0zcnqMi$ Yrd. Dog. DT. GOKHAN DURUKSU

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1 0zcnqMi$ Yrd. Dog. DT. GOKHAN DURUKSU Yazryma Adresi Telefon Faks : : : e-posta KOGEM (K6k Hiicre ve Gen Tedavileri A.U.M.) Umutepe YerleqkesiTrp Fak. Morfoloji Binasr 1. Kat /Ttirkiye gokhan.duruksu@kocae : I i. edu.tr BGirinn Fakiilte/Enstitii tiniversite Utxe nilcilnni Tiirkiye Orta Dolu Teknik FEN BiLiMLERi ENSTiTUSU Ttirkiye Orta Do[u Teknik Miihendislik Fakiiltesi Mezuniyet Yrlr 6grenim Alanr Derece BIYOTEKNOLOJi Doktora 2007 Lisans 2001 GIDA NAUHgNOiSLiGi AKADEMiK/MESLEKTE DENEYiM Kurum/I(urulug Orta Dopu Teknik Une Tiirkiye $ehir Btiliim/Birim Kok Hticre ve Gen Tedavileri Aragtrrma ve Uygulama Merkezi (KOGEM) Kok Hiicre ve Gen Tedavileri Ttirkiye Aragtrrma ve Uygulama Merkezi(KOGEM) Tiirkiye Ankara BIYOTEKNOLOJi Giirev Giirev Tiirii Diinemi Yrd. Dog. Dr. Aragtrrma Gorevlisi (Dr.) 20ll Aragtrrma Gdrevlisi 2009 UZMANLIK ALANLARI Uzmanhk Alanlan Biyoteknoloji, Hayvan Doku Kiilttirti, Genetik Miihendisli[i, Hayvan Histolojisi Ve Sitolojisi Kdk Hiicre, Hiicre Ktilfiirii, Genetik Mtihendisligi, Hiicre Biyolojisi PROJE DENEYIMi Proje Adr Kurum Biitge Tarih Giirev Proje Tiirii

2 60000 in Vitro Koqullarda Apoptoza Ydnlendirilen Kondrositlerin Prolaktin Geni Aktarrlmrg Mezenkimal Kok Hi.icrelere Yanttt insan Kemik Danrgman Yiiriitticii Danryman iligi raynakh Mezenkimal Kok Hticrelerin, Meme Kanser Hiicrelerinin Eksozomlanna Gdsterdi[i Kanser Kargttr Tepkinin Araqtrnlmast. Metastatik Osteosarkom Hayvan Modelinde Bmp2 Salgrlayan Mezenkimal KOk Hiicrelerin Intravenciz Uygulama Sonrast Viicutta Da[rhmr Ve Osteosarkom t t Hiicrelerinin Diferansiasyon Ve Qofialmalart Uzerine Etkileri. -Farkh Kanser Hattt Hticrelerinden Elde Edilen Eksozomlarm Stroma ve Ktik Hiicreler Uzerine Yiiriitiicii Aragtrrmac/Uzman Yiiriiflicii Etkisi Yeni Bor Bazh Biyomalzemelerin Sentezleri, Formtilasyonlart Ve Teronostik Etkilerinin incelenmesi Pankreatik Adacrk Neogenezinden Sorumlu Genlerin (Mafa, Ngn3, Pax4) Onciil K<)k Hticrelere Aktanlmasryla Fonksiyonel instilin Ureten Hiicrelerin Eldesi ve Doku Miihendisli[i Yaklaqrmr Multiple Myeloma Kaynakh Mezenkimal KOk Hticrelerin ve Bu Hiicrelerden Elde Edilen Uyanlmrg Pluripotent Kdk Hiicrelerin Osteojenik Farkhlaqma Potansiyelinin Kargrlagtrrmah Olarak incelenmesi t AraqtrrmacrNzman 0l

