CURRICULUM VITAE of Prof. Dr. MERT ULGEN

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1 CURRICULUM VITAE of Prof. Dr. MERT ULGEN Name, Surname: Prof. Dr. Mert Ülgen Birth Date: Academic Degrees Obtained: Degree Area University Year University Pharmacy Marmara University 1981 M.Sc. Pharmaceutical Chemistry Marmara University 1987 Ph.D. Biopharmacy-Drug Metabolism University of London, King s College, Dept. of Pharmacy 1992 Academic Titles Obtained Assistant Professor Pharmacy-Pharmaceutical Chemistry Marmara Un Associated Professor Pharmacy-Pharmaceutical Chemistry Marmara Un Full Professor Pharmacy-Pharmaceutical Chemistry Marmara Un July 2009 (retired) Full Professor- Acibadem University The School of Associated Health Sciences and Professor of Pharmaceutical Chemistry (June to date) PRESENT ADDRESS Acıbadem University Gulsuyu mah. Fevzi Cakmak Caddesi. Divan sok. No.: 1 Maltepe İstanbul Tel: (direct) mert.ulgen@acibadem.edu.tr ulgenmert2002@yahoo.com M. Sc. Students (M.Sc. thesis supervised) Erçak, K Bazı aromatik amid grubu taşlyan model bileşiklerin in vitro mikrozomal metabolizmaları M.Ü. Institute of Health Sciences (1995) Özer, U. N-Etil-N-benzilanilin ve N-etil-N-benzil-p-toluidin bileşiklerinin in vitro mikrozomal metabolizmaları M.Ü. Institute of Health Sciences (1995) Ünsalan, S. N,N-Dibenzilisopropilamin, N,N-dibenzil-2,4,6-trimetil ve N,N-dibenzil-2,6-diklorobenzilamin'in in vitro mikrozomal metabolizmaları M.Ü. Institute of Health Sciences (1996) Yılmaz, F. N,N-Dibenzilmetilamin, N,N-dibenzil-4-nitro ve N,N-dibenzil-2,4-diklorobenzilamin'in in vitro mikrozomal metabolizmaları M.Ü. Institute of Health Sciences (1996) Özcan, A. Matbaacılıkta Sağlığı ve Üretimi Etkileyen Faktörler M.Ü. Fen Bilimleri Enstitüsü (2000) Kahvecioğlu, E. Bazı Alifatik-Aromatik İminlerin ve Metabolik Ara Ürünlerinin in vitro mikrozomal metabolizmaları M.Ü. Institute of Health Sciences (2003)

2 Bulut, G. Bazı aralkil nitronların sentez, stabilite ve in vitro mikrozomal metabolizmaları M.Ü. Institute of Health Sciences (2004) Bekçe, B. Bazı azo bileşiklerinin sentezi ve in vitro, in vivo metabolizmaları M.Ü. Institute of Health Sciences (2004) İyicioğlu, L Işık Algılama ve Görüntü Oluşturma Yöntemlerine Göre Dijital Fotoğraf Makinelerinin İncelenmesi M.Ü. Fen Bilimleri Enstitüsü (2006) Kaymaz, S. İndol-3-karbinol ün in vitro mikrozomal metabolik reaksiyonlarının incelenmesi M.Ü. Institute of Health Sciences (2006) Çakmak, A. Bazı Substitüe Alifatik-Aromatik Amidlerin ve Hidroksamik Asitlerin İn Vitro Mikrozomal Metabolizmaları M.Ü. Institute of Health Sciences (2007) Yılmaz, E. Azot Biyotransformasyonu Üzerinde Çalışmalar M.Ü. M.Ü. Institute of Health Sciences (2007) Türkiye Teker, C. Yeni Farmasötik Katı Dozaj Formülasyonlarında Tramadol, Asetaminofen Ve İlişkili Maddelerin Hplc Metodu İle Belirlenmesi, Miktar Tayini Ve Validasyonu M.Ü. Institute of Health Sciences (2007) Türkiye Yükselen, P. İlaç Metabolitlerinin Sentezi M.Ü. Institute of Health Sciences (2008) Türkiye Koç, E. İnce Tabaka Kromatografisi M.Ü. Institute of Health Sciences (2008) Türkiye Kesim, N Hipertansiyon ve Kandesartan ın Farmakolojik Özellikleri ile Safsızlıklarının İncelenmesi M.Ü. Institute of Health Sciences (2008) Türkiye Ph. D. Students (Ph.D. thesis supervised) Küçükgüzel, İ. Aromatik sekonder ve tersiyer aminlerin ve muhtemel ara ürünlerinin sentez, stabilite ve metabolizmaları M.Ü. Institute of Health Sciences (1998) Selimbeyoğlu, C. Geri dönüşümlü kağıtlar üzerine renkli baskılarda densitometrik parametrelerin belirlenmesi M.Ü. Fen Bilimleri Enstitüsü (2002) Türkiye Yılmaz, F. Nikotin ara metabolitlerinin ve nikotin analoglarının sentez, analiz ve Metabolizmaları M.Ü. Institute of Health Sciences (2002) Türkiye Yavuz, S. Matbaacılıkta kullanılan boyar maddelerin kromatografik analizleri M.Ü. Fen Bilimleri Enstitüsü (2005) Türkiye International Publications 1. Rollas, S., Buyuktimkin, S., Buyuktimkin, N., Ulgen, M., Yemni, E. "Evaluation of some arylhydrazones of N 2 -arylidene benzylic acid hydrazide as antimicrobial agents" Pharmazie, 43, 511 (1988). 2. Buyuktimkin, S., Rollas, S., Ulgen, M., Otuk, G. "Some 1,3,4-oxadiazoline derivatives prepared by starting from benzylic acid aryl hydrazones and their antimicrobial evaluation" Pharmazie, 45, 865 (1990). 3. Ulgen, M., Gorrod, J.W. "Microsomal formation of N-benzyl-4-hydroxymethylaniline from N-benzyl-4-methylaniline" J. Pharm. Pharmacol, 44, (1992). 4. Low,C. M., Ulgen, M., Gorrod, J.W. "The recognition of a diarylimine as a metabonate produced during incubation of N-benzyl-4-chloroaniline with hepatic microsomal preparations" J.Pharm.Pharmacol., 46, (1994).

