5th International Congress of Molecular Medicine Dokuz Eylul University May 20-22, 2015 Izmir, Turkey

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2 5th International Congress of Molecular Medicine Dokuz Eylul University May 20-22, 2015 Izmir, Turkey 2

3 Table of Contents WELCOME ORGANISERS SCIENTIFIC PROGRAM SPEAKERS SUMMARIES POSTER PRESENTATIONS

4 Welcome Dear Colleagues, On behalf of the Organizing Committee, it is our great pleasure and honor to welcome you to the 5th International Congress of Molecular Medicine. The Congress is continuing the tradition of the Turkish Society of Molecular Medicine and will be organised for the fifth time. Many distinguished scientists have joined the faculty and will take part in this Congress therefore we hope that you will enjoy the scientific and social program & your stay in Izmir. Sincerely yours, Prof. Dr. Hüray İşlekel Dokuz Eylül University, Faculty of Medicine, Department of Biochemistry, Institute of Health Sciences, Department of Molecular Medicine, Izmir, Turkey Prof. Dr. Ümit Zeybek Istanbul University, Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul, Turkey. Chairperson of the Turkish Society of Molecular Medicine 4

5 Organisers Honorary President Turgay İsbir Congress Co-Presidents Ümit Zeybek Hüray İşlekel Board of the Turkish Society of Molecular Medicine Bedia Çakmakoğlu Arzu Ergen Nevin İlhan Oğuz Öztürk Sadrettin Pençe Hülya Yılmaz-Aydoğan Canan Cacına Güldal İnal-Gültekin Özlem Küçükhüseyin Özlem Timirci-Kahraman Organization Committee Ümit Zeybek Gül Güner-Akdoğan Necip İlhan İlhan Yaylım Engin Ulukaya Yusuf Baran Uzay Görmüş İsmail Cem Küçükali Zahide Çavdar Mehtap Yüksel Eğrilmez Serpil Tanriverdi-Akhisaroğlu Yasemin Soysal Harun Said Congress Secretariat Kerem Özyavuz Congress Assistant Secretariat Faruk Çelik Servet Tunoğlu Burcu Çelikel Melike Gezen Ece Gizem Işıkören Ezgi Nurdan Yenilmez Merve Kalkan Gamze Tuna Roghaiyeh Safari Melis Dinç Kant Duygu Harmancı Ayşe Koçak Merve Akış Cemre Ural Emre Tuncer Duygu Ünivar Purcu Muammer Yücel Nur Gökçe Çetiner 5

6 Scientific Committee Oğuz Altungöz, Izmir, Turkey Hasan Alpak, Istanbul, Turkey Nejat Akar, Ankara, Turkey Figen Aksoy, Istanbul, Turkey Kemal Altaş, Istanbul, Turkey Soykan Arıkan, Istanbul, Turkey Altan Armutak, Istanbul, Turkey Elif İlkay Armutak Istanbul, Turkey Nur Aslan, Izmir, Turkey Erkut Attar, Istanbul, Turkey Filiz Aydın, Istanbul, Turkey Seval Aydın, Istanbul, Turkey Gülseren Bağcı, Denizli, Turkey Hüseyin Bağcı, Denizli, Turkey Hüveyda Başağa, Istanbul, Turkey Ercan Baştu, Istanbul, Turkey Bülent Bayraktar, Istanbul, Turkey Ahmet Belce, Istanbul, Turkey Merih Birlik, Izmir, Turkey Halit Canatan, Kayseri, Turkey Atahan Çağatay, Istanbul, Turkey Mehmet Çalan, Izmir, Turkey Tunç Çatal, Istanbul, Turkey Aydın Çevik, Istanbul, Turkey Altay Burak Dalan, Istanbul, Turkey Feyza Darendeliler, Istanbul, Turkey Esen Özalp Dural, Istanbul, Turkey Nesrin Emekli, Istanbul, Turkey Ebru Emekli-Alturfan, Istanbul, Turkey Özcan Erel, Ankara, Turkey Veysel Sabri Hançeri Istanbul, Turkey Serap İnal, Istanbul, Turkey Mehmet İsbir, Antalya, Turkey Selim İsbir, Istanbul, Turkey Cem İyibozkurt, Istanbul, Turkey International Scientific Committee Tasneem Ahmad, Pakistan Angelo Azzi, Italy Peter Butterworth, United Kingdom George Delinassios, Greece John George Delinassios, Greece Mehmet Laszlo Dux, Hungary Ahmad Ammad Farooqi, Pakistan Detlev Ganten, Germany Robert Mahley, United Kingdom Shant Kumar, United Kingdom Pat Kumar, United Kingdom Luciano Saso, Italy Abdelaziz Soukri, Morocco Franz Theuring, Germany Tomas Zima, Italy Mukaddes Gümüştekin, Izmir, Turkey Ali Osman Gürol, Istanbul, Turkey Hüsrev Hatemi, Istanbul, Turkey Nezih Hekim, Istanbul, Turkey Ali Kafadar, Istanbul, Turkey Emin Kansu, Ankara, Turkey Özcan Karaman, Istanbul, Turkey Mehmet Kaya, Istanbul, Turkey Önder Kılıçoğlu, Istanbul, Turkey Hikmet Koçak, Istanbul, Turkey Hilal Koçdor, Izmir, Turkey Mehmet Kurtoğlu, Istanbul, Turkey Serap Erdem Kuruca, Istanbul, Turkey Abdullah Melekoğlu, Kastamonu, Turkey Fehmi Narter, Istanbul, Turkey Mustafa Naziroğlu, Isparta, Turkey İlhan Odabaş, Istanbul, Turkey Vakur Olgaç, Istanbul, Turkey Fatma Oğuz, Istanbul, Turkey Tamer Önder, Istanbul, Turkey Tuğba Bağcı Önder, Istanbul, Turkey Tomris Özben, Antalya, Turkey Ayşe Kevser Özden, Ankara, Turkey Nazmi Özer, Girne, Northern Cyprus Nesrin Kartal Özer, Istanbul, Turkey Erdener Özer, Izmir, Turkey Murat Özgören, Izmir, Turkey Elif Özkök, Istanbul, Turkey Hale Şamlı, Bursa, Istanbul Ertuğrul Taşan, Istanbul, Turkey M. İbrahim Tuğlu, Manisa, Turkey Akif Turna, Istanbul, Turkey Ayfer Ülgenalp, Izmir, Turkey Emin Ünüvar, Istanbul, Turkey Ayşen Yarat, Istanbul, Turkey VAROL 6

