ÖZGEÇMİŞ VE ESERLER LİSTESİ

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1 ÖZGEÇMİŞ VE ESERLER LİSTESİ 1. Adı Soyadı: Narçın Ünsal İletişim Bilgileri: Adres: İstanbul Kültür Üniversitesi, Fen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, MOBIGEN Bakırköy-İstanbul Telefon: Mail: n.palavanunsal@iku.edu.tr 2.Doğum Tarihi : 3 Kasım Unvanı: Prof. Dr. 4.Öğrenim Durumu : Derece Alan Üniversite Yıl Lisans Biyoloji İstanbul Üniversitesi 1972 Y. Lisans - İstanbul Üniversitesi - Doktora Bitki Fizyolojisi İstanbul Üniversitesi Akademik Unvanlar Görev Unvanı Görev Yeri Yıl Yrd. Doçent İstanbul Üniversitesi, Bitki Fizyolojisi 1982 Doçent İstanbul Üniversitesi, Bitki Fizyolojisi 1983 Profesör İstanbul Üniversitesi, Bitki Fizyolojisi Yönetilen Yüksek Lisans ve Doktora Tezleri 6.1 Yönetilen Yüksek Lisans Tezleri 1. BERKAY GÜRKAN Roskovitinin GSK3 temelli taupatilerde etkisinin sinir hücre modellerinde incelenmesi (Devam ediyor) 2. ESİN GÜVENİR SW480 ve DLD-1 Kolon kanseri hücre hatlarında epibrassinolid ile tetiklenen apoptozun moleküler hedeflerinin araştırılması DENİZ COŞKUN HCT 116 ve HT 29 Kolon Karsinoma hücrelerinde epibrassinolid tarafından tetiklenen apoptotik süreçte poliaminlerin rolü HAKAN COKSUER Jinekolojik kanserlerin farklı biyomarkırlarla incelenmesi ( ). 5. SEMİN MERVE ALOĞLU Boheminin sıçan prostat hücre hatlarında teröpatik öneminin çeşitli biyomarkırlarla araştırılması (2005). 6. MEHMET ALİ TÜFEKÇİ Meta-topolin ve olomisinin hücre devri-poliamin ilişkisine etkisi (2003). 7. NEVAL AKTAN Helianthus annuus bitkisinde kurşunun poliamin içeriğine etkisi (1994) 8. ZEPÜR ZEHİR Yatay durumda bırakılan Helianthus annuus fidelerinde kotiledon senesensinin incelenmesi (1991) 1

2 6.2 Yönetilen Doktora Tezleri PINAR OBAKAN Farklı Prostat Kanseri Hücre Hatlarında Epibrassinolidle Tetiklenen Apoptotik Süreçte Poliaminlerin Rollerinin Araştırılması ( ) 6.1. Yüksek Lisans Tezleri 6.2. Doktora Tezleri 7. Yayınlar 7.1. Ulusla arası hakemli dergilerde yayınlanan makaleler 1. Pelin Ozfiliz, Tuğba Kızılboga, Salih Demir, Gizem Alkurt, Narçin Palavan-Ünsal, Elif Damla Arısan, Gizem Dinler Doğanay. Bag-1 promotes cell survival through c-myc-mediated ODC upregulation that is not preferred under apoptotic stimuli in MCF-7 cells. Cell Biochemstry&Function, 2015 (baskıya Kabul edildi).) 2. Pınar Obakan, Şeyma Yıldırım, Mert Burak Ozturk, Ozge Berrak, Ajda Coker Gurkan, Elif Damla Arısan, Zeynep Narçin Unsal. CDK inhibitors, induced SSAT expression requires NFκB and PPARγ in MCF-7 breast cancer cells. Turkish Journal of Biology, (DOI: BIY , 2015) (Araştıma Makalesi) 3. Ajda Coker Gurkan, Elif Damla Arisan, Pınar Obakan, Kubra Akalın, Utku Ozbey, Narcin Palavan- Unsal. Induction of endoplasmic reticulum stress-mediated apoptosis and autophagy by purvalanol in HCT 116 colon cancer cells. Oncology Reports, 33 (6) doi: /or Epub 2015 Apr Ajda Coker Gurkan, Deniz Coskun, E. Damla Arisan, Pinar Obakan, Özer Soylu, Narcin Palavan Unsal. Fetuin-A 742 (C/T) and 766 (C/G) polymorphic sitesare associated with increasing risk of myocardial infarction in older patients ( 40 years of age). Molecular Medicine Reports, 12: , Elif Damla Arisan, Yunus Akkoç, Kaan Gencer Akyüz, Ezgi Melek Kerman, Pinar Obakan, Ajda Çoker-Gürkan, Narçin Palavan-Ünsal. Polyamines modulate roscovitine-induced cell death decision as autophagy or apoptosis in MCF-7 and MDA-MB-231 breast cancer cells, Molecular Medicine Reports, 11: (6): , Y.Akkoc, O.Berrak, ED Arısan, P.Obakan, A. Coker Gurkan, Narcin Palavan-Unsal. Inhibition of PI3K signaling triggered apoptotic potential of curcumin which is hindered by Bcl-2 through activation of autophagy in MCF-7 cells. Biomedicine & Pharmacotheraphy, 71: , A.Coker Gurkan, ED Arısan, P.Obakan, P.Ozfiliz, B. Kose, G. Bıckıcı, Narcin Palavan-Unsal. Roscovitine-treated HeLa cells finalize autophagy later than apoptosis by downregulating Bcl 2, Molecular Medicine Reports, 11(3): A Coker-Gurkan, ED Arısan, P.Obakan, N.Palavan-unsal. Lack of functional p53 renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon cancer cells. Amino Acids, 45(1): , Elif Damla Arisan, Yunus Akkoç*, Kaan Gencer Akyüz*, Ezgi Melek Kerman*, Pinar Obakan, Ajda Çoker-Gürkan, Narçin Palavan Ünsal, Polyamines modulate roscovitine-induced cell death decision as autophagy or apoptosis in MCF-7 and MDA-MB-231 breast cancer cells, Molecular Medicine Reports, Ajda Çoker-Gürkan, Elif Damla Arisan, Yunus Akkoç, Pinar Obakan, Pelin Özfiliz, Narçin Palavan Ünsal Roscovitine finalized autophagy later than apoptosis by downregulating of Bcl-2 in HeLa cells Molecular Medicine Reports, 11 (3): , Pinar Obakan, Elif Damla Arisan, Ajda Çoker-Gürkan, Narçin Palavan Ünsal, Epibrassinolide- Induced Apoptosis Regardless of p53 Expression via Activating Polyamine Catabolic Machinery, a Common Target for Androgen Sensitive and Insensitive Prostate Cancer Cells. The Prostate, 74: ,

3 12. Coker-Gurkan, ED Arısan, P.Obakan, E Guvenir, NP Unsal. Inhibition of autophagy by 3-MA potentiates purvalanol-induced apoptosis in Bax deficient HCT-116 colon cancer cells. Experimental Cell research, 328: 87-98, P.Obakan, G. Alkurt, B. Köse, A. Çoker-Gürkan, E.D.Arisan, D. Coşkun. N. Unsal, Downregulation of c-myc mediated ODC expression after purvalanol treatment is under control of upstream MAPK signaling axis in MCF-7 breast cancer cells. Turkish Journal of Biology, 38: , E. D. Arisan, P. Obakan, A. Çoker-Gürkan, A. Calcabrini, E. Agostinelli, N. Palavan Ünsal, CDK inhibitors induce mitochondria-mediated apoptosis through the activation of polyamine catabolic pathway in LNCaP, DU145 and PC3 prostate cancer cells. Current Pharmaceutical Design, 20: (9), 2014 (Araştırma Makalesi). 15. Ozfiliz P, Arisan ED, Coker A, Obakan P, Eralp T, Doganay-Dinler G, Palavan-Unsal N, Bag-1L mediated chemoresistance mechanism through preventing downregulation of Mcl-1 and c- Raf by heat shock proteins in HeLa cells, Asian Pacific Journal of Cancer Prevention, 15 (11): , Çoker-Gürkan, S. Arısan, E.D. Arısan, N. Palavan Ünsal, Lack of evidence for the association of ornithine decarboxylase (+316 G>A), spermidine/spermine acetyl transferase (-1415 T>C) gene polymorphisms with calcium oxalate stone disease, Biomedical Reports,2(1): 69-74, 2014, DOI: /br (Araştırma Makalesi) 17. P. Obakan, P. Ozfiliz, E.D. Arısan, A. Çoker-Gürkan, N. Palavan Ünsal, Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells, Molecular Biology Reports, 41 (1): , DOI: /s (Araştırma Makalesi). 18. Pinar Obakan, Elif Damla Arısan, Annarica Calcabrini, Enzo Agostinelli, Sehna Bolkent, Narçin Palavan-Ünsal Activation of Polyamine Catabolic Enzymes Involved in Diverse Responses Against Epibrassinolide-Induced Apoptosis in LNCaP and DU145 Prostate Cancer Cell Lines" Amino Acid, 2013 (DOI: /s ) (Araştırma Makalesi) 19. Çoker-Gurkan, E. D. Arisan, P. Obakan, N. Palavan-Ünsal, Inhibition of polyamine oxidase prevented cyclin dependent kinase inhibitor-induced apoptosis in HCT116 colon carcinoma cells Apoptosis, Dec;18(12): , 2013 doi: /s (Araştırma Makalesi). 20. A. Çoker-Gurkan, S. Arisan, E. D. Arisan, N.C. Sönmez, N. Palavan-Ünsal, Association between IL-1RN VNTR, IL and IL-6 ( 174, 572, 597) Gene Polymorphisms and Urolithiasis Urol Int. 91(2): doi: / Epub 2013 Jan 26. (Araştırma Makalesi) 21. Elif Damla Arisan, Pınar Obakan, Ajda Çoker and Narçin Palavan-Ünsal, Inhibition of ornithine decarboxylase alters the roscovitine-induced mitochondrial-mediated apoptosis in MCF-7 breast cancer cells. Molecular Medicine Reports, 5: , 2012, (Araştırma Makalesi) 22. Ajda Çoker, Elif Damla Arısan and Narçin Palavan-Ünsal. Silencing of the polyamine catabolic key enzyme SSAT prevents CDK inhibitor-induced apoptosis in Caco-2 colon cancer cells. Molecular Medicine Reports, 5: , 2012, (Araştırma Makalesi) 23. Elif Damla Arısan, Ajda Çoker, Narçin Palavan-Ünsal. Polyamine depletion enhances the roscovitine-induced apoptosis through the activation of mitochondria in HCT116 colon carcinoma cells. Amino Acids, 42: , 2012, (Araştırma Makalesi) 24. K. Balci, Y. Akkaya, S. Akyuz and N. Palavan-Unsal. DFT and MP2 based quantummechanical calculations and a theoretical vibrational spectroscopic investigation on roscovitine, a potential drug to treat cancers. Journal of Raman Spectroscopy, 42: , 2011, (Araştırma Makalesi) 25. S. Akyuz, A. E. Ozel, K. Balci, T. Akyuz, A. Coker, E. D. Arisan, N. Palavan-Unsal, A. Ozalpan Raman micro-spectroscopic analysis of cultured HCT116 colon cancer cells in the presence of roscovitine. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy A 78: , , (Araştırma Makalesi) 3