3 5. Gorrod, J.W., Ulgen, M. "Metabolic N-oxidation of diarylimines: A new metabolic reaction of potential toxicological significance" Drug.Met.Rev., 26, (1994). 6. Ulgen, M., Gorrod, J.W. "Metabolic & chemical studies on N,-diarylnitrones" Drug Metab. Drug Interact., (1994). 7. Ulgen, M., Gorrod, J.W., Barlow, D. "Structure-activity relationships in the formation of amides from substituted N-benzylanilines" Xenobiotica, 24, (1994). 8. Ulgen, M., Kajbaf, M., Lamb, J., Jahanshahi, M., Gorrod, J.W., Naylor, S. "Characterization of N-benzylcarbazole and its metabolites from microsomal mixtures by tandem mass spectrometry" Europ.J.Drug Met. Pharmacokin., 19, (1994). 9. Komurcu, S.G., Rollas, S., Ulgen, M., Gorrod, J.W., Cevikbas,A. "Evaluation of some arylhydrazones of p-aminobenzoic acid hydrazide as antimicrobial agents and their in vitro microsomal metabolism" Boll.Chim.Farm., 134, (1995). 10. Gulerman, N., Rollas, S., Ulgen, M., Gorrod, J.W. "Synthesis and evaluation of some substituted 1,3,4-thiadiazole derivatives" Boll.Chim.Farm., 134, (1995). 11. Ulgen, M., Yilmaz, F., Unsalan, S., Gorrod, J.W. "Chemical and metabolic studies on N-benzyl-tert-butylamine and its potential metabolites" Drug Metab. Drug Interact., 12, (1995). 12. Ulgen, M., Gorrod, J.W. "The failure of Substrate pka to influence the Microsomal formation of Amides from N-Benzylamines : The Microsomal metabolism of N-benzylpyrrolidine, N-benzylcarbazole and N-acetyl-N-benzyl-4- methylaniline J.Pharm.Pharmacol., 48, (1996). 13. Ulgen, M., Erçak, K., Küçükgüzel, I., Gorrod, J.W. "In vitro microsomal metabolic studies on secondary aromatic amides" Boll.Chim.Farm., 136, (1997). 14. Ulgen, M., Durgun, B.B., Rollas, S., Gorrod, J.W. "The in vitro hepatic microsomal metabolism of benzoic acid benzylidene hydrazide" Drug Metab. Drug Interact., 13, (1997). 15. Ulgen, M., Ozer, U., Kucukguzel, I., Gorrod, J. W. "Microsomal metabolism of N-benzyl-N-ethylaniline and N-benzyl-N-ethyl-ptoluidine" Drug Metab. Drug Interact., 14, (1997). 16. Kucukguzel, I., Ulgen, M., Gorrod, J.W. "In vitro microsomal metabolism of nuclear chlorine substituted secondary amines and imines" Europ.J.Drug Met. Pharmacokin., 22, (1997). 17.Tunc, N.,Yilmaz, F., Ulgen, M., Gorrod, J.W. "In vitro metabolic N- and C-oxidation of Phenanthridine" Europ.J.Drug Met. Pharmacokin., 22, (1997). 18. Eldirdiri, N., Ulgen, M., Jacob, P., Gorrod, J.W. "The in vitro metabolism of norcotinine and related biotransformation products by microsomal preparations"

4 Europ.J.Drug Met. Pharmacokin., 22, (1997). 19. Jacob, P., Ulgen, M., Gorrod, J.W. "Metabolism of (S)-(-) Nicotine by guinea pig and rat brain: Identification of cotinine" Europ.J.Drug Met. Pharmacokin., 22, (1997). 20. Gülerman, N., Rollas, S., Ulgen, M. "Synthesis and in vitro microsomal metabolism of 4-ethyl-5-(4-fluorophenyl)- 2,4-dihydro-3H-1,2,4-triazole-3-thione and its potential metabolites" Boll.Chim.Farm., 137, (1998). 21. Ulgen, M. "Chemical Artifacts in Drug Metabolism Research" Boll. Chim. Farm., 138, (1998). 22. Kaymakçıoğlu, B., Oruç, E., Rollas, S., Ulgen, M. "The in vitro hepatic microsomal metabolism of 3,5-dimethyl-4-phenylazo (1H) pyrazole in rats" Drug Metab. Drug Interact., 15, (1999). 23. Yılmaz, F., M. Ulgen, M., Gorrod, J.W. "The in vitro hepatic microsomal metabolism of N-benzyladamantanamine in rats" Drug Metab. Drug Interact., 15, (1999). 24. Ulgen, M., Yılmaz, F., Doğruer, D.S., Şahin, M.F. " The in vitro hepatic microsomal metabolism of methyl 2-(2(3H)- benzoxazolone-3-yl)acetate in rats" Drug Metab. Drug Interact., 15, (1999). 25. Yılmaz, F., Ulgen, M., Doğruer, D,S., Çakır, B., Şahin, M.F. The in vitro hepatic metabolism of 1-phenyl-2-(2-benzothiazolinone- 3-yl)ethanone and their reduced derivatives Experimental and Toxicological Pathology, 51, (1999). 26. Kucukguzel, I., Ulgen, M., Gorrod, J.W. "In vitro hepatic microsomal metabolism of N-benzyl-N-methylaniline" Farmaco, 54, (1999). 