CURRICULUM VITAE. Academic title/position: Professor Doctor/ Head of Medical Biochemistry Department

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1 CURRICULUM VITAE Personal Details Surname: ĐLHAN First Name: Necip Academic title/position: Professor Doctor/ Head of Medical Biochemistry Department Key Qualifications: Clinical Biochemistry, Laboratory Management Research Interest: Free radical and antioxidants, Molecular Diagnostic Tests, Laboratory Management, Accreditation International Experience/Collaborations: Contact Details Work Address: University of Firat, Medical faculty, Biochemistry Department Name of Hospital: Firat University Street Town: Elazig Country: Turkey Post Code: Date of Birth: Phone/Fax: external Place and Country of Birth: Elazig Country of Citizenship: Turk Country of Training: Turkey First Language: Turkish Languages: English

2 Academic Details Faculty/University (name and address) University of Gazi, Pharmacy Faculty Date of Graduation: 1984 Postgraduate Training: (Name and address of Center and Supervisor[s] in charge of Training) Fırat University, Medical Faculty, Biochemistry Department ( Medical Expert) Fırat University, Health Sciences Institues, medical Biochemistry Department ( Doctorate) SUPERVISOR IN CHARGE OF TRAINING: Prof. Dr. Şendoğan GÜLEN From To (Medical Expert) (Doctorate) Title of thesis: The Levels of Thyroid Hormone in Patients Lived in Endemic Goitre Region of Palu Town of Elazig Province The Kinetic Properties of Human Thyroid Tissue arginase ( Doctorate) Accreditation: (Name, number and date of certificate issued by University, Medical Association or Government Body) Firat University Academic Experience: Assistant Professor Associated Professor Professor Biochemistry Biochemistry Biochemistry Firat University, Medical School Firat University, Medical School Firat University, Medical School currently Memberships: Turkish Biochemical Society( membership/ ) Turkish Clinical Biochemical Society (membership/ ) Association of Clinical Biochemistry Expert ( president ) American Association Clinical Chemistry (membership/ ) Turkish Molecular Medicine Society (membership/ )

3 International Publications: 1)Çiğdem Gökçe, Özcan Gökçe, Can Baydinç, Necip Ilhan, Erhan Alaşehirli, Ferhat.Özküçük, Mustafa Taşcı, M. Kemal Atikeler, Harika Çelebi, Nadi Arslan., Use of Random Urine Samples to Estimate Total Urinary Calcium and Phosphate Excretion., Arch. Intern. Med., Vol 151, , Ağustos,1991 2) A Özden, N Đlhan, Z Yumbul, H Aksulu., L- Arginine Attenuates Normothermic Ischemia and Reperfusion Injury of Liver in Rats, Acta. Chirurgica Mediterranea, 10,(4), , ) Yüksel Özdemir, Necip Ilhan, A Possible Geographical Effect Upon The Thyroid Hormone Levels., Acta.Medica Mediterranea, 10 (1), 45-48, ) A Özden, E Kasarcı, R Özercan, N Ilhan,.Effects of Ginkgo Biloba Extract on Intestinal Ischemia and Reperfusion Injury in Rats., Act. Chirur. Med., 10(3), , ) B Üstündağ, M Çay, M Naziroğlu, N Dilsiz, MJ.Crabbe, N Đlhan, The Study of Renin Angiotensin Aldosterone in Experimental diabetes Mellitus., Cell Biochem Func., 17 (3), , ) Yusuf Özkan, Emir Dönder, Gıyasettin Baydaş, Halil Doğan, Necip Đlhan, Yasemin Açık., Prevalence of Type 2 Diabetes, Mellitus and Impaired Glucose Tolerance Among> 30 years of Age in an Urban Community of Elazığ, Biomedical Research, 10 (3), , ) Nevin Đlhan, Đhsan Halifeoğlu, and Necip Đlhan, The Changes in Oxidative and Antioxidative Systems in Experimental Liver Ischemia Reperfusion Damage, Biomedical Research, 11 (3), , ) Nevin Đlhan, Đhsan Halifeoğlu, H.