4 26. S. Akyuz, A. E. Ozel, K. Balci, T. Akyuz, A. Coker, E. D. Arisan, N. Palavan-Unsal, A. Ozalpan Raman micro-spectroscopic investigation of the interaction of cultured HCT116 colon cancer cells with alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase. Journal of Molecular Structure, 993: , 2011, (Araştırma Makalesi) 27. Narcin Palavan-Unsal and Elif Damla Arisan. Nitric Oxide Signalling in Plants. Botanical Review, 75: , Elif Damla Arisan, Serdar Arisan, Gökhan Atuş, Narçin Palavan-Unsal, Erbil Ergenekon. Serum adipocytokine levels in prostate cancer patients. Urologia Internationalis. 82: , 2009, (Araştırma Makalesi). 29. Unal M, Tufekci MA, Palavan-Unsal N. Effects of polyamines and polyaminebiosynthetic inhibitors on mitotic activity of Allium cepa root tips. Acta Biologica Hungarica, 59:93-102, 2008, (Araştırma Makalesi). 30. Narcin Palavan-Ünsal, Elif Damla Arısan and Salih Terzioğlu Polyamines in tea processing. International Journal of Food Sciences and Nutrition. 58: , 2007, (Araştırma Makalesi). 31. Narçin Palavan-Ünsal and Elif Damla Arısan. Distribution of peroxidase activity and polyamine pattern of Heliotropium europeum in potassium deficiency conditions. Int. J. Environment and Pollution, Vol. 29: , 2007, (Araştırma Makalesi). 32. Narcin Palavan-Unsal, Semin Merve Aloglu-Senturk, Elif Damla Arısan, The function of polyamine metabolism in prostate cancer. Experimental Oncology, 28:1-6, 2006, (Araştırma Makalesi). 33. Elif Damla Arısan, Serdar Arisan, MC Kiremit, Hatice Tigli, T Çaskurlu, Narçin Palavan-Unsal ve E Ergenekon Manganase superoxide dismutase polymorphism in chronic pelvic pain syndrome patients Prostate Cancer and Prostatic Diseases 2006, 1 6, (Araştırma Makalesi). 34. Serdar Arısan, Elif Damla Büyüktunçer, Narcin Palavan Ünsal, Turhan Çaşkurlu, Ömer Onur Çakır, Erbil Ergenekon. Increased expression of EZH2, a polycomb group protein, in bladder carcinoma. Urol. Int., 75: , 2005, (Araştırma Makalesi). 35. Meral Unal, Narcin Palavan-Unsal ve Isil Ismailoglu, The effect of putrescine and difluoromethylornithine on cell division activity of wheat in different ploidy level. Caryologia, 58, 1:15-20, 2005, (Araştırma Makalesi). 36. Elif Damla Büyüktuncer ve Narçin Palavan-Ünsal, Future molecular markers in childhood acute leukemias: Polyamines. Turkish J. of Cancer, 34:5-10, 2004, (Araştırma Makalesi). 37. Narçın Palavan-Ünsal, Elif Damla Buyuktuncer ve Asuman Efe, Polyamine and protein profiles of Plantago species exhibiting different allergic significance. Biotechnol and Biotechnol. Eq., 18: , 2004, (Araştırma Makalesi). 38. Serap Çağ, Narçın Palavan-Ünsal ve Elif Damla Büyüktuncer, Comparison of the effect of meta-topolin and other cytokinins on chlorophyll and protein contents and peroxidase activity in cucumber cotyledons. Israel Journal of Plant Sciences, 51: , 2003, (Araştırma Makalesi). 39. Asım Kadıoğlu, Rabia Turgut, Narçın Palavan-Ünsal ve N Saruhan, Effect of polyamines on leaf rolling in Ctenanthe setosa. Israeli Journal of Plant Sciences, 50:19-23, 2002, (Araştırma Makalesi). 40. Meral Ünal, Narçın Palavan-Ünsal ve Mehmet Ali Tüfekçi, Role of putrescine and its biosynthetic inhibitor on seed germination, root elongation and mitosis in Hordeum vulgare L. Bull. Pure and Applied Sciences, 21B: 33-38, 2002, (Araştırma Makalesi). 41. Narçın Palavan-Ünsal, Serap Çağ ve Ergül Çetin, Growth responses of excised radish cotyledons to meta-topolin. Canadian J. Plant Sci, 82: , 2002, (Araştırma Makalesi). 42. Narçın Palavan-Ünsal, Ergül Çetin ve Asım Kadıoğlu, Boron stress affects peroxidase activity. Plant Peroxidases Newsletter, 15: 37-44, 2000, (Araştırma Makalesi). 43. Ergül Çetin, Cansev Yıldırım, Narçın Palavan-Ünsal ve Meral Ünal, Effect of spermine and cyclohexylamine on in vitro pollen germination and tube growth in Helianthus annuus. Canadian Journal of Plant Science, 80: , 2000, (Araştırma Makalesi). 4

5 44. Narçın Palavan-Ünsal, Stimulation of diamine oxidase and peroxidase activities in potassium deficiency conditions in chick-pea stems. Plant Peroxidases Newsletter 11: 13-18, 1998, (Araştırma Makalesi). 45. Palavan-Ünsal, N. Stress and polyamine metabolism. Bulg. J. Plant Physiol., 21: 3-14, 1995, (Araştırma Makalesi). 46. Z. Zehir-Delibaşoğlu ve Narçın Palavan-Ünsal, Effect of gravity on senescence and polyamine content of Helianthus annuus cotyledons. Phytochemistry, 35: , 1994, (Araştırma Makalesi). 47. Nermin Gözükırmızı, Şule Arı, Güler Oraler, Okatan, Y. ve Narçın Palavan-Ünsal, Callus induction. Plant regeneration and chromosomal variations in barley. Acta Bot. Neerl., 39 (4): , 1990,(Araştırma Makalesi). 48. Palavan-Ünsal, N., Zehir, Z. and Sağlam, S. Inhibition of alpha-amylase release from germinating wheat embryos by abscisic acid and cyclohexylammonium. In: Polyamines and ethylene: Biochemistry, Physiology and Interactions. H.E.Flores, R.N. Arteca, J.C. Shannon, Eds. American Society of plant Physiologists, Proceedings 5th annual Penn state symposium in plant physiology, pp May 17-19, 1990, (Araştırma Makalesi). 49. Narçın Palavan-Ünsal. Polyamine metabolism in the roots of Phaseolus vulgaris. Interaction of the inhibitors of polyamine biosynthesis with putrescine in growth and polyamine biosynthesis (doçentlik tezi). Plant and Cell Physiol., 28: , 1987, (Araştırma Makalesi). 50. Narçın Palavan-Ünsal, Goren, R. ve Galston, A.W. Effects of some growth regulators on polyamine biosynthetic enzymes in etiolated pea seedlings. Plant and Cell Physiol., 25: , 1984, (Araştırma Makalesi). 51. Narçın Palavan-Ünsal ve Arthur W Galston. Polyamine biosynthesis and titer during various developmental stages of Phaseolus vulgaris. Physiol. Plant. 55: , 1982, (Araştırma Makalesi). 52. Goren, R., Narçın Palavan-Ünsal, Flores, H. ve Galston, A.W. Changes in polyamine titer in etiolated pea seedlings following red light treatment. Plant and Cell Physiol., 23: 19-26, 1982, (Araştırma Makalesi). 53. Goren, R., Narçın Palavan-Ünsal ve Galston, A.W. Separating phytochrome effects on arginine decarboxylase activity from its effect on growth. J.Plant Growth., 1: 61-73, 1982, (Araştırma Makalesi) Uluslar arası bilimsel toplantılarda sunulan ve bildiri kitabında (Proceeding) basılan bildiriler. 1. Pinar Obakan*, Elif Damla Arisan, Ajda Coker-Gurkan, Narcin Palavan-Unsal, Epibrassinolide Induced Apoptosis via Endoplasmic Reticulum Stress Regardless of p53 Expression in Prostate Cancer Cells, International Conference on Prostate Cancer, June 2015, Florida USA, (Sözlü Sunum: Pınar Obakan) 2. Elif Damla Arisan, Çağri Gümüşkaptan, Özge Berrak, Pinar Obakan, Ajda Coker-Gurkan, Narcin Palavan Ünsal, Roscovitine treatment inhibited cell proliferation and induced apoptosis via modulating activity of Stat3 and Foxo1 under control of Akt in LNCaP prostate cancer cells, International Conference on Prostate Cancer, June 2015, Florida USA, (Sözlü Sunum: Elif Damla Arisan) 3. K. Adacan, P. Obakan, E. D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal, EBR induced autophagy in colon carcinoma cell lines, 40th FEBS Congress, The Biochemical Basis of Life, P09-015, p:110, 4-9 July, 2015, Berlin, Germany 4. O. Berrak, E. D. Arısan, P. Obakan, A. Coker Gurkan, N. Palavan Unsal Investigation the potential role of FoxO members in the purvalanol and roscovitine- induced autophagy in LNCaP and DU 145 prostate cancer cells, 40th FEBS Congress, The Biochemical Basis of Life, LB-081, p:383, 4-9 July, 2015, Berlin, Germany. 5

