ÖZGEÇMİŞ Yrd. Doç. Dr. DENİZ YÜCEL

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1 ÖZGEÇMİŞ Yrd. Doç. Dr. DENİZ YÜCEL Ünvanı: Doğum Tarihi: Yardımcı Doçent, Doktor 6 Mayıs 1979 Yazışma Adresi : Acıbadem, Tıp Fakültesi, Histoloji ve Embriyoloji ABD Kerem Aydınlar Kampüsü İçerenköy Mah, Kayışdağı Caddesi No: 32 Ataşehir/İSTANBUL İstanbul/Türkiye Telefon : e-posta : denyucel@gmail.com EĞİTİM BİLGİLERİ Ülke Üniversite Fakülte/Enstitü Öğrenim Alanı Derece Türkiye Türkiye Türkiye FEN BİLİMLERİ ENSTİTÜSÜ FEN BİLİMLERİ ENSTİTÜSÜ FEN-EDEBİYAT FAKÜLTESİ BİYOTEKNOLOJİ Doktora 2009 BİYOTEKNOLOJİ Yüksek Lisans Mezuniyet Yılı 2003 Biyoloji Lisans 2001 AKADEMİK/MESLEKTE DENEYİM Kurum/Kuruluş Ülke Şehir Bölüm/Birim Acıbadem Türkiye İstanbul Türkiye Ankara Türkiye Ankara Acıbadem Tıp Fakültesi ODTÜ, Merkezi Laboratuvar, Moleküler Biyoloji, Biyoteknoloji AR-GE Merkezi Biyoloji Görev Türü Yrd. Doç. Dr. Uzman (Dr.) Araştırma Görevlisi Görev Dönemi

2 UZMANLIK ALANLARI Uzmanlık Alanları Biyomateryal, Biyosensör, Polimerlerin Tıbbi Uygulamaları Biyomalzemeler, Doku Mühendisliği (Sinir ve Kemik), Kök hücre kültürü, Mikroakışkan sistemlerde hücre kültürü, Biyobozunur ve biyobozunmaz polimerler, 2 ve 3 boyutlu hücre taşıyıcısı tasarlanması, Mikroskopi teknikleri (Floresan ve Konfokal Mikroskoplar), Moleküler biyoloji teknikleri (RNA izolasyonu ve RT-PCR), Biyosensörler, Enzim ve protein immobilizasyon yöntemleri ÖDÜLLER Young Histochemist Award Ödülün Adı Alındığı Kuruluş Yılı 14th International Congress of Histochemistry and Cytochemistry (ICHC) 2012 Prof. Dr. Türkan ERBENGİ Araştırma Ödülü- Jüri Özel Ödülüü Fen Bilimleri Enstitüsü Lisansüstü Tez Ödülü Türk Elektron Mikroskopi Derneği ESB 2003 Young Scientist Travel Award European Society for Biomaterials 2003 YAYINLARI SCI, SSCI, AHCI indekslerine giren dergilerde yayınlanan makaleler G. Erkanlı Senturk, K. Erkanlı, U. Aydın, D. Yucel, N. Isıksacan, F. Ercan, S. Arbak, The protective effect of oxytocin on ischemia/reperfusion injury in rat urinary bladder, Peptides 2013, 40:82-8. O. Karadas, D. Yucel, H. Kenar, G. Torun Kose, V. Hasirci, Collagen scaffolds with in situ-grown calcium phosphate for osteogenic differentiation of Wharton s Jelly and menstrual blood stem cells, Journal of Tissue Engineering and Regenerative Medicine 2012, DOI: /term D. Yucel, G. T. Kose, V. Hasirci, Tissue Engineered, Guided Nerve Tube Consisting of Aligned Neural Stem Cells and Astrocytes, Biomacromolecules 2010, 11: D. Yucel, G. T. Kose, V. Hasirci, Polyester Based Nerve Guidance Conduit Design, Biomaterials 2010, 31: D. Yucel, N. Ozer, V. Hasirci. Construction of a choline biosensor through enzyme immobilization on a poly(2-hydroxyethyl methacrylate) grafted Teflon film. Journal of Applied Polymer Science 2007; 1004:

3 Diğer dergilerde yayınlanan makaleler C. Padeste, H. Özçelik, J. Ziegler, A. Schleunitz, M. Bednarzik, D.Yücel, V. Hasırcı. Replication of high aspect ratio pillar array structures in biocompatible polymers for tissue engineering applications, 36th International Conference on Micro & Nano Engineering (MNE) Abstracts, Microelectronic Engineering, 2011, 88 (8), D. Yucel, H. Kenar, G. T. Kose, V. Hasirci. Mesenchymal Stem Cell Behaviour on Topographical Cues, TERMIS-EU 2008 Annual Porto Meeting Abstracts, Tissue Engineering Part A 2008, 14(5), 878. Kitap Bölümleri Yucel D, Kanneci Ia, Arslantunali D, Torun Kose G, Hasirci V, Spinal Cord Injury Tissue Engineering Using Stem Cells. In Hayat Ma, Ed, Tumors Of The Central Nervous