ÖZGEÇMİŞ. 1. Adı Soyadı: Gülaçtı TOPÇU. 2. Doğum Tarihi: Unvanı: Prof.Dr.

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1 ÖZGEÇMİŞ 1. Adı Soyadı: Gülaçtı TOPÇU 2. Doğum Tarihi: Unvanı: Prof.Dr. 4. Öğrenim Durumu: Derece Bölüm/Program Üniversite Yıl Lisans Eczacılık Fakültesi İstanbul Üniversitesi Doktora Eczacılık Fakültesi İstanbul Üniversitesi Akademik Ünvanlar: Profesör: 1999 (Temel Eczacılık Bilimleri) 2006 (Organik Kimya) 2011 (Farmakognozi) Doçent: 1989 Doktora: Istanbul University, Faculty of Pharmacy (Health Sciences Institute) Istanbul, TURKEY Title of Thesis: The Investigations on Triterpenoid and Flavonoid Compounds of Salvia verticillata subsp. verticillata and Salvia pinnata 6. Yönetilen Yüksek Lisans ve Doktora Tezleri : 6.1. Yüksek Lisans Tezleri: 1. Lavandula stoechas ssp. stoechas Bitkisinin Uçucu Yağının ve Uçucu Olmayan Organik Bileşenlerinin İncelenmesi ve Biyolojik Aktivitelerinin Belirlenmesi. Meral Nil Ayral (Marmara Üniversitesi 1997, Yüksek Lisans Tezi) Danışmanlar: Prof.Dr. Adnan Aydın, Doç.Dr. Gülaçtı Topçu. 2. Sideritis athoa Papanikolau et Kokkini Bitkisinin Diterpenik Bileşiklerinin İzolasyonu ve Yapı Karakterizasyonu. Ahmet Ceyhan Gören (Balıkesir Üniversitesi, 1997) Danışmanlar: Doç.Dr. Yaşar Kemal Yıldız, Doç.Dr. Gülaçtı Topçu. 3. Sideritis sipylea Boiss. Bitkisindeki Diterpenik Yapılarının İzolasyonu ve Karakterizasyonu. Turgut Kılıç (Balıkesir Üniversitesi, Fen Bilimleri Enstitüsü, 1998) Danışmanlar: Doç.Dr. Yaşar Kemal Yıldız, Doç.Dr. Gülaçtı Topçu. 4. Bazı Triterpen-Flavon Kombinasyonlarının Hazırlanması ve Biyomembranlarda Flouresans Prob olarak Kullanılabilirliğinin Araştırılması. Zeynep Türkmen (İstanbul Üniversitesi, İstanbul Üniversitesi, Sağlık BilimleriEnstitüsü, 2004) Danışman: Prof. Dr. Gülaçtı Topçu. 5. Endemik İki Sideritis Türü Sideritis arguta ve S. congesta nın Diterpenik Bileşiklerinin İzolasyonu ve Biyolojik Aktivitelerinin İncelenmesi. Abdulselam Ertaş (İstanbul Üniversitesi, İ.Ü. Sağlık Bilimleri Enstitüsü, 2005) Danışman: Prof. Dr. Gülaçtı Topçu. 6. Türkiye de Yetişen Vinca Türlerinin Antioksidan Aktiviteleri Mehmet Boğa (İstanbul Üniversitesi, İ.Ü. Sağlık Bilimleri Enstitüsü, 2005) Danışman: Doç. Dr. Ufuk Kolak ve Prof. Dr. Gülaçtı Topçu. 7. Salvia adenophylla ve S. verticillata subsp. amasiaca Bitkilerindeki Sekonder Metabolitlerin Aktivite Odaklı İzolasyonu ve Yarı Sentetik Türevlerinin Antioksidan ve Antikolinesteraz

2 Aktivitelerinin İncelenmesi. Seda Damla Hatipoğlu (İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2010 Haziran) Danışman: Prof. Dr. Gülaçtı Topçu. 8. Ferulago idea ve F. trojana Bitkilerindeki Sekonder Metabolitlerin İzolasyonu, Antioksidan and Anticholinesteraz Aktivitelerinin İncelenmesi. Begüm Çakar (İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2010 Haziran), Danışman: Prof. Dr. Gülaçtı Topçu. 9. Sternbergia fischeriana (Herbert) Rupr. Alkaloidlerinin Kimyasal Analizi ve Biyolojik Aktivitelerinin Belirlenmesi. Tuba Baygar (İstanbul Üniversitesi, Fen Bilimleri Enstitüsü, 2009) Danışman: Prof. Dr. Keriman Günaydın ve Prof Dr. Gülaçtı Topçu. 10. Salvia chrysophylla ve Salvia trichoclada Bitkilerindeki Sekonder Metabolitlerin İzolasyonu, Yarı Sentetik Türevlerinin Eldesi, Antioksidan ve Antikolinesteraz Aktivitelerinin İncelenmesi. Burcu Çulhaoğlu (İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2011 Ocak) Danışman: Prof. Dr. Gülaçtı Topçu. 11. Encapsulation of Anticancer Drugs with Polymeric Micelles and Their Characterization. Kerem Karakuş (İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2011 Haziran) Danışman: Prof. Dr. Gülaçtı Topçu. 12. Prangos ilanea ve Heracleum platytaeinium Bitkilerinden Sekonder Metabolitlerin İzolasyonu ve Karakterizasyonu, Antioksidan ve Antikolinesteraz Aktivitelerinin İncelenmesi. Demet Dinçel (İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2011 Haziran) Danışman: Prof. Dr. Gülaçtı Topçu. 13. Nepeta sorgerae ve Nepeta obtusicrena Bitkilerinin Antioksidan ve Anti-Alzheimer Bileşenlerinin İzolasyonu ve Yapılarının Belirlenmesi. Anıl Yılmaz (İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2011 Haziran) Danışman: Prof. Dr. Gülaçtı Topçu. 14. Evaluation of cationic polymer vectors for non-viral gene delivery. H. İmran Güngördü (İstanbul Teknik Üniversitesi, Yüksek Lisans Tezi, Haziran 2012) Danışman: Prof. Dr. Gülaçtı Topçu. 15. ph ve Sıcaklığa Duyarlı Kontrollü İlaç Salımı. Tuba Başkan (İstanbul Teknik Üniversitesi, Yüksek Lisans Tezi, Haziran 2013) Doktora Tezleri: 1. Teucrium alyssifolium ve Teucrium sandrasicum Bileşiklerinin Neo-Clerodane Diterpenleri. Ecz. Canan Kesikoğlu Eriş, Ankara Üniversitesi, Sağlık Bilimleri Enstitüsü, 1994), Danışman: Prof. Dr. Semra Kurucu ve Doç. Dr. Gülaçtı Topçu. 2. Bazı Sideritis (Sideritis argyrea, Sideritis dichotoma, Sideritis trojana) Türlerinin Diterpenik Bileşenlerinin İzolasyonu ve Yapılarının Tayini. Ahmet Ceyhan Gören (Balıkesir Üniversitesi, Fen Bilimleri Enstitüsü, 2002) Danışmanı: Prof. Dr. Gülaçtı Topçu. 3. Sideritis lycia ve Sideritis leptoclada Türlerinin Diterpen Bileşiklerinin İzolasyonu ve Karakterizasyonu. Turgut Kılıç (Balıkesir Üniversitesi, Fen Bilimleri Enstitüsü, 2002) Danışmanlar: Doç.Dr. Yaşar Kemal Yıldız, Prof. Dr. Gülaçtı Topçu. 4. Cyathobasis fruticulosa (Bunge) Aellen Alkaloitleri Üzerinde Çalışmalar, Ecz. Arzu Küçükosmanoğlu Bahceevli (Ankara Üniversitesi, Sağlık Bilimleri Enstitüsü, 2002). Danışman: Prof. Dr. Semra Kurucu ve Prof. Dr. Gülaçtı. Topçu.