27. Ülgen, M., Gorrod, J.W. Studies on the in vitro hepatic microsomal formation of amides during the metabolism of certain secondary and tertiary benzylic amines Europ.J.Drug Met. Pharmacokin., 25, (2000). 28. Küçükgüzel, G., Küçükgüzel, İ., Ülgen, M. Metabolic and chemical studies on N-(4-chlorobenzyl)-N -benzoylhydrazine Farmaco, 55, (2000). 29. Şimşek,R., Şafak,C., Erol, K., Ataman, Ş., Ülgen, M., Linden, A. Synthesis, evaluation of the Calcium Antagonistic Activity and Biotransformation of Hexahydroquinoline and Furoquinoline Derivatives Arzneimittel Forschung Drug Research, 53, (2003). 30. Bilgiç, D., Pekin, M., Karaderi, S., Ulgen, M. The determination of Stability Constants of para Substituted N-Benzylideneaniline Metal Complexes by a Potentiometric Method Reviews in Analytical Chemistry, 23 (2), (2004). 31. Bulut, G., Oktav, M., Ulgen, M. The Stability Studıes and In Vıtro Hepatic Microsomal Metabolism of Some α-phenyl-n-substıtuted Nitrones in Rats Europ.J.Drug Met. Pharmacokin., 29 (4), (2004). 32. Yılmaz, F., Arıcıoğlu Kartal, F., Ulgen, M. and Gorrod, J.W. In Vitro Hepatic Microsomal Metabolism of N-Benzyl and N-Benzoylnornicotine Derivates by Rat Europ.J.Drug Met. Pharmacokin., 29 (4), (2004). 33. Bekce, B., Sener, G., Oktav, M., Ulgen, M. And Rollas, S.

5 In vitro and in vivo metabolism of ethyl 4-[(2-hydroxy-1-naphthyl)azo]benzoate Europ.J.Drug Met. Pharmacokin., 30 (2), (2005). 34. Oktav, M. and Ulgen, M. The Evaluation of Printability and Biochemical Stability of 4 -Chlorophenylazo-2-Naphtole for use as a Printing Dye Surface Coatings International, 88 (3), (2005). 35. Aydın, F., Şafak, C., Şimşek, R., Erol, K., Ülgen, M., Linden, A. Studies on condensed 1,4-dihydropyridine derivatives and their calcium modulatory activities Pharmazie, 61 (8), (2006). 36. Oruç, E.E., Koçyiğit-Kaymakçıoğlu, B., Yılmaz-Demircan, F., Gürbüz, Y., Kalaça, S., Küçükgüzel, Ş.G., Ülgen, M., Rollas, S. An high performance liquid chromatographic method for the quantification of cotinine in the urine of preschool children Pharmazie, 61 (10), (2006). 37. Bülbül, B., Oztürk, GS., Vural, M., Şimşek, R., Sarioğlu, Y., Lindeni A., Ulgen, M., Şafak, C. Condensed 1,4-dihydropyridines with various esters and their calcium channel antagonist activities Eur J Med Chem, Nov 1 (2008). 38. Yenidoğan, S., Oktav, M. and Ulgen, M. The development of thin layer and high performance liquid chromatographic methods for the analysis of colourings substances used in the printing inks Asian Journal of Chemistry 21, (2009) 39. Yenidoğan, S., Oktav, M. and Ulgen, M. High performance liquid chromatographic and biological studies on 2-[(4-methyl-2-nitrophenyl)azo]- 3-oxo-N-phenylbutanamide (pigment yellow one) Asian Journal of Chemistry 22, in the press (2010) Abstracts Prestented in International Meetings 1. M.Ulgen, J.W.Gorrod "Microsomal metabolism of N-benzyl-4-methyl and 2,4,6-trimethylaniline Fourth Stowe School Symposium on Drug Metabolism April 2-5,1990, Stowe School, Buckinghamshire, UK. 2. M.Ulgen, J.W.Gorrod "The effect of ring substitution on the formation of amide metabolites 3. M.Ulgen, M.Kajbaf, J.W.Gorrod "Microsomal metabolism of N-benzylcarbazole" UK Drug Metabolsm Spring Meeting 17-18th April,1991, University of Nottingham, Nottingham,UK. 4. M.Ulgen, J.W.Gorrod "Screening for microsomal formation of amides from certain benzylic amines" Third International ISSX Meeting, Drug Metabolism: Molecules,models and man June,1991, Amsterdam,The Netherlands. 5. M.Ulgen, J.W.Gorrod "Nitrones as precursors of amides in metabolic studies" Fourth European ISSX Meeting Toxicological Evaluation of Chemical Interactions: Relevance of Social Enviromental and Occupational Factors", July 3-6,1992. Bologna, Italy. 6. M.Ulgen, B.B.Durgun, S.Rollas, G.Altuntas, J.W. Gorrod "The in vitro hepatic oxidative microsomal metabolism of N-benzilidenebenzoic acid hydrazide" 3 rd International Symposium of Pharmaceutical Sciences. Ankara University, Faculty of Pharmacy, June 15-18,1993, Ankara.