6 5. U. Ozbey, P. Obakan, E. D. Arisan, A. Coker Gurkan, N. Palavan-Unsal, EBR promotes p53 independent apoptosis in colon carcinoma cell lines. 40th FEBS Congress, The Biochemical Basis of Life, P11-028, p:227, 4-9 July, 2015, Berlin, Germany. 6. M. Celik, A. Coker Gurkan, E. Damla Arisan, P. Obakan, N. Palavan Unsal, Curcumin inducedapoptotic cell death in GH overexpressed MDA-MB-231 breast cancer in time dependent manner, 40th FEBS Congress, The Biochemical Basis of Life, P15-126, p:273, 4-9 July, 2015, Berlin, Germany. 7. Berna Somuncu, Pinar Obakan, Ajda Coker-Gurkan, Elif Damla Arisan, Narcin Palavan Unsal, Endoplasmic reticulum stress induced both intrinsic/extrinsic pathway of apoptosis following epibrassinolide treatment in colon cancer cells 3rd AntiCancer Agent Development Congress, PP-011, p: 68, Mayıs 2015, İzmir, Türkiye 8. Busra Alper, Ajda Coker-Gurkan, Elif Damla Arisan, Pınar Obakan, Narcin Palavan Unsal, The role of autocrine GH expression in the diferuloylmethane inducedapoptotic cell death in T47D breast cancer cells 3rd AntiCancer Agent Development Congress, PP-017, p:74, Mayıs 2015, İzmir, Turkey. 9. Didem Baran, Pinar Obakan, Ajda Coker-Gurkan, Elif Damla Arisan, Narcin Palavan-Unsal, Epibrassinolide-induced endoplasmic reticulum stress activated extrinsic pathway of apoptosis in HCT116 Bax-/- colon carcinoma cell lines 3rd AntiCancer Agent Development Congress, PP-025, p: 82, Mayıs 2015, İzmir, Turkey. 10.Gizem Damla Yalcın, Elif Damla Arısan, Ajda Coker-Gurkan, Pınar Obakan, Deniz Coskun, Narcin Palavan-Unsal, Cox-2 inhibitor ibuprofen induced apoptosis via altering different signalling routes in HT-29 and DLD-1 colon cancer cells, 3rd AntiCancer Agent Development Congress, PP-054, p: 111, Mayıs 2015, İzmir, Turkey. 11.Gulnihal Bozdag*, Elif Damla Arısan, Pınar Obakan, Ajda Coker-Gurkan, Deniz Coskun, Narcin Palavan-Unsal, NSAIDs, ibuprofen and diclofenac induced apoptosis via altering MAPKs and de novo protein synthesis regardless of COX-2 expression in SW480 colon cancer cells, 3rd AntiCancer Agent Development Congress, PP-059, p: 116, Mayıs 2015, İzmir, Turkey. 12.Harbiye Hacıbektasoglu, E. Damla Arisan, Ozge Berrak, Cagrı Gumuskaptan, Ajda Coker- Gurkan, Pınar Obakan, Narcin Palavan-Unsal, Investigation the role of CDK inhibitors on ER stress-mediated apoptosis in LNCaP prostate cancer cells, 3rd AntiCancer Agent Development Congress, PP-063, p: 120, Mayıs 2015, İzmir, Turkey. 13.Sevilay Acar, Ozge Berrak, Cagrı Gumuskaptan, Pınar Obakan, Ajda Coker-Gurkan, E. Damla Arısan, Forced Bcl-2 expression induced prevented roscovitine induced-autophagy via in PC3 cells 3rd AntiCancer Agent Development Congress, PP-112, p: 169, Mayıs 2015, İzmir, Turkey. 14.Sinem Kadıoglu, Ajda Coker-Gurkan, Merve Celik, Pınar Obakan, Elif Damla Arısan, Determination of Growth hormone (GH) and GH Releasing Hormone (GHRH) expression profile in breast cancer cell lines with different HER2/PR/ER genotype, 3rd AntiCancer Agent Development Congress, PP-114, p: 171, Mayıs 2015, İzmir, Turkey. 15.Tugce Demirel*, Ajda Coker-Gurkan, Pınar Obakan, Elif Damla Arisan, Narcin Palavan Unsal, NF-κB and PPAR-" mediated diferuloylmethane induced apoptotic cell death in MCF-7 breast cancer cells in time dependent manner, 3rd AntiCancer Agent Development Congress, PP-121, p: 178, Mayıs 2015, İzmir, Turkey. 16.Tugce Dogruel, Ozge Berrak, Elif Damla Arısan, Pınar Obakan, Ajda Coker Gurkan, Narcın Palavan Unsal, Purvalanol and roscovitine exert their apoptotic effect differently in terms of mtor downstream signalling route, 3rd AntiCancer Agent Development Congress, PP-123, p: 180, Mayıs 2015, İzmir, Turkey. 17.Utku Ozbey, Deniz Coskun, Pinar Obakan, Ajda Coker-Gurkan, Elif Damla Arisan, Narcin Palavan Unsal, Epibrassinolide induces p53-independent apoptosis in colon cancer cell lines, 3rd AntiCancer Agent Development Congress, PP-124, p: 181, Mayıs 2015, İzmir, Turkey. 6

7 18.Zehragul Ergul*, Elif Damla Arisan, Deniz Coskun, Ajda Coker-Gurkan, Pınar Obakan, Narcin Palavan-Unsal, Non-steroidal anti-inflammatory drugs; ibuprofen and diclofenac are potent apoptotic inducers, which are altered PI3K/AKT/MAPK signalling axis in HCT 116 colon cancer cells 3rd AntiCancer Agent Development Congress, PP-131, p: 188, Mayıs 2015, İzmir, Turkey. 19.Elif Damla Arısan, Özge Berrak, Pinar Obakan, Ajda Çoker-Gürkan, Narcin Palavan-Unsal mtor inhibisyonunun androjen bağımlı ve bağımsız prostat kanseri hücrelerinde yeni CDK inhibitörlerinin terapötik özelliklerini arttırması EACR Sponsored 2nd Anticancer Agents Congress& 5th Multidisciplinary Cancer Research Congress, Nisan 2014, Bodrum, Türkiye (Davetli Konuşmacı). 20.Ajda Çoker-Gürkan, Kübra Akalın, Utku Özbey, Elif Damla Arısan, Pınar Obakan, Narçin Palavan-Ünsal, Induction of Endoplasmic Reticulum (ER) stress-mediated apoptosis and autophagy by Purvalanol in HCT 116 colon cancer cells EACR Sponsored 2nd Anticancer Agents Congress& 5th Mutlidisciplinary Cancer Research Congress, PP13, Sayfa: 99, Nisan 2014, Bodrum, Türkiye, (Seçili Poster-Sözlü Sunum). 21.P. Obakan, E.D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal, ER stress is involved in Epibrassinolide-induced apoptotic cell death EACR Sponsored 2nd Anticancer Agents Congress& 5th Mutlidisciplinary Cancer Research Congress, PP61, Sayfa: 147, Nisan 2014, Bodrum, Türkiye, (Seçili Poster-Sözlü Sunum). 22.Deniz Coskun, Pınar Obakan, Elif Damla Arisan, Ajda Çoker Gürkan, Narcin Palavan-Unsal, Epibrassinolide-induced Apoptosis is Modulated by AKT-FOXO3a Signaling Pathway, EACR Sponsored 2nd Anticancer Agents Congress& 5th Mutlidisciplinary Cancer Research Congress, PP24, Sayfa: 110, Nisan 2014, Bodrum, Türkiye, (Seçili Poster-Sözlü Sunum). 23.Özge Berrak, Elif Damla Arisan, Pinar Obakan, Ajda Çoker-Gürkan, Narcin Palavan-Unsal, The combination of rapamycin with purvalanol and roscovitine induces autophagy through PI3K/AKT and Ras/Raf/Erk pathways regulation in DU 145 prostate cancer cells EACR Sponsored 2nd Anticancer Agents Congress& 5th Mutlidisciplinary Cancer Research Congress, PP57, Sayfa: 143, Nisan 2014, Bodrum, Türkiye, (Seçili Poster-Sözlü Sunum). 24. Pelin Özfiliz, Elif Damla Arısan, Pınar Obakan, Ajda Çoker-Gürkan, Gizem Dinler Doğanay, Narçin Palavan Ünsal, Silencing of Bag-1 enhanced the cisplatin or paclitaxel-induced apoptosis via regulating PI3K, Akt and MAPK signaling axis in MCF-7 breast cancer cells. EACR Sponsored 2nd Anticancer Agents Congress& 5th Mutlidisciplinary Cancer Research Congress, PP59, Sayfa: 145, Nisan 2014, Bodrum, Türkiye, (Seçili Poster-Sözlü Sunum). 25.P. Obakan, E.D. Arisan, S. Bolkent, N. Palavan-UnsalUnderstanding the roles of polyamines in EBR-induced autophagy. Gordon Research Conferences: Polyamines, Regulation and Role of Polyamines in Biology and Disease, June 16-21, 2013, Waterville Valley, NH, USA 26.Pelin Özfiliz, Elif Damla Arısan, Narçin Palavan-Ünsal, Gizem Dinler Doğanay Bag-1 silencing modulated MAPK signaling cascade to alter drug-induced polyamine metabolic regulation in MCF-7 breast cancer cells. Gordon Research Conferences: Polyamines, Regulation and Role of Polyamines in Biology and Disease, June 16-21, 2013, Waterville Valley, NH, USA 27.Ozge Berrak, Elif Damla Arisan, Pinar Obakan, Ajda Coker-Gurkan Narcin Palavan-Unsal, Cotreatment of rapamycin prevented activation of polyamine oxidase and apoptosis via triggering autophagy after CDK inhibitor treatment in LNCaP cell. Gordon Research Conferences: Polyamines, Regulation and Role of Polyamines in Biology and Disease, June 16-21, 2013, Waterville Valley, NH, USA 28.Deniz Coskun, Pinar Obakan, Elif Damla Arisan, Ajda Coker-Gurkan and Narçin Palavan-Unsal The Potential Role of Polyamines in Epibrassinolide-Induced Apoptotic Cell Death in HCT116 and HT29 Colon Carcinoma Cells. Gordon Research Conferences: Polyamines, Regulation and Role of Polyamines in Biology and Disease, June 16-21, 2013, Waterville Valley, NH, USA 29.Yunus Akkoç, Elif Damla Arisan, Pınar Obakan, Ajda Çoker-Gürkan, Narçin Palavan-Ünsal, Cotreatment of PI3K inhibitor and curcumin overcomes Bcl-2 mediated drug-resistance in MCF-7 7