3 5. Micromeria cilicica ve M. juliana Türlerinde Antioksidan Bileşiklerin HPLC ile Analizi ve Yapılarının Tayini. Mehmet Öztürk (İstanbul Üniversitesi, İ.Ü. Sağlık Bilimleri Enstitüsü, 2005) Danışman: Doç. Dr. Ufuk Kolak ve Prof. Dr. Gülaçtı Topçu. 6. Isolation and Structure Elucidation of Vinca Alkaloids from Vinca species and Investigation of Cytotoxic Activity of Vinorelbine Loaded Nanodrug Delivery Systems Fatemeh Bahadori (İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2011 Haziran) Danışman: Prof. Dr. Gülaçtı Topçu. Devam Eden Doktora Tezleri 1. Van Yöresi ne ait bazı Fritillaria türlerinin Potansiyel Sitototoksik Bileşenlerinin Eldesi ve Yapılarının Spektroskopik Yollarla Belirlenmesi Tuba Kuşman Danışman: Doç Dr.Nur Tan ve Prof.Dr. Gülaçtı Topçu. 2. Bilgisayar-destekli Antikolinesteraz Flavonoid Türevlerinin Sentezi ve İntraoperatif Kanser Görüntüleme Özelliklerinin İncelenmesi. Burcu Çulhaoğlu. Danışman: Prof.Dr. Turan Öztürk ve Prof.Dr. Gülaçtı Topçu. 3. Teucrium Türlerinin Diterpen Bileşenlerinin İzolasyonu ve Biyoaktif Analoglarının Sentezi Anıl Yılmaz. Danışman: Prof.Dr. Turan Öztürk ve Prof.Dr. Gülaçtı Topçu. 4. Biyolojik Sıvılardan Meropenem ve İmipenem in Yüksek Performanslı Sıvı Kromatografisi ile Miktar Tayini, Demet Dincel. Danışman: Doç.Dr. A. Olcay Sağırlı ve Prof.Dr. Gülaçtı Topçu. Devam Eden Yüksek Lisans Tezleri 1. Salvia maraschica Bitkisinin Biyoaktif Bileşenlerinin Belirlenmesi Sibel Kıran Danışman: Prof. Dr. Gülaçtı Topçu. 2. Ferulago blancheana Bitkisinin Sekonder Metabolitlerinin İzolasyonu, Antioksidan ve Antikolinesteraz Aktivitelerinin İncelenmesi Esin Aslan Danışman: Prof. Dr. Gülaçtı Topçu. 7. Yayınlar 7.1. Uluslararası hakemli dergilerde yayınlanan makaleler (SCI and SCI exp. indexed SSCI (Citation : 2319, h index: 25) 1. Ulubelen, A., Topçu, G., Mabry, T.J., Dellamonica, G., Chopin, J., C-Glycosylflavonoids from Passiflora foetida var. hispida and P.foetida var. hibiscifolia. J. Nat. Prod. 45, 103, Ulubelen, A., Topçu, G., Triterpenoids from Salvia pinnata. Phytochemistry 23, , Ulubelen, A., Topçu, G., Flavonoids and Triterpenoids from Salvia verticillata and S. pinnata. J. Nat. Prod. 47, 1068, Ulubelen, A., Topçu, G., Terem, B., Abietane Diterpenoids from The Roots of crypthanta. Phytochemistry 26, , 1987.

4 5. Öksüz, S., Topçu, G., Triterpene Fatty Acid Esters and Flavonoids from Inula britannica. Phytochemistry 26, , Topçu, G., Cordell, G.A., Farnsworth, N.R., Fong, H.H.S., Studies on Zoapatle VIII. Novel Cytotoxic Sesquiterpene Lactones from Montanoa tomentosa ssp. microcephala. J. Pharmaceut. Sci. 77, , Topçu, G., Ulubelen, A., Diterpenoids from Salvia wiedemannii. Phytochemistry, 29, , Topçu, G., Che, C.T., Cordell, G.A., Ruangrungsi, N., Iridolactones from Alyxia reinwardtii. Phytochemistry 29, , Cordell, G.A., Pezzuto, J.M., Lin, L.-Z.,Lin, L.-J., Shieh, Topçu, G., Öksüz, S., Guainolides from Inula anatolica. Phytochemistry 29, , Ulubelen, A., Topçu, G., Abietane Diterpenoids from Salvia microstegia. Phytochemistry 30, , Topçu, G., Ulubelen, A., Diterpenoids from Salvia wiedemannii. Phytochemistry 30, , Pezzuto, J.M., Che, C.T., Mcpherson, D.D., Zhu, J.P., Topçu, G., Erdelmeier, C.A.J., Cordell, G.A., DNA as an Affinity Probe Useful in Detection and Isolotion of Biologically Active Natural Compounds. J. Nat. Prod. 54, , Ulubelen, A., Topçu, G., Chen, S., Cai, P., Snyder, J.K., A New Abietane Diterpene from Salvia wiedemanni Boiss. J. Org. Chem. 56, , Öksüz, S., Topçu, G., A Eudesmanolide and Other Constituents from Inula graveolens. Phytochemistry 31, , Ulubelen, A., Topçu, G., New Abietane Diterpenoids from Salvia montbretii. J. Nat. Prod. 55, , Ulubelen, A., Topçu, G., Tan, N., Lin, L., Cordell, G.A., Microstegiol, A Rearranged Diterpene from Salvia microstegia. Phytochemistry 31, , Ulubelen, A., Topçu, G., Tuzlacı, E., New Diterpenoids from Salvia divaricata. J. Nat. Prod. 55, , Ulubelen, A., Topçu, G., Tan, N., Rearranged Abietane Diterpenes from Salvia candidissima.phytochemistry 31, , Ulubelen, A., Topçu, G., Abietane Diterpenoids from Salvia pomifera.phytochemistry 31, , Ulubelen, A., Topçu, G., Tan, N., Diterpenoids from candidissima.tetrahedron Lett. 33, , Lin, L., Topçu, G., Lotter, H., Ruangrungsi, N., Wagner, H., Pezzuto, J.M., Cordell, G.A., Wrightiadione from Wrightia tomentosa. Phytochemistry 31, , Topçu, G., Öksüz, S., Shieh, H.L., Cordell, G.A., Pezzuto, J.M., Bozok-Johansson, C., Cytotoxic and Antibacterial Sesquiterpenes from Inula graveolens. Phytochemistry 32, , Öksüz, S., Serin, S., Topçu, G., Sesquiterpene lactones from Centaurea hermannii. Phytochemistry 35, , 1994.

5 24. Gil, R.R. Cordell, G.A., Topçu, G., Ulubelen, A., Montbretol and Salvinolone are Identical. J. Nat. Prod. 57, , Ulubelen, A., Topçu, G., Sönmez, U., Eriş, C., Terpenoids from Salvia nemorosa. Phytochemistry 35, , Ulubelen, A., Topçu, G., Kaya, Ü., Steroidal Compounds from Teucrium chamaedrys subsp. chamaedrys. Phytochemistry 36, , Ulubelen, A., Topçu, G., Lotter, H., Wagner, H., Eriş, C., Triterpenoids from the Aerial Parts of Salvia montbretii.phytochemistry 36, , Topçu, G., Ulubelen, A., Eriş, C., Di-and Triterpenoids of Salvia pomifera. Phytochemistry 36, , Ulubelen, A., Topçu, G., Eriş, C., Sönmez, U., Kartal, M., Kurucu, S., Bozok-Johansson, C., Terpenoids from Salvia sclarea. Phytochemistry 36, , Öksüz, S., Topçu, G., Guaianolides from Centaurea glastifolia. Phytochemistry 37, , Ulubelen, A., Topçu, G., Ölçal, S., Reaarranged Abietane Diterpenes from Teucrium divaricatum subsp. villosum. Phytochemistry 37, , Ulubelen, A., Topçu, G., Tan, N., Ölçal, S., Bozok-Johansson, C., Üçer, M., Birman, H., Tamer, Ş., Biological activities of Turkish Medicinal Plant, Prangos platychlaena, J. Ethnopharmacology 45, N.3, , Topçu, G., Tan, N., Ulubelen, A., Sun, D., Watson, W.H., Terpenoids and Flavonoids from the Aerial Parts of Salvia candidissima. Phytochemistry 40, 501-4, Topçu, G., Eriş, C., Ulubelen, A., Krawiec, M., Watson, W.H., New Rearranged Neoclerodane Diterpenoids from Teucrium alyssifolium. Tetrahedron 51, , Ulubelen, A., Topçu, G., Sönmez, U., Choudhary, M.I., Atta-ur-Rahman, Abietane Diterpenes from Salvia napifolia. Phytochemistry 40, , Ulubelen, A., Topçu, G., Tan, N., Diterpenoids from Salvia heldrichiana. Phytochemistry 40, , Topçu, G., Öksüz, S., Herz, W., Diaz, J.G., Structurally Related Guaianolides from Inula thapsoides. Phytochemistry 40, , Göker, H., Ölgen, S., Ertan, R., Akgün, H., Topçu, G., Synthesis of Some New Benzimidazol-5(6)-Carboxylic AcidsJournal Heterocyclic Chemistry 32, , Topçu, G., Eriş, C., Ulubelen, A., Rearranged Abietane Diterpenes from Salvia limbata. Phytochemistry 41, , Topçu, G., Ulubelen, A., Tam, T.C.M., Che, C.T., Norditerpenes and Norsesterterpenes from Salvia yosgadensis. J. Nat. Prod. 59, , Ulubelen, A., Sönmez, U., Topçu, G., Bozok-Johansson, C., An Abietane Diterpene and Two Phenolics from Salvia forskahlei. Phytochemistry 41, , Topçu, G., Eriş, C., Che, C.T., Ulubelen, A., C-10 Oxygenated Neo-Clerodane Diterpenes from Teucrium sandrasicum. Phytochemistry 42, , Topçu, G., Ulubelen, A., Tam, T.C.M., Che, C.T., Sesterterpenes and Other Constituents of Salvia yosgadensis. Phytochemistry 42, , 1996.