6 7. N.N.Gulerman, S.Rollas, M.Ulgen "Synthetic routes to some substituted 1,3,4-thiadiazole derivatives starting from 1- aroyl-4-substituted thiosemicarbazides" 3rd International Symposium of Pharmaceutical Sciences.Ankara University, Faculty of Pharmacy, June 15-18,1993, Ankara. 8. M.Ulgen, J.W.Gorrod. "Metabolic and chemical determinants of amide formation from benzylic amines" 3rd International Symposium of Pharmaceutical Sciences. Ankara University, Faculty of Pharmacy, June 15-18,1993, Ankara,Turkey. (Sözlü Bildiri) 9. J. W. Gorrod, M. Ulgen "Metabolic N-oxygenation of diarylimines: A new metabolic reaction" Nato Advanced Study Institute, Molecular aspects of oxidative drug metabolising enzymes and their significance in enviromental toxicology, chemical carcinogenesis and health, June 20-July 2,1993, Kuşadası, Turkey. (Sözlü Bildiri) 10. Komurcu, S.G., Ulgen,M., Rollas,S., Sezen,S. "The in vitro hepatic oxidative microsomal metabolism of 4-aminobenzoic acid p-fluorobenzalhydrazone" World Congress of Pharmacy and Pharmaceutical Sciences (FIP'93), September 5-10,1993, Tokyo,Japan. 11. Kucukguzel,I., Rollas,S., Ulgen,M. "Synthesis and anti-bacterial activity of certain thiourea derivatives obtained from 1,3,4-triazoline-3-thiones. World Congress of Pharmacy and Pharmaceutical Sciences (FIP'93), September 5-10,1993, Tokyo,Japan. 12. M.Ulgen., J.W.Gorrod, S.Unsalan, F.Yilmaz. "Metabolic and chemical studies on aryl-alkylimines and their potential metabolites" First International Meeting on Scientific Basis of Modern Pharmacy, June 8-11,1994, Athens, Greece. 13. G.Aislaitner, M.Ulgen, J.W. Gorrod. "In vitro microsomal metabolic studies on secondary aromatic amides: Comparative rates of hydrolysis" First International Meeting on Scientific Basis of Modern Pharmacy, June 8-11,1994, Athens, Greece. 14. M.Ulgen, J.W.Gorrod. "Chemical artifacts in drug metabolism research" First International Meeting on Pharmacy and Pharmaceutical Sciences, 4-7 September 1994, Istanbul,Turkey. (Lecture) 15. M.Ulgen, F.Yilmaz, S.Unsalan, J.W.Gorrod. "Chemical and metabolic studies on N-benzyl-tert-butylamine and its potential metabolites" First International Meeting on Pharmacy and Pharmaceutical Sciences, 4-7 September 1994, Istanbul. 16. I.Kucukguzel, M.Ulgen, J.W.Gorrod. "In vitro microsomal metabolism of N-benzylic tertiary amines" First International Meeting on Pharmacy and Pharmaceutical Sciences, 4-7 September 1994, Istanbul.

7 17. N.Gulerman, S.Rollas, M.Ulgen, J.W.Gorrod. "Synthesis and evaluation of some substituted 1,3,4-thiadiazole derivatives as antimicrobial agents" First International Meeting on Pharmacy and Pharmaceutical Sciences, 4-7 September 1994, Istanbul. 18. S.Unsalan, F.Yilmaz, I.Kuçukguzel, M.Ulgen, J.W.Gorrod. "Synthesis,characterisation and chromatographic studies on benzylic tertiary amines and their potential metabolites" 4th International Symposium of Pharmaceutical Sciences.Ankara University, Faculty of Pharmacy, June , Ankara. 19. M.Ulgen, K.Erçak, I.Kuçukguzel, J.W.Gorrod. "In vitro microsomal metabolic studies on secondary aromatic amides" 2 nd Xenobiotic Metabolism and Toxicity Workshop of Balkan Countries, October 1995, Ioannina, Greece. 20. P. Jacob III, M. Ulgen and J.W. Gorrod. "The metabolism of (S)-(-)-Nicotine by Guinea Pig and Rat Brain: Identification of Cotinine" The Society for Research on Nicotine and Tobacco 3 rd Annual Scientific Conference June 13-14, 1997, Nashville, TN, USA. 21. I. Kucukguzel and M. Ulgen In vitro metabolic fate of N-substituted dibenzylamines: Investigation of biological oxidation site on nitrogen compounds with different pka 5th International Symposium on Pharmaceutical Sciences June 24-27,1997, Ankara University, Faculty of Pharmacy, Ankara. 22. N.Tunç, F. Yılmaz, M.Ulgen and J.W.Gorrod In vitro rat hepatic microsomal metabolism of phenanthridine 5th International Symposium on Pharmaceutical Sciences June 24-27, 1997, Ankara University, Faculty of Pharmacy, Ankara. 23. N. Eldirdiri, M. Ulgen, P. Jacob and J. W. Gorrod, "The in vitro metabolism of norcotinine and related biotransformation products by microsomal preparations" Symposium on Drug Metabolism : "Towards to the next millenum" King's College, Chelsea Department of Pharmacy, August 25-27, 1997, London, UK. 24. I. Kuçukguzel, M. Ulgen and J. W. Gorrod "In vitro microsomal metabolism of chlorine substituted secondary amines and imines" Symposium on Drug Metabolism : "Towards to the next millenum" King's College, Chelsea Department of Pharmacy, August 25-27, 1997, London, UK. 25. N. Gülerman, S. Rollas and M. Ulgen. "Synthesis and in vitro microsomal metabolism of 4-ethyl-5-(4-fluorophenyl)- 2,4-dihydro-3H-1,2,4-triazole-3-thione and its potential metabolites" First International Symposium on Pharnaceutical Chemistry Hacettepe University, Faculty of Pharmacy, Ankara Turkey September 24-26, 1997 Ankara. 26. I.Kuçukguzel, M.Ulgen and J.W.Gorrod. Effect of nitrogen pka on the microsomal oxidation of N-benzylic eterocycles First International Symposium on Pharnaceutical Chemistry Hacettepe University, Faculty of Pharmacy, Ankara Turkey September 24-26, 1997 Ankara.