8 breast cancer cells via activating SSAT Gordon Research Conferences: Polyamines, Regulation and Role of Polyamines in Biology and Disease, June 16-21, 2013, Waterville Valley, NH, USA 30.E. Damla Arisan, Mert Burak Öztürk, Ajda-Çoker-Gürkan, Pinar Obakan, Narçin Palavan- Ünsal Ibuprofen induced apoptosis through c-myc signalling pathway related to polyamines in p53 null pc3 cells. Gordon Research Conferences: Polyamines, Regulation and Role of Polyamines in Biology and Disease, June 16-21, 2013, Waterville Valley, NH, USA 31.Ajda Coker Gurkan, Elif Damla Arısan, Halime İlhan, Pınar Obakan, Narcin Palavan Unsal, Inhibition of Cellular Autophagic Responses against N1, N11-Diethylnorspermine (DENSpm) Enhanced Apoptosis in HCT116 and SW480 Colon Cancer Cells Gordon Research Conferences: Polyamines, Regulation and Role of Polyamines in Biology and Disease, June 16-21, 2013, Waterville Valley, NH, USA 32.K. Balci, Y. Akkaya, S. Akyüz N. Palavan-Ünsal. The effects of hydrogen bonding on the structure and vibrational properties of difluoromethylornithine. Turkish Physical Society, 30th International Physical Congress, 2-5 September 2013, 33. D. Coşkun, P. Obakan, ED Arisan, AC Gürkan, NP Ünsal. Epibrassinolide induced apoptotic cell death in HCT 116 and HT29 colon carcinoma cells. 1st International Congress of the Molecular Biology Association of Turkey November, 2012,Istanbul, p. 64, (Poster Sunum: Deniz Coşkun). 34. P.Obakan, ED Arisan, S. Bolkent, NP Ünsal. Epibrassinolide induces apoptosis by targeting polyamine catabolism in LNCaP prostate cancer cells. 1st International Congress of the Molecular Biology Association of Turkey November, 2012, Istanbul, p. 82, (Poster Sunum: Pınar Obakan). 35. O. Berrak, Y. Akkoç, ED Arisan, P. Obakan, AC Gürkan, NP Ünsal. Effect of CDK inhibitors and rapamycin combination on autophagy with status of AR expression on androgen dependent LNCaP and androgen independent DU145 prostate cancer cells. 1st International Congress of the Molecular Biology Association of Turkey November, 2012, Istanbul, p. 62, (Poster Sunum: Özge Berrak). 36. Y. Akkoç, ED Arisan, AC Gürkan, P. Obakan, NP Ünsal. Understanding the role of Bcl-2 in curcumin induced aotophagic/apoptotic cell death mechanism in MCF-7 and MDA-MB-231 breast cancer cells.1st International Congress of the Molecular Biology Association of Turkey November, 2012, Istanbul, p. 55, (Poster Sunum: Yunus Akkoç). 37. Yunus Akkoc, Merve Çelik, Pınar Obakan, Ajda Çoker Gürkan, E.Damla Arisan and Narçin Palavan-Ünsal, The functional role of Bcl-2 in the regulation of curcumin induced autophagic/apoptotic cell death in MCF-7 breast cancer cells. Conference on Apoptosis and Cancer, Cambridge, UK, June ,(Poster Sunum: Yunus Akkoç). 38. Elif Damla Arısan, Pınar Obakan, Özge Berrak, NarçinPalavan-Ünsal, Cyclin Dependent Kinases Exert their Apoptotic Potential by Acting on mtor Mediated Energy Signaling Cascade in the Presence of Activated Polyamine Catabolism in LNCap, DU145 and PC3 Prostate Cancer Cells. International Congress on Polyamines Biological and Clinical Perspectives 2-7 September, Istanbul, L20, p.54, 2012, (Sözlü Sunum: Narçın Palavan Ünsal). 39. Ajda Çoker Gürkan, Pınar Obakan, Elif Damla Arısan, Annarica Calcabrini, Enzo Agostinelli, Narçin Palavan-Ünsal, The Effect of Polyamine Catabolism Products on CDK Inhibitors-Induced on HCT116 wt and Bax -/- Colon Carcinoma Apoptotic Cell Death International Congress on Polyamines Biological and Clinical Perspectives 2-7 September, Istanbul, P15, p.126, 2012, (Seçili Poster Sunum: Ajda Çoker Gürkan). 40. Ajda Çoker Gürkan, Elif Damla Arısan, Narçin Palavan-Ünsal, Which is the Most Prominent Cellular Decision Against CDK Inhibitors in the Presence of Modulated Polyamine Pool? Autophagy or Apoptosis, International Congress on Polyamines Biological and Clinical Perspectives 2-7 September, Istanbul, P16, p.127, 2012 (Poster Sunum: Damla Arisan). 41. Betsi Köse, Gizem Alkurt, Ajda Çoker Gürkan, Elif Damla Arısan, Pınar Obakan, Narçin Palavan- Ünsal, ODC is a Mediator of the Purvalanol-A-Induced Apoptotic Signaling via the p38 Mitogen-Activated Protein Kinase Pathway in MCF-7 Breast Cancer Cells, International 8

9 Congress on Polyamines Biological and Clinical Perspectives 2-7 September, Istanbul, P18, p.130, 2012, (Poster Sunum: Betsi Köse-Gizem Alkurt). 42. Deniz Coşkun, Pınar Obakan, Elif Damla Arısan, Ajda Çoker Gürkan, Narçin Palavan-Ünsal The Potential Role of Polyamines in EBR-Induced Apoptotic Cell Death in HCT116 Colon Carcinoma Cells. International Congress on Polyamines Biological and Clinical Perspectives 2-7 September, Istanbul, P20, p.134, 2012, (Poster Sunum: Deniz Çoşkun). 43. Halime İlhan, Ajda Çoker Gürkan, Pınar Obakan, Elif Damla Arısan, Narçin Palavan-Ünsal, Timing is Critical in the Decision of Apoptosis or Autophagy by N1, N11-Diethylnorspermine (DENSpm) treatment in HCT116 Colon Cancer Cells, International Congress on Polyamines Biological and Clinical Perspectives 2-7 September, Istanbu, P24, p.142, 2012, (Poster Sunum: Halime İlhan). 44. Onur Irmak, Elif Damla Arısan, Ajda Çoker-Gürkan, Pınar Obakan, Narçin Palavan-Ünsal, The Role of Polyamine Catabolic Enzymes in Cisplatin-Induced Apoptotic Cell Death, in MCF-7 Cells. International Congress on Polyamines Biological and Clinical Perspectives 2-7. September, Istanbul, P29, p.151, 2012, (Poster Sunum: Onur Irmak). 45. P. Obakan, Elif Damla Arısan, A. Calcabrini, E. Agostinelli, Ş. Bolkent, Narçin Palavan-Ünsal, Epibrassinolide Targets Polyamine Catabolism and Triggers Apoptosis in LNCaP, DU145 and PC3 Cell Lines. International Congress on Polyamines Biological and Clinical Perspectives 2-7. September, Istanbul, P31, p.153, 2012, (Seçili Poster Sunum: Pınar Obakan). 46. S. Akyüz, T. Akyüz1, P. Obakan, E. D. Arısan, Ş. Bolkent, N. Palavan-Ünsal, FTIR Spectroscopic Investigation of the Effects of Polyamine Oxidase Inhibitor MDL on the Interaction of Epibrassinolide with Cultured LNCaP Prostate Cancer Cells. International Congress on Polyamines Biological and Clinical Perspectives 2-7. September, Istanbul, P32, p.154, 2012, (Poster Sunum: Sevim Akyüz). 47. Şeyma Yıldırım, Mert Burak Özturk, Elif Damla Arısan, Pınar Obakan, Ajda Çoker- Gürkan, Narçin Palavan-Ünsal, PPAR is the Critical Upstream Factor in Cyclin-Dependent Kinase Inhibitors Roscovitine and Purvalanol A- Induced SSAT Upregulation in MCF-7 Cells. International Congress on Polyamines Biological and Clinical Perspectives 2-7. September, Istanbul, P33, p.156, 2012, (Poster Sunum:Şeyma Yıldırım, Mert Burak Özturk). 48. Zeynep Akyol, Ajda Çoker-Gürkan, Elif Damla Arısan, Narçin Palavan-Ünsal, N1, N11- Diethylnorspermine (DENSpm) Modulates the Paclitaxel-Induced Apoptosis in MCF-7 wt and Bcl-2 Overexpressing Breast Cancer Cells. International Congress on Polyamines Biological and Clinical Perspectives 2-7. September, Istanbu, P39, p.168, 2012, (Poster Sunum: Zeynep Akyol). 49. Yunus Akkoç, Gencer Kaan Akyüz, Ezgi Melek Kerman, Elif Damla Arısan, Ajda Çoker-Gürkan, Pınar Obakan, Narçin Palavan-Ünsal, Potential Role of Polyamines in Roscovitine-Induced Autophagic/Apoptotic Cell Death in MCF-7 and MDA-MB-231 Breast Cancer Cells.International Congress on Polyamines Biological and Clinical Perspectives 2-7. September, Istanbul, P41, p.170, 2012 (Poster Sunum: Yunus Akkoç). 50. Özge Berrak, Elif Damla Arısan, Pınar Obakan and Narçin Palavan-Ünsal, Investigation of possible role of mtor in CDK inhibitors induced apoptotic cell death in LNCap, DU145 and PC3 prostate cancer cells. International Graduate Student Immunology Congress, Harvard University, Boston, April 27-28, 2012, (Poster Sunum: Özge Berrak). 51. E.D. Arısan, P. Obakan, N. Palavan-Unsal. CDK inhibitors induced apoptosis and activated polyamine catabolic pathway in androgen dependent LNCaP (p53 wt), DU145 (p53 wt) and PC3 (p53 null) prostate cancer cells Congress on Biogenic Amines: Biochemical, Physiological and Clinical Perspectives (Trento, Italy) September, 2011, (Poster Sunum: Damla Arısan). 52. P. Obakan, E.D. Arisan, S. Bolkent, N. Palavan-Unsal, 24-Epibrassinolide induces SSAT and causes caspase-dependent apoptosis in different prostate cancer cell lines. Congress on Biogenic Amines: Biochemical, Physiological and Clinical Perspectives (Trento, Italy) September, 2011, (Seçili Poster Sunum: Pınar Obakan). 9

