10 th NANOSCIENCE AND NANOTECHNOLOGY CONFERENCE

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1 10 th NANSCIENCE AND NANTECHNLGY CNFERENCE June, 2014

2 Biodegradable Poly(acrylic acide)(paa)/hydroxyapatite(nhap)/rgano-modified Hydroxyapatite(o-nHAp) Bionanocomposites: Preparation, Characterization, Antimicrobial activity and Biocompatibility Mehmet Emin DİKEN, Serap DĞAN, Yasemin TURHAN, Mehmet DĞAN Science and art Faculty, Balikesir University,Balikesir 10100, Turkey Abstract (PAA)/nHAp bionanocomposites are synthesized to use different loading filler (%1, %2.5 and %5 wt) via solution intercalation method. These nanocomposites were performed with TGA, DSC, UV-Visible Spectrofotometer, XRD, FTIR-ATR, BET surface analyzer, contact angle and TEM. The XRD and TEM results confirmed that the nhap/o-nhaps distributed homogenously in the matrix. In presence of nhap the nanocomposites showed better thermal stability than PAA. Nanocomposites showed better biocompatible than PAA., Two bacterias as Escherichia coli and Streptecoccus aureus were used for antibacterial testing and PAA, nhap and nanocomposites shown different proportions antimicrobial properties against both of them. Polymer/inorganic nanocomposites are important materials for used medical and industry applications. Poly(acrylic acid) (PAA) is a water soluble polymer which finds applications in sensor heads for the photochemical detection of ph and C 2 compound of water solutions, drug consignment applications and as cleaning agents[1,2]. Hydroxyapatite (HAp) has two important characteristics as biocompatibility and bioactivity. nhap is widely used as bone replacement or reconstructive and prosthetic material for osseous tissue, due to its properties. But the poor mechanical property of HAp restricts its further application [3,4]. In this study, nanocomposites were synthesized with different relative compositions based on PAA and both natural nhap and modified nhap s by solution intercalation method. [3-(2-aminoethilamino)propyl]trimethoxysilane (3apt), N 1 -[3- (trimethoxisililpropyl)]-diethiltriamin (n3tmpeda), 3- (chloropropyl)trimethoxysilane (3cptms) were used as modifier. nhap surface modification was conducted by the following method of Aleskes N. Vasiliev et al.[5] The surface area of nhap and o-nhaps were determined by BET surface analyzer and obtained values were given in table-i. It is clear that the modification enhanced surface area of o-nhaps. Table-I Surface area of filler Sample Surface Area (m²/g) nhap nhap/3apt nhap/n3tmpeda nhap/3cptms Nanocomposites showed higher thermal stability than PAA, with increasing filler amount in matrix. TEM images showed that the nanocomposites have intercalated and dispersed morphology as shown Figure 2. H H H CH3 H Hidroksiapatit H + CH3 CH2CH2CH2 C 2 H H CH3 H 1-(3-(trimetoksisilil)propoil)üre Refluks Toluen, 80 0 C, 24 saat HN 2 CH3 CH3 CH3 CH3 CH3 CH3 CH3 CH3 N Hidroksiapatit 2 H CH3 CH3 CH3 CH3 CH3 CH3 CH3 CH3 2 Figure-1: Possible structure of interaction between organic modifier compound and nanohydroxyapatite Finally, PAA and its nanocomposites thermal stability were analyzed by TG/DTA and DSC. The morphology properties were determined by XRD and TEM. The intercation between organic modifier compound, nanohydroxyapatite and polymer was investigated with FTIR-ATR. 2 Figure-2: TEM images of PAA/nHAp Biocompatibility tests showed different results for PAA, PAA/nHAp and modified nhap nanocomposites. PAA/o-nHAps were better biocompatible than others. For antibacterial testing, were used two bacterias as Escherichia coli and Streptecoccus aureus and, PAA, nhap and nanocomposites shown different proportions antimicrobial activities against both of the bacterias. *Corresponding author: mediken@balikesir.edu.tr [1] M.R. Pokhrel and S.H. Bossmann. J Phys Chem B;104:2215 (2000). [2] Yang S et al., J Pharm Pharmacol. 56:429 (2004). [3] M. Hamad et al., JCG (1986). [4] G. Batin et al., Powder Metallurgy Progress, Vol.11: 3-4 (2011), [5] A.N. Vasiliev et al., Scripta Materialia 58: (2008).

loading filler (%1, %2.5 and %5 wt) via solution intercalation method.