6 44. Topçu, G., Ulubelen, A., Abietane and Rearranged Abietane Diterpenes from Salvia montbrettii. J. Nat. Prod. 59, , Ulubelen, A., Topçu, G., Sönmez, U., Eriş, C., Özgen, U., Norsesterterpenes and Diterpenes from the Aerial Parts of Salvia limbata. Phytochemistry 43, , Topçu, G., Eriş, C., Kurucu, S., Ulubelen, A., A New Flavanone from Teucrium alyssifolium. Turk. J. Chem. 20, , Topçu, G., Kartal, M., Ulubelen, A., Terpenoids from Salvia tchihatcheffii. Phytochemistry 44, , Ulubelen, A., Sönmez, U., Topçu, G., Diterpenoids from the Roots of Salvia sclarea. Phytochemistry 44, , Topçu, G., Tan, N., Kökdil, G., Ulubelen, A., Terpenoids from Salvia glutinosa. Phytochemistry 45, , Ulubelen, A., Tan, N., Topçu, G., Terpenoids from Salvia candidissima subsp. candidissima. Phytochemistry 45, 6, , Topçu, G., Eriş, C., Ulubelen, A., Neo-Clerodane Diterpenoids from Teucrium alyssifolium. J. Nat. Prod. 60, , Kökdil, G., Topçu, G., Sönmez, U., Ulubelen, A., Terpenoids and Flavonoids from Salvia cyanescens. Phytochemistry 46, , Öksüz, S., Topçu, G., Krawiec, M., Watson, W.H., Eudesmanolides and Other Constituents of Inula thapsoides. Phytochemistry 46, , Ulubelen, A., Topçu, G., Bozok-Johansson, C., Norditerpenoids and Diterpenoids from Salvia multicaulis with Antituberculous Activity. J. Nat. Prod. 60, , Sönmez, U., Topçu, G., Ulubelen, A., Constituents of Salvia verticillata. Turk. J. Chem. 21, , Ulubelen, A., Tan, N., Sönmez, U., Topçu, G., Diterpenoids and Triterpenoids from Salvia multicaulis. Phytochemistry 47, , Tan, N., Topçu, G., Ulubelen, A., Norabietane Diterpenoids and Other terpenoids from Salvia recognita. Phytochemistry 49, , Kökdil, G., Topçu, G., Krawiec, M., Watson, W.H., Nepetanudone, a dimer of the - pyrone 5,9-dehydronepetalactone. J. Chem. Crystallogr. 28, , Topçu, G., Erenler, R., Çakmak, O., Johansson, C.B., Çelik, C., Chai, H.B., Pezzuto, J.M., Diterpenes from the Berries of Juniperus excelsa. Phytochemistry 50, , Kökdil, G., Yalçın, S.M.,Topçu, G., Nepetalactones and Other Constituents of Nepeta nuda ssp. albiflora. Turk J. Chem. 23, , Ulubelen, A., Topçu, G., Chai, H.B., Pezzuto, J.M., Cytotoxic Activity of Diterpenoids Isolated from Salvia hypargeia. Pharm. Biology 37, , Topçu, G., Ulubelen, A., Terpenoids from Salvia kronenburgii. J. Nat. Prod. 62, , Topçu, G., Gören, A.C., Yıldız, Y.K., Tümen, G., Ent-Kaurene Diterpenes from Sideritis athoa. Nat. Prod. Lett., 14 (2), 123-9, 1999.

7 64. Topçu, G., Kökdil, G., Yalçın, S.M., Constituents of Nepeta caesarea Boiss. J. Nat. Prod., 63, , Ulubelen, A., Topçu, G., Salvimultine, A New Noricetexane Diterpene from the Roots of Salvia multicaulis. J. Nat. Prod., 3, , Topcu, G., Gören, A.C., Kılıç, T., Yıldız, Y.K., Tümen, G., Diterpenes from Sideritis argyrea. Fitoterapia 72, 1-4, Ulubelen, A., Öksüz, S., Topçu, G., Gören, A.C., Voelter, W., Antibacterial Diterpenes from the Roots of Salvia bleapharochleana, J. Nat. Prod. 64, , Topçu, G., Ayral, M. N., Aydın, A., Gören, A. C., Chai, H.B., Pezzuto, J. M. Triterpenoids of the roots of Lavandula stoechas ssp. stoechas. Pharmazie 56, , Ulubelen, A, Öksüz, S, Topçu, G, Gören, A.C., Johannson C.B, Çelik, C, Kökdil, G., Voelter, W. A New Antibacterial Diterpene from the Roots of Salvia caespitosa. Nat. Prod. Lett. 15, , Kurucu, S., Kartal, M., Choudhary, M.I., Topçu G. Pyrrolizidine Alkaloids from Symphytum sylvaticum Boiss. subsp. sepulcrale. (Boiss. & Bal.) Greuter & Burdet var. sepulcrale and Symphytum aintabicum Hub.-Mor. & Wickens Turk. J. Chem. 26 (2), , Topçu, G., Gören, A.C., Kılıç, T, Yıldız, Y.K., Tümen, G., Diterpenes from Sideritis sipylea and S. dichotoma. Turk. J. Chem. 26, , Günaydın, K., Topçu, G, Ion, R.M. 1,5-Dihydroxyanthraquinones and an Anthrone from Roots of Rumex crispus, Nat. Prod. Lett. 16, 65-70, Gören, A.C., Topçu, G, Öksüz, S., Kökdil, G., Voelter, W., Ulubelen, A. Diterpenoids from Salvia ceratophylla. Nat. Prod. Lett. 16, 47-52, Topcu, G., Gören, A.C., Kılıç, T., Yıldız, Y.K., Tümen, G. Diterpenes from Sideritis trojana. Nat. Prod. Lett. 16, 33-37, Kökdil, G.,., Gören, A.C., Volter, W. Steroids and Terpenoids from Ajuga relicta. Zeitschrift für Naturforschung B Journal of Chemisty 57 b, , Ulubelen, A., Birman, H., Öksüz, S., Topcu, G., Kolak, U., Barla, A., Voelter, W. Cardioactive Diterpenes from Salvia eriophora. Planta Med. 68, , Goren, A.C., Topcu, G., Bilsel, G., Bilsel, M., Aydoğmuş, Z., Pezzuto, J. M., Chemical Constituents and Biological Activity of Essential Oil of Lavandula stoechas ssp. stoechas. Zeitschrift für Naturforschung C 57, , Kartal, M., Yıldız, S., Kaya, S., Kurucu, S., Topcu, G. Antimicrobial Activity of Propolis Samples from two Different Regions of Anatolia J. Ethnopharmacology 86, 69-73, Topcu, G., Altıner, E. A., Gözcü, Ş., Halfon, B., Pezzuto, J.M., Kingston, D.G.I. Cytotoxic Di and Triterpenoids from Salvia staminea, Planta Med. 69, 464-7, Topcu, G., Aydogmus, Z., Imre, S., Gören, A.C., Pezzuto, J.M., Clement, J., Kingston, D.G.I. Brominated Sesquiterpenes from Red Alga Laurencia obtusa. J. Nat. Prod. 66, , Kılıç, T, Yıldız, Y.K., Gören, A.C., Tümen, G., Topçu, G., Phytochemical Analysis of Some Sideritis Species of Turkey Chem. Nat. Compds 39, , 2003.

8 82. Gören, A.C., Topçu, G., Bilsel, G., Bilsel, M., Wilkinson, J.M., Cavanagh, H.M.A. Analysis of Essential Oil of Satureja thymbra by Hydrodistillation, Thermal Desorber and Head Space GC/MS Techniques and Its Antimicrobial Activity. Nat. Prod. Res. 18, , Topcu, G., Türkmen Z., Schilling, J.K., Kingston, D.G.I. Highly Hydroxylated Triterpenes from Salvia kronenburgii. J. Nat. Prod. 67, , Topcu, G., Kökdil, G., Türkmen, Z., Voelter, W., Adou, E., Kingston, D.G.I. A New Clerodane Diterpene and Other Constituents from Ajuga chamaepitys ssp. laevigata. Zeitschrift für Naturforschung B Journal of Chemisty 59 b, , Topçu, G., Gören, A.C., Bilsel, G., Bilsel, M., Çakmak, O., Schilling, J., Kingston, D.G.I., Cytotoxic Activity and Essential Oil Composition of Leaves and Berries of Juniperus excelsa Pharm. Biology 43, , Kolak, U., Topcu, G., Birteksöz, S., Ötük, G., Ulubelen, A. Terpenoids and Steroids from the Roots of Salvia blepharochelana. Turk. J. Chem. 29, , Gören, A.C., Zhou, B.N., Topcu, G., Kökdil, G., Kingston, D.G.I. DNA Damaging Activities of Methanol Extract of Ajuga postii and Iridoid Glucoside Reptoside. Nat. Prod. Res. 19, , Bahçeevli, A.K., Kurucu, S., Kolak, U., Topçu, G., Adou, E., Kingston, D.G.I. Alkaloids and Aromatics of Cyathobasis fruticulosa (Bunge) Aellen J. Nat. Prod. 68, , Kılıç, T., Yıldız, Y.K., Topçu, G., Gören A.C., Ay, M., Bodige, S.G., Watson, W.H. X-Ray Analysis of Sideroxol from Sideritis leptoclada. J. Chem. Crystallogr. 35, , Türkmen, Z., Klymchenko, A.S., Öncül, Ş., Duportail, G., Topcu, G. Demchenko, A.P. A triterpene oleanolic acid conjugated with 3-hydroxyflavone derivative as a new membrane probe with two-color ratiometric response. J. Biochem. and Biophys. Meth. 64, 1-18, Uydeş-Doğan, B.S., Takır, S., Özdemir, O., Kolak, U., Topçu, G., Ulubelen, A. The comparison of the relaxant effects of two methoxylated flavones in rat aortic rings, Vasc. Pharmacology 43, , Topcu, G., Barla, A., Gören, A.C., Bilsel, G., Bilsel, M., Tümen, G. Analysis of the Essential Oil Composition of Sideritis albiflora Using Direct Thermal Desorption and Headspace GC-MS Technique. Turk. J. Chem. 29, , Aslan, I., Kılıç, T., Gören, A.C., Topçu, G., Toxicity of acetone extract of Sideritis trojana and 7-epicandicandiol, 7-epicandicandiol diacetate and 18-acetylsideroxol against stored pests Acanthoscelides obtectus (Say), Sitophilus granarius (L.) and Ephestia kuehniella (Zell.) Indust. Crops and Prod., 23, , Topçu, G., Bioactive Triterpenoids From Salvia Species J. Nat. Prod. 69, , Aydoğmuş, Z., Yeşilyurt, V., Topcu, G., Constituents from Salvia microphylla. Nat. Prod. Res. 20, , Topçu, G., Herrmann, G., Kolak, U., Gören, A.C., Porzel, A., Kutchan, T.M., Isolation of fatty acids and aromatics from cell suspension cultures of Lavandula angustifolia, Nat. Prod. Res. 21, , 2007.