3 Mezenkimal Ktik Hticrelerin Tiroid Kanseri Hticre Hatlarr Uzerindeki Qo[alma Engelleyici Etkisinin incelenmesi Deneysel in vitro Tip 1 Modeli Diyabet Geliqtirme s r Y urutucu 0t AraqtrrmactNzman. I l Stirekli Kiiltiir Sisteminde Kolajen Kaplanmrg MikroTaqryrcrlar Uzerine immobilize Edilmig Mezenkimal Kok I Yiiriitticti Hticrelerde Rekombinant Tirozin Hidroksilaz Enziminin Ekspresyonu Mezenkimal Kok Hiicreden Farkhlaqmrg Endotel Benzeri Hiicrelerin Anj iogenez Yeteneklerinin Gergek Zamanh PZR ile Molektiler Dtizeyde incelenmesi Yiiriitiicii l AragtrrmactNzman Yiiriitticti Yiiriitticii AraqtrmacrNzman Ratlarda deneysel olarak olugturulan glokom modelinde, intravitreal kdk hticre implantasyonunun gangliyon hiicre rejenerasyonu tizerine etkisi Srgan yap dokusu kaynakh mezenkimal kok hticrelerine elektroporator kullanrlarak GFP geni aktanmrnrn optimizasyonu. Farkh insan Doku Hiicrelerinde Telomer Uzunlu[u ve Telomeraz Aktivitesi Aspergillus fumigatus endo-beta mannanaz Orta Do[u enziminin Aspergillus Teknik sojae ve Pichia pastoris 'te t iiretilmesi oicnn AKADEMiK FAALiYETLER Son Bir Yrlda Uluslararasl indekslere Kayrth Makale/Derleme igin Yaprlan Danlgmanhk Sayst Son Bir Yrlda Projeler igin Yaprlan Danrymanhk Sayrsr

4 r68 Yaylnlara Ahnan Toplam Atrf Saylsr o'n Devam Tamamla Ed"o Yiiksek Danrymanltk Yaprlan Ogrenci Sayrsl Lrsans Z Doktora 5 I Uzmanhk VII. Temel Kdk Hiicre Teknikleri Ve Molekiiler Biyoloji Uygulamalart Kursu Dtizenleme Kurulu Uyesili[i, Ekim 2009,. VIII. Temel Kok Hticre Teknikleri Ve Molekiiler Biyoloji Uygulamalarr Kursu Dtizenleme Kurulu Uyeli[i, 2-6 Kasrm 2009,. IX. Temel Ktik Hiicre Teknikleri Ve Molektiler Biyoloji Uygulamalarr Kursu Dtizenleme Kurulu UyeliEi, 22-26Mart 2010,. X. Temel Kok Hi.icre Teknikleri Ve Molekiiler Biyoloji Uygulamalart Kursu Dtizenleme Kurulu Uyeli[i, I 4- I 8 Hazir an 2010,. XII. Temel Kdk Hticre Teknikleri Ve Molekiiler Biyoloji Uygulamalan Kursu Dtizenleme Kurulu Uyelifi,29 Kasrm-3 Arahk Difer Faaliyetler (Eser/gii rev/faaliyet/so rumlu luk/olay/iiyelik 2010,.Xl[. Temel Kdk Hticre Teknikleri Ve Molektiler Biyoloji Uygulamalart Kursu vb.) Diizenleme Kurulu Uyeli[i, l3-17 Arahk 2010,.XlV. Temel Kdk Hi.icre Teknikleri Ve Molektiler Biyoloji Uygulamalan Kursu Diizenleme Kurulu Uyeli[i, 2l-25 Mart20ll,.XV. Temel Kok Hiicre TeknikleriVe Molekiiler Biyoloji Uygulamalart Kursu Dtizenleme Kurulu Uyeli[i, 9-13 Mayrs 201l,.l. Uluslararast Kattltmlt Kok Hiicre Araqtrrmalan Kongresi Diizenleme Kurulu Uyel igi, 2SEylnl-2 Ekim 2011, SakaryaXVl. Temel Kiik Hiicre Teknikleri Ve Molekiiler Biyoloji.. Uygulamalart Kursu Dtizenleme Kurulu Uyelili, 28 Kasrm-2 Arahk 2011,. 6otit lnn Sdzlii Bildirileri Sozli.i l. 6autu Bildiri Mansiyon l.odiilii VI. Dr Aysun - Ahmet Ktigiikel Trp Odtilleri Poster Kdk Hiicre ve Hticresel Tedavi Derne[i Bildiri Mansiyon 3. Odtilii Katrltmlt Kdk Hticre Araqttrmalart Kongresi Poster Bildiri odtitti z.si 1. Uluslararast 6zel Ankara Giiven Hastanesi Kok Hiicre ve Hticresel TedaviDerne[i