10 53. A. Coker, E.D. Arisan, N. Palavan-Ünsal, Roscovitine modulated autophagic cell death related to polyamine metabolism in HCT-116 cells Congress on Biogenic Amines: Biochemical, Physiological and Clinical Perspectives (Trento, Italy) September, 2011, (Seçili Poster Sunum: AJDA Çoker). 54. A. Çoker, S. Arısan, D. Coşkun, A. Yavuz, E.D. Arısan, N.C. Sönmez, N. Palavan-Ünsal. Investigation of Fetuin-a single nucleotide gene polymorphism in urinary stone disease patients. IV. International Congress on Molecular Medicine, p.67, June 2011, (Poster Sunum: Deniz Çoşkun). 55. S. Akyuz, A. E. Ozel, K. Balci, T. Akyuz, A. Coker, E. D. Arisan, N. Palavan-Unsal, A. Ozalpan. Micro Raman spectroscopic investigation of the interaction of cultured HCT116 colon cancer cells with alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase. EUCMOS 30th European congress on molecular spectroscopy with GISR 2010, PS2-21, pp.107, 2010, (Poster Sunum: Sevim Akyüz). 56. K. Balci, Y. Akkaya, S. Akyuz, N. Palavan-Unsal. An IR and Raman spectroscopic investigation on a- difluoromethylornithine (DFMO), a potential target as chemotherapeutic agent. EUCMOS 30th European congress on molecular spectroscopy with GISR 2010, PS2-38, pp N. Palavan-Unsal, E.D. Arisan, P. Obakan, A. Coker and I. Ozdemir, Cyclin Dependent Kinase Inhibitors Modulates Polyamine Metabolism in MDA-MB-231 Cells. 2nd International Conference on the Role of Polyamines and their Analogs in Cancer and other Diseases 1-6 December, 2010, Sapienza University of Roma Italy, L39, pp.131 (Sözlü Sunum: Narçın Palavan Ünsal) 58. Arisan ED, Obakan P, Coker A and Palavan-Unsal N. Investigation of purvalanol-induced apoptosis in MCF-7 breast cancer cell lines. 2nd International Conference on the Role of Polyamines and their Analogs in Cancer and other Diseases 1-6 December, 2010, Sapienza University of Roma Italy, p17, pp.193 (Poster Sunum: Damla Arısan). 59. Obakan P, Arisan ED, Palavan-Unsal N and Coker A., Combined treatment of Roscovitine and DFMO induced caspase dependent-apoptosis in MCF-7"cells. "2nd International Conference on the Role of Polyamines and their Analogs in Cancer and other Diseases 1-6 December, 2010, Sapienza University of Roma Italy, L39, p.131, P22, pp.205, (Seçili Poster Sunum: Pınar Obakan). 60. Coker A. Arisan ED, Palavan-Unsal N. Modulation of catabolic pathway in ROSC treated Caco-2 cells. "2nd International Conference on the Role of Polyamines and their Analogs in Cancer and other Diseases 1-6 December, 2010, Sapienza University of Roma Italy, p19, p.131, P22, pp.199, (Seçili Poster Sunum: Ajda Çoker) 61. Arisan E.D., Palavan-Unsal, N. and Obakan P. Investigation of roscovitine (CYC202)-induced apoptosis related with polyamine metabolism in MCF-7 human breast cancer cell line. IUBMB LIFE, 61: 370, 2009 (Poster Sunum: Pınar Obakan). 62. S. Akyuz, A. E. Ozel, K. Balci, T. Akyuz, A. Coker, E. D. Arisan, N. Palavan-Unsal, A. Ozalpan. Micro Raman spectroscopic investigation of the interaction of cultured HCT116 colon cancer cells with roscovitine. 5th International Conference on Vibrational Spectroscopy (ICAVS5) (12-17 July 2009) 63. K. Balcı, Y. Akkaya, S. Akyuz, N. Palavan-Unsal.Quantum chemical calculations and vibrational spectral investigation of roscovitine, a potential drug to treat cancers. 5th International Conference on Vibrational Spectroscopy (ICAVS5) (12-17 July 2009) 64. Çoker A., Arısan E.D., Palavan-Unsal N. The involvement of polyamines in Seliciclib Induced Apoptosis and ROS Generation in HCT116 Colon Carcinoma Cells. Joint 4th Eortic Pathobiology Group Annual Meeting and 1st International Multidisciplinary Cancer Research Congress May, Antalya-Turkey. P.13, 2009, (Poster Sunum: Ajda Çoker). 65. Palavan-Ünsal N and Arisan ED., a-difluoromethylornithine Sensitize the Rat Prostate Cancer Cells Against Olomoucine II and Bohemine Treatment. TASSA 2008 Annual Conference, April 10

11 11-13, Innovation as Driver for Social Transformation and Economic Growth. Harvard Medical School, Boston, USA Mehmet Ali Tufekci, Narcin Palavan-Unsal, Nezih Hekim, Damla Arisan, Tuğsan Tezil. Phytotoxicity of hydrogen peroxide: Comparison of phytotoxic response in in vitro and in vivo, XV FESPB Congress, 17-21, July, 2006, Lyon, France. 67. Narcin Palavan-Unsal, Nezih Hekim, Mehmet Ali Tufekci. Benzene induces programmed cell death features in cultured Arabidopsis thaliana cells in dose-dependent manner, XV FESPB Congress, 17-21, July, 2006, Lyon, France. 68. Serdar Arısan, Damla Buyuktuncer, Murat Can Kiremitci, Turhan Çaşkurlu, Narcin Palavan- Ünsal and Erbil Ergenekon MNSOD and IL-10 polymorphisms in chronic pelvic pain syndrome patients, European Association of Urology, Annual EAU Congress, Paris, France 5-8 April, Narcin Palavan Unsal, Semin Merve Aloglu, Mehmet Ali Tüfekci, Damla Arısan,Miroslav Strnad, Libor Havlicek, Marek Zatloukal and Mustafa Djamgoz. Effects of olomoucine II on ODC and Bax mrna levels in rat prostate cancer cell lines. P 223, 13th Euroconference on Apoptosis, 1-4 October, Budapest, Hungary Narcin Palavan Unsal, Semin Merve Aloglu, Mehmet Ali Tüfekci, Damla Arısan, Miroslav Strnad, Libor Havlicek, Marek Zatloukal and Mustafa Djamgoz, Suppression of ODC and Bax mrna levels in bohemine threated rat prostate cancer cell lines. P 4, 13th Euroconference on Apoptosis, 1-4 October, Budapest, Hungary Elif Damla Buyuktuncer, Serdar Arisan, Murat Can Kiremitci, Hatice Tigli, Narcin Palavan Unsal, Turhan Caskurlu, Erbil Ergenekon. Mn-SOD polymorphism in chronic pelvic pain syndrome patients. AUA San Antonio Elif Damla Buyuktuncer, Serdar Arısan, Hatice Tığlı, Turhan Çaşkurlu, Ayhan Dalkılınç, Narcin Palavan Unsal, Erbil Ergenekon. Frequency of PSA-mRNA bearing cells in the peripheral blood of patients after prostate biopsy. Advances in Molecular Medicine suppl. Vol 1: 422 (P082), Tüfekçi, Mehmet Ali, Ünal, M and Palavan-Ünsal N. The effect of olomoucine on polyamine content and mitosis in root tips of Allium cepa 14th FESPP Congress August 23-27, 2004 Cracow-Poland. 74. Unsal Palavan N, Ozalpan A, Aloglu M,Strnad M, Havlicek L, Zatloukal M, Djamgoz M. Investigation of therapeutic importance of cycline dependent kinase inhibitors by different biomarkers in rat prostate cell lines. Cell cycle senescence, apoptosis and cancer, Haziran, 2004, Glasgow Scotland 75. Damla Buyuktuncer, Beyazıt Çırakoğlu, Narçın Palavan-Ünsal, AtillaÖzalpan and Kürşat Özdilli. Polyamine profiles in the peripheral blood leucocytes of childhood acute lymphoblastic leukemia patients Biochemical Society Meeting 678, Polyamines and their Role in Human Disease. Abstract book, p.35, December 2002, Imperial Collage, London. 76. Palavan-Ünsal N., Atak Ç., Büyüktuncer D., Özdilli K. Role of meta-topolin in tissue culture of Arabidopsis thaliana.1st Eurasia Congress on Molecular Biotechnology. p. 48, October Trabzon, Turkey. 77. Palavan-Ünsal N., Çağ S., Büyüktuncer D. Comparison of the effect of different cytokinins on chlorophyll, protein content and peroxidase activity.17th International Conference on Plant Growth Substances. 101, 1-6 July Brno, Czech Republic. 78. Ünal M., Palavan-Ünsal N., Tüfekçi M.A. Role of putrescine and its biosynthetic inhibitor on seed germination, root elongation and mitosis in Hordeum vulgare L. XX.Congress of the Scandinavian Society for Plant Physiology. 32, June Roros, Norway. 79. Palavan-Ünsal N., Çağ S., Çetin E.Retardation senescence by meta-topolin in wheat leaves. II. Stimulation of peroxidase activity, nitrogen content and their relation with polyamines. XIIth Congress of the Federation of European Societies of Plant Physiology August, Budapest, Hungary. 38(Suppl.): S04-05L 11

