1. Adı Soyadı: Aslı F. CEYLAN 2. Doğum Tarihi: 01 Haziran 1977 3. Unvanı: Doçent 4. Öğrenim Durumu: Derece Alan Üniversite Yıl Lisans Eczacılık Ankara Üniversitesi 1998 Y. Lisans Farmakoloji Ankara Üniversitesi 2001 Doktora Farmakoloji Ankara Üniversitesi 2007 5. Akademik Unvanlar: Yardımcı Doçentlik Tarihi : 2008 Doçentlik Tarihi : 2012 Profesörlük Tarihi : 6. Yönetilen Yüksek Lisans ve Doktora Tezleri 6.1. Yüksek Lisans Tezleri Role of Apelin Receptor in Obesity-Induced Heart Dysfunction Gender as a Potential Risk in Cardiac Dysfunction The Modulatory Role of Estrogen in the Heart Role of Taurodeoxycholic Acid in Obesity-Induced Cardiac Dysfunction 6.2. Doktora Tezleri - 7. Yayınlar 7.1. Uluslararası hakemli dergilerde yayınlanan makaleler (SCI & SSCI & Arts and Humanities) 1. Ceylan-Isik AF, Dong F, Turdi S, Yanagisawa M, Ren J. Cardiomyocyte-specific deletion of endothelinreceptor A rescues aging-associated cardiac hypertrophy and contractile dysfunction: Role of autophagy. Aging Cell- in press. 2. Ceylan-Isik AF, Machender R. Kandadi, Ren J. Nair S. MiR-133a reglation by Apelin rescues the heart from high-fat diet-induced cardiac hypertrophy. J Mol Cell Cardiol. in press. 3. Ceylan-Isik AF, Ren J, Nair S. Cardiac Spesific Deletion of Endothelin Receptor-1A (ET A ) Attenuates Obesity-Associated Cardiac Dysfunction. Diabetes-in press. 4. Ceylan-Isik AF, Li Q, RenJ.Insulin-Like Growth Factor I (IGF-1) Deficiency Ameliorates Sex Difference in Cardiac Contractile Function and Intracellular Ca2+ Homeostasis. Tox Lett. 2011, 206: 130-138. 5. Hua Y*, Zhang Y*, Ceylan-Isik AF, Nunn JM, Ren J. Chronic Akt activation accentuates aginginduced cardiac hypertrophy and myocardial contractile dysfunction: Role of autophagy. Basic Res. Cardiol. 2011, 106: 1173-1191. 6. Ceylan-Isik AF, Sreejayan Nair, RenJ. Endoplasmic reticulum Chaperon Tauroursodeoxycholic Acid Alleviates Obesity-Induced Myocardial Contractile Dysfunction. J Mol Cell Cardiol. 2011, 50: 107-116. 1
7. Ceylan-Isik AF, Ari N, Stefek M, Sotnikova R, Ozansoy G, Horakova L, Karasu C. Effects of longterm treatment with an antioxidant pyridoindole on vascular responsiveness in diabetes-induced aging rats. Curr Aging Sci. 2011, 4: 150-157. 8. Ceylan-Isik AF, Mc Bride SM, Ren J. Sex difference in alcoholism: Who is at a greater risk for development of alcoholic complication? Life Sci. 2010, 87: 133-138. 9. Ceylan-Isik AF, Zhao P, Zhang B, Xiao X, Su G, Ren J.Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis. J Mol Cell Cardiol. 2010, 48: 367-378. 10. Ceylan-Isik AF, Erdogan-Tulmac OB, Ari N, Ozansoy G, Ren J. Impact of 17-beta Estradiol Replacement on Vascular Responsiveness in Ovariectomized Diabetic Rats. Clin Exp Pharmacol Physiol. 2009, 36: 65-71. 11. Ceylan-Isik AF, Guo KK, Carlson EC, Privratsky JR, Liao SJ, Cai L, Chen AF, Ren J. Metallothionein Abrogates GTP Cyclohydrolase I inhibition-induced Cardiac Contractile and Morphological Defect: Role of Mitochondrial Biogenesis. Hypertension. 2009, 6: 1023-1031. 