5 l. Uluslararasr Katrhmh Kdk Hticre Sempozyumu, Sdzlii Bildiri odtitti z.si Ondokuz Mayrs YAYINLARI SCI, SSCI, AHCI indekslerine giren dergilerde yaylnlanan makaleler Hakki, Sema S.; Kayis, Seyit Ali; Hakki, Erdogan E.; Bozkurt, S. Buket; Duruksu, Gokhan; Unal, Zehra Seda; Turac, Gizem; Karaoz, Erdal, Comparison of Mesenchymal Stem Cells lsolated From Pulp and Periodontal Ligament,2015, JOURNAL OF PERIODONTOLOGY Akpinar, Gurler; Kasap, Murat; Aksoy, Ayca; Duruksu, Gokhan; Gacar, Gulcin; Kataoz, Erdal, Phenotypic and Proteomic Characteristics of Human Dental Pulp Derived Mesenchymal Stem Cells from a Natal, an Exfoliated Deciduous, and an Impacted Third Molar Tooth, 2014, STEM CELLS INTERNATIONAL Ogulur,lsmail; Gurhan, Gulben;Aksoy, Ayca;Duruksu, Gokhan; Inci, Cigdem;Filinte, Deniz; Kombak, Faruk Erdem;Karaoz,Erdal;Akkoc, Tunc, Suppressive effect of compact bone-derived mesenchymal stem cells on chronic airway remodeling in murine modelof asthma, 2014, INTERNATIONAL IMMLTNOPHARMACOLOGY Simsek, T.; Duruksu, G.; Okcu, A.;Aksoy, A.; Erman, G.;Utkan, Z.;Canturk,Z.;Karaoz,E., Effect of hypothyroidism in the thyroidectomized rats on immunophenotypic characteristics and differentiation capacity of adipose tissue derived stem cells,20l4, EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES Aydin, Adem; Duruksu, Gokhan;Erman, Gulay; Subasi, Cansu;Aksoy, Ayca; Unal, Zehra Seda; Karaoz, Erdal, Neurogenic Differentiation Capacity of Subacromial Bursal Tissue-Derived Stem Cells,2014, JOURNAL OF ORTHOPAEDIC RESEARCH Cakici, Cihangir; Buyrukcu, Bugra; Duruksu, Gokhan; Haliloglu, Ahmet Hakan; Aksoy, Ayca; Isik, Ayca; Uludag, Orhan; Ustun, Huseyin; Subasi, Cansu; Karaoz,Erdal, Recovery of Fertility in Azoospermia Rats after Injection of Adipose-Tissue-Derived Mesenchymal Stem Cells: The Sperm Generation, 201 3, BIOMED RESEARCH INTERNATIONAL Erdem, Arzum; Duruksu, Gokhan; Congur, Gulsah; Karaoz, Erdal, Genomagnetic assay for electrochemical detection of osteogenic differentiation in mesenchymal stem cells, 2013, ANALYST Karaoz,Erdal;Okcu, Alparslan; ljnal,zehra Seda; Subasi, Cansu; Saglam, Ozlem; Duruksu, Gokhan, Adipose tissue-derived mesenchymal stromal cells efficiently differentiate into insulinproducing cells in pancreatic islet microenvironment both in vitro and in vivo, 2013, CYTOTHERAPY Yilmaz, Sema; Inandiklioglu, Nihal; Yildizdas, Dincer; Subasi, Cansu; Acikalin, Arbil; Kuyucu, Yurdun; Bayram, Ibrahim; Topak, Ali; Tanyeli, Atila; Duruksu, Gokhan; Kataoz, Erdal, Mesenchymal Stem Cell: Does it Work in an Experimental Modelwith Acute Respiratory Distress Syndrome?,2013, STEM CELL REVIEWS AND REPORTS Karaoz, Erdal; Kabatas, Serdar; Duruksu, Gokhan; Okcu, Alparslan; Subasi, Cansu; Ay, Birol; Musluman, Murat; Civelek, Erdinc, Reduction