8 27. F. Yılmaz, M. Ulgen, D.S. Doğruer, B. Çakır and M.F. Şahin The in vitro hepatic metabolism of 1-phenyl-2-(2-benzothiazolinone- 3-yl)ethanone and (+)-1-phenyl-2-(2-benzothiazolinone-3-yl)ethanol, Microsomes and Drug Oxidations, 1998 Upsala, Sweeden. 28. F. Yılmaz, M. Ulgen and J.W. Gorrod The in vitro hepatic microsomal metabolism of N-benzyladamantanamine in rats Second International Meeting on Pharmacy and Pharmaceutical Sciences, 6-9 September 1998, Istanbul. 29. B. Kaymakçıoğlu, E. Oruç, S. Rollas and M. Ulgen The in vitro hepatic microsomal metabolism of 3,5-dimethyl-4-phenylazo (1H) pyrazole in rats Second International Meeting on Pharmacy and Pharmaceutical Sciences, 6-9 September 1998, Istanbul. 30. M. Ulgen, F. Yılmaz, D. S. Doğruer and M. F. Şahin The in vitro hepatic microsomal metabolism of methyl 2-(2(3H)- benzoxazolone-3-yl)acetate in rats Second International Meeting on Pharmacy and Pharmaceutical Sciences, 6-9 September 1998, Istanbul. 31. G. Küçükgüzel, İ. Küçükgüzel and M. Ülgen In vitro microsomal metabolism of N-(4-chlorobenzyl)-N'-benzoylhydrazine Second International Meeting on Pharmacy and Pharmaceutical Sciences, 6-9 September 1998, Istanbul. 32. M. Ulgen and J.W. Gorrod Studies on the in vitro hepatic microsomal formation of amides during the metabolism of certain secondary and tertiary benzylic amines 9 th North American ISSX Meeting Nashville, Tennessee, Ş.G.Küçükgüzel, İ. Küçükgüzel and M. Ulgen Metabolic and chemical studies on N-(4-chlorobenzyl)-N -benzoylhydrazine 9 th North American ISSX Meeting, Nashville, Tennessee, B. Çakır, D.S. Doğruer, M.F. Şahin, F. Yılmaz and M. Ulgen The in vitro hepatic microsomal metabolism of 3-(3-morpholinylpropyl) 2- benzothiazolinone in rats 9 th North American ISSX Meeting Nashville, Tennessee, Yılmaz,F. And Ulgen, M. In vitro metabolism of N-benzoylnornicotine and N-(p-chlorobenzyl)nornicotine 4th Xenobiotic Metabolism and Toxicity Workshop of Balkan Countries April, 2000, Antalya, Türkiye. 36.Oktav,M., Sözen,M., Zelzele,Ö., Özakun, C. And Ulgen, M. Xenobiotics in Printing Industry 4th Xenobiotic Metabolism and Toxicity Workshop of Balkan Countries April, 2000, Antalya, Türkiye. 37.Önkol, T., Şahin, M.F., Kartal, F., and Ulgen, M. The in vitro hepatic microsomal metabolism of 1-[2-[2(3H)-benzothiazolone-3-yl]acetyl]piperidine in rats DMW/ISSX 2000 Meeting, June 11-16,2000, St.Andrews, Scotland. 38. Şimşek,R., Şafak,C., Oral,B., Bulut,G., Ulgen,M. The in vitro hepatic microsomal metabolism of 2,6,6-trimethyl-3-carbmethoxy-4-(2-bromophenyl)-5-oxo- 1,4,5,6,7,8-hexahydroquinoline in rats 10th North American ISSX Meeting, Indianpolis,Indiana, Şekercioğlu,Y., Oktav,M., Dölen,E., Rollas,S., Ulgen, M. In vitro rat microsomal metabolism of aromatic azo dyes used in the printing inks 10th North American ISSX Meeting, Indianpolis,Indiana,2000.