System Volume 10, 2013, Pp D. Yücel, H. Kenar, A. Ndreu, T. Endogan, N. Hasirci, and V. Hasirci. Nanotechnology in Biomaterials: Nanofibers in Tissue Engineering, Book Chapter in Bionanotechnology II Global Prospects, pp , Ed. David E. Reisner, CRC Press, Taylor and Francis Group, FL, USA, 2012, ISBN: P. Yilgor, D. Yucel, H. Kenar, V. Hasirci. Polyhydroxyalkanoates: A Versatile Class of Biopolymers and their Biomedical Potential. Book chapter in Brazilian Network of Green Chemistry 2008, pp , Ed. Prof. Dr. JOB Carioca, ISBN: V. Hasirci and D. Yucel. Polymers Used in Tissue Engineering. Encyclopedia of Biomaterials and Biomedical Engineering 2007; 1(1): Hakemli konferans/sempozyumların bildiri kitaplarında yer alan yayınlar P Köroğlu, G Erkanlı Şentürk, D Yücel, Ö Bingöl Özakpınar, F Uras, S Arbak, Streptozotosin (stz) ile oluşturulan deneysel diyabette dışarıdan uygulanan oksitosinin testis üzerine olan etkisinin incelenmesi, Uluslararası Katılımlı 21. Ulusal Elektron Mikroskopi Kongresi, 2013 T. Dursun, D. Yücel, V. Hasırcı,Nerve Guides with Different Architecture for Use in the Treatment of Spinal Cord Injury, Tissue Engineering and Regenerative Medicine International Society TERMIS-EU-2013, 2013 D. Yucel, Nerve Tissue Engineering Using Stem Cells, 2nd International Students? Stem Cell Congress, 2013 D. Yucel, Doku Mühendisliğinde Güncel Konular, Üsküdar 1. Biyomühendislik ve Genetik Günleri, 2013 R. G. Aktas, S. Karahuseyinoglu, O. E. Tok, M. Karabork, D. Yucel. Actin Distribution in HepG2 cell-spheroids: A fluorescence microscopic study. Annual meeting of The American Society For Cell Biology (ASCB), poster no: 536, page 80, San Francisco, CA, USA, December 15-19, R. G. Aktas, S. Karahuseyinoglu, O. E. Tok, M. Karabork, D. Yucel. Actin Mito Tracker labeling in HepG2 Cell Cultures: Influence of different staining techniques on the morphology of mitochondria. Annual meeting of The American Society For Cell Biology (ASCB), poster no: 2195, page 183, San Francisco, CA, USA, December 15-19, 2012.

4 P. Koroglu, G. Erkanli Senturk, D. Yucel, M.I. Tansoker, M.M. Canturk, S. Arbak, Histopathological evaluation of exogenous oxytocin on Streptozotocin (STZ)-induced diabetic adult rat testes, 15th European Microscopy Congress, September 16-21, 2012, Manchester Central, UNITED KINGDOM G. Erkanli Senturk, K. Erkanli, U. Aydin, D. Yucel, S. Arbak, F. Ercan, N. Isıksacan, I. Bakir, Oxytocin protects against ischemia/reperfusion injury in urinary bladder, 14th International Congress of Histochemistry and Cytochemistry (ICHC 2012), August 26-29, 2012, Kyoto, JAPAN P. Koroglu, G. Erkanli Senturk, D. Yucel, S. Arbak. Histopathological evaluation of exogenous oxytocin on Streptozotocin-induced diabetic adult rat testes, 11th National Histology and Embryology Congress, Mayıs, 2012, Denizli, TURKEY D. Yucel, O. Karadas, H. Kenar, G. Torun Kose, V. Hasirci, Mesenchymal Stem Cells and Their Applications in Tissue Engineering, 14th International Congress of Histochemistry and Cytochemistry (ICHC 2012), August 26-29, 2012, Kyoto, JAPAN D.Yucel, G. Torun Kose, V. Hasirci. İnsan Mezenkimal Kök Hücrelerinin Fiber Yapı Hücre Taşıyıcıları üzerindeki Davranışları, 20. Ulusal Elektron Mikroskopi Kongresi (Uluslararası Katılımlı), Antalya, Türkiye, Ekim, D. Yucel, Sinir Doku Mühendisliği, Doku Mühendisliği Sempozyumu, Ege Bilim Teknoloji Topluluğu (EBİLTET), İzmir, TÜRKİYE, 11 Nisan D. Yucel, G. Torun Kose, V. Hasirci, Sinir Doku Mühendisliği Yöntemleri Kullanarak Kök Hücre İçeren yönlü Nöral Tüp Tasarimi, Biyomalzemeler Ve Tipta Uygulanmasi Sempozyumu, Istanbul, Türkiye, Aralik 16, 2010 D. Yucel, G. Torun Kose, V. Hasirci, Sinir hücresi olmak üzere indüklenmiş mezenkimal kök hücrelerinin sinir doku mühendisliğinde kullanımı. 1st International Participating Stem Cell Symposium, OP-5, p.:61, Samsun, TÜRKİYE, Eylül 29 - Ekim 1, D. Yucel, H. Kenar, H. Ozcelik, V. Hasirci. Nano/Microfibrous Scaffolds For Tissue Engineering. 23rd European Conference on Biomaterials (ESB2010), Tampere, FINLAND, September 11-15, 2010 H. Kenar, D. Yucel, O. Karadas, G. Kose, V. Hasirci, Wharton Jelly MSC Behavior on Electrospun Biodegradable Polymer Mats. 1st Annual Meeting of the Expertissues EEIG, European Institute of Excellence in Tissue Engineering and Regenerative Medicine, OP17, p.:32, AvePark, Guimaraes, PORTUGAL, July 26-27, 2010 D. Yucel, H. Kenar, O. Karadas, B. Bayyurt, G. Torun Kose, N. Hasirci, V. Hasirci, Fetal Stem Cells in Tissue Engineering Applications. 1st Annual Meeting of the Expertissues EEIG, European Institute of Excellence in Tissue Engineering and Regenerative Medicine, OP16, p.:31, AvePark, Guimaraes, PORTUGAL, July 26-27, H. Özçelik, D. Yücel, C. Padeste, V. Hasırcı. The Effect of Surface Nanotopography on Neural Stem Cell Alignment. 6th Nanoscience and Nanotechnology Conference (NanoTR6), p.:513, Izmir, TURKEY, June15-18, 2010 D.Yucel, G. Torun Kose, V. Hasirci. Stem cell based guided nerve tissue engineering. International Neuroimplantation Congress 2010, January 22-23, Istanbul, TURKEY (oral presentation) D.Yucel, G. Torun Kose, V. Hasirci. Stem Cell Behavior on Polyester Based Electrospun Fibers. International Neuroimplantation Congress 2010, January 22-23, Istanbul, TURKEY (poster presentation)

5 H.Kenar, D. Yucel, P.Yilgor, N.Hasirci, V.Hasirci. Polyhydroxyalkanoates in Tissue Engineering. 5th European Symposium on Biopolymers, ESBP 2009, November 18-20, Funchal, PORTUGAL (oral presentation) D.Yucel, G. Torun Kose, V.Hasirci. Astrocyte Guidance on Patterned Polyester Surfaces, 22nd European Conference on Biomaterials (ESB 2009), September 7-11, Lausanne, SWITZERLAND (poster presentation) D. Yucel, G. Torun Kose, V. Hasirci. Guided Tissue Engineered Nerve Tube Using Human Mesenchymal Stem Cells, 15th Biomedical Science & Technology Symposium 2009, August 16-19, Guzelyurt, Turkish Republic of Northern Cyprus (TRNC) (oral presentation) O. Karadas, H. Kenar, D. Yucel, V. Hasirci. Mesenchymal Stem Cells Of Menstrual Blood And Wharton&#8217s Jelly Origin And Collagen-Hap Composite Scaffolds İn Bone Tissue Engineering, 15th International Biomedical Science And Technology Symposium 2009, August 16-19, Güzelyurt, Turkish Republic Of Northern Cyprus (Trnc) (Poster Presentation) V. Hasırcı, H. Kenar, D. Yücel, P. Zorlutuna, P. Yılgör, G. Köse, N. Hasırcı. Collagen and polyester-based scaffolds for tissue engineering. 237th ACS National Meeting & Exposition 2009, March 22-26, Salt Lake City, UT, USA (oral presentation) D. Yucel, H. Kenar, G. T. Kose, V. Hasirci. Mesenchymal Stem Cell Behaviour on Topographical Cues, TERMIS-EU 2008 Annual Meeting, June 22-26, Porto, PORTUGAL (poster presentation) H. Kenar, D. Yücel, V. Hasirci. Mikrokanalli Polimerik Yapilar Wharton s Jelly Mezenşimal Kök Hücrelerinin Bölünmesinde Etkili Mi? Biyomut 2008, May 29-31, Metu, Ankara, Turkey (Poster Presentation) H. Kenar, D. Yucel, L. Akhmetova, V. Hasirci. Is Wharton&#8217s Jelly Msc Division Influenced By Substrate Microgrooves? 14th International Biomedical Science & Technology Symposium 2008, May 03-07, Muğla, Turkey (Poster Presentation) D. Yucel, H. Kenar, E. Bella, G. Kose, C. Migliaresi, A. Motta, V. Hasirci. Fabrication of Nano Size Polyester Fibers by Electrospinning, Trento Innovation Conferences in Materials Engineering (TICME) 2007, 1st Meeting: Advances in Polymers, Composites and Biomaterials, December 16-19, Trento, ITALY (poster presentation) P. Yilgor, D. Yucel, H. Kenar, V. Hasirci. Polyhydroxyalkanoates: A Versatile Class of Biopolymers, and Their Biomedical Potential, 1st Brazilian Workshop On Green Chemistry 2007, November 18-21, Fortaleza, BRAZIL (oral presentation) V. Hasirci, H. Kenar, D. Yucel, P. Zorlutuna, P. Yilgor, B. Basmanav, B. Bayyurt, A. Ndreu, G. Torun Kose, N. Hasirci. Polymeric Nanobiomaterials in Drug Delivery and Tissue Engineering, International Workshop on Nanobiotechnology and Genome technologies 2007, 31 October - 3 November, Antalya, TURKEY (oral presentation) H. Kenar, D.Yucel, E. Bella, G. Kose, C. Migliaresi, V. Hasirci. Effect Of Polyester Type And Fiber Size On Wharton&#8217s Jelly Mesenchymal Stem Cell Attachment, Annual Review Meeting Of Expertissues 2007, October 5-6, Kusadasi, Izmir, Turkey (Oral Presentation) D. Yucel, H. Kenar, E. Bella, G. Kose, C. Migliaresi, V. Hasirci. Effect Of Polyester Type And Fiber Size On Wharton&#8217s Jelly Mesenchymal Stem Cell Attachment, 4th European Symposium On Biopolymers (Esbp 2007), October 2-4, Kusadasi, Izmir, Turkey (Poster Presentation) D. Yucel, G. Kose, V. Hasirci. Influence of Physical and Chemical Cues on Neural Stem Cell

6 Behavior on Tissue Engineering Scaffolds, 13th Biomedical Science & Technology Symposium 2007, August 26-28, Istanbul, TURKEY (oral presentation) H. Kenar, D. Yucel, D. Kaplan, M. Toner, G. Kose, V. Hasirci. Neural And Cardiomyogenic Lineage Markers Expressed By Wharton&#8217s Jelly Mesenchymal Stem Cells, 13th Biomedical Science & Technology Symposium 2007, August 26-28, Istanbul, Turkey (Oral Presentation) N.G. Durmus, E. Bayam, S. Keskil, D. Yucel, V. Hasirci. In vitro Antitumor Activity of Temozolomide and Celecoxib Loaded PLGA Discs Against Saos 2 and Glioma C6 Cells, 13th Biomedical Science & Technology Symposium 2007, August 26-28, Istanbul, TURKEY (poster presentation) G. T. Köse, H.Kenar, D. Yücel, V. Hasırcı. Bone and neural tissue engineering, National Artificial Organs and Support Systems Congress (TUYOD) 2007, June 15-17, Istanbul, TURKEY (sözlü sunum) D. Yucel, H. Kenar, P. Sethu, N. Parashurama, V. Hasirci, D. Kaplan, M. Toner, Expression Of Neural And Cardiomyogenic Lineage Markers By Mesenchymal Stem Cells From Human Bone Marrow And Wharton&#8217s Jelly, 2nd Annual Methods İn Bioengineering Conference 2007, July 12-13, Boston, Ma, Usa (Poster Presentation) H. Kenar, D. Yücel, G. Torun Köse, V. Hasirci. Polycondensation polymers of natural and synthetic origin as biomedical materials (Invited talk), Koç Üniv. 2006, Istanbul, TURKEY (oral presentation) D. Yücel, G. Torun Köse, V. Hasirci. Effect of Topography and Chemical Cues on Behaviour of Neural Stem Cells, Regenerate World Congress on Tissue Engineering and Regenerative Medicine 2006, April 24-27, Pittsburgh, PA, USA (poster presentation) V. Hasırcı, D. Yücel, H. Kenar, G. Torun Köse. Behaviour of Osteoblasts and Osteosarcoma Cells on Micropatterned, Biological and Synthetic Polyesters (Invited talk), European Symposium on Biopolymers 2005, November 24-25, Madrid, SPAIN (oral presentation) V. Hasırcı, D. Yücel, H. Kenar, G. Torun