9 97. Kabouche, A., Kabouche, Z., Öztürk, M., Kolak, U., Topçu, G. Antioxidant abietane diterpenoids from Salvia barrelieri. Food Chem. 102, , Topçu, G., Ay, M., Sarıkürkcü, C., Öztürk, M., Ulubelen, A.A new flavone from antioxidant extracts of Pistacia terebinthus. Food Chem. 103, , Öztürk, M., Aydogmus Oztürk, F., Duru, M.E., Topçu, G., Antioxidant activity of stem and root Extracts of Rhubarb (Rheum ribes): An Edible Medicinal Plant, Food Chem. 103, , Topçu, G. and Ulubelen, A. Structure elucidation of organic compounds from natural sources using 1D- and 2D- NMR techniques, in J. Molecular Structure , 57-73, Barla, A., Topçu, G., Öksüz, S., Tümen, G., Kingston, DGI Identification of Cytotoxic Sesquiterpenes from Laurus nobilis. L. Food Chem. 104, , Topçu, G., Ertaş, A., Kolak, U., Öztürk, M., Ulubelen, A. Antioxidant activity tests on novel triterpenoids from Salvia macrochlamys, Arkivoc vii, , Topcu, G. Kolak, U., Balci, K. and Ulubelen, A. Structure elucidation of a new rearranged diterpene from a biologically active plant,salvia eriophora, Nat. Prod. Commun. 2, , Ay, M., Bahadori, F., Öztürk,M., Kolak, U. and Topçu, G. AntioxidantActivity of Erica arborea. Fitoterapia 78, , Topçu, G., Gören, A. C., Biological Activity of Diterpenoids Isolated from Anatolian Lamiaceae Plants.Rec.Nat. Prod. 1 (1), 1-16, Yesilyurt V, Halfon B, Ozturk M, Topcu, G. Antioxidant potential and phenolic constituents of Salvia cedronella. Food Chem. 108, 31-39, Topçu, G., Z. Turkmen, J.K. Schilling, D.G.I. Kingston, J.M. Pezzuto Cytotoxic Activity Studies on Some Anatolian Salvia Extracts,Pharmaceutical Biology 46, , Nazemiyeh, H., Bahadori, F., Delazar, A., Ay, M., Topcu, G., Kolak, U., Nahar, L., Auzie, A.A., Sarker, S.D. Tricetin 4 -O-alpha-L-rhamnopyranoside: A new flavonoid from the aerial Antioxidant phenolic compounds from the leaves of Erica arborea (Ericaceae) Chem. Nat. Compds. 44, , Aydogmuş, Z. Topcu, G., Guven, K.C. Studies on chemical constituents of Gracilaria verrucosa. Nat. Prod. Res. 22, , Nazemiyeh, H., Bahadori, F., Delazar, A., Ay, M., Topcu, G., Nahar, L., Majinda R.R. T., Sarker, S.D Antioxidant phenolic compounds from the leaves of Erica Arborea (Ericaceae). Nat. Prod. Res. 22, , Ertaş, A., Ozturk, M., Boga M, Topcu G. Antioxidant and Anticholinesteras Activity Evaluation of Sideritis arguta extracts and isolated ent-kaurane diterpenoids, J.Nat Prod. 72, , Kıvrak, I. Duru, M.E., Öztürk, M., Mercan, N., Harmandar, M., Topcu, G. Antioxidant, anticholinesterase and antimicrobial constituents from the essential oil and ethanol extract of Salvia potentillifolia. Food Chem. 116, , Kolak U, Kabouche A, Ozturk M, Kabouche, Z, Topcu, G. Ulubelen, A. Antioxidant from the Roots of Salvia barrelieri. Phytochem. Anal. 20, , 2009.

10 114. Sabudak, T., Oztürk, M., Gören, A.C., Kolak, U., Topcu, G. Fatty acids and Other Lipid Composition of Five Trifolium Species with Antioxidant Activity. Pharm. Biology 47, , Öztürk, M., Tel, G., Duru, M.E, Harmandar, M., Topcu, G. The Effect of Temperature on the Essential Oil Components of Salvia potentillifolia Obtained by Various Methods.Nat. Prod. Commun. 4, , Kolak, U., Hacibekiroglu, I., Ozturk, M., Ozgokce, F., Topcu, G., Ulubelen, A., Antioxidant and Anticholinesterase Constituents of Salvia poculata, Turk J. Chem., 33, , Kilic, T., Carikci, S., Topcu, G., Aslan. I., Goren, A.C., Diterpenoids from Sideritis condensata. Evaluation of Chemotaxonomy of Sideritis Species and Insecticidal Activity, Chem Nat. Compds, 45, , Öztekin, N., Başkan, S., Kepekçi, SE, Erim, FB, Topcu, G. Isolation and analysis of bioactive diterpenoids in Salvia species (Salvia chionantha and Salvia kronenburgii) by micellar electrokinetic capillary chromatography. J. Pharm. and Biomed. Anal, 51, , Demirkiran, O., Topcu, G. Bahadori, F., Ay, M., Nazemiyeh, H., Choudhary, M.I., Two New Phenylpropanoid Glycosides from the Leaves and Flowers of Erica arborea.helv. Chim. Acta 93, 77-83, Tel, G, Öztürk, M., Duru, ME, Harmandar, M and Topcu, G. Chemical Composition of the Essential Oil and Hexane Extract of Salvia chionantha and Their Antioxidant and Anticholinesterase Activity. Food and Chem. Toxic..48, , M. Oztürk, M.E. Duru, B. Memikoglu, M. Harmandar, Topçu, G. A New Rapid Spectrophotometric Method to Determine Rosmarinic Acid Level in Plant Extracts. Food Chem. 123, , Goren, A.C., Bilsel, G., Ozturk, A.H., Topcu G, Chemical Composition of Natural Colophony from Pinus brutia and Comparison with Synthetic Colophony, Nat Prod Comm., 5, , M. Oztürk, U. Kolak, G. Topçu, S. Öksüz, MI. Choudhary, Antioxidant and anticholinesterase active constituents from Micromeria cilicica by radical scavenging activity guided fractionation. Food Chem. 126, 31-38, Halfon, B., Goren, AC., Ertas, A., Topcu, G. Complete (13)C NMR assignments for entkaurane diterpenoids from Sideritis species. Mag. Res.Chem., 49, , Ozturk, M., Tumen, I., Ugur, A., Aydogmus, Z., Topcu, G. Evaluation of fruit extracts of six Turkish Juniperus species for their antioxidant, anticholinesterase and antimicrobial activities. J. Sci. of Food and Agric., 91, 867, Topcu, G. Antioxidant activity and flavonoids of Stachys ocymastrum. Chem. Nat. Compds., 46, , Baskan, T., Topcu, G., Aydogmus, Z., Constituents of the Red Alga Laurencia obtusa. Planta Medica 77, (2011) (SCI) 128. Culhaoglu, B., Topcu, G., Biologically Active Lupane Triterpenoids from Anatolian Salvia species. Planta Medica 77, (2011) (SCI)