Đbrahim Özercan, Necip Đlhan., Tissue Malondialdehyde and Adenosine Triphosphatase Level After Experimental Liver Ischemia /Reperfusion Damage, Cell Biochem Funct, 19(3), , Eylül,2001 9)Đrfan Orhan, Rahmi Onur, Necip Đlhan, Arslan Ardıçoglu, Seminal plasma cytokine levels in the diagnosis of chronic pelvic pain syndrome, Int.J.Urol, 8 (9), , Eylül, )Y Eroksuz, H Eroksuz, H Özer, N Đlhan, A Çevik, Đ Yaman, AO Çeribaşı, Toxicity of dietary Heliotropium Dolosum seed to japanese quail., Veterinary and Human Toxicology, 44(5), , ) Rahmi Onur, Đrfan Orhan, Necip Đlhan, Atilla Semerciöz, Role of tissue polypeptide spesifik antigen in the detection of prostate cancer, Urologia Internationalis, 69, , ) Ulkü Çeliker, Necip Đlhan, Đbrahim Özercan, Tamer Demir, Hüseyin Çeliker, Ocreotide reduces ischaemiareperfusion injury in the retina., Acta Ophthalmologica Scandinavica, 80, , ) Ulkü Çeliker, Necip Đlhan., Nitric oxide and ocreotide in retinal ischemia reperfusion injury., Documenta Ophthalmologica, 105, , ) Necip Đlhan, Nevin Đlhan, Mehmet Şimşek, The changes of trace elements, malondialdehyde levels and superoxide dismutase activities in pregnancy with or without preeclampsia., Clinical Biochemistry, 35, , ) E Ozerol, H Ulvi, N Đlhan, M Güleç, A Đlhan, N Đlhan, Ö Akyol., Determination of copper, zinc and manganese in nail and serum from patients with migraine, Trace Elements and Electrolytes., 20(4), , 2003

4 16) Nevin Đlhan, Necip Đlhan,. Vascular endothelial growth factor and oxidative damage in cancer., Clinical Biochemistry, 36, , ) Rahmi Onur, Necip Đlhan, Đrfan Orhan, Nevin Đlhan, Increased discrimination between beningn prostatic hyperplasia and prostate cancer with equimolar total prostate spesific antigen measurement., World Journal of Urology, 21, 43-47, ) V Kavuncu, S Şahin, G Baydaş, N Đlhan, Đ Özercan, A Yaşar, Đ Pekkutucu, N Đlhan, R Özercan, A comparison of estrogen and two different doses of calcitonin in ovariectomized rats, Yonsei Medical Journal, 44(3);, , ) A Đlhan, E Özerol, M Güleç, B Işık, N Đlhan, N Đlhan, Ö Akyol, The comparison of nail and serum trace elements in patients with epilepsy and healthy subjects, Progress in Neuro-Psychopharmacology Biological Psychiatry, 28;, , ) N Đlhan, N Đlhan, Y Đlhan, H Akbulut, M Küçüksu, C-reaktive protein, procalcitonin, interleukin-6, vascular endothelial growth factor and oxidative metabolites i diagnosis of infection and staging in patients with gastric cancer, World J Gastroenterol, 10 (8), , ) H Eröksüz, Y Eröksüz, H Özer, AO Çeribaşı, I Yaman, N Đlhan, Equine goiter associated with excess dietary iodine, Vet Hum Toxicol, 46(3):, 147-9, ) N Đlhan, A Kamanlı, R Özmerdivenli, N Đlhan., Variable effects of exercise intensity on reduced glutathione, thiobarbituric acid reactive substance levels and glucose concentration, Archives of Medical Research, 35, , ) N Đlhan, N Đlhan, F Deveci, Functional significance of vascular endothelial growth factor and its receptor ( receptor-1) in various lung cancer types, Clinical Biochemistry, 37, , ) Ogetürk M, Kuş Đ, Kavaklı A, Zararsız Đ, Đlhan N, Sarsılmaz M.Effects of melatonin on carbon tetrachloride-induced changes in