12. Ceylan-Isik AF, Fliethman RM, Wold LE, Ren J. Herbal and traditional Chinese medicine for the treatment of cardiovascular complications in diabetes mellitus. Curr. Diabetes Rev. 2008, 4: 320-328. 13. Li Q, Ceylan-Isik AF, Li J, Ren J. Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction. Rejuvenation Res. 2008, 11: 725-733. 14. Ren J, Zhu BH, Relling DP, Esberg LB, Ceylan-Isik AF. High-fat Diet-induced Obesity Leads to Resistance to Leptin-induced Cardiomyocyte Contractile Response. Obesity (Silver Spring). 2008, 16: 2417-2423. 15. Ceylan-Isik A, Hünkar T, Aşan E, Kaymaz F, Ari N, Söylemezoğlu T, Renda N, Soncul H, Bali M, Karasu C; (Antioxidants in Diabetes-Induced Complications) The ADIC Study Group. Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats. J Pharm Pharmacol. 2007, 59: 1629-1641. 16. Yulek F, Or R, Ozogul C, Ceylan-Isik A, Ari N, Stefek M, Bauer V, Karasu C. The effect of Stobadine and Vit E in diabetes-induced retinal abnormalities: Involvement of oxidative strees. Arch Med Res. 2007, 38: 503-511. 17. Sahilli M, Irat AM, Işık AC, Karasu C, Ozansoy G, Ari N. A Lack of synergistic interaction between insulin and pioglitazone on reactivity of rat aorta from chronically high dose insulin - treated diabetic rats. Gen Physiol Biophys. 2007, 26: 48-55. 18. Li SY, Yang X, Ceylan-Isik AF, Du M, Sreejayan N, Ren J. Cardiac contractile dysfunction in Lep/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca +2 -ATP-ase and myosin heavy chain isozyme switch. Diabetologia. 2006, 49: 1434-1446. 19. Wold LE, Ceylan-Isik AF, Fang CX, Yang X, Li SY, Sreejayan N, Privratsky JR, Ren J. Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ 2
cycling proteins, NADPH oxidase, poly (ADP-Ribose) polymerase and myosin heavy chain isozyme. Free Radic Biol Med. 2006, 40: 1419-1429. 20. Ceylan-Isik AF, LaCour KH, Ren J. Gender disparity of streptozotocin-induced intrinsic contractile dysfunction in murine ventricular myocytes: role of chronic activation of Akt. Clin Exp Pharmacol Physiol. 2006, 33: 102-108. 21. Ceylan-Isik AF, Lacour KH, Ren J. Sex difference in cardiomyocyte function in normal and metallothionein transgenic mice: the effect of diabetes mellitus. J Appl Physiol. 2006 100: 1638-1446. 22. Ceylan-Isik AF, Wu S, Li Q, Li SY, Ren J. High-dose benfotiamine rescues cardiomyocyte contractile dysfunction in streptozotocin-induced diabetes mellitus. J Appl Physiol.2006, 100: 150-156. 23. Wold LE, Ceylan-Isik AF, Ren J. Oxidative Stress and Stress Signaling: The Menace of Diabetic Cardiomyopathy. Acta Pharmacol Sin. 2005, 26:908-17. 24. Li SY, Fang CX, Aberle NS 2nd, Ren BH, Ceylan-Isik AF, Ren J. Inhibition of PI-3 kinase/akt/mtor, but not calcineurin signaling, reverses insulin-like growth factor I-induced protection against glucose toxicity in cardiomyocyte contractile function. J Endocrinol. 2005, 186: 491-503. 25. Li SY, Du M, Dolence EK, Fang CX, Mayer GE, Ceylan-Isik AF, LaCour KH, Yang X, Wilbert C, Sreejayan N, Ren J. Aging Induces Cardiac Diastolic Dysfunction, Oxidative Stress, Accumulation of Advenced Glycation Endproducts and Protein Modification. Aging Cell. 2005, 4: 57-64. 