7 Scientific Program Tuesday (19 May 2015) 12:30-17:30 Applied Workshop Bioinformatic Tools for Exome Sequencing Data Analysis Wednesday (20 May 2015) 8:30-9:45 Registration 9:45-10:00 Coffee 10:00-10:30 Opening Remarks 10:30-12:15 SESSION 1 MOLECULAR METABOLISM AND OXYDATIVE STRESS 12:30-13:30 Social Programme 13:30-14:15 Lunch 14:15-15:15 Opening Lecture 15:15-15:30 Coffee Break 15:30-16:30 TUBITAK SESSION Session Chairs: Nesrin Kartal-Özer & Hüray İşlekel Nesrin Kartal-Özer The Role of Oxidative and Endoplasmic Reticulum Stress in Cardiac Failure Luciano Saso Pharmacalogical Applications of Antioxidants: Lights and Shadows Hüray İşlekel Measurement of Oxidative Stress Parameters Using LC-MS/MS Mehmet Çalan A Novel Metabolic and Cardiovascular Regulator Hormone; Adropin Detlev Ganten The Future of Medicine: New Developments Require New Structures Yusuf Baran Ulusal Akademik Ar Ge Proje Destekleri 16:30-18:30 SESSION 2 WOUND HEALING AND EXTRACELLULAR MATRIX Session Chairs: Serpil Tanriverdi Akhisaroğlu & Mehtap Yüksel Eğrilmez 7

8 Karin Scharffetter-Kochanek The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms Cenk Demirdöver Clinical Aspects of Wound Healing 19:00-20:00 Welcome Cocktail Mehtap Yüksel Eğrilmez Matrix Metalloproteinases and Wound Healing Harun Muayad Said TGF-β signaling De-regulation in Hypertrophic Scar Fibroblast Cells by the Regulative Functional Activity of Smad7 Thursday (21 May 2015) 8:45-10:45 SESSION 3 NEW TRENDS IN STEM CELL SCIENCES Session Chairs: Turgay İsbir & Necip İlhan Fatima Aerts Kaya Current Concepts in Stem Cell Biology and Stem Cell Types Tamer Önder Induced Pluripotent Stem (ips) Cells and Future of Regenerative Medicine Betül Çelebi - Saltık Stem Cell Engineering 10:45-11:00 Coffee Break 11:00-13:00 SESSION 4 POST-GRADUATE TRAINING IN MOLECULAR MEDICINE Session Chairs: Gül Güner Akdoğan & İlhan Yaylım Turgay İsbir Post-Graduate Training in Molecular Medicine: A Global View Laszlo Dux Postgraduate (PhD) Training in Molecular Medicine, a New Approach in Szeged, Hungary Gül Güner Akdoğan Molecular Medicine Programmes in Dokuz Eylul University: Where Are We Heading? 13:00-13:30 Erdem Yılmaz, Elips Co. Novocyte, the New Star of Benchtop Flow Cytometry 13:30-14:30 Lunch & Poster Session 14:30-16:30 SESSION 5 SPORTS AND MEDICINE Session Chairs: Mehmet Kurtoğlu & Ümit Zeybek Laszlo Dux Muscle Exercise and Adaptation at the Molecular Level 8