12 80. Palavan-Ünsal N., Çağ S., Çetin E.Growth responses of meta-topolin excised radih cotyledones. XIIth Congress of the Federation of European Societies of Plant Physiology August, Budapest, Hungary. 38(Suppl.): S04-06L 81. Palavan-Ünsal N., Çağ S., Buyuktuncer D.Retardation of senescence by meta-topolin in wheat leaves. I. Inhibition of protease activity and chlorophyll loss. XIIth Congress of the Federation of European Societies of Plant Physiology August, Budapest, Hungary. 38 (Suppl.):S04-12L 82. Palavan-Ünsal, N.Distribution of peroxidase activity and polyamine pattern in Heliotropium europeum in potassium deficiency conditions. Second Balkan Botanical Congress, May-14-18, Abstract book p Kadıoğlu, A., Palavan-Ünsal, N., Turgut, R. and Ayaz, F.A. Effect of polyamines on leaf rolling in Ctenanthe setosa. Second Balkan Botanical Congress, May-14-18, Abstract book p Palavan-Ünsal, N. Tissue distribution of peroxidase in Heliotropium europeum seedlings. Second Balkan Botanical Congress, May-14-18, Abstract book p Narçin Palavan-Unsal, Ergül Çetin and Asım Kadıoğlu Boron stress affects the peroxidase activity. Bulgarian Journal of Plant Physiology, 11th FESPP Congress, 7-11 September, Varna, Bulgaria, Special Issue S 16-03, p 266, Ergül Çetin, Cansev Yıldırım, Narçin Palavan-Ünsal and Meral Ünal The effect of spermine and cyclohexylamine on in vitro polen germination and tube growth in Helianthus annuus, Bulgarian Journal of Plant Physiology, Special Issue S 01-23, p 19, Palavan-Unsal, N. Stimulation of DAO and POD activities in potassium deficiency conditions in chick pea stems. 10 th FESPB Congress, 9-13 September, Firense, Italy, Plant Physiology and Biochemistry, Suppl., S 18-20, Aktan, N. and Palavan-Unsal, N.The effect of lead on polyamine content in Helianthus annuus plants. 9th FESPB Congress, Brno, Czech Republic, Biologia Plantarum, Suppl., 36: 1701, Palavan-Unsal, N., Zehir, Z. and Önder, N. The effect of gravity and horizontal clinostat on polyamine content in Helianthus annuus hypocotyls, 8th Congress of FESPB, Antwerpen, Belgium, Physiologia Plantarum, Suppl. 85(3), 164, Zehir, Z. and Palavan, N. Effect of unilateral gravity on senescence and polyamine content in the cotyledons of Helianthus annuus seedlings. Plant Physiol. Suppl., 99: 817, Palavan-Unsal, N., Çağ, S., Zehir, Z. and Okatan, Y. The investigation of seed-induced senescence in non-monocarpic Gleditschia pods. Plant Physiol. Suppl., 96: 1017, Palavan-Unsal, N., Zehir, Z. and Sağlam, S.Detection of abscisic acid and difluoromethylornithine inhibited α-amylase release from wheat embryos. Plant Physiol. Suppl., 93: 857, Gözükırmızı, N., Arı, Ş., Oraler, G., Okatan, Y., Palavan, N. A comparative study on callus induction plant regeneration and chromosomal variations from different explants of barley.international Conference.The impact of biotechnology in agriculture July, Amiens, France, Po.Vo. 8, Palavan, N. The relation between polyamine biosynthesis with root growth in Phaseolus vulgaris. Plant Physiol., Suppl., 69: 118, USA Goren, R., Palavan, N., Flores, H. and Galston, A.W. Polyamines in Plants: Phytochrome control of polyamine biosynthesis and titer in etiolated pea seedlings. Plant Physiol., Suppl., 67: 132, USA, Palavan, N. and Galston, A.W.Polyamines in Plants: Activities of biosynthetic enzymes during flower development in Phaseolus vulgaris. Plant Physiol., Suppl., 67: 11, USA, Goren, R., Palavan, N., Flores, H. and Galston, A.W. Polyamines in Plants: Phytochrome control of polyamine biosynthesis and titer in etiolated pea seedlings. Northeastern Section American Society of Plant Physiologists.Annual meeting, May 1-2, USA, Palavan, N. and Galston, A.W.Polyamine in Plants: Activities of biosynthetic enzymes during flower development in Phaseolus vulgaris. Northeastern Section American Society of Plant Physiologists.Annual meeting, May 1-2, USA,

13 7.3. Yazılan Uluslar arası kitaplar veya kitaplarda bölümler. 1. Palavan-Ünsal, N.,(Editör), eisbn: , 2010, Mechanism of Lansdscape Rehabilitation and Sustainability, Authors: Kefeli V and Blum W. (Bentham Publishing) 2. Özalpan, A.,Palavan-Ünsal, N. (2008),(Editör), Genomik Uygulamalar, İstanbul Kültür Üniversitesi Yayınları 3. Narçin Palavan-Ünsal, Bitki Fizyolojisi, Oksin: Büyüme Hormonu (19. Bölüm)(Plant Physiology, Taiz and Zeiger, (Chapter 19 çeviri), Palme Yayıncılık, Narçin Palavan-Ünsal, Bitki Hormonları Uygulamaları, ISBN: 3001 DK , Haliç Üniversitesi Yayınları 5. Narçin Palavan-Ünsal, 1993, Bitki Büyüme Maddeleri, İstanbul Üniversitesi Yayınları 6. Narçin Palavan-Ünsal, 1990, Genel Biyoloji Laboratuarı Botanik, İstanbul Üniversitesi Yayınları Ekim 2006 Journal of Cell and Molecular Biology, Associate Editor (5 Volume, 10 Issue). 8. Advances in Molecular Biology Associate Editor, 2006, 2007, 2008, 2009 (3 Volume 6 Issue). Ders Notları Kanser Moleküler Biyolojisi, 2009 Sinyal Mekanizması (2006) Hücre Moleküler Biyolojisi (2004) Enzimoloji (2003) Hücre Biyolojisi Laboratuar Uygulamaları (2002) Hücre Biyolojisi I (2002) Hücre Biyolojisi II (2002) Genel Biyoloji (Biyolojik Çeşitlilik) (2001) Genel Biyoloji (Bitki Biyolojisi) (2001) Genel Biyoloji (Biyoenerjetik) 2001 Poliaminler (2012) 7.4. Ulusal hakemli dergilerde yayınlanan makaleler 1. Narcin Palavan-Unsal and E. Damla Arısan. Evidences for the presence of caspase-like activities in plants. Marmara Üniversitesi Fen Bilimleri Dergisi, 23: Arısan ED and Palavan-Ünsal N. Resveratrol: Chemoprevention with red wine. Advances in Molecular Biology, 1: 13 22, Arısan ED, Arısan S, Kiremit MC, Palavan-Ünsal N, Ergenekon E. Antioxidant enzyme profile in chronic pelvic pain syndrome patients. Advances in Molecular Biology, 1: 41 46, Narçin Palavan-Ünsal, Elif Damla Büyüktuncer and Mehmet Ali Tüfekçi. Programmed cell death in plants. Journal of Cell and Molecular Biology, 4: 9 23,

14 5. Palavan-Unsal, S., Cag, S. ve Cetin, E., The role of meta-topolin in senescence of wheat leaf segments. Journal of Cell and Molecular Biology 3: 23-31, İsmailoğlu, I., Ünal, M. ve Palavan-Ünsal, N. Effects of spermidine, spermine and cyclohexylamine on mitotic activity of 2X, 4X and 6X wheats. Journal of Cell and Molecular Biology. 3: 83-88, Duman İ, Arisan S, Büyüktunçer, Çaşkurlu T, Sönmez C, Palavan-Unsal N. Apoptosis detection by TUNEL assay in BPH patients. Journal of Cell and Molecular Biology 3: , Çağ S ve Palavan-Ünsal N The effect of meta-topolin on protein profile in radish cotyledons. Journal of Cell and Molecular Biology. 2: 31-34, Palavan-Ünsal, N., Çağ, S., Çetin, E. and Büyüktunçer, D. Retardation of senescence by metatopolin in wheat leaves. Journal of Cell and Molecular Biology. 1: , Palavan-Ünsal, N., Çotuk, A. and Kalaç-Martini, Y. a-difluoromethylornithine inhibits the growth of fungus Macrophomina phaseoli. Turkish Journal of Botany, 26: 43-46, Narçin Palavan-Ünsal. Bitkilerde stres ve poliaminler. Bitkilerde Stres Fizyolojisinin Moleküler Temelleri Semineri Kitabı. E.Ü.Ziraat Fakültesi, EBİLTEM, p , Palavan-Ünsal, N. Hızlı Büyüme ve Kanserde Poliaminler. Doğa Bilim Dergisi, C 14, S 1, 1-19, Palavan-Ünsal, N. Bitkilerdefotomorfogenez ve fotoreseptörler. Doğa Bilim Dergisi, C 12, S 1, 58-70, Palavan-Ünsal, N. Bitki steroidleri ve Fizyolojik İşlevleri. Doğa Bilim Dergisi, Seri. A 2, C 8, S , Palavan-Ünsal, N. Poliamin Biyosentez ve Mekanizması. Doğa Bilim Dergisi, Ser. 2,C 8, S 2, , Palavan-Ünsal, N. Lastik ağacı: Guayule. Bilim ve Teknik Dergisi, Sayı: 183: 36-38, Palavan, N. Çiçeklenme Fizyolojisi. Doğa Bilim Dergisi, C 4: 73-84, Palavan The effects of some growth regulators on flowering, estrogen content and growth. Ist. Univ. Fen fak. Mec. Sei B 45: 43-62, Ulusal bilimsel toplantılarda sunulan bildiri kitabında basılan bildiriler 1. Narçın Palavan Ünsal, Semin Merve Aloğlu, Mehmet Ali Tüfekçi, Damla Arısan, Miroslav Strnad, Libor Havlicek, Marek Zatloukal ve Mustafa Djamgoz. Boheminin sıçan prostat kanseri hücre dizilerinde terapötik öneminin çeşitli biyomarkırlarla araştırılması. S 24, XXXI. Ulusal Fizyoloji Kongresi (Uluslar arası katılımlı) Eylül, Gaziantep, Elif Damla Büyüktunçer, Serdar Arısan, Hatice Tığlı, Turhan Çaşkurlu, Ayhan Dalkılınç, Narçin Palavan Ünsal, Erbil Ergenekon, Frequency of PSA-mRNA bearing cells in the peripheral blood of patients after prostate biopsy. I. Ulusal Moleküler Tıp Kongresi, Nisan, İstanbul, (Poster bildirisi) 14