11 129. Boğa, M., Kolak, U., Topcu, G., Bahadori, F., Kartal, M., Farnsworth, N.R. Two New Indole Alkaloids from Vinca herbacea L. Phytochem. Lett, 4, SI, , Topcu, G., Ertaş, A., Öztürk, M., Dincel, D., Kiliç, T., Halfon, B. Ent-kaurane diterpenoids isolated from Sideritis congesta. Phytochem. Lett., Topcu, G., Yapar, G., Türkmen Z., Gören, A.C., Öksüz, S., Schilling, JK., Kingston D.G.I. Ovarian antiproliferative activity directed isolation of triterpenoids from fruits of Eucalyptus camaldulensis Dehnh. Phytochem. Lett. 4, , Demirkiran, O., Topcu, G, Hussain, J, Ahmad, VU, Choudhary, MI. Structure elucidation of two new unusual monoterpene glycosides from Euphorbia decipiens, by 1D and 2D NMR experiments, Magn. Res. Chem., 49, , Lakhal, H., Boudiar, T., Kabouche, A., Laggoune, S., Kabouche, Z. Topçu, G.. Antioxidant Activity and Flavonoids of Stachys ocymastrum. Chem. Nat. Compds, 46, 6, , Esen H., Demirkiran, O., Yagar, H., Topcu, G., MAO Inhibitory Activity of Xanthones from Dichloromethane Extract of Polygala supina. Planta Medica 77, (2011) (SCI) 135. Yilmaz, A., Caglar, P.,Dirmenci, T., Goren, N., Topcu, G. A Novel Isopimarane Diterpenoid with Acetylcholinesterase Inhibitory Activity. Nat. Prod. Comm. 7 (6), , Bahadori, F., Topcu, G., Boga, M., Turkekul, A., Kolak, U., Kartal, M. Indole Alkaloids from Vinca major and V. minor Growing in Turkey. Nat. Prod. Comm. 7 (6), , Carikci, S., Kilic, T., Azizoglu, A., Topcu, G. Chemical Constituents of Two Endemic Sideritis Species from Turkey with Antioxidant Activity. Rec. Nat. Prod., 6 (2), , Topçu, G., Akdemir, A., Ozturk, M., Boga, M., Kolak, U. Abietane diterpenoids as butyrylcholinesterase inhibitors from Salvia species. Planta Med. 78, 11, , Çulhaoğlu B., Yapar G., Dirmenci T., Topçu G. Bioactive constituents of Salvia chrysophylla Stapf. Nat. Prod. Res. 27, , Topcu, G., Kolak, U., Oztürk, M., Boğa, M., Hatipoğlu, S.D., Bahadori, F. Çulhaoglu, B., Dirmenci, T.Investigation of Anticholinesterase Activity of a Series Salvia Extracts and Constituents of Salvia staminea. The Natural Product Journal, 3(1), 3-9, Topçu, G., Öztürk, M., Kuşman, T., Demirkoz, A.A.B., Kolak, U., Ulubelen, A. Terpenoids, essential oil composition and fatty acids profile, and biological activities of Anatolian Salvia fruticosa Mill. Turk.J.Chem. 37, 4, , Dincel, D., Hatipoğlu, S.D., Gören, A.C., Topçu, G. Anticholinesterase furocoumarins from Heracleum platytaenium, a species endemic species to Ida Mountains. Turk. J. Chem. 37, 4, , Halfon, B., Çiftçi, E., Topçu, G. Flavonoid constituents of Sideritis caesarea. Turk. J. Chem. 37, 3, , 2013.

12 144. Sabudak, T., Demirkıran, Ö., Öztürk, M., Topçu, G.. Phenolic compounds from Trifolium echinatum Bieb. and investigation of their tyrosinase inhibitory and antioxidant activities. Phytochemistry, 96, , Demirkiran, O., Sabudak, T., Ozturk, M., Topcu, G. Antioxidant and Tyrosinase Inhibitory Activities of Flavonoids from Trifolium nigrescens subsp petrisavi. J.Agric. and Food Chem. 61, , Bahadori, F., Dag, A., Durmaz, H., Cakir, N., Onyuksel, H., Tunca, U., Topcu, G., Hizal, G. Synthesis and characterization of biodegradable amphiphilic star and Y-shaped block copolymers as potential carriers for vinorelbine. Polymers, 6, , Bahadori F, Topçu G, Eroğlu M, Önyüksel H. A new lipid based nano formulation of Vinorelbine. AAPS Pharmscitech, 15, 5, Ertas, A ; Boga, M ; Hasimi, N ; Yesil, Y ; Goren, AC ; Topcu G. ; Kolak, U. Antioxidant, anticholinesterase, and antimicrobial activities and fatty acid constituents of Achillea cappadocica Hausskn. et Bornm. Turkish Journal of Chemistry, 38, 4, , Abdulselam Ertaş, Mehmet Boğa, Murat Kızıl, Bircan Ceken, Ahmet C. Gören, Nesrin Haşimi, Serpil Demirci, G. Topcu & U. Kolak. Chemical profile and biological activities of Veronica thymoides subsp. pseudocinerea. Pharmaceutical Biology. (ID: , DOI: / ) Uluslararası diğer hakemli dergilerde yayınlanan makaleler 1. Ulubelen, A., Topçu, G., Triterpenic and Steroidal compounds from The Roots of five Salvia species. Fitoterapia, LVIII , Ulubelen, A.,Topçu, G., Terem, B., Diterpenoids from The Roots of Salvia pisidica. Fitoterapia LVIII, , Ulubelen,A., Topçu, G., Terpenoids from the Roots of Salvia tomentosa. Nat. Prod. Lett. 1, , Topçu, G., Sultana, N., Akhtar, F., Habib-ur-Rahman, Hussain, T., Choudhary, M.I. and Attaur-Rahman,Taxane Diterpenes from Taxus baccata. Nat. Prod. Lett. 4, , Kökdil, G., Kurucu, S., Topçu, G., Composition of the Essential Oil of Nepeta nuda ssp. albiflora (Boiss) Gams. Flav. and Fragr. Journal 11, , Kökdil, G., Tanker, M., Kurucu, S., Topçu, G., Essential Oil Analysis of Nepeta cilicia Boiss. Flavour and Fragrance Journal 12, , Kökdil, G., Kurucu, S., Topçu, G., Chemical Constituents of the Essential Oils of Nepeta italica L. and Nepeta sulfuriflora P.H. Davis. Flavour and Fragrance Journal 12, 33-35, Topcu G., Kuşman T.; Lamiaceae Family Plants as a Potential Anticholinesterase Source in the Treatment of Alzheimer s Disease. Bezmialem Science; 1 (2), 1-25, Uluslararası bilimsel toplantılarda sunulan ve bildiri kitabında (Proceedings) basılan bildiriler 1. Pezzuto, J.M., Che, C-T., McPherson, D.D., Topçu, G., Erdelmeier, C.A.J., and Cordell, G.A.

13 Development of a HPLC Method for the Detection of Potential Antitumor Agents that Interact with DNA. American Society of Pharmacognosy, Kingston, RI, July 1987 (Sözlü). 2. G.Topçu, G.A. Cordell, N.R. Farnsworth, H.H.S. Fong, Novel Cytotoxic Sesquiterpene Lactones from Montanoa tomentosa ssp. microcephala, The American Society of Pharmacognosy, 28th Annual Meeting, The University of Rhode Island, Kingston, RI-USA, July 19-22, 1987 (Poster). 3. A.Ulubelen and G.Topçu, Abietane Diterpenoids from the Roots of Salvia crypthantha, International Symposium on Medicinal Plants Chemistry, İzmir-Turkey, May 14-16, 1987 (Sözlü). 4. S.Öksüz and G.Topçu, Triterpene Fatty Acid Esters and Flavonoids from Inula britannica, International Symposium on Medicinal Plants Chemistry, İzmir-Turkey, May 14-16, 1987 (Sözlü). 5. J.M. Pezzuto, C.T.Che, D.D.McPherson, G.Topçu, C.A.J. Eldelmeier and G.A. Cordell, Biospecific Identification and Isolation of Naturally Occuring Potential Antitumor Agents, NIH Workshop: Biossays for Discovery of Antitumor and Antiviral Agents from Natural Sources, Lister Hill Auditorium, National Library of Medicine, Bethesda, MD-USA, October 18-19, 1988 (Sözlü). 6. Pezzuto, J.M., Che, C-T., McPherson, D.D., Topcu, G., Erdelmeier, C.A.J., and Cordell, G.A. Biospecific Identification and Isolation of Naturally Occurring Potential Antitumor Agents. NIH Workshop: Bioassays for Discovery of Antitumor and Antiviral Agents from Natural Sources Lister Hill Auditorium, National Library of Medicine, Bethesda, MD, Oct ,1988 (Sözlü). 7. Pezzuto, J.M., Che, C-T., McPherson, D.D., Topcu, G., Erdelmeier, C.A.J., and Cordell, G.A. DNA as an Affinity Probe Useful in the Isolation of Biologically Active Natural Product (Workshop on Simple Bioassays ). International research congress on Natural Products, San Juan, Puerto Rico, August 6-10, 1989 (Sözlü). 8. G.Topçu and A.Ulubelen, Diterpenoids from Salvia wiedemannii, 50th International Congress of FIP (Federation Internationale Pharmaceutique) Istanbul, September 7-11, 1990 (Poster). 9. S.Öksüz and G.Topçu, The Phytochemical Investigation of Inula Species Growing in Türkiye, 50th International Congress of FIP, İstanbul-Turkey, September 7-11, 1990 (Poster). 10. Mar, W., Cordell, G.A., Lin, L.-Z., Che, C.-T., Tan, G.T., McPherson, D.D., Topçu, G., Erdelmeier, C.A.J., Neszmelyi, A., Jurcic, K., Offermann, F., Redl, K., Steinke, B., Wagner, H. and Pezzuto. J.M. DNA Based Isolation of Natural Products. 28th Annual Medicinal Chemistry Meeting-in-Miniature, Lawrence, Kansas, April 25-27, 1991 (Poster) 11. Mar, W., Cordell, G.A., Lin, L.-Z., Che, C.-T., Tan, G.T., McPherson, D.D., Topçu, G., Erdelmeier, C.A.J., Neszmelyi, A., Jurcic, K., Offermann, F., Redl, K., Steinke, B., Wagner, H. and Pezzuto. J.M., DNA Based Isolation of Natural Products. International Research Congress on Natural Products, 32nd Annual Meeting of the American Society of Pharmacognosy, Chicago, Illinois, July 21-26,1991 (Poster). 12. Topçu, G., A.Ulubelen, L.Z. Lin and G.A. Cordell, Determination of A New Diterpene Skeleton Through Selective INEPT NMR Spectroscopy, International Research Congress on Natural Products, The 32nd Annual Meeting of Society of Pharmacognosy, July 21-26, 1991, Chicago, Illinois-USA (Poster).