4 NanoTr10 Web site KURULLAR KNFERANS BAŞKANI Prof. Dr. Mustafa Culha RGANİZASYN KMİTESİ Assoc. Prof. Dr. Seyda Bucak Assist. Prof. Dr. Andrew Harvey Assist. Prof. Dr. Ali zhan Aytekin Assist. Prof. Dr. Huseyin Cimen YÜRÜTME KURULU Ünvan Ad & Soyad Kurumu Dr. Mehmet ERTUĞRUL Atatürk Üniversitesi Dr. Atilla AYDINLI Bilkent Üniversitesi Dr. ğuz GÜLSEREN Bilkent Üniversitesi Dr. Sezai ELAGÖZ Cumhuriyet Üniversitesi Dr. Emir Baki DENKBAŞ Hacettepe Üniversitesi Dr. Mustafa ÜRGEN İstanbul Teknik Üniversitesi Dr. ğuzhan GÜRLÜ İstanbul Teknik Üniversitesi Dr. Çetin ARIKAN İstanbul Üniversitesi Dr. Salih KUR İzmir Katip Çelebi Üniversitesi Dr. Ahmet RAL Nanomagnetics Instruments Company Dr. Raşit TURAN rta Doğu Teknik Üniversitesi Dr. Volkan ÖZGÜZ Sabancı Üniversitesi Dr. Mustafa ÇULHA Yeditepe Üniversitesi BİLİM KURULU Ünvan Ad & Soyad Kurumu Dr. Servet TURAN Anadolu Üniversitesi Dr. Yüksel ERGÜN Anadolu Üniversitesi Dr. Yalçın ELERMAN Ankara Üniversitesi Dr. Hasan EFEĞLU Atatürk Üniversitesi Dr. Mehmet ERTUĞRUL Atatürk Üniversitesi Dr. Ümit DEMİR Atatürk Üniversitesi data:text/html;charset=utf 8,%3Ch1%20style%3D%22margin%3A%200px%3B%20padding%3A%200px%3B%20list style%3a%20none%3b%20font size 1/2

Sezai ELAGÖZ Cumhuriyet Üniversitesi Dr. Emir Baki DENKBAŞ Hacettepe Üniversitesi Dr. Mustafa ÜRGEN İstanbul Teknik Üniversitesi Dr. ğuzhan GÜRLÜ İstanbul Teknik Üniversitesi Dr.

5 NanoTr10 Web site Dr. Atilla AYDINLI Bilkent Üniversitesi Dr. Aykutlu DANA Bilkent Üniversitesi Dr. Ekmel ÖZBAY Bilkent Üniversitesi Dr. ğuz GÜLSEREN Bilkent Üniversitesi Dr. Ömer DAĞ Bilkent Üniversitesi Dr. Hadi ZAREIE Gediz Üniversitesi Dr. Ali TUNCEL Hacettepe Üniversitesi Dr. Emir Baki DENKBAŞ Hacettepe Üniversitesi Dr. Mustafa ÜRGEN İstanbul Teknik Üniversitesi Dr. Afif SIDDIKİ İstanbul Üniversitesi Dr. Çetin ARIKAN İstanbul Üniversitesi Dr. Salih KUR İzmir Katip Çelebi Üniversitesi Dr. Hakan ÜREY Koç Üniversitesi Dr. Ahmet RAL Nanomagnetics Instruments Company Dr. Macit ÖZENBAŞ rta Doğu Teknik Üniversitesi Dr. Raşit TURAN rta Doğu Teknik Üniversitesi Dr. Vasıf HASIRCI rta Doğu Teknik Üniversitesi Dr. İsmet İnönü KAYA Sabancı Üniversitesi Dr. Candan TAMERLER University of Kansas Dr. Mehmet Özsöz Gediz Üniversitesi İzmir Dr. Mustafa ÇULHA Yeditepe Üniversitesi data:text/html;charset=utf 8,%3Ch1%20style%3D%22margin%3A%200px%3B%20padding%3A%200px%3B%20list style%3a%20none%3b%20font size 2/2

Afif SIDDIKİ İstanbul Üniversitesi Dr. Çetin ARIKAN İstanbul Üniversitesi Dr. Salih KUR İzmir Katip Çelebi Üniversitesi Dr. Hakan ÜREY Koç Üniversitesi Dr.

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