15 3. Narçin Palavan-Ünsal Hücre Sağkalımı. I. Ulusal Moleküler Tıp Kongresi, Nisan, İstanbul, (Davetli konuşmacı) 4. Narçin Palavan-Ünsal. Poliaminler ve kanser. I. Ulusal Moleküler Tıp Kongresi, Nisan, İstanbul, (davetli konuşmacı). 5. Narcin Palavan-Ünsal. Polyamines and cancer. Advances in Molecular Medicine suppl. Vol 1: , Meral Ünal, Narcin Palavan-Ünsal, Zekiye Huyluoğlu ve Mehmet Ali Tüfekçi. Çeşitli sitokininlerin arpada tohum çimlenmesi, kök uzaması ve mitoz bölünmeye etkileri. XVII. Ulusal Biyoloji Kongresi, Haziran, Çukurova Üniversitesi, Adana, Isıl İsmailoglu, Meral Ünal ve Narcin Palavan-Ünsal. Diploid, tetraploid,heksaploid buğdaylarda spermidin, spermin ve sikloheksilaminin tohum çimlenmesi, kök uzaması ve mitotik aktiviteye etkileri. XVII. Ulusal Biyoloji Kongresi, Haziran, Çukurova Üniversitesi, Adana, Atilla Özalpan, Narçin Palavan-Ünsal, Merve Aloğlu, Damla Büyüktuncer, Mehmet- Ali Tüfekçi, Seyhan Altun, Mustafa Djamgöz, Kürşat Özdilli. Sıçan prostat kanseri hücre hatlarında olomisinin poliamin düzeyine etkisi. II. Klinik Biyokimya ve Kanser Sempozyumu, P 2, Nisan, Bursa, Narçın Palavan-Ünsal, E. Damla Büyüktunçer. Biyogenik Aminlerin Gıdasal Önemi. Tübitak-MAM I. Ulusal Gıda ve Beslenme Kongresi bildiri özetleri kitabı, p.40, 29 Eylül 1 Ekim, İstanbul, Serdar Arısan, E. Damla Büyüktunçer, Turhan Çaşkurlu, Erbil Ergenekon, Narçin Palavan Ünsal. Mesane tümörlerinde erken moleküler tanı. XV. Ulusal Kanser Kongresi bildiri özetleri kitabı p.203, Nisan, Kemer, Antalya, Narçin Palavan-Ünsal, Atilla Özalpan, E. Damla Büyüktunçer ve Kürşat Özdilli. Olomisinin terapötik etkisinin ALL hücre hatlarında poliamin parametresi ile belirlenmesi. XV. Ulusal Kanser Kongresi bildiri özetleri kitabı p. 106, Nisan, Kemer, Antalya, Atilla Özalpan, Narçın Palavan-Ünsal, Merve Aloglu, Damla Büyüktunçer, Mehmet-Ali Tüfekçi, Seyhan Altun, Mustafa Djamgöz ve Kürşat Özdilli Prostat kanseri hücre hatlarında olomisinin terapötik öneminin poliamin biyomarkırları ile gösterilmesi. XV. Ulusal Kanser Kongresi bildiri özetleri kitabı p. 203, Nisan, Kemer, Antalya, Palavan-Ünsal, N. Bitkilerde stres fizyolojisinin moleküler temelleri. (Davetli konuşmacı) Haziran, İzmir, Ayten Aydın ve Palavan-Unsal, N. Poliaminlerin eğreltilerdeki morfogenetik etkileri. I. Putresinin Platiserium bifurcatum C. Chr. nin gelişimine etkisi. XIII. Ulusal Biyoloji Kongresi bildiri ve poster özetleri kitabı, p. 13, Palavan-Ünsal, N. Yayın Etiği 15 Kasım, TUBITAK, Ankara (Dinleyici olarak katılım),

16 16. Narçin Palavan-Ünsal, Aysun Çotuk, Yeşim Kalaç ve Zepür Delibaşoğlu. DL-α-difluorometilornitinin fitopatojenik mantarların üremesine etkisi. Ege Üniv. Fen. Fak. Der. Seri B Ek 16/1, Palavan-Unsal, N.,Çotuk, A., Kalaç, Y. Ve Delibaşoğlu, Z. DL-α-difluorometilornitinin fitopatojenik mantarların üremesine etkisi. I. Ulusal Ekoloji ve Çevre Kongresi özet kitapçığı, 5-7 Ekim, İzmir. P:95, Narçin Palavan-Ünsal ve Rudiger, W. Fitokrom içeriğinin etiyole yulaf fidelerinin farklı kısımlarında immuno-blotting yöntemle belirlenmesi. X. Ulusal Biyoloji Kongresi kitabı, Temmuz, Erzurum, Palavan-Ünsal, N. Türkiye de biyoloji eğitimi ve sorunları kongresi Haziran, İÜFF, Biyoloji Bölümü, İstanbul, Diğer Yayınlar 1. A. Coker-Gurkan, E. D. Arisan, H. İlhan, P. Obakan, N. Palavan-Unsal, Inhibition of Cellular Autophagic Responses against N1, N11-Diethylnorspermine (DENSpm) Enhanced Apoptosis in HCT116 and SW480 Colon Cancer Cells, Haziran 2013, Waterville Valley, Amerika (Poster sunum: Ajda Çoker Gürkan) 2. E. D. Arısan, M.B Öztürk, A. Çoker-Gürkan, P. Obakan, N. Palavan-Ünsal, Ibuprofen induced apoptosis through c-myc sifgnaling pathway related to polyamines in p53 null PC3 cells, Haziran 2013, Waterville Valley, Amerika (Poster sunum: Damla Arısan) 3. D. Coskun, P. Obakan, E.D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal, The Potential Role of Polyamines in Epibrassinolide-Induced Apoptotic Cell Death in HCT116 and HT29 Colon Carcinoma Cells, Haziran 2013, Waterville Valley, Amerika (Poster sunum: Narçın Palavan Ünsal). 4. O. Berrak, E.D. Arisan, P. Obakan, A. Coker- Gurkan, N. Palavan-Unsal, Co-treatment of rapamycin prevented activation of polyamine oxidase and apoptosis via triggering autophagy after CDK inhibitor treatment in LNCaP cells, Haziran 2013, Waterville Valley, Amerika (Poster sunum: Özge Berrak) 5. Y. Akkoç, E.D. Arisan, P. Obakan, A. Çoker-Gürkan, N. Palavan-Ünsal, Co-treatment of PI3K inhibitor and curcumin overcomes Bcl-2 mediated drug-resistance in MCF-7 breast cancer cells via activating SSAT, Haziran 2013, Waterville Valley, Amerika (Poster sunum: Yunus Akkoç) 6. N. Palavan-Unsal, A. Coker, E. D. Arisan, Alterations in Apoptotic and Polyamine Catabolic Pathway in HCT-116wt and HCT-116 Puma -/- Cell Lines Treated with Cdk Inhibitors. Gordon Research Seminar and Gordon Research Conference, Polyamines in Cell Metabolism. June Waterville Valley NH (USA). 7. E.D. Arisan, P. Obakan, A. Çoker, N. Palavan-Ünsal, Roscovitine induced apoptosis and activated polyamine catabolic pathway in LNCap, DU145 and PC3 prostate cancer cell lines. Gordon 16

17 Research Seminar and Gordon Research Conference, Polyamines in Cell Metabolism June Waterville Valley NH (USA). (Oral presentation) 8. P. Obakan, E.D. Arısan, S. Bolkent, N. Palavan-Ünsal. Epibrassinolide induced apoptosis by modulating polyamine catabolic pathway in different prostate cancer cell lines. Gordon Research Seminar and Gordon Research Conference, Polyamines in Cell Metabolism. June 18-24, Waterville Valley NH (USA) (Poster presentation) 9. A.Coker, E.D.Arisan, N. Palavan-Unsal, Alterations in Apoptotic and Polyamine Catabolic Pathway in HCT-116wt and HCT-116 Bax -/- Cell Lines Treated with Cdk Inhibitors. Gordon Research Seminar and Gordon Research Conference, Polyamines in Cell Metabolism. June 18-24, Waterville Valley NH (USA). (Poster presentation) 10. Palavan Unsal N, Arısan E.D, Çoker A. Roscovitine induced apoptosis is enhanced by ODC inhibition in HCT116 colon carcinoma cells. Gordon Research Conferences on Polyamines. Polyamine Genetics, Metabolism, Cellular Homeostasis and Drug Discovery. June 21-26, 2009, Waterville Valley,USA 11. Arısan E.D, Palavan-Unsal N, Çoker A. ODC sirna sensitizes HCT116 colon carcinoma cells to roscovitine induced apoptosis. Gordon Research Conferences on Polyamines. Polyamine Genetics, Metabolism, Cellular Homeostasis and Drug Discovery. June 21-26, 2009 Waterville Valley, USA 12. Palavan-Ünsal, N Yarının Dünyası İçin Çözümler. Belgelerle Türk Tarihi Dergisi, 23: Projeler 8.1 Kültür Üniversitesi nde gerçekleştirilen projeler 1. Kolon Karsinoma hücrelerinde epibrassinolid tarafından tetiklenen apoptotik süreçte poliaminlerin rolü. (TUBITAK-212 T 168) 2014 de sonlandı. 2. Cdk İnhibitörü Roskovitinin (CYC 200) Kolon Kanseri Hücrelerindeki (HCT116) Etkisinin Apoptotik Sinyal Molekülleri ve Poliamin Parametreleri ile Araştırılması [TUBİTAK T630] Sonlanan proje 3. CDK inhibitörü Roskovitin tarafından tetiklenen apoptotik yolakta poliamin katabolizmasının rolünün LNCap, DU145 ve PC3 prostat kanseri hücre hatlarında incelenmesi (TUBiTAK T107) Sonlanan proje 4. mtor İnhibitörü Rapamisin in CDK İnhibitörleri tarafından Tetiklenen Hücre Ölümü Mekanizmasındaki Potansiyel Rolünün Androjen Reseptörü Pozitif LNCaP ve Androjen Reseptörü negatif DU145 ve PC3 Proatat kanseri Hücrelerinde Araştırılması [TÜBİTAK--3501KARİYER PROJESİ- 112T433 ] Devam eden Proje 5. Kolon Karsinoma Hücrelerinde Epibrassinolid Tarafından Tetiklenen Apoptotik Süreçte Poliaminlerin Rolü [TÜBİTAK T168] Devam ediyor 17