of Lesion in Injured Rat Spinal Cord and Partial Functional Recovery of Motility after Bone Marrow Derived Mesenchymal Stem Cell Transplantation, 201 2, TURKI SH NEUROSURGERY Karaoz, Erdal; Demircan, Pmar Cetinalp; Saglam, Ozlem; Aksoy, Ayca; Kaymaz, Figen; Duruksu, Gokhan, Human dental pulp stem cells demonstrate beffer neural and epithelial stem cell properties than bone marrow-derived mesenchymal stem cells,2011, HISTOCHEMISTRY AND CELL BIOLOGY

6 Karaoz,Erdal; Ayhan, Selda; Okcu, Alparslan; Aksoy, Ayca; Bayazit, Gulay; Gurol, A. Osman; Duruksu, Gokhan, Bone marrow-derived mesenchymal stem cells co-cultured with pancreatic islets display beta cell plasticity, 2011, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE Karaoz, Erdal; Ayhan, Selda; Gacar, Guelcin; Aksoy, Ayca; Duruksu, Goekhan; Okcu, Alparslan; Demircan, P. Cetinalp; Sariboyaci, A. Eker; Kaymaz, Figen; Kasap, Murat,Isolation and characterization ofstem cells from pancreatic islet: pluripotency, differentiation potential and ultrastructural characteristics, , CYTOTffiRAPY Karaoz, E.; Genc, Z. S.; Demircan, P. C.; Aksoy, A.; Duruksu, G., Protection of rat pancreatic islet function and viability by coculture with rat bone marrow-derived mesenchymal stem cells,2010, CELL DEATH & DISEASE Karaoz, Erdal; Dogan, Burcu Nur; Aksoy, Ayca; Gacar, Guelcin; Akyuz, Serap; Ayhan, Selda; Genc, Zehra Seda; Yuruker, Sinan; Duruksu, Goekhan; Demircan, Pinar Cetinalp; Sariboyaci, Ayla Eker, Isolation and in vitro characterisation of dental pulp stem cells from natal teeth,2010, HISTOCHEMISTRY AND CELL BIOLOGY Duruksu, Goekhan; Ozturk, Bengu; Biely, Peter; Bakir, Ufuk; Ogel, ZumrutB., Cloning, Expression and Characterization of Endo-beta-1,4-Mannanase from Aspergillus fumigatus in Aspergillus sojae and Pichia pastoris, 2009, BIOTECHNOLOGY PROGRESS makaleler Erdal Karaoz, Soykan Ankan, Ayga Aksoy,Zehra Seda Unal, Mine Adaq, Gdkhan Ada5, Gdkhan Duruksu, Stromal Stem Cells from Parathyroid Glands of Patients with Secondary Hyperparathyroidism Demonstrate Higher Telomerase Activity and Osteogenic Differentiation Ability than Normal Bone Marrow Derived Stromal Stem Cells, 2013, British Journal of Medicine and Medical Research Hakemli kon lann bildiri alan yayrnlar Modification of Collagen to Enhance The Differentiation of Rat Pancreatic Islet Derived Stem Cells into Insulin Producing Cells, Beta Cell Workshop (BCW-ISG-2O15),2015 Different Responses of Stromal and Mesenchymal Stem Cells to the Extracellular vesicles derived from Malign Stromal Cells and Cancer Cell Lines, EMBO/EMBL Symposium: Frontiers in Stem Cells and Cancer, 