5 Date Institue Title Budget Position Description USA-National Heart Lung and Blood Institute (RO1HL092173, in part); Predict Warfarin Dosage for African Americans $ Researche r With complex traits and diseases having potential genetic contributions of thousands of genetic factors, and with current genotyping arrays consisting of millions of single nucleotide polymorphisms (SNPs), powerful high-dimensional statistical techniques are needed to comprehensively model the genetic variance. Machine learning techniques have many advantages including lack of parametric assumptions, and high power and flexibility. Therefore I have used different machine learning-data mining algorithms to find new model on predicting Warafarin dose EU Research on Truck Driver s Behaviour Analyst In this project, we evaluate the behavior of truck drivers in Turkey. There lots of problems on the roads: road conditions, driver s education etc. I analyzed two surveys in this project. I proposed two different driver class to the project manager. These are very important to understand the driver s behavior The Scientific and Technological Research Council of Turkey (TÜBİTAK) Finding Responsible Genes for Limb- Girdle Disease TL Scholar- Analyst In the project, in order to identify novel chromosomal regions responsible for the disease, genome-wide genotyping and homozygosity mapping will be carried out in these families with the high resolution 250 NspI SNP arrays and candidate genes harbouring in those chromosomal regions will be analyzed for mutations. If we detect more than one chromosomal loci in these LGMD2 families, only one of them will be selected for identifying a novel mutant gene/mutation by using whole exome sequencing technology. I have analyzed clinical and genetic factors with Data Mining methods. I tried to figure out many interactions between factors. This results may have use on disease treatment The Scientific and Technological Research Council of Turkey (TÜBİTAK) Cost-Effective Analysis of Library of Hacettepe University s Electronic Databases TL Scholar- Analyst The aim of this study is to investigate how efficiently the full text accessible electronic databases and journals of Hacettepe University Libraries are used. For this purpose the usage data obtained from COUNTER Software regarding to the electronic databases of Hacettepe University Libraries subscribed in 2007 were examined. Moreover, the results obtained from the questionnaire survey conducted on a random sample of academic staff, the data obtained from the citations of publications originated from Hacettepe University and the costs of the databases were evaluated Turkish Ministry of Science, Industry and Technology Genetic Data Mining Tool TL General Director In this project, I worked on as a project general manager. I have tried to create a new computer software that analyze genetic data with data mining method. This tool has many methods like clustering, classification and descriptive data mining. We have focused on reduce the costs of genetic material with extract more information from existed data Hacettepe Technopolis A New Hospital Data Mining Approaches TL General Director In this project, I and my engineering team are try to analyze the hospital databases with data mining method. We aimed to reduce the cost of diagnostic tests with finding relevant tests. Motivation is come from Hacettepe University s president. Project is still continue.

6 Turkish State Planning Organisatinon EU Emprical Analysis of Turkish Political Systems from 1982 to 2013 Technical Assistance for Preparation of the Veterinary Strategy Document Project TR.2010/ /SER/024/001 Europeaid/133669/D/ SER/TR Project Coordinato r- Analyst Data Analyst In this project, we collected different data from political sciences.we have focused on the time interval between Main aim is to put the results on stage for social analyst. Project is still on process. Create strategic program of animal healty and welfare.

7 b) Scientific Papers +Science Citation Index Article Number Article Information 1 "Laparoskopik Ayarlanabilir Stomalı Mide bantı Uygulamalarında nadir bir komplikasyon: Bant ta açılma, İbrahim Sakçak, Fatih Mehmet Avşar, Enver Okan Hamamcı, Settar Bostanoğlu, Muhittin Sonışık, Akın Bostanoğlu, Nihal Zekiye Erdem, Erdal Coşgun (Turkish Journal of Surgery,2009) 2 Comparison of Early and Late Changes in Immunoglobulins and Acute Phase Reactants after Laparoscopic Adjustable Gastric Banding in Patients with Morbid Obesity, Sakçak İbrahim, M.D., Avşar Mehmet Fatih, M.D., Hamamcı Enver Okan, M.D., Bostanoğlu Settar, M.D., Sonışık Muhittin, M.D., Bostanoğlu Akın, M.D., Erdem Nihal Zekiye, Ph.D., Coşgun Erdal, OBES SURG, Jan.2010, DOI /s y (SCI), 2010, Obesity Surgery 3+ Changes in comorbid diseases in morbidly obese patients treated by laparoscopic adjustable gastricbanding, Sakçak İbrahim, M.D., Avşar Mehmet Fatih, M.D., Erdem Nihal Zekiye, Ph.D., Hamamcı Enver Okan, M.D., Bostanoğlu Settar, M.D., Sonışık Muhittin, M.D., Bostanoğlu Akın, M.D., Coşgun Erdal, Pak J Med Sci Jan - Mar 2010; 26(1):6-10. (SCI) 4 İbrahim Sakçak, Fatih Mehmet Avşar, Erdal Coşgun (June 2010), Comparison of The Application of Low Concentration and 80% Phenol Solution in Pilonidal Sinus Disease, J R Soc Med Sh Rep, 1:5 5 İbrahim Sakçak, Fatih Mehmet Avşar, Enver Okan Hamamcı, Özgür Akmeşe, Erdal Coşgun,(Sept. 2010), Akın Bostanoğlu, Muhittin Sonışık, The effects of weight loss on glucose metabolism and insulin resistance in morbidly obese patients with laparoscopic adjustable gastric band,endokrinolojide Diyalog, 7 (3): İbrahim Sakçak, Mehmet Fatih Avşar, Erdal Coşgun (Haziran 2010), Morbid Obez Tedavisinde Laparoskopik Ayarlanabilir Gastrik Bant Uygulamaları: İlk 134 Olgunun Sonuçları,Ortadoğu Tıp Dergisi, 2(2), Bostanoglu S, Sakcak I, Avsar FM, Cosgun E, Hamamci EO. Comparison of Karydakis technique with Limberg Flap Procedure in Pilonidal Sinus Disease: Advantages of Karydakis technique. Pak J Med Sci 2010;26(4): (SCI) 8+ İbrahim S, Mehmet AF, Erdal C, Zekiye EN. The development of migration in laparoscopic adjustable gastric banding and the approach to treatment. Pak J Med Sci 2010;26(3): (SCI)

8 9+ İbrahim SAKÇAK, Fatih Mehmet AVŞAR, Esra Uçar YILMAZ, Hakan ATAŞ, Kemal KILIÇ,Erdal COŞGUN, İpek MUMCUOĞLU, Sevilay SEZER, Settar BOSTANOĞLU, Attila İŞGÖREN, The Prevention of the Development of Peritonitis with Different Disinfectants to Compare the Efficacy of Gastric Lavage at the NOTES, The journal of The Faculty of Veterinary Medicine, Univ. Of Kafkas. 17 (Suppl A): S37-S42, 2011 (SCI) 10 Serap DURUKAN, Çağdaş AKYÜREK, Erdal COŞGUN, Hacettepe Üniversitesi Erişkin Hastanesi nde Çalışan Hemşirelerin Örgütsel Güven, Güçlendirme Ve Bağlılık Düzeylerinin Belirlenmesi, Süleyman Demirel Üniversitesi, İktisadi ve İdari Bilimler Fakültesi Dergisi, Y.2010, Vol.15, No.3 pp İbrahim İ., Barış D Yıldız,Fatih M., Avsar,Saadet A.,K.Kılıc,Erdal COŞGUN,Orhan G. Ozbilen, Enver O. Hamamcı, Does N ratio Affect Survival in D1 and D2 Lymph node Dissection for Gastric Cancer?, World Journal of Gastroenterology, In Press, Accepted Date: (SCI) 12+ Erdal COŞGUN, Nita Limdi, Christine W.Duarte, High Dimensional Pharmacogenetic Prediction of a Continuous Trait using Machine Learning Techniques with Application to Warfarin Dose Prediction in African American, Bioinformatics, 2011 May 15;27(10): (SCI) 13+ Dr.Enver Okan HAMAMCI, Dr. Rıfat PİYADE, Dr. Settar BOSTANOĞLU,Dr. İbrahim SAKÇAK, Dr.Mehmet Fatih AVŞAR, Erdal COŞGUN, Preoperative Localization in Primary Hyperparathyroidism Surgery,Turkiye Klinikleri J Med Sci 2011;31(3): (SCI) 14 Serap DURUKAN;Doç. Dr. Elif DİKMETAŞ; Erdal COŞGUN, Bir Kamu Hastanesinde Tıbbi Sekreterlerin işgücü Verimliliğine ilişkin Algılamalarına Yönelik Bir Araştırma, YIL: 2011 / CİLT: 20 / SAYI: Sakcak, Ibrahim; Avsar, Fatih Mehmet; Cosgun, Erdal; Yildiz, Baris Dogu, Management of concurrent cholelithiasis in gastric banding for morbid obesity, European Journal of Gastroenterology & Hepatology, In Press, 2011, doi: /MEG.0b013e adb (SCI) 16+ Avsar FM, Sakcak I, Yildiz BD, Cosgun E, Hamamci EO Is Gastro-Gastric Fixation Suture Necessary ın Laparoscopic Adjustable Gastric Banding? A Prospective Randomized Study.,.J Laparoendosc Adv Surg Tech A., 21,10, , 2011(SCI) 17 Erdal COŞGUN, Ergun Karaağaoğlu, Veri Madenciliği Yöntemleri ile Mikrodizilim Gen İfade Analizi (Microarray Gene Expression Data Analysis With Data Mining Methods), Hacettepe Tıp Dergisi, 42: , 2011