rat serum. J Physil Biochem.2004 Sep;60(3): ) Ogetürk M, Kuş Đ, Çolakoğlu N, Zararsız Đ, Đlhan N, Sarsılmaz M.Caffeic acid phenethyl ester protects kidneys against carbon tetrachloride toxicity in rats. J Ethnopharmacol.2005 Feb 28; ) Bahçecioğlu IH, Yalnız M, Đlhan N, Ataseven H, Özercan ĐH.Levels of serum vitamin A, alpha-tocopherol and malondialdehlyde in patients with non-alcoholic steatohepatitis:relationship with histopathologic severity.int J Clin Pract.2005 Mar;59(3): ) Aydın S, Halifeoğlu Đ, Özercan ĐH,Erman F, Kılıç N, Aydın S, Đlhan N, Đlhan N, Özkan Y, AkpolatN, Sert L, Çaylak E.A comparison of leptin and ghrelin levels in plasma and saliva of young healthy subjects. Peptides Apr;26(4): ) Bülbüller N, Đlhan YS, Kirkil C, Çetiner M, Göğebakan O, Đlhan N.Can angiotensin converting enzyme inhibitors prevent postoperative adhesions? J Surg Res.2005 May 1; 125(1): ) Bahçecioğlu ĐH, Yalnız M, Ataseven H, Đlhan N, Özercan ĐH, Seçkin D.Levels of serum hyaluronic acid, TNF-alpha and IL-8 in patients with nonalcoholic steatohepatitis. Hepatogastroenrology.2005 Sep- Oct;52(65):

5 30)Seckin D, Ilhan N, Ilhan N, Ozbay Y.The relationship between ACE insertion/deletion polymorphism and coronary artery disease with or without myocardial infarction. Clin Biochem Jan;39(1): ) Seckin D, Ilhan N, Ilhan N, Ertugrul S.Glycaemic control, markers of endothelial cell activation and oxidative stress in children with type 1 diabetes mellitus.diabetes Res Clin Pract Aug;73(2): ) Yılmaz B, Canpolat S, Sandal S, Akpolat N, Kutlu S, Đlhan N, Keleştimur H. Paint thinner exposure inhibits testosterone synthesis and secretion in a reversible manner in the rat. Reprod Toxicol Nov;22(4): ) Đlhan N, Kahraman N, Seçkin D, Đlhan N, Çolak R Apo E gene polymorphism on development of diabetic nephropathy.cell Biochem Funct Sep-Oct;25(5): ) Đlhan N, Seçkin D, Đlhan N, Ozbay Y.Abnormal asymmetric dimethylarginine/nitric oxide balance in patients with documented coronary artery disease: relation to renal function and homocysteine.j Thromb Thrombolysis Jun;23(3): ) Kavalci C, Pekdemir M, Durukan P, Ilhan N, Yildiz M, Serhatlioglu S, Seckin D.The value of serum tau protein for the diagnosis of intracranial injury in minor head trauma.am J Emerg Med May;25(4): ) Đlhan N, Kucuksu M, Kaman D, Đlhan N, Ozbay Y. The 677 C/T MTHFR polymorphism is associated with essential hypertension, coronary artery disease, and higher homocysteine levels. Arch Med Res Jan;39(1): Erol FS, Kaplan M, Tiftikci M, Yakar H, Ozercan I, Ilhan N, Topsakal C. Comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury.j Clin Neurosci Jul;15(7): Onur R, Tasdemir C, Seckin D, Ilhan N, Kutlu S, Akpolat N. Combined use of melatonin and terazosin restores bladder contractility in rabbits with partial outlet obstruction.urology Aug;72(2): Epub 2008 May 2. Presentations at International Scientific Meetings 1. Çiğdem Gökçe, Osman Onat, Özcan Gökçe, Engin Arısoy, Sami Arısoy, Nadi Aslan, Hüseyin Çeliker, Yüksel Özdemir, Necip Ilhan. The effects of hemodialysis on thyroid functions. Kidney International. 41( 5), p 1469, Đsmail Temel, Necip Đlhan, Hanefi Emre, Ahmet Çığlı, Saim Yoloğlu. Aflatoksin B1 in tavşan Eritrosit, karaciğer, Böbrek, Arginaz Aktiviteleri ile Serum, ALP, AST, ALT Düzeylerine Etkisi. XII. Ulusal Biyokimya Kongresi(Uluslararası Katılımlı).Poster No: C Nisan, Istanbul.

6 3 Necip Ilhan, Ahmet Çekirdekçi, Güzide Yücebilgiç, Turgay Isbir. Hipertansiyonda Plazma Eser Element Düzeylerinin Değişimi. XII. Ulusal Biyokimya Kongresi(Uluslararası Katılımlı).Poster No:C Nisan 1994, Istanbul. 4 Necip Đlhan, Şendoğan Gülen. Tiroid Arginaz Enzim Aktivitesi Üzerine Aminoasitlerin Etkisi. XII. Ulusal Biyokimya Kongresi(Uluslararası Katılımlı).Poster No:C Nisan, 1994, Istanbul.. 5.Y Özdemir, I Halifeoğlu, N Đlhan. Trace Elements Levels in Serum of Uremic Patients on Hemodialysis. 23 rd meeting of The federation of European Biochemical Societies, August, 1995, Switzerland. 6. Emin Akgül, Necip Đlhan, Đhsan Halifeoğlu, Nevin Đlhan, Ahmet Var. Plasma Lipid Peroxide Levels and Antioxidant Enzyme Activities in Type II Diabetes: Relationship with Diabetic Microangiopatic Complications. 68.th. Meeting of the European Atherosclerosis Society Molecular Cell Biology and Atherogenesis.,7-10 May 1997, Brugge, Belgium. 7.Fatma Đnanç, Nimet Kabakuş, Necip Đlhan, Hakan Aydınlıoğlu. Yaş Gruplarına Göre Pediatrik Referans Değerleri. XIV. Ulusal Biyokimya Kongresi ve Klinik Laboratuvarlarda Otomasyon Sempozyumu (Uluslararası Katılımlı). C-722, Ekim 1997, Đzmir. 8. Ahmet Var, Nevin Đlhan, Necip Đlhan, Yusuf Özkan, Đhsan Halifeoğlu. Kronik Böbrek Yetmezliği Bulunan Hastalarda Antioksidan Enzim Aktiviteleri ve Hemodiyaliz ile Olan Etkileşimleri XIV. Ulusal Biyokimya Kongresi ve Klinik Laboratuvarlarda Otomasyon Sempozyumu (Uluslararası Katılımlı). C-722, Ekim 1997, Đzmir. 9.Đhsan Halifeoğlu, Nevin Đlhan, Necip Đlhan. Deneysel Olarak Siroz Oluşturulan Sıçanlarda Karaciğer Arginaz Enzim düzeyi. XIV. Ulusal Biyokimya Kongresi ve Klinik Laboratuvarlarda Otomasyon Sempozyumu (Uluslararası Katılımlı). C-126, Ekim 1997, Đzmir. 10. Seval Yılmaz, Bilal Üstündağ, Necip Đlhan. Streptozosin Đle Oluşturulan Diabetik Ratlarda Pirüvat Kinaz Aktivite Düzeyleri. XIV. Ulusal Biyokimya Kongresi ve Klinik Laboratuvarlarda Otomasyon Sempozyumu(Uluslararası Katılımlı). C-524, Ekim 1997, Đzmir.

7 11. Seval Yılmaz, Necip Đlhan. Bazı Metal Đyonlarının Đnsan Eritrosit Pirüvat Kinazı Üzerine Etkisi XIV. Ulusal Biyokimya Kongresi ve Klinik Laboratuvarlarda Otomasyon Sempozyumu (Uluslararası Katılımlı). C-115, Ekim 1997, Đzmir. 12. B Üstündağ, M Çay, M Naziroğlu, N Dilsiz, MJ.Crabbe, N Đlhan, ĐH Ozercan..Effect of vitamin E on serum glucose levels and complications of nephropathy in streptozotocin-induced diabetic rats. Sixth International symposium The Maillard Reaction, P 84, Royal Collage of Physicians, London UK, July B Üstündağ, M Çay, M Naziroğlu, N Đlhan N Dilsiz, MJ.Crabbe. The Study of Renin Angiotensin Aldosterone in Experimental diabetes Mellitus rats. Sixth International symposium The Maillard Reaction, P 121, Royal Collage of Physicians, London UK, July A Çekirdekçi, H.E. Aksulu, Ç Çifter, N Đlhan, A Ağaoğlu, T Darçın, Ö Tetik, O Yüksel. Diclofenac But not Aspirin Prevents The Development of Thrombus in The replacement of Vena Cava Inferior By an Autogenous Fascio- peritoneal Graft. III. International congress of Pathophysiology.28June- 3July, 1998, Finland. 15.Ahmet Var, Necip Đlhan, Nevin Đlhan, Çağatay Çifter, Zübeyir Bozdağ. The Variations in Plasma Interleukin 6 (IL-6) Levels After Laparoscopic surgery. 50.th AACC Meeting August 2-6, Chicago Illinois. 16. Đhsan Halifeoğlu, Fikret Karataş, Bilal Üstündağ, Halit Canatan, Necip Đlhan. Tiner ile Çalışan Kişilerde Tiner Đnhalasyonunun Antioksidan Vitaminler Üzerine Etkisi. The First International Biosciences days. P- 517, April 1999,Antalya. 17 Yusuf Özkan, Emir Dönder, Gıyasettin Baydaş, Halil Doğan, Necip Đlhan, Yasemin Açık. Prevalence of Type 2 Diabetes mellitus and Impaired Glucose Tolerance Among> 30 years of Age in an Urban Community of Elazığ. Diabetes care and research in Europe St Vincent Declaration Ten Years on The Targets, The Progress, The Vision 124, 9-12 October 1999, Đstanbul.

8 18. Mehmet Hamdi Muz, Necip Đlhan, Osman Öz, Nevin Đlhan, Tevfik Turgut. CYFRA 21.1 and CEA for diagnosis of malignant pleural effusions. European Respiratory Journal World Congress on Lung Health and 10 th ERS annual Congress, P August 30- September 3, Florence Italy Mehmet Hamdi Muz, Necip Đlhan, Osman Öz, Ş Şahin, Tevfik Turgut.Clinical evaluation of CYFRA 21.1 in malignant and benign pleural effusions. European Respiratory Journal World Congress on Lung Health and 10 th ERS annual Congress, P- 2499, August 30- September 3, Florence Italy Đrfan Orhan, Rahmi Onur, Necip Đlhan Şemsettin Şahin, Yılmaz Salatan.Kronik nonbakterial prostatit olgularında seminal plazma sitokin düzeyleri. 16. Ulusal Üroloji kongresi( Uluslararası katılımlı) 8-12 Ekim, P-61, Đzmir, Türkiye. 21. Gıyasettin Baydaş, Nevin Đlhan, Ayşe Bozkurt, Necip Đlhan, Mehmet Şimşek. Lipid peroxidation and antioxidant enzyme activities in term, preterm, babies and their mothers. Euromed Lab2001, 14. th IFCC- FESCC, European Congress of Clinical Chemistry and Laboratory Medicine, 5 th Czech National Congress of Clinical Biochemistry,P.O- B 033 Prague, Czech Republic May 26-31, Ülkü Çeliker, Necip Đlhan. Nitric oxide and ocreotide in retinal ischemia reperfusion ınjury, XIII congress of the European Socety of Ophthalmology, SP-583, 3-7 June, istanbul /Turkey Nevin Đlhan, Necip Đlhan, Şemsettin Şahin. The changes of trace element and malondialdehyde levels in pregnancy with or without preeclampsia. 9. th meeting of the Balkan Clinical laboratory Federation,, PP-109, September 12-15, 2001, Ionnia, Greece. 24..Necip Đlhan, Şemsettin Şahin. Evaluation of oxidant Stress in patients with acute bacterial meningitis. 9. th meeting of the Balkan Clinical laboratory Federation, PP-108, September 12-15, 2001, Ionnia, Greece. 25. Şemsettin Şahin Necip Đlhan. The changes of apolipoproteins and lipoprotein (a) concentrations in cerebrospinal fluids of patients with acute bacterial meningitis. 9. th meeting of the Balkan Clinical laboratory Federation, PP-072, September 12-15, 2001, Ionnia, Greece.