2015 The effect of extracellular matrix proteins on cell viability and growth of pancreatic beta cell line BRIN-BDl l, Tissue Engineering andregenerative Medicine International Society Asia-Pacific Annual Conference (TERMIS-AP 201 4), 2014 Hiicre Nakli Tedavilerinde Uyanlmrg Pluripotent K<ik Hticrelerin Kullanrmr (Merkezi Sinir Sistemi), Santral Sinir Sistemi Hastahklannda K<ik Hiicre Uygulamalan Sempozyumu,20l4 Comparative Analysis of Beta Cell Marker Expression in Pancreatic Islet Derived and Adipose Tissue Derived Adult Stem Cells, ISLET Society Meeting 2014,2014 The effect ofpax4 gene expression on the differentiation ofpancreatic islet and adipose tissue derived stem cells into insulin producing cells, Meeting of the Tissue Engineering and Regenerative Medicine International Society (TERMIS/EU 201 4), The synergistic effect of NGN3 and PAX4 expressions on in pancreatic islet derived stem cells, Meeting of the Tissue Engineering and Regenerative Medicine lnternational Society (TERMIS/EU 2014),2014

7 Saphkh ve Multiple Myeloma Olgularrnrn Kemik iligi-faynakh Mezenkimal Kok Hiicrelerinin Osteojenik Farkhlagma Potansiyelinin Kargrlagtrrmah Olarak incelenmesi, 1. KOk Hiicre ve Hticresel Tedaviler Kongresi, 2014 Pankreatik Beta Hiicrelerin Hiicre Drgr Matriks Proteinlerine Yantfi: Canltltk, Qo[alma ve Fonksiyon, l. Kdk Hticre ve Hticresel Tedaviler Kongresi,2014 Farkh Meme Kanser Hticrelerinden Elde Edilmig Eksozomlarm Meme Stroma ve Kemik ili[i Kaynakh Krik Hiicrelerinde Kanserlegtirme Potansiyeli, l. KOk Hiicre ve Hiicresel Tedaviler Kongresi,20l4 Kemik iligi faynakh Mezenkimal Kdk Hiicrelerde Rekombinant Tirozin Hidroksilaz Ekspresyonunun Norojenik Farkhlagma Potansiyeli Uzerindeki Etkisi, 1. Kdk Hiicre ve Hiicresel Tedaviler Kongresi, Uyarrlmrq Pluripotent K<ik Hiicrelere Genel Bakrg, l. Kdk Hiicre ve Hiicresel Tedaviler Kongresi, 2014 Pax4 Geni Aktanlmrg Pankreatik Adacrk Kaynakh Kdk Hiicrelerin Endokrin hiicre Yoniinde Farkhlagma Potansiyeli, i. Kdk Hiicre ve Hiicresel Tedaviler Kongresi, 2014 Pankreatik Adacrk- ve Adipoz Doku- Kaynakh Kok Hticrelerin Endokrin Hiicre Ytiniinde Fark lagma Potansiyellerinin Karqrlagtrnlmah Olarak incelenmesi, 4. Kdk Hticre Sempozyumu, 20t3 Recovery of Motility in Rats with Spinal Cord Injury after Treatment with VEGF+ Mesenchymal Stem Cells, Biological and Clinical Aspects of the Use of Somatic Stem Cells in Regenerative Medicine,20l3 Mezenkimal Kdk Hiicrelerin Ba[rgrk Baskrlayrcr Ozellikleri, 1. Uluslararasr Kattltmh Hiicre Oltimti Aragtrrma Kongresi, 2013 Modifuing Collagens from Wharton?s Jelly for Improvement of Mesenchymal Stem Cells Adhesion and Proliferation, TERMIS-AP 2013, 2013 Improvement