9 18 İbrahim Sakçak, Fatih Mehmet Avşar, Barış Doğu Yıldız, Kemal Kılıç, Muhittin Sonışık, Akın Bostanoğlu, Erdal Coşgun-- Surgical Methods And Complications Of Hyperthyroidism With Euthyroid In Terms Of Applied Comparison, The Journal of Medical Sciences,Solidarity Association,2011, Vol: 3, 2, Koray Ergunay, Yasemin Balaban, Erdal Cosgun, Alpaslan Alp, Halis Simsek, Burcin Sener, Gonca Tatar, Gulsen Hascelik, Epidemiologic trends in HBV infections at a reference centre in Turkey: an 11-year retrospective analysis, Ann Hepatol,September-October, Vol. 11 No. 5, 2012 (SCI) 20 Erdal Cosgun, Ergun Karaağaoğlu, Veri Madenciliği ve Yeni Nesil Yöntemleri, N den n ye Gezinti Dergisi, Sayfa:34-39,Yıl:2, Sayı:9, Kasım-Aralık Cem Sahin, Ergin A., Ayyildiz S. ve Erdal Coşgun,, Effect of biofilm formation, and biocorrosion on denture base fractures, JOURNAL OF ADVANCED PROSTHODONTIC,Vol:5,Issue:2, Page: ,May 2013 (SCI) 22+ Elif Oztürk, Yu-Chih Chiang, Erdal Coşgun et al., Effect of resin shades on opacity of ceramic veneers and polymerization efficiency through ceramics, Journal of Dentistry, 415 (2013) (SCI) 23 C. Tuba GÜNEBAK ŞAHİN, Berkan SAYAL, Erdal COŞGUN, H. Tanju BESLER, M. Sinan BEKSAÇ, Methylenetetrahydrofolate Reductase Enzyme Mutations and Relationship of Homocysteine Vitamin B12 and Folate Blood Levels,Gynecology Obstetrics & Reproductive Medicine,Vol:19,No:1, Birben E., Sahiner U., Karaaslan C., Yavuz T.S, Cosgun E., Kalayci O., Sackesen C., The Genetic Variants of Thymic Stromal Lymphopoietin Protein in Children with Asthma and Allergic Rhinitis,Int Arch Allergy Immunol 2014;163: , (DOI: / ) (SCI) 25 Cem Şahin, S.T.Ayyıldız,Cumhur Korkmaz, Erdal Coşgun,AKRİLİK MATERYALLERDE AĞIRLIK VE BOYUT DEĞİŞİMİNİN SIVI ABZORPSİYONUNA VE ZAMANA BAĞLI OLARAK MİKRO ÖLÇÜTLERDE İNCELENMESİ, Türkiye Klinikleri Diş Hekimliği Dergisi, 2014 (Accepted)

10 b) International Book Chapters 1 Erdal COŞGUN, Ergun Karaağaoğlu, Ph.D., The New Hybrid Method for Classification of Patients by Gene Expression Profiling, Biomedical Engineering: Healthcare Systems, Technology and Techniques, 2011, Page , Springer 2 Erdal Coşgun, Gökmen Zarasız, mirnomics: MicroRNA Biology and Computational Analysis Introduction to Statistical Methods, Methods in Molecular Biology book, 2014, XII, 333 p. 69 illus., Springer 3 Alper Bayazit, Petek Askar, Erdal Cosgun, Predicting Learner Answers Correctness Through Eye Movements With Random Forest, Educational Data Mining, Peña-Ayala, Alejandro (Ed.), 2014, XVIII, 468 p. 139 illus. Springer