26. Ceylan-Isik AF, Ren J. Gender Difference in Cardiac Excitation-Contraction Coupling: Role of Estrogen. The Cardiology. 2005, 1: 01-07. 27. Gunes A, Ceylan A, Sarioglu Y, Stefek M, Bauer V, Karasu C. The Antioxidants in Diabetes-induced Complications (ADIC) Study Group. Reactive oxygen species mediate abnormal contractile response to sympathetic nerve stimulation and noradrenaline in the vas deferens of chronically diabetic rats: effects of in vivo treatment with antioxidants. Fundam Clin Pharmacol. 2005, 19: 73-9. 28. Ren J, Ceylan-Isik AF. Diabetic Cardiomyopathy: Do Women Differ From Men? Endocrine. 2004, 25: 73-84. 29. Ceylan A, Karasu C, Aktan F, Ozansoy G. Simvastatin treatment restores vasoconstriction and the inhibitory effect of LPC on endothelial relaxation via affecting oxidizing metabolism in diabetic rats. Diabetes Nutr Metab. 2004, 17: 203-210. 30. Ozansoy G, Guven C, Ceylan A, Can B, Aktan F, Oz E, Gonul B. Effects of simvastatin treatment on oxidant/antioxidant state and ultrastructure of streptozotocin-diabetic rat lung. Cell Biochem Funct. 2004, 12: 297-302. 31. Ceylan A, Karasu C, Aktan F, Guven C, Can B, Ozansoy G. Effects of simvastatin treatment on oxidant/antioxidant state and ultrastructure of diabetic rat myocardium. Gen Physiol Biophys. 2003, 22: 535-47. 3
32. Hunkar T, Aktan F, Ceylan A, Karasu C. Antioxidants in Diabetes-Induced Complications (ADIC) Study Group. Effects of cod liver oil on tissue antioxidant pathways in normal and streptozotocindiabetic rats. Cell Biochem Funct. 2002, 20: 297-302. 7.2. Uluslararası diğer hakemli dergilerde yayınlanan makaleler 7.3. Uluslararası bilimsel toplantılarda sunulan ve bildiri kitabında (Proceedings) basılan bildiriler 1. Ceylan-Isik AF, Kandadi MR, Ren J, Nair S. Cardiac specific deletion of endothelin-1 receptor A rescues the heart from high fat diet-induced cardiac dysfuncton via regulating autophagy. American Heart Association Scientific Session 2011. November 12-16, 2011. FLORIDA, USA (oral presantation). 2. Ceylan-Isik AF, Kandadi MR, Ren J, Nair S. Apelin alleviates high fat diet-induced cardiac remodeling and myocardial contractile dysfunction: Role of mirna-133a. FASEB J. 25:1085.2, April 2011. WASHINGTON DC, USA. 3. Ceylan-Isik AF, Ren J, Nair S. The chemical chaperone tauroursodeoxycholic acid alleviates cardiac contractile dysfunction in obesity: Role of endoplasmic reticulum-stress in cardiac functionality. Experimental Biology Meeting, FASEB J. 24: 573.8, April 24-28, 2010. CALIFORNIA, USA. 4. Arıcıoğlu A, Ozansoy G, Ceylan-Işık A, Cumaoğlu A, Yüksel E, Akhayeva T, Karasu Ç, Aktan F, Arı N. Effects of low dose statin therapy on diabetic ventricular myocyte dysfunction in mouse. 5 th Int. Congress on Cardiovascular Disease (ICC-2009) Abstract Book. June 4-7, 2009. KOSICE, SLOVAK REPUBLIC. 5. Ozansoy G, Ulusoylar S, Akhayeva T, Ceylan-Isik A, Erdogan-Tulmac O, Arı N. Comparison of effect of estrogen / HRT and atorvastatin treatment on endothelium dependent relaxation in ovariectomized rats. International Coronary Artery Disease Congress Abstract Book, October 11-14. 2009. PRAGUE-CZECH REPUBLIC. