REME. ISTANBUL MEDIPOL UNIVERSITIY REGENERATIVE AND RESTORATIVE MEDICINE RESEARCH CENTER Dr. Gürkan Öztürk MD, PhD

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Mehmed Gökmen
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1 ISTANBUL MEDIPOL UNIVERSITIY REGENERATIVE AND RESTORATIVE MEDICINE RESEARCH CENTER Dr. Gürkan Öztürk MD, PhD Supported by The Ministry Development of REME 1

2 Established in 2009

3 Education started in 2010 at Haliç Site

9 SCHOOLS Dentistry Engineering and Natural Sciences Electrical and Electronics Engineering Biomedical Engineering Computer Engineering - NEW Molecular Biology and Genetics - NEW Fine Arts Design and Architecture Turkish Music Architecture NEW

Engineering Computer Engineering - NEW Molecular Biology and

10 Health Sciences Nutrition and Dietetics Physical Therapy and Rehabilitation Nursing Health Management Child Development Midwifery Audiology Orthotics - Prosthetics

11 Humanities and Social Sciences Psychology Law Medicine (Int. School of Medicine) Medicine Pharmacy

12 ~ 4000 undergraduate students ~ 500 graduate students ~ 300 faculty

13 Graduate Programs / Institute of Sciences MSc Biomedical Engineering and Bioinformatics Electric Electronics and Cyber Systems PhD Biomedical Engineering and Bioinformatics Electric Electronics and Cyber Systems

Electronics and Cyber Systems PhD Electronics and

14 Graduate Programs / Institute of Health Sciences MSc Anatomy Nutrition and Dietetics Biochemistry Physiotherapy and Rehabilitation Nursery Histology and Embryology Clinical Pharmacy Health Management Health Physics Neuroscience Physiology

and Rehabilitation Nursery Histology and Embryology

15 Graduate Programs / Institute of Health Sciences PhD Clinical Anatomy Nutrition and Dietetics Biochemistry Physiotherapy and Rehabilitation Oral, Dental and Mandibular Surgery Prosthetic Dental Therapy Histology and Embryology Clinical Pharmacy Health Management Neuroscience

Rehabilitation Oral, Dental and Mandibular Surgery Prosthetic Dental

16 Graduate Programs / Institute of Social Sciences MSc Special Law Health Law Public Law Occupational Health and Safety

17 Graduate Programs / Institute of Social Sciences PhD Special Law Health Law Public Law

18 Project proposal submitted in 2011 with a total budge of 35 m TL. Approval and start in mid First labs launched in 2013.

19 REME Core Animal house. Advanced microscopy lab. Bioinformatics lab. Dental research and biomechanics lab. Cell culture lab. s Cell sorter lab. Electrophysiology and optogenetics lab. Molecular biology and histology labs. Pharmaceutical chemistry and pharmacognosy. Systems biology: Genomics and proteomics labs. Facilitie

Electrophysiology and optogenetics lab. Molecular biology and histology labs.

20 REME Animal House Housing and breeding of in- and outbred strains of Mouse Rat Rabbit Axolotl Zebra fish License for transgenic animal production, housing and breeding. Infrastructure for SPF and germ free animal housing. Fully equipped units for surgery, monitorization and behavioral tests.

21 REME Advanced Microscopy Lab Two photon microscope with two femtosecond infraded lasers and live animal imaging stage. Laser scanning confocal microscope with five visible and one femtosecond infrared lasers, based on an inverted microscope. Spinning disk microscope with two EM, one cooled cameras, advanced incubation equipment, providing ultra fast and long term time lapse imaging. Fluorescence zoom microscope for imaging large specimens at high magnification. Additional Equipment and software for FRAP, FLIP, FLIM and FRET analyses. Laser microdissection and optical tweezer combi system with incubation equipment. Scanning electron microscope with TEM capability and EDS. Several operation microscopes.

22 REME

23 REME Cell Culture and Cell Sorter Labs Class II cell culture hoods. Regular and cooled incubators with CO 2 and O 2 regulation. Inverted microscope with fluorescene attachment and intracellular injection system. Automated cell monitoring and analysis system. Cell viability test instrument. All other equipment needed for working with primary cells and cell lines.

24 REME Advanced cell sorter with five lasers: 355, 405, 488, 561, 640 nm Theoretical capacity to sort 14 colors. Simultaneous sorting through six different channels. Housed in class II cabinet.

25 REME Electrophysiology and Optogenetics Labs Cellular electrophysiology: Patch clamp recording system. Clinical electrophysiology: Transcranial magnetic stimulator. MRI compatible analytic EEG systems. Optogenetic station.

26 REME

27 REME Molecular Biology and Histology Labs Equipments for immunohistochemistry. In vivo and in vitro electroporation device. Western blot systems including high end gel imaging station. Multiplate reader. Conventional and real time PCR systems. Clean lab space and hood for DNA and RNA isolation.

28 REME Dental and Biomechanics Lab Bench-top spectrophotometer for colorimetric analysis of dental tissues and materials. Micro-hardness tester for Vickers and Knoop Hardness Testing. Grinder-polisher and precision cutting machine used for prepare and examine biomaterial specimens Computer-driven universal testing machine for tensile, compression, shear, fatigue testing Multi angle glossmeter.

29 Pharmaceutical Chemistry and Pharmacognosy Labs Equipments for isolation and characterization of plant extracts. Equipments for synthesis of active compounds for drug discovery. In vivo and in vitro assay setups. REME

30 REME

31 REME Systems Biology: Genomics and Proteomics Labs MALDI TOF, LC- MS and triple quadruple MS systems. NextGen genome sequence platforms. All other lab equipments required for sample preparation. Bacteriology and virology culture systems.

32 REME

33 REME Research Scope at REMER Basic and translational research on Regenerative processes in the nervous system. Regenerative processes in the cardiovascular system. Regenerative processes in the musculoskeletal system. Epimorphic and organ regeneration in axolotl. Role of stem cells in cancer. Degenerative mechanisms in different organ and systems. Discovery of biologically active compounds in traditional herbal preparations. Investigation of effectiveness and mechanism of action of complementary and traditional medicine applications. Host - microbiome interactions. Epigenetic inheritance. Development of biocompatible materials. Drug and vaccine development. Feeding, nutrition and metabolism. Neuroprosthetics

34 People FACULTY Gürkan Öztürk (MD, PhD) Ertuğrul Kılıç (PhD) Duran Üstek (PhD) Hakan Cangül (MD., PhD) Mustafa Öztürk (MD) Lütfü Hanoğlu (MD) Tangül Müdok (PhD) Şeref Demirayak (PhD) Mutlu Özcan* (DDS, PhD) Ergin Koçyıldırım* (MD) Süleyman Yıldırım (PhD * Consultant Ülkan Kılıç (PhD) Mustafa Güzel (PhD) Burak Yuluğ (MD) Esra Çağavi (PhD) Mehmet Ozansoy (PhD) Yalçın Günal (MD, PhD) Ahmet Tarık Baykal (PhD) Deniz Durali (MD, PhD) Deniz Atasoy (PhD) Emir Yüzbaşıoğlu (DDS, PhD) Aylin Yaba Uçar (PhD) STUDENTS About 40 graduate students (MSc and PhD) OTHER About 10 administrative and technical staff REME

35 Beyin Ekstraselüler Matrisinin Nörodejenerasyondaki Rolünün Alzheimer'da Araştırılması Melatoninin İskemi Sonrası Beyin Plastisitesi ve Onarımı Üzerine Olan Etkileri CDNF ve MANF Nörotrofik Faktörlerinin İskemi Sonrası Beyin Plastisitesi ve Onarımı Üzreine Etkileri Genetik Kökenli Kalp Ritim Bozukluklarının Uyarılmış Pluripotent Kök Hücre Kullanılarak Modellenmesi ve Hücresel Tedavi Yöntemleri Geliştirilmesi Nogo-A nın Stres Koşulları Altında Agrezom İle İlişkisinin İncelenmesi Hastane Enfeksiyonu Etkenlerinin Hızlı Tespiti İçin Otomatize Meloküler Analiz Cihaz ve Kitlerin Geliştirilmesi Fare Oositi ve Preimplantasyon Dönemi Embriyolarında Mtert Telomeraz Katalitik Alt Ünitesinin C-Abl Protein Tirozin Kinaz Tarafından Düzenlenmesi Yüksek-Üretimli DNA Dizileme Platformları İçin Verimli Depolama ve Erişim Sisteminin Tasarımı ve Gerçeklenmesi Parkinson Hastalığının Tedavisi İçin Yeni A2A Atenosin Reseptör Antagonistlerinin Sentezi ve Aktivitelerinin Değerlendirilmesi Beslenme ve Glikoz Dengesinin Hipotalamik Sinir Ağları Nörodejeneratif Beyin Dokusundaki Protein Değişikliklerin MALDI-MS Görüntüleme Tekniği İle Belirlenmesi

38 Thank you Kavacık Mah. Ekinciler Cad. No: Beykoz, Istanbul remer.medipol.edu.tr 20 r REME

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