Köse. Influence of Surface Topography, Chemistry and Cell Type on Cell-TE Carrier Interactions (Invited talk), 12th Biomedical Science and Technology Symposium 2005, September 20-23, Izmir, TURKEY (oral presentation) D. Yücel, G. Torun Köse, V. Hasirci. Cell Behaviour on Patterned Polyesters, 12th Biomedical Science and Technology Symposium 2005, September 20-23, Izmir, TURKEY (poster presentation) D.Yucel, F.N. Kok, V.Hasirci. Construction of an Enzyme Biosensor, 10th Biomedical Science and Technology Symposium 2003, October 10-12, Girne, Turkish Republic of Northern Cyprus (TRNC) (poster presentation) D.Yucel, F.N. Kok, V.Hasirci. Construction of a teflon Based Hema-Grafted Enzyme Biosensor, 18th European Conference on Biomaterials (ESB 2003), October 1-4, Stuttgart, GERMANY (poster presentation) D. Yucel, F.N. Kok, V.Hasirci, Immobilization of Choline Oxidase for a Choline Biosensor, 9th International Symposium on Biomedical Science and Technology 2002, September 19-22, Kemer, Antalya, TURKEY (poster presentation)

7 PROJE DENEYİMİ TÜBİTAK SBAG - Mikrodesenli PHBV8-PLLA Filmlerinin Sinir Hücrelerinin Çoğalma ve Farklılaşmasına Etkisi ve Bu Oluşumun Moleküler Yaklaşımlarla Tanısı: İn Vitro Sinir Doku Mühendisliği BİLİMSEL KURULUŞLARA ÜYELİKLER 1. The Tissue Engineering and Regenerative Medicine International Society (TERMIS) 2. Biyomalzeme ve Doku Mühendisliği Derneği (Türkiye) 3. Türk Elektron Mikroskopi Derneği DÜZENLENEN TOPLANTILAR 1. 13th International Biomedical Science and Technology Symposium (BIOMED 2007) (Organizasyon Komitesi Üyesi), Istanbul, TURKEY, Ağustos, th European Symposium on Biopolymers (ESBP 2007) (Organizasyon Komitesi Üyesi), Kuşadası, TURKEY, Ekim, Workshop on Nanobiomaterials: Tissue Engineering and Nanobiotechnology (Organizasyon Komitesi Üyesi), METU, Ankara, TURKEY, 1-2 Eylül, th International Biomedical Science and Technology Symposium (BIOMED 2009) (Organizasyon Komitesi Üyesi), METU NCC, Güzelyurt, Turkish Republic of Northern Cyprus (TRNC), Ağustos, 2009 YURTDIŞI DENEYİMİ 22 June- 20 August 2007 Research on culture and characterization of human bone marrow and Wharton s Jelly mesenchymal stem cells, differentiation to osteoblasts and adipocytes, culture in a microfluidic system at MGH BIOMEMS, Charlestown MA & Shriners Hospital for Children, Boston, MA, and TERC, Tufts University, Medford, MA, USA as part of my Integrated National-International PhD Programme Optimization of Stem Cell Culture Conditions for Cell Preservation and Differentiation, Application on Guided Nerve Tissue Engineering

8 22 April- 5 May 2007 Nanofiber production from polyesters by electrospinning at DIMTI (Univ. of Trento), Trento, ITALY as part of FP6 EXPERTISSUES project 25 Feb- 4 March 2007 Isolation of mesenchymal stem cells from umbilical cord matrix (Wharton s Jelly) through explant culture and from adipose tissue at Ludwig Boltzmann Institute (LBI), Linz, AUSTRIA as part of FP6 EXPERTISSUES project 7 Nov Sep 2006 Research on isolation of human mesenchymal stem cells from umbilical cord blood, culture and characterization of human bone marrow and Wharton s Jelly mesenchymal stem cells, culture in a microfluidic system at MGH BIOMEMS, Charlestown MA & Shriners Hospital for Children, Boston, MA, and TERC, Tufts University, Medford, MA, USA as part of my TUBITAK Integrated National-International PhD Programme Optimization of Stem Cell Culture Conditions for Cell Preservation and Differentiation, Application on Guided Nerve Tissue Engineering