9 26. E Özerol, A Đlhan, M Güleç, N Đlhan, H Ulvi, N Đlhan, Ö Akyol. The levels of trace elements functioning as prostetic groups of superoxide dismutase in patients with epilepsy. 2nd International Meeting on Free Radicals in Health and Disease, P-9, May 8-12, Đstanbul /Turkey. 27 E Özerol, H Ulvi, N Đlhan,, M Güleç, A Đlhan, N Đlhan, Ö Akyol. Determination of copper, zinc, and manganase in nail and serum of patients with migraine. 2nd International Meeting on Free Radicals in Health and Disease, P-94, May 8-12, Đstanbul /Turkey. 28. Nevin Đlhan, Necip Đlhan. Vascular endothelial growth factor and oxidative damage in cancer. Reactive oxygen and nitrogen species: Diagnostic, preventive and therapeutic values. International Symposium. P- 2-10, St. Petesburg, 8-12 July, 2002 Russia. 29. Necip Đlhan, Şemsettin Şahin, Nevin Đlhan. Plasma Nitric oxide, malondialdehyde and antioxidative enzyme levels after experimental cardiac ischemia reperfusion damage. Reactive oxygen and nitrogen species: Diagnostic, preventive and therapeutic values. International Symposium. P- 2-09, St. Petesburg, 8-12 July, 2002 Russia. 30. Necip Đlhan, Şemsettin Şahin, Nevin Đlhan. The changes of nitric oxide and free radical levels in tissues of rats with cardiac ischemia reperfusion damage. Reactive oxygen and nitrogen species: Diagnostic, preventive and therapeutic values. International Symposium. P- 2-08, St. Petesburg, 8-12 July, 2002 Russia. 31. Necip Đlhan, Nevin Đlhan. Protective effect of Nigella sativa seeds on CCL 4 induced hepatotoxicity. 28. meeting of the Federation of European Biochemical Society (EJB). AP5-010, 269, Suppl 1 Đstanbul, October 2002, Turkey. 32. Ekrem Sapmaz, Necip Đlhan. The effect of using Vitamins C and E as antioxidants in autologous intra peritoneal ovary transplantation in rats. 28. meeting of the Federation of European Biochemical Society (EJB). AP5-011, 269, Suppl 1 Đstanbul, October 2002, Turkey.

10 33. Ekrem Sapmaz, Nevin Đlhan, Necip Đlhan, Nusret Akpolat..The effect of using melatonin and oxytetracyline as antioxidants in autologous intra peritoneal ovary transplantation in rats. 28. meeting of the Federation of European Biochemical Society (EJB). PS5-127, 269, Suppl 1 Đstanbul, October 2002, Turkey. 34. Ekrem Sapmaz, Necip Đlhan, Nevin Đlhan, Nusret Akpolat. The effect of using Vitamins C and E as antioxidants in autologous subcutenous ovary transplantation in rats. 28. meeting of the Federation of European Biochemical Society (EJB). PS5-126, 269,Suppl 1 Đstanbul, October 2002, Turkey