14 13. G.Topçu, S.Öksüz, G.A. Cordell and C. B.Johannson, Biologically Active Constituents of Inula species, 4th World Congress Holistic Approach Health for All, December 28-31, 1991, Bangalore-India (Sözlü). 14. A.Ulubelen and G.Topçu, Structures and Activities of Some Diterpenoids from Turkish Salvia species, 4th World Congress Holistic Approach Health for All, December 28-31, 1991, Bangalore-India (Sözlü). 15. G.Topçu, A.Ulubelen, S.Chen, P. Chai and J.K. Snyder, A New Abietane Diterpene from Salvia wiedemannii Boiss, Int. Res. Congress on Natural Products, The 32nd Annual Meeting of Society of Pharmacognosy, July 21-26, 1991, Chicago, Illinois-USA (Poster). 16. G.Topçu, S.Öksüz, C.Johannson, H.L. Shieh, G.A. Cordell and J.M. Pezzuto, Active Constituents of Two Inula species, 5th International Symposium on Natural Product Chemistry, January 5-9, 1992, Karachi-Pakistan (Davetli). 17. A.Ulubelen and G.Topçu, Diterpenoids from Salvia Species and Their Pharmacological Activities, 5th International Symposium on Natural Product Chemistry, January 5-9, 1992, Karachi-Pakistan (Sözlü). 18. G. Topçu and A. Ulubelen, Biological Effects of the Diterpenoids from Turkish Salvia species, 4th International Congress on Phytotherapy, Sept , 1992, Munich-Germany (Poster). 19. G. Topçu, N. Tan and A.Ulubelen, Diterpenoids from Salvia candidissima, 18th IUPAC Symposium on the Chemistry of Natural Products, August 30- Sept. 4, 1992, Strasbourg- France (Poster). 20. G.A. Cordell, J.M. Pezzuto, L.Z. Lin, H.L. Shieh, W. Mar, K. Kikhitwitayawiud, C.K. Angerhofer, D.C. Lankin, L. Xue, M.E. Balandrin, A. Ulubelen, G. Topçu, N. Ruangrungsi, E. Saifay, A. Neszmely and B. Wagner, Anticancer and Antimalarial Agents from Plants, ASOMPS VII. Meeting, February 3-8, 1992, Manila (Sözlü). 21. S. Öksüz and G. Topçu, Sesquiterpene Lactones from Centaurea glastifolia, 18th IUPAC Symposium on the Chemistry of Natural Products, August 30- Sept. 4, 1992, Strasbourg- France (Poster). 22. G. Topçu, N. Tan and A. Ulubelen, Diterpenoids from Salvia candidissima, Natural Products and Drugs, Marion Merrell Dow Research Institute, Sept. 4-5, 1992, Strasbourg-France (Poster). 23. A. Ulubelen and G. Topçu, Terpenoid Compounds from Salvia species, 34th IUPAC Congress, Beijing-China, August 15-20, 1993 (Sözlü). 24. S. Öksüz and G. Topçu, Sesquiterpene Lactones from Centaurea species growing in Turkey, 34th IUPAC Congress, August 15-20, 1993, Beijing-China (Sözlü). 25. Ulubelen and G. Topçu, Abietane Diterpenoids from Turkish Salvia species and Their Biological Activity, Regional Seminar on Chemistry of Medicinal Plants, August 22-25, 1993 Chengdu-China (Sözlü). 26. S. Öksüz and G. Topçu. Sesquiterpene Lactones from Centaurea species growing in Turkey, Regional Seminar on Chemistry of Medicinal Plants, August 22-25, 1993, Chengdu-China (Sözlü). 27. G. Topçu and Atta-ur-Rahman, Taxane Diterpenes from Taxus baccata, XXIII. Semaine Medicale Balkanique, August 24-27, 1994, Istanbul- Turkey (Sözlü).

15 28. N. Tan, G. Topçu and A. Ulubelen, First International Meeting on Pharmacy and Pharmaceutical Sciences, Sept. 4-7, 1994, Istanbul, Turkey (Poster). 29. G. Topçu, C. Eriş, S. Kurucu, A. Ulubelen, M. Krawiec and W.H. Watson, New Rearranged Neo-clerodane Diterpenoids from Teucrium alyssifolium with Novel Skeleton, 4th Int. Symposium on Pharmaceutical Sciences, Faculty of Pharmacy, University of Ankara, June 27-30, 1995, Ankara- Turkey (Sözlü). 30. G. Topçu, A. Ulubelen, T.C.M. Tam and C.T. Che, New Norlabdane Diterpenes from Salvia yosgadensis, 36. Annual Meeting of the American Society Pharmacognosy, July, 2-5, 1995, Missisipi, USA (Poster). 31. G. Topçu, A. Ulubelen, T.C.M. Tam and C.T.Che, Novel Sesterterpenes and Norsesterterpenes from Salvia yosgadensis, 36. Annual Meeting of the American Soc. of Pharmacognosy, July, 2-5, 1995, Mississipi, USA (Poster). 32. G. Topçu, N. Tan and A. Ulubelen, Rearranged Diterpenoids from Salvia microstegia, S. candidissima and S. montbretii, 35th IUPAC Congress, August 14-19, 1995, Istanbul, Turkey (Sözlü). 33. G. Topçu and A. Ulubelen, New Neo-Clerodane Diterpenes from Two Teucrium Species, 44th Annual Congress of the Society for Medicine Plant Research and a Joint Meeting with the Czech Biotechnology Society, Sept 3-7, 1996, Prague- Czechkoslavakia (Sözlü). 34. G. Kökdil, S. Kurucu and G. Topçu, Composition of the Essential Oils of Some Turkish Nepeta Species, 27th International Symposium on Essential Oils, Sept 8-11, 1996, Wien- Austria (Poster). 35. G. Topçu, A.C. Gören, G. Tümen, Y.K. Yıldız, Ent-Kaurene diterpenes from Sideritis athoa, 5th International Symposium. for Pharmaceutical Sciences, University of Ankara, May, 24-27, 1997, Ankara (Sözlü). 36. G.Kökdil, G.Topçu, Nepetalactones and Other Constituents of Some Nepeta Species, XIIth International Symposium on Plant Originated Crude Drugs, Mayıs 1998, (Ankara) (Sözlü). 37. G. Topçu, Vth Congress of the Mediterranean Society of Clinical Pharmacology, Pharmacological Properties of Turkish Salvia Species, Marrakech, Fas, Oct ,1998 (Davetli). 38. G. Topçu, Diterpenoids and Norditerpenoids from Salvia multicaulis with Antituberculous Activity 2000 Years of Natural Products Research-Past, Present and Future- Joint Meeting of the ASP, AFERP, GA and PSE, July 2-August , Amsterdam, Holland (Poster ). 39. G.Topçu, Terpenes in Labiatae Family Plants: Implications for Extinction of Herbivorus During Late Cretaceous-Early Tertiary, 19th International Meeting on Organic Geochemistry, Istanbul, 6-10 Sept. 1999, Turkey (Poster). 40. Y.K. Yıldız, T. Kılıç, A.C. Gören, G. Tümen, G.Topçu, Phytochemical Analysis of Some Sideritis Species of Turkey, 4th International Symposium on the Chemistry of Natural Compounds (SCNC-2001), Eğirdir-Isparta, Turkey 6-8 June 2001 (Sözlü). 41. O.Özdemir, S.Takır, S.U.Doğan, U.Kolak, G.Topçu, The Investigation of VascularEffects of Salvigenin on Isolated rat Aorta, Pharmacy and Pharmaceutical Sciences World Congress 2002, 62nd Congress of FIP, Nice, France 2002 (Poster).