9 40.Yurtsever,E., Şener,A., Göker,B., Ulgen,M., Yardımcı,T. Effect of tenoxicam on plasma and liver lipid peroxidation and glutathione levels in wistar albino rats 10th North American ISSX Meeting, Indianpolis,Indiana, Ulgen,M., Gorrod,J.W. The source of amides observed during the microsomal metabolism of N-benzylamines 10th North American ISSX Meeting, Indianpolis,Indiana, Oktav, M., Sözen, M., Zelzele, Ö., Özakun, C., Ülgen, M. A toxicity evaluation of printing chemicals used in the packaging of pharmaceutical formulations 1st International Pharmaceutical Congress, April 28-29,2001, Athens 43. Kaymaz, S., Bulut, G., Ülgen, M. In vitro microsomal metabolic studies on secondary aromatic hydroxamic acids and their corresponding amides 1st International Pharmaceutical Congress, April 28-29,2001, Athens 44. Ulgen, M. The sources of chemical artifacts in the in vitro metabolism of xenobiotics 3rd International Symposium on Pharnaceutical Chemistry Hacettepe University, Faculty of Pharmacy, Ankara Turkey September 17-19, 2001, İstanbul (oral presentation) 45. Yılmaz,F., Ulgen, M., Gorrod, J.W. The In Vitro Hepatic Microsomal Metabolism Of Some Alkylated And Acylated Nornicotine Derivatives 14th International Symposium on Microsomes and Drug Oxidations Sapporo, Japan, July 22-26, Duran, A., Bekçe, B., Doğan,N. And Ulgen, M. "Simultaneous determination of salmeterol and fluticasone propionate by high performance liquid chromatography Fourth International Symposium on Pharnaceutical Chemistry Hacettepe University, Faculty of Pharmacy, Ankara Turkey September 17-19, 2003 İstanbul. 47. Banu Bekçe, Göksel Şener, Mehmet Oktav, Mert Ulgen and Sevim Rollas In vitro and in vivo metabolism of ethyl 4-[(2-hydroxy-1-naphthyl)azo] benzoate 19th European Workshop on Drug Metabolism October 03-08, Antalya-Turkey. 48. Gülen Bulut, Mehmet Oktav and Mert Ulgen The stabılıty studies and in vıtro hepatic microsomal metabolism of some α-phenyl-n-substituted nitrones in rats 19th European Workshop on Drug Metabolism October 03-08, Antalya-Turkey. 49. Demircan, F.Y., Ulgen, M. High pressure liquid chromatographic method for the determination of nicotine metabolites and their in vitro metabolism by rat brain MCRD 2005 International Symposium on Medicinal Chemistry Research and Development 2005 Kuşadası Turkey p Koçyiğit-Kaymakçıoğlu, B., Oruç, E.E., Yılmaz-Demircan, F., Gürbüz, Y., Kalaça, S., Küçükgüzel, Ş.G., Ülgen, M., Rollas, S. An high performance liquid chromatographic method for the quantification of cotinine in the urine of preschool children MCRD 2005 International Symposium on Medicinal Chemistry Research and Development 2005 Kuşadası Turkey p Ö. Algül, M. Ülgen, "The In Vitro Hepatic Microsomal Metabolism of 2-Substitutedbenzimidazoles in Rats"

10 8th. International Symposium of Pharmaceutical Sciences. P-215, Haziran 2006, Ankara, Turkey National Publications (in Turkish Journals) 1. Yars, U., Ulgen, M. "The assay of some sedative drugs by high pressure liquid chromatography" J.Pharm.Univ.Mar., 4, (1988). 2. Rollas, S., Dogan, N., Ulgen, M., Ozger, Y. "Synthesis and spectrometric analysis of some new azopyrazole substituted 1,2,4-triazole-5-thiones" J.Pharm.Univ.Mar., 6, (1990). 3. Güldür, T., Ulgen, M., Ulutin, T. "Şilomikron ve Şilomikron Artık Metabolizması" Endokrinolojide yönelişler, 2, (1990) 4. Ulgen, M., Gorrod, J.W. "Synthesis and characterization of some new 2,4,6-trisubstituted N,N-dibenzylanilines" J.Pharm.Univ.Mar., 7, (1991). 5. Ulgen,M., Gorrod, J.W. "Synthesis,characterization and chromatographic studies on some substituted α,n-diphenylnitrones" J.Pharm.Univ.Mar., 8, (1992). 6. Ulgen, M. "İn vitro Oksidatif Mikrozomal 1.faz İlaç Metabolizması Teknikleri" J.Pharm.Univ.Mar., 9, (1993). 7. Ulgen, M., Gorrod, J.W. "Synthesis, isolation and characterisation of some substituted N-benzyl and N-benzoylanilines". J. Fac. Pharm. Ist., 30, 1-9 (1994). 8. Gulerman, N., Rollas, S., Ulgen, M. "Synthesis of some substituted 1,2,4-thiadiazole derivatives" J.Pharm.Univ.Mar., 10, (1994). 9. Kucukguzel, I., Rollas, S., Ulgen, M. "Synthesis and characterization of some thiourea derivatives from 1,3,4- triazoline-3-thiones" J.Pharm.Univ.Mar., 10, (1994). 10. Yılmaz, F., Ulgen, M. "In vitro microsomal metabolism of some N-benzyl substituted tertiary amines in the rat" Acta Pharm. Turcica, 4, , (1997). 11. Unsalan, S., Ulgen, M. "In vitro microsomal metabolism of N,N-dibenzylmethylamine, N,N-dibenzyl-4-nitro and N,N-dibenzyl-2,4-dichlorobenzylamine" Fabad J. Pharm. Sci., 22, , (1997). 12. Kucukguzel,I., Ulgen, M. "In vitro metabolic fate of N-substituted Dibenzylamines : Investigation of Biological Oxidation Site on Nitrogen Compounds with Different pka" J. Fac. Pharm. Ist., 32, 69-86, (1998). 13. Bulut, G., Oktav, M. ve Ülgen, M. "Nikotin ve günümüzde sigara kullanımı" Basev dergisi, 20, (2000). 14. Ulgen, M. İlaçların eliminasyonuna yardım eden önemli bir mekanizma : İlaç metabolizması Havan, 2, (2000)