9 Adnan Bağrıaçık The Qualification Requirements for Elite Basketball Player Kerem Özgünen Effect of exercise on body: From a physiological point of view Faruk Çelik Investigation of the Novel Genes Which Related with Athletic Performance 16:30 17:00 Aydın Duygu / BioTailor Labs Tailored Amino Acid Supplementation Based on Metabolic Profiling 17:00-17:15 Coffee Break 17:15-18:15 SESSION 6 BIONFORMATIC IN MOLECULAR MEDICINE Session Chairs: Arzu Ergen & Yasemin Soysal 20:00-22:00 Gala Dinner Mustafa Kolukırık New Diagnostic Molecular Tools for a New Era of Clinical Microbiology Serkan Türkeli Human Body as a (Big) Data Source Friday (22 May 2015) 8:45-10:45 SESSION 7 CANCER-MOLECULAR ASPECTS FOR IN VITRO AND IN VIVO TECHNIQUES Session Chairs: Uzay Görmüş & Harun Said 10:45-11:00 Coffee Break Devrim Gözüaçık Autophagy regulation: Novel Connections and Relevance to Human Diseases Erdal Karaöz Filling the Gap in the Relationship Between Cancer and Stem Cells Tunç Akkoç Immunologic Aspects of Cancer Cell Yavuz Dizdar The Idea Behind the Gene: Implications for Cancer 11:00-13:00 SESSION 8 CANCER-MOLECULAR ASPECTS IN DIAGNOSIS AND PROGNOSIS Session Chairs: Mustafa Naziroğlu & Engin Ulukaya Mustafa Djamgoz A New Vision of Metastasis: Voltage-Gated Ion Channels and Membrane Excitability Engin Ulukaya Cell Death Biomarkers in the Prediction of Response to Chemotherapy Helpful or Doubtful? 9

10 Selma Düzenli Nutrigenetics and Cancer Shant Kumar Angiogenesis: Progress From Concept to Clinical Trials Wen-Hui Fang Oncogene PAX3 contributes to the survival and metastasis in childhood cancer neuroblastoma and human melanoma through TGF-beta and CD105 signalling pathway 13:00-13:30 Elif Yaman Şaşmaz, SACEM Co. Infrared Technology in In vitro and In vivo İmaging 13:30-14:30 Lunch & Poster Session 14:30-16:15 SESSION 9 NEUROLOGIC DISEASE-MOLECULAR ASPECTS Session Chairs: Erdem Tüzün & Hacer Durmuş 16:15-16:30 Coffee Break Hacer Durmuş Inflammatory Myopathies-Molecular Aspects Erdem Tüzün Molecular Mechanisms Behind Autoimmune Channelopathies Aslı Demirtaş-Tatlıdede Inflammatory Aspects of Alzheimer s Disease Elif Uğurel Inflammatory Mechanisms in Neuro-Behcet s Disease 16:30-17:45 CLOSING SESSION (FUTURE OF MOLECULAR MEDICINE) 10

11 PP-010 Anti-cancer and anti-angiogenic activities of a lichen-derived substance: α- collatolic acid Ayşegül Varol 1, Mehmet Candan 1, Turgay Tay 2, Ayşen Türk 1, Ayşe Tansu Koparal 1, Mehmet Varol 1,3 1 Department of Biology, Faculty of Science, Anadolu University, Yunusemre Campus, 26470, Eskişehir, TURKEY. 2 Department of Chemistry, Faculty of Science, Anadolu University, Yunusemre Campus, 26470, Eskişehir, TURKEY. 3 Department of Molecular Biology and Genetic, Muğla Sıtkı Koçman University, Kötekli Campus, 48000, Muğla, TURKEY. Background: One way to search for potentially new effective ingredients of anti-cancer drugs is the testing of various naturally synthesized substances. Angiogenesis, the development of new branching vessel from existing vasculature, is an attractive target for anti-cancer therapy due to its key role in tumor growth and invasion. Lichen-derived α-collatolic acid is therefore investigated as anti-cancer and anti-angiogenic natural substance for the first time. Materials and Methods: Α-Collatolic acid was isolated from acetone extract of Tephromela atra (Fée). Chemical characterization was performed by 1 H-NMR, IR and melting point analyses. MTT assay was performed on A549 adenocarcinoma cells, NS20Y neuroblastoma cells, HepG2 hepatocarcinoma cells and HUVEC endothelial cells for 24h and 48h treatments. Anti-angiogenic potential of the substance was determined by endothelial tube formation assay. Results: α-collatolic acid showed the most cytotoxic effect on NS20Y cells by 41,82+1,22 µm and the less toxicity on HUVEC cells by 221,01+2,05 µm, for 48h. However, the sub-cytotoxic concentrations as µm significantly prevented endothelial tube formation. Conclusion: The findings suggest that α-collatolic acid might be a potential ingredient of anti-cancer and antiangiogenic drugs. 58