of Differentiation Efficiency into Insulin-Secreting Cells by Ngn3 and Pax4 Expression, Meeting of the Tissue Engineering and Regenerative Medicine International Society (TERMIS-EU 2013),2013 Gen Aktanm Yontemleri ve Kdk Hiicre Uygulamalarr, TEMD Bilimsel Etkinlik Programr,2013 Functionalized PEG Hydrogels as Immunoactive Barriers for Pancreatic Islet Cell Encapsulation Beta Cell Workshop 2013,2013, Hemocompatibility andcell-surface Interaction, Nanomaterials in Medicine Workshop,2013 Infiltrated Bone Marrow insan Dig Pulpasi Kaynakli K<ik HiicrelerinK562 (insan Kronik Myeloid L<isemi) Hiicre Dizisi Uzerine Sitotoksik Etkisinin Aragttrrlmast, 1. Uluslararast Kattltmlt Kdk Hiicre Aragtrrmalan Kongresi, Uzun Stire Ktiltiire Edilen Srgan Kemik iligi faynat<h Mezenkimal K<ik Hiicrelerde Genomik Kararhhlrn Karyotipik Analizlerle incelenmesi, 1. Uluslararasr Katrhmh KOk Hiicre Ara;trmalart Kongresi, 2011 Mezenkimal K<ik Hiicrelerde Trail Gen Ekspresyonunun Karakterizasyonu, Katrhmh Kok Hiicre Aragttrmalarr Kongresi, 2011 l. Uluslararast ileri Derece Uzun Siireli Kiilttiriin Sigan Kemik iligi faynakli Mezenkimal Kdk Hiicreler Uzerindeki Etkilerinin Ayrintili incelenmesi, l. Uluslararast Kattltmh Kok Hiicre Araqttrmalart Kongresi, 2011

8 Telomerase Activity: Indicator for Stable Transformation Efficiency in Mesenchymal Stem Cells, 5th World Congress on Preventive and Regenerative Medicine, Pancreatic Islets Protected by Pancreatic Islet Derived Stem Cells Through Cytokines,5th World Congress on Preventive and Regenerative Medicine, 2010 Mezenkimal Krik Hiicrelerine Kahcr Gen Aktarrmrnda 6n Gdsterge Olarak Telomeraz Enzim Aktivitesi Kullanrlabilir mi?, l.uluslararasr Katrhmh Kdk Hiicre Sempozyumu, 2010 Pankreas Adacrk Kaynakh Kdk Hiicrelerce Salgrlanan Sitokinlerin Streptozotosin ile Hasar Olugturulmug Pankreatik Adacrklar Uzerine Koruyucu Etkisi, l.uluslararasr Katrhmh Kdk Hiicre Sempozyumu, 2010 Characterization ofcatalytic Activity of Endo-Mannanase, lnternational Symposium On Biotechnology: Developments And Trends (BTMETU2009, 2009 Heterologous Expression ofglycosidases of A.fumigatus in A.sojae and P.pastoris for Synthesis of Novel Carbohydrates, 12. lntemational Congress of Mycology (IUMS 2008),2008 Production of Endo-1,4-b-Mannanase of Aspergillus fumigatus in Aspergillus sojae and Pichia Pastoris,3. CONFERENCE ON PHYSIOLOGY OF YEASTS AND FILAMENTOUS FUNGI (PYFF3),2007 lslets oflangerhans,2. ed., Stem Cells in Pancreatic Islets, ISBN: ,2014 Geligim Biyolojisi, Sistem Biyolojisi. Geligim Biyolojisinin Trp, Ekoloji ve Evrime Uzanmast, ISBN: , Geligim Biyolojisi, KOk Hiicre Kavramr Organogeneze Giriq, ISBN: ,2013 Diizenleme Tarihi :