11 15. Ulgen, M. İlaçların ve diğer kimyasalların metabolizması Kimya Teknolojileri, 5, (2001) 16. Oktav, M., Şekercioğlu, Y., Zelzele, Ö., Ülgen, M. Karton ambalaj sektöründe sağlığı ve işgüvenliğini olumsuz etkileyen faktörlerin önlenmesine yönelik inceleme Plastik ve Ambalaj Teknolojisi, 67, (2002). 17. Yılmaz, F., Ulgen, M. Organizmamızı tehdit eden bir bileşik : Nikotin Kimya Teknolojileri,17, (2002). 18. Ulgen,M., Yılmaz, F. Yüksek Basınçlı Sıvı Kromatografisinin İlaç Endüstrisinde Kullanımı Kimya Teknolojileri,23, (2002). National Abstracts presented in Turkish Scientific Meetings 1. M. Ulgen "İlaç metabolizmasının ve bu konuda yapılacak çalışmaların Eczacılık mesleği açısından önemi" V. Türkiye Eczacılık Kongresi, Mayıs 1993, Sherton Oteli, İstanbul. (Sözlü Bildiri) 2. I.Kuçukguzel, M.Ulgen and J.W.Gorrod "In vitro hepatıc microsomal metabolism of N-benzyl-N-methylaniline by rat : The detection of p-hydroxylated metabolites by HPLC" 2nd National Congress of Toxicology with International Participation April 3-6, 1997 İberotel-Berpark, Antalya, Turkey 3. M. Ülgen "Organik Bileşiklerin Metabolizması" XIII. Kimya 99 Ulusal Kimya Kongresi 31 Agustos-4 Eylül 1999 Ondokuz Mayıs Üniversitesi Fen - Edebiyat Fakültesi Kimya Bölümü, Samsun (Sözlü Bildiri) 4. Oktav, M., Özhakun, C., Ülgen,M. "Matbaacılıkta Sağlık ve Üretimi Etkileyen Kimyasal Faktörler" XIII. Kimya 99 Ulusal Kimya Kongresi 31 Agustos-4 Eylül 1999 Ondokuz Mayıs Üniversitesi Fen - Edebiyat Fakültesi Kimya Bölümü, Samsun 5. Oktav, M., Şekercioğlu, Y., Zelzele, Ö., Ülgen, M. Karton ambalaj sektöründe sağlığı ve işgüvenliğini olumsuz etkileyen faktörlerin önlenmesine yönelik inceleme II. Uluslararası ambalaj kongresi ve sergisi 30 Mayıs- 1 Haziran, 2001 Dokuzeylül Üniversitesi Sempozyum Salonları Desem İzmir 6. Ülgen, M., Özcan, A., Yaman, Ö., Karatepe, A.K. Basım İşletmelerinde Gürültünün İşgörenin Performansı Üzerine Olumsuz Etkisinin İncelenmesi 1. Uluslararası katılımlı Kağıt-Karton, Mürekkep, Matbaa Sempozyumu Sergisi Eylül 2002, Narlıdere İzmir Books 1. Mert Ülgen Organik bileşikler ile İlaçların Adlandırılması ve Temel Organik Reaksiyonlar M.Ü. Yayın no: 654 ; Eczacılık Fak. Yayın no: 14 (1999)

12 2. Mert Ülgen, Mehmet Oktav, Efe N. Gençoğlu Matbaacının Kağıt Hakkında Bilmesi Gerekenler Çeviri Kitap (Yazar: Lawrence A. Wilson) Basev Yayınları, 2008 Projects Assisted In Abroad : 1. "The role of imines and oxaziridines as intermediates in the metabolism of N-benzylanilines" Sponsor : Wellcome Trust, England (1 July-1 September 1993) (Proje yürütücüsü : Prof. J. W. Gorrod) 2. "In vitro metabolism of nicotine in the brain" Sponsor : Verum Foundation, Germany (15 Jan 15 Apr 1997) Proje supervisor Prof. J. W. Gorrod; other assistant scientist: Dr P. Jacob III) (Both projects were carried out in University of London, King's College, Chelsea Department of Pharmacy, Biopharmacy laboratories) In Turkey : 1. Bazı Hipnotik-Sedatif İlaç Maddelerinin Yüksek Basınçlı Sıvı Kromatografisi ile Miktar Tayinleri (Marmara Üniversitesi Araştırma Fonu Projesi, Ekim 1985-Şubat 1987) (Proje yürütücüsü : Doç. Dr. Ü. Yars) 2. Antidiabetik aktivite göstermesi muhtemel bazı yeni 2,4-dihidro-3H-1,2,4-triazolin-3-tiyon, 1,3,4-tiyadiazol ve pirazol türevlerinin sentezleri (Marmara Üniversitesi Araştırma Fonu Projesi, ) (Proje yürütücüsü : Doç. Dr. S. Rollas ; diğer yardımcı araştırıcılar : Y. Özger ve N. Doğan) 3. Salmeterol Ksinafoat ve Flutikazon Propiyonat ın Miktar Tayinleri (Marmara Üniversitesi Araştırma Fonu Projesi, 2004) (Proje Yürütücüsü: Y. Doç. Dr. H. Neşe Doğan) Supervised: Abroad : 1. "The development of foreign compound metabolism studies in Turkey and the in vitro microsomal metabolism of aromatic nitrogenous compounds & their intermediate products Sponsor : British Council, England "Academic Link for Turkey" (20 Temmuz-20 Eylül 1995) (Other coordinator of this project is Prof J. W. Gorrod (This project was carried out in University of London, King's College, Chelsea Department of Pharmacy, Biopharmacy laboratories) In Turkey : 1. Tersiyer amin grubu taşıyan bileşiklerin in vitro mikrozomal metabolizmaları konulu ylll M.Ü. Araştlrma Fonu projesinin yürütücülüğü (yardımcı araştırıcılar : İ. Küçükgüzel, S. Ünsalan, F. Yılmaz ve U. Özer) 2. Klor substitue aromatik ve alifatik sekonder aminlerin ve iminlerin in vitro mikrozomal metabolizmaları (M.Ü. Araştırma Fonu 1996 yılı Öncelikli proje) projesinin yürütücülüğü (yardımcı araştırıcı : İ. Küçükgüzel)