16 42. G.Topçu, Bioactive Triterpenoids from Turkish Salvia species, International Organic Chemistry Meeting, Mustafa Kemal Üniversitesi, Antakya, Mart 2002 (Davetli). 43. G.Topçu, Diterpenoids from some Endemic Turkish Sideritis Species with Biological Activity, 1st International Congress on the Chemistry of Natural Products (ICNP), Karadeniz Technical University, Trabzon, Turkey, 44. G.Topçu, Z.Türkmen, A.Ulubelen, Highly Hydroxlated Triterpenoids from Salvia kronenburgii, 1st International Congress on the Chemistry of Natural Products (ICNP), Karadeniz Teknik Üniversitesi, Fen-Edebiyat Fakültesi, Kimya Bölümü, Trabzon,16-19 Ekim 2002 (Poster). 45. T.Kılıç, A.C.Gören, Y.K.Yıldız, G.Tümen, G.Topçu, Ent-Kaurane Diterpenesfrom Sideritis leptoclada Karadeniz Teknik Üniversitesi, Fen-Edebiyat Fakültesi, Kimya Bölümü, 1st International Congress on the Chemistry of Natural Products(ICNP), Trabzon, Ekim 2002 (Poster). 46. A. Bilici, M. Ay, G. Topçu. Phytochemical Investigation of Pistacia terebinthus, Karadeniz Teknik Üniversitesi, Fen-Edebiyat Fakültesi, Kimya Bölümü, 1st International Congress on the Chemistry of Natural Products (ICNP) Kongresi Ekim 2002 (Poster). 47. Z.Aydoğmuş, G.Topçu, S.İmre, A.C.Gören, J.M.Pezzuto, D.G.I. Kingston, Brominated sesquiterpenes from the Red Alga Laurencia obtusa, 1st International Congress on the Chemistry of Natural Products (ICNP) Kongresi, Karadeniz Teknik Üniversitesi, Fen- Edebiyat Fakültesi, Kimya Bölümü, Trabzon, Ekim 2002 (Poster). 48. G.Topçu, G.Bilsel, M.Bilsel, A.C.Gören, G.Tümen, Analysis of Essential Oil Composition of Sideritis albiflora Using Direct Thermal Desorber GC-MS, 3rd Aegean Analytical Chemistry Days Kongresi, Midilli, Greece, 29 Sept.-3 Oct (Poster). 49. G.Topçu, Diterpenes from Turkish Sideritis species with biological activities, 3rd International Symposium on Natural Drugs Sempozyumu, Napoli, İtaly, 2-4 Oct (Sözlü). 50. Z.Türkmen, G.Topçu, A.Klymchenko, G.Duportail, A.Demchenko, Triterpene Oleanolic Acid Conjugated with 3-Hydroxyflavone Derivate As A New Biomembrane Probe, 12th International Biotechnology Symposium and Exhibition, Santiago, Chile, Oct. 004 (Poster). 51. G. Topçu, Biologically Active Kaurane Diterpenes from Turkish Sideritis Species,10th International Symposium on Natural Product Chemistry, University of Karachi, Jan 6-9, 2006, Karachi-Pakistan (Davetli). 52. H. Nazemiyeh, F. Bahadori, A. Delazar, M. Ay, G.Topçu, Flavonoid Glycosides from Erica arborea, 9th Eurasia Conference on Chemical Sciences, (EuAs C2S-9) September 9-13, 2006, Antalya-Turkey, PP G. Topcu, U. Kolak, M. Öztürk, M. Boğa, F. Bahadori and S.D. Hatipoglu, Anticholinesterase activity search on abietane diterpenoids isolated from Anatolian Salvia species, 42nd IUPAC Congress, Chemistry for Health, 2-7 August 2009, Glasgow, England. P207_074, M. Boğa, M. Öztürk, S. Damla Hatipoğlu, F. Bahadori, U. Kolak and G. Topçu (2010). Potential Antioxidant Activity of Six Salvia Species with Total Phenolic and Flavonoid Content 3rd International Meeting on Pharmacy and Pharmaceutical Sciences (IMPPS-3), Marmara University, Faculty of Pharmacy, Istanbul-Turkey, 9-12 June 2010 (Poster).

17 55. G. Topçu, G.Tümen, T. Kılıç, A.C. Gören, A. Barla, Z. Türkmen, D.G. I. Kingston, Bioactive Turkish Plant Extracts and Their Constituents in Innovations in Chemical Biology, Bilge Sener (Ed).pp 61-81,Chapter 6 (2009) (Springer-Verlag). 56. M. Öztürk, M.E. Duru, B. Memikoğlu, M.Harmandar, G. Topçu, A new Spectroscopic Method to Determine Rosmarinic Acid Level In Plant Extracts Using Some Salvia Species by Complexation with Zr4+ Ions ISOPS 9th International Symposium on Pharmaceutical Sciences, Ankara University, June 23-26, 2009 (Poster). 57. Bioactive Constituents of Salvia triloba. G. Topçu, A. Barla, T. Kuşman, M. Öztürk, M. Boğa, U. Kolak. 3rd International Meeting on Pharmacy & Pharmaceutical Sciences (IMPPS-3), 9-12 June 2010, Istanbul-Turkey (Poster). 58. Öztürk M, Boğa M, Dincel D., Hatipoğlu S.D., Bahadori F, Kolak U, Topçu G. Cholinesterase Inhibitory Activity of a Series Salvia Species, 3th International Meeting on Pharmacy and Pharmaceutical Sciences Congress, Marmara University, Istanbul-Turkey, 2010 (Poster). 59. Çulhaoğlu B., Boğa M.,Yapar G.,Topçu G. Biological activities and chemical composition of Salvia chrysophylla, Third International Meeting on Pharmacy and Pharmaceutical Sciences Congress, Marmara University-IMPPS-3, 2010, Istanbul-Turkey. 60. Topcu, G., Bahadori, F., Durmaz, H, Dag, A.,Karakus K., Tunca, U., Hizal, G., Onyuksel, H., Block copolymers as drug nanocarriers 11 th Eurasia Conference on Chemical Sciences 6-10 October, 2010 (Davetli). 61. Culhaoglu, B., Topcu, G., Biologically Active Lupane Triterpenoids from Anatoliıan Salvia species, 59th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, September 2011, Antalya-Turkey), 77, pp. 1442, (Planta Medica). 62. Başkan, T., Aydoğmuş Z., Topcu, G., Constituents of the Red Alga Laurencia obtusa, 59th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, September 2011, Antalya-Turkey), 77, pp (Planta Medica). 63. Esen, H., Demirkıran., Ö., Yağar, H., Topçu, G., MAO İnhibitory Activity of Xanthones from Dichloromethane Extract of Polygala supine (59th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, September 2011, Antalya- Turkey), 77, pp (Planta Medica). 64. Yılmaz A., Çağlar P., Dirmenci T., Topçu G. The Isolation and Structure Elucidation of The Terpenoids from Nepeta obtusicrena with Antioxidant and Anti-Alzheimer Activities, New Challenges in Natural Products Chemistry, September 12-13, 2011, İstanbul, Turkey (Poster). 65. Çulhaoğlu B., Sındırgılı B., Başkan T., Kolak U., Topçu G. Antioxidant Activities of Salvia heldreichiana Boiss. Ex Bentham s Extracts, New Challenges in Natural Products Chemistry, September 12-13, 2011, Istanbul, Turkey (Poster). 66. Boğa M., Bahadori F., Kartal M., Kolak U., Topçu G. Indole Alkaloids from Vinca Species Growing in Turkey, New Challenges in Natural Products Chemistry, September , İstanbul, Turkey (Poster).