18 6. The effects of Bohemin, a new generation chemotherapeutic, on the diagnosis and treatment of prostate cancer (Terry Fox Cancer Reserach Society destekli) Sonlanan proje 7. Farklı Prostat Kanseri Hücre Hatlarında Epibrassinolidle Tetiklenen Apoptotik Süreçte Poliaminlerin Rollerinin Araştırılması (Doktora tez desteği) İstanbul Üniversitesi destekli. Devam eden Proje 8. Farklı kolon ve prostat kanseri hücre hatlarında roskovitin ve purvalanolün flow sitometrik gösterimi (İstanbul Kültür Üniversitesi destekli ve Roma La Sapienza Üniversitesi ile ortak proje) 9. Melanoma ve LoVo kolon kanseri hücre hatlarında roskovitin ve purvalanol etkilerinin flow sitometrik gösterimi (İstanbul Kültür Üniversitesi destekli ve Roma La Sapienza Üniversitesi ile ortak) 10. Roscovitinin HCT 116 kolon kanseri hücrelerinde otofajik hücre ölümü ve poliamin metabolizması ilişkisi (İstanbul Kültür Üniversitesi destekli) 11. Böbrek taş hastalarında Fetuin-A gen polimorfizminin moleküler düzeyde incelenmesi (İstanbul Kültür Üniversitesi) Sonlanan proje 12. Böbrek taş hastalarında ODC 316 G/C gen polimorfizminin moleküler düzeyde incelenmesi ( İstanbul Kültür Üniversitesi ve Şişli Etfal Araştırma ve Eğitim Hastanesi) 13. Böbrek taş hastalarında SSAT -1415TC gen polimorfizminin moleküler düzeyde incelenmesi ( İstanbul Kültür Üniversitesi ve Şişli Etfal Araştırma ve Eğitim Hastanesi) 14. Sikline bağımlı kinaz inhibitörleri, roskovitin ve purvalanol'ün kimyasal yapılarının ve sitotoksik etkilerinin mikroraman spektroskopi ile araştırılması (İstanbul Kültür Üniversitesi) 15. Epibrassinolide'in HCT116 Puma -/- ve Bax-/- kolon kanseri hücre hatlarında apoptotik ve otofajijk etkilerinin gösterilmesi (YL. Tezi) (İstanbul Kültür Üniversitesi) 16. Denspm-paclıtaksel kombine terapisinin mcf-7 wt ve bcl-2+ hücre hatlarında etkisinin apoptotik parametreler ile araştırılması (yl. Tezi) (İstanbul Kültür Üniversitesi) 17. p53 ifadesinin PC3 (p53 null) prostat kanseri hücrelerinde klonlama vektörü ile kazandırılarak NSAID'lere cevap mekanizmasının araştırılması (İstanbul Kültür Üniversitesi) 18. Diklofenak (NSAID türevi) terapotik etkisinin SW480 ve DLD-1 kolon kanseri hücre hatlarında gösterilmesi (İstanbul Kültür Üniversitesi) 19. Curcumin'in AKT yolağının baskılanması yolu ile terapotik etkisinin MCF-7 WT ve BCL-2+ hücrelerde gösterimi (İstanbul Kültür Üniversitesi) 20. Rapamycin'in terapotik etkisinin anderogenden bağımsız prostat kanseri hücrelerinde araştırılması (İstanbul Kültür Üniversitesi) 21. Roscovitin ve Purvalanol HeLa serviks kanseri hücre hatlarında araştırılması (İstanbul Kültür Üniversitesi) 22. Roscovitine resistant prostat kanseri hücre hatlarının oluşturulması (İstanbul Kültür Üniversitesi) 18

19 23. Gossypol'ün (Bcl-2 inhibitörü) prostat kanserinde terapotik etkisinin araştırılması (İstanbul Kültür Üniversitesi) 24. CDK inhibitörlerinin MCF-7 ve MDA-MB-231 meme kanseri hücrelerinde terapotik etkisinin poliamin metabolizması ile ilişkili olarak gösterimi (İstanbul Kültür Üniversitesi) Sonlanan Proje 25. DFT and MP2 based quantummechanical calculations and a theoretical vibrational spectroscopic investigation on roscovitine, a potential drug to treat cancers (İstanbul Kültür Üniversitesi) Sonlanan proje 26. Raman micro-spectroscopic investigation of the interaction of cultured HCT116 colon cancer cells with alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (İstanbul Kültür Üniversitesi) Sonlanan Proje 27. Purvalanol'ün neden olduğu apoptotik hücre ölümünün otofaji ve endoplazmik retikulum stresi ile ilişkisinin HCT-116 kolon kanseri hücrelerinde araştırılması (TUBITAK öğrenci projesi) (2209, TUBITAK öğrenci projesi) 28. Poliamin analoğu DENSpm in otofaji ve apoptoz üzerine etkilerinin doğal tip ve Bcl-2 aşırı ifadesi görülen MCF-7 meme kanseri hücrelerinde araştırılması (2209, TUBITAK öğrenci projesi) 29. Bag-1 aşırı ifadesine sahip HeLa hücrelerinde Cisplatin in HSP-70 ve HSP-90 şaperonları ve Raf kinazlar üzerine etkisi (2209, TUBITAK öğrenci projesi) 30. Roscovitine uygulanan MCF-7 ve MDA-MB-231 hücrelerinde poliamin metabolizmasının apoptotik ve otofajik hücre ölümü ile ilişkisi (2209, TUBITAK öğrenci projesi) 31. MCF-7 ve MDA-MB-231 Meme Kanseri Hücre Hatlarında Sikline Bağımlı Kinaz İnhibitörleri Roskovitin ve Purvalanol Tarafından Tetiklenen Poliamin Katabolizması ve Apoptotik Düzenlemede NFkB nin Rolü (2209, TUBITAK öğrenci projesi) TUBITAK ÖĞRENCİ DESTEK PROJELERİ numaralı Hacer Esra Gürses ve numaralı Taha Bartu Hayal Sikline bağımlı kinazların poliamin katabolizmasına etkisinin MCF-7 meme kanseri hücrelerinde gösterimi başlıklı projeleri ile Tübitak 2209 no.lu Üniversite Öğrencileri Yurt içi/yurt dışı Araştırma Projeleri Destekleme Programı kapsamında proje desteği almaya hak kazanmışlardır. (Danışman Narcin Palavan-Ünsal) 1000 TL (2009) numaralı Betsi Köse ve numaralı Gizem Alkurt Sikline Bağımlı Kinaz İnhibitörü Tarafından Tetiklenen Apoptotik Yolakta MAPK Sinyal Yolağı ve Poliamin Katabolizması Arasındaki İlişkinin MCF-7 ve MDA-MB-231 Meme Kanseri Hücrelerinde Gösterimi (Danışman Narcin Palavan-Ünsal) 1500 TL (2010) 19

20 8.2.Haliç Üniversitesi nde Gerçekleşenler 1. Prostat kanserine amonyum klorür etkisinin apoptotik parametrelerle araştırılması. 2. Roskovitinin insan prostat kanseri hücre hatlarında terapötik öneminin araştırılması. 3. Jinekolojik kanserlerin çeşitli biyomarkırlarla incelenmesi. 4. Arabidopsis thaliana iki alt varyetesi Landsberg erecta ve Columbia'nın doku ve hücre süspansiyon kültürlerinin kurulması ve kültürlerin devamlılığının sağlanması. 5. Arabidopsis thaliana hücre süspansiyon kültürlerinde hidrojen peroksidin toksik etkilerinin apoptotik parametrelerle saptanması. 6. Benzenin toksik değerlerinin bitki doku kültürü sisteminde moleküler markırlarla saptanması. 7. Yağların sitotoksik ve genotoksik etkilerinin bitki hücre süspansiyon kültürü kullanılarak belirlenmesi. 8. Arabidopsis thaliana'da mikrotübül organizasyonu, poliamin ve apoptoz ilişkileri. 9. Yeni bir aromatik sitokinin olan meta-topolinin senesens ile ilgisi 10. Farklı sitokininlerin klorofil, protein ve peroksidaz aktivitesine etkileri 11. Poliaminlerin farklı ploidi derecesine sahip bitkilerde mitotik aktiviteye etkisi 12. Allerjik ve allerjik olmayan Plantago polenlerinde poliaminler ve allerji ilişkisi 13. Poliaminler lerin soğan kök hücrelerinde mitotik aktiviteye etkileri 14. Meta-topolinin Arabidopsis thaiana nın doku kültüründeki etkileri 15. Olomisinin ALL (ccrf-cbm) ve AML (kg-1) lösemi hücre dizilerinde hücre çoğalması ve poliamin sentezine etkisi. 16. Çayın İşlenmesi sırasında poliamin içeriğinde meydana gelen değişiklikler 17. Boheminin sıçan prostat hücre hatlarında terapötik öneminin farklıbiyomarkırlarla araştırılması 18. Olomisin II nin sıçan prostat hücre hatlarında terapötik öneminin farklı biyomarkırlarla araştırılması 19. Benign prostat hiperplazisinde (bph) apoptozun tunel yöntemi ile gösterilmesi ve sonuçların hasta profilleri ile karşılaştırılması 20. EZH ve BMI 1 nin koekspresyonunun mesane tümörlerinde gösterilmesi. 21. Mesane kanserli hastaların idrar örneklerinde EZH2 gen ekspresyonunun prognostik önemi Ulusal Projeler: 1. Yerçekiminin ve ışığın Pisum sativum ve Helianthus annuus fidelerinde poliamin metabolizmasına etkisi (İstanbul Üniversitesi Araştırma Fonu projesi) 2. Heliotropium bitkisinde potasyum eksikliğinin poliamin ve poliamin türevi alkaloid metabolizmasına etkisi (İstanbul Üniversitesi Araştırma Fonu projesi) 3. DL- -Difluorometilornitinin fitopatojenik mantarların üremesine etkisi (İstanbul Üniversitesi Fen Fakültesi Biyoloji Bölümü projesi) 20