13 3. N-Benziladamantanamin ve N-benzilidenadamantanamin'in in vitro hepatik metabolizması (M.Ü. Araştırma Fonu 1998 yılı Öncelikli proje) projesinin yürütücülüğü (yardımcı araştırıcı : F. Yılmaz) 4. Aromatik ve Alifatik Tersiyer Amin N-Oksitlerinin in vitro metabolizmaları (M.Ü. Araştırma Fonu 1998 yılı Öncelikli proje) projesinin yürütücülüğü (yardımcı araştırıcılar : G. Küçükgüzel, İ. Küçükgüzel) 5. N-(4-Klorobenzil)-N'-benzoilhidrazin'in İn vitro metabolizması (M.Ü. Araştırma Fonu 1998 yılı Öncelikli proje) projesinin yürütücülüğü (yardımcı araştırıcılar : G. Küçükgüzel, İ. Küçükgüzel) 6. Nikotin ara metabolitlerinin ve nikotin analoglarının sentez, analiz ve metabolizmaları (M.Ü. Araştırma Fonu 1998 yılı Öncelikli proje) projesinin yürütücülüğü (yardımcı araştırıcılar : F. Yılmaz, F. Kartal) 7. 3-(Benziltiyo)-5-(4-nitrofenil)-4-fenil-4H-1,2,4-triazol'ün in vitro metabolizması (M.Ü. Araştırma Fonu 1998 yılı Öncelikli proje) projesinin yürütücülüğü (yardımcı araştırıcılar : S. Rollas, E. Oruç, B. Oral) 8. Bazı Substitue Alifatik-Aromatik Amidlerin ve Hidroksamik Asitlerin In Vitro Mikrozomal Metabolizmaları (M.Ü. Araştırma Fonu 2005 yılı Öncelikli proje SAĞ-YYP ) projesinin yürütücülüğü (yardımcı araştırıcı : Ali çakmak) 9. Bazı Substitue Alifatik-Aromatik İminlerin Stabiliteleri ve In Vitro Mikrozomal Metabolizmaları (M.Ü. Araştırma Fonu 2005 yılı Öncelikli proje SAĞ-YYP ) projesinin yürütücülüğü Administrative Duties a. Marmara University Faculty of Pharmacy (MUFP) Faculty Council Member , , b. MUFP Deputy Dean c. MUFP Vice Dean September-October 2002 d. MUFP Head of Professional Sciences Department e. Turkish Pharmacists Academia Council Member f. Administrative Council Member of Acibadem University, Vocational School of Health Services (2009- to date) g. Faculty Council Member of Acibadem University, Faculty of Health Sciences (2009- to date) h. Vice President of Enstitute of Health Sciences, Acibadem University (2009- to date) i. Institutional Erasmus Coordinator (2010- to date) j. Management in Pharmaceutical Industry Post-Graduate MSc Program (Coordinator of the Program (2010- to date)) Memberships : ISSX Turkish Pharmaceutical and Medicinal Chemistry Society Awards obtained : Marmara University Superior Scientist Award (1997)

14 Some selected undergraduate and postgraduate lectures by Prof. Dr. Mert Ulgen: Pharmaceutical Chemistry Professional English for Pharmacists Drug Metabolism Drug Metabolism Techniques Chromatagraphic Separation Techniques Organic Nomenclature Chemistry for Medicine Chemistry for School of Associated Health Sciences International Congress Organised : 1. First International Meeting on Pharmacy and Pharmaceutical Sciences, 4-7 September 1994, Istanbul, TÜRKİYE 2. Symposium on Drug Metabolism : "Towards to the next millenum" 25,26,27 August, 1997 King's College, Chelsea Department of Pharmacy, London, UK 3. Second International Meeting on Pharmacy and Pharmaceutical Sciences, 6-9 September 1998, Istanbul, TÜRKİYE 4. 4 th Xenobiotic Metabolism and Toxicity Workshop of Balkan Countries April 2000, Antalya, TÜRKİYE 5. XIII. Bitkisel laç Hammaddeleri toplantısı Marmara Üniversitesi Eczacılık Fakültesi, Eylül 2000, İstanbul 6. 1st International Meeting on Medicinal and Pharmaceutical Chemistry IMMPC-1 September 25-28, 2002 Gazi University, Ankara Turkey th European Workshop on Drug Metabolism October 03-08, Antalya-Turkey. Certificate Programs Organised in Acıbadem Üniversity (ASEGEM) 1. Patent for Pharmaceutics 2. HPLC Analyst Certificate Program Editorial Board Memberships : 1. Drug Metabolism and Drug Interactions ( to date) 2. Drug Metabolism Letters ( to date) 3. Current Drug Metabolism ( to date) 4. Kimya Teknolojileri ( to date) 5. Marmara Pharmaceutical Journal ( to date)