18 67. Hatipoğlu S.D., Özgen U., Topçu. G., Investigation of Antioxidant and Anticholinesterase Constituents of Salvia verticillata subsp. amasiaca (Freyn&Bornm.) Bornm, New Challenges in Natural Products Chemistry, September 12-13, 2011, İstanbul, Turkey (Poster). 68. Bahadori, F., Topçu, G., Dağ, H.D., Çakır, N., Önyüksel, H. Investıgation Of Cytotoxic Activity of Vinorelbine Loaded Polymeric Micelles, 10th Symposium on Pharmaceutical Sciences, June 2012, Ankara, Turkey (Sözlü). 69. Bahadori, F., Topçu, G., Eroğlu, M., Önyüksel, H. Nano Micellar Vinorelbine with Enhanced Cytotoxic Activity, 8. International Türkiye Nano Science and Nano Technology Congress, June 2012, Ankara, Turkey (Sözlü). 70. Topcu, G., Akdemir, A., Ozturk, M., Boga, M., Kolak, U. Abietane diterpenoids as butyrylcholinesterase inhibitors from Salvia species. International Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF, New York, NY July 28 - August 1, G. Topcu, Terpenoids from Anatolian Salvia species with Potential Anti-Alzheimer Activitiy XVIII èmes Journées Internationales de Chimie December 11-14, 2012, Constantine, Algeria (Davetli). 72. Topcu G., Terpenoids of Salvia Species as Potential Anti-Alzheimer Drugs 44th World Chemistry Congress, Istanbul, August 2013 (Sözlü). 73. Tekkeli S.E., Kiziltas M.V., Dincel D., Önal A., Erkoç R., Topcu G. A HPLC Method for Simultaneous Determination of Phenol and p-cresol in Human Urine, 44th World Chemistry Congress, Istanbul, August 2013 (Poster). 74. Topcu G., Ertas A., Boga M., Dincel D., Kolak U. Phytochemical Investigation of Sideritis albiflora with Antioxidant Activity, 44th World Chemistry Congress, Istanbul, August 2013 (Poster). 75. Boğa M., Ertaş A., Kolak U., Topçu G., Gören A.C., Yeşil Y. Fatty Acid and Essential Oil Compositions and Biological Activity of Hypericum capitatum var. capitatum 44 th IUPAC World Chemistry Congress, August 2013, İstanbul (Poster). 76. Ertaş A, Boğa M, Yeşil Y, Kızıl M, Çeken B, Gören A.C., Topçu G, Kolak U. Fatty Acid and Essential Oil Compositions and DNA Damage of Melissa officinalis L. subsp. altissima (SM.) Arcangeli 11 th Int. Ethnobotany Symposio, Antalya, Turkey, November 2-5, 2013 (Poster). 77. A. Ertaş, M. Boğa, M. Kızıl, B. Çeken, S. Demirci, N. Haşimi, A.C. Gören, G.Topçu, U. Kolak. Investigation on Endemic Veronica thymoides subsp. pseudocinerea 11 th International Ethnobotany Symposio, November 2-5, 2013, Antalya, Turkey (Poster). 78. A. Ertaş, M. Boğa, Y. Yeşil, N. Haşimi, A.C. Gören, G. Topçu. Phytochemical Investigation of two Alcea L. Species from Anatolia with Antimicrobial Activity 11th International Ethnobotany Symposio, Antalya, Turkey, November 2-5, 2013 (Poster). 79. Ertaş A., Boğa M, Deveci Ö, Haşimi N., Yeşil Y., Topçu G., Gören A.C., Kolak U. Antioxidant, anticholinesterase, antimicrobial activities and fatty acid components of endemic Achillea cappadocica The 5th Eurasia Congress of Infectious Diseases (EACID), Tirana, Albania, Mayıs 2014 (Poster). 80. Topcu G. Abietane Diterpenoids as Cholinesterase Inhibitors in Drug Discovery from Natural Sources, 2nd Int. BAU Drug Design Congress, İstanbul, April 2014 (Davetli).

19 81. Topcu, G. Terpenes as Potential Anti-Alzheimer Agents 18th International Congress PHYTOPHARM 2014, St. Petersburg, Russia, July 2-4, 2014 (Sözlü). 82. Topcu G. Potential Anti-Alzheimer Agents from Lamiaceae Family Plants, 4th International Meeting on Pharmacy & Pharmaceutical Sciences (IMPPS-4), Istanbul, September Topcu G. Phytochemicals of Salvia species with high cytotoxic/anticancer activity, ISNFF - 7th International Conference and Exhibition on Nutraceuticals and Functional Foods, Istanbul, October 2014 (Davetli). 84. Topcu G. Radical scavenging compounds from Lamiaceae family plants growing in Anatolia, International Workshop on Determining Antioxidants as Reactive Species Scavengers, Istanbul, October 2014 (Davetli). 85. Çelik G., Özgün O., Hacıbekiroğlu I., Arslan Ş., Topçu G., Şen A. (2014). Effect of Capparis ovata Water Extract on the Lipid Metabolism Used as an Alternative and Complementary Treatment for Multiple Sclerosis. Proceeding of III. International Congress of the Molecular Biology Association. Sep Izmir Institute of Technology; page 114 (P83). 86. Alaattin SEN, Gulacti TOPCU, Ozden OZGUN, Ufuk KOLAK, Isil HACIBEKIROGLU, Gurbet CELİK, Sevki ARSLAN. Anti-Neuroinflammatory Effect of Butanolic Fraction of Capparis ovata Water Extract Used as an Alternative and Complementary Treatment for Multiple Sclerosis. Journal of Neuroimmunology, 2014; 275: Yazılan uluslararası kitaplar veya kitaplarda bölümler 1. G. Topçu, S. Öksüz, C. Bozok-Johansson, H.L.Shieh, G.A. Cordell and J. M.Pezzuto. Active Constituents of Turkish Inula Species, in Advances in Natural Product Chemistry,Atta-ur Rahman (Ed), pp (1992), Harwood Academic Publishers. 2. A. Ulubelen and G. Topçu Diterpenoids from Salvia Species and Their Pharmacological Activities in Advances in Natural Product Chemistry, Atta-ur-Rahman (Ed), pp (1992), Harwood Academic Publishers. 3. A.Ulubelen and G. Topçu, Essays on Science: (Ed) Prof. Atta-ur-Rahman Chemistry and Pharmacology of Turkish Salvia species, Felicitation Volume, Hamdart Foundation-Pakistan, pp (1992). 4. A. Ulubelen and G. Topçu. Advances in Natural Product Chemistry, Harwood Academic Publishers Ed. Atta-ur-Rahman, Diterpenoids from Salvia Species and Their Pharmological Activities, pp (1992). 5. G. Topçu, S. Öksüz, C. Bozok-Johansson, H.L.Shieh, G.A. Cordell and J. M. Pezzuto Advances in Natural Product Chemistry, Harwood Academic Publishers, Ed. Atta-ur-Rahman, Active Constituents of Turkish Inula Species pp (1992). 6. A. Ulubelen and G. Topçu, Studies in Natural Product Chemistry Structure andchemistry, Part F, (Ed) Atta-ur- Rahman, Chemical and Biological Investigations of Salvia Species Growing in Turkey, Vol. 20, pp (1998) Elsevier Science. 7. A.Ulubelen, G. Topçu and U. Kolak, Studies in Natural Product Chemistry,Bioactive Natural Products (Part D), (Ed) Atta-ur-Rahman Chemical and Biological Evaluation of Genus Teucrium Vol.23, pp (2000) Elsevier Science.

20 8. A. Ulubelen, G. Topçu and U. Kolak, Studies in Natural Product Chemistry, Labiatae Flavonoids and Their Bioactivity (Ed) Atta-ur-Rahman, Vol. 30, (2005) Elsevier, Amsterdam. 9. G. Topçu and O. Demirkiran, in Topics in Heterocyclic Chemistry, (Series Ed) R.R.Gupta in Bioactive Heterocycles V, (Vol Ed) M.T.H. Khan, V. 11, pp (2007) Berlin/Heildelberg Springer. 10. G. Topçu, G.Tümen, T. Kılıç, A.C. Gören, A. Barla, Z. Türkmen, D.G. I. Kingston. (Ed) Bilge Sener, Bioactive Turkish Plant Extracts and Their Constituents, Innovations in Chemical Biology, pp 61-81, (2009) Springer-Verlag Ulusal hakemli dergilerde yayınlanan makaleler (CA= Chemical Abstracts) 1. Ulubelen, A., İskender, G., Topçu, G., Atmaca, S., Flavonoids of Cured Tobacco Leaves from Black Sea Area. J. Faculty Pharmacy, Istanbul 17, 71-76, Ulubelen, A., Topçu, G., Spectral data of the New Diterpenoids from Turkish Salvia Species. J. Faculty Pharmacy, Istanbul, 26-28, 59-79, Tan, N., Topçu, G., Ulubelen, A., A New Aromatic Ester and Other Constituents of Salvia aucheri var. canescens. J. Faculty Pharmacy, Istanbul, 29, 53-57, (CA) Salan, Ü., Topçu, G., Öksüz, S. Flavonoids of Centaurea kliea and C. salonitana, J. Fac. Pharmacy 34, 55-61, G. Topçu, T. Kuşman. Lamiaceae Family Plants as a Potential Anticholinesterase Source in the Treatment of Alzheimer s Disease. Bezmialem Science. 2014; 2: Ulusal bilimsel toplantılarda sunulan ve bildiri kitabında basılan bildiriler Ulusal ve uluslararası toplam 200 ü aşkın sözlü veya poster bildiri 8. Projeler Proje Adı Kurum Başlangıç -Bitiş Tarihi Bütçe Proje Türü Görev Balıkesir Kazdağı Yöresinde Yetişen Sideritis Türlerinin Diterpen Bileşikleri Üzerinde Araştırmalar (S.trojana, S.dichotoma, S.athoa) 196T Ulusal Araştırmacı/ Uzman Cell Culture Sudies on Salvia Species to obtain Their Secondary Metabolites DFG Uluslararası Eş Yürütücü Bioactive Turkish Plant Constituents Constituent of Some Turkish Plants; Their Biological Activities and Preparation of the Active Analogous NSF INT T Uluslararası Eş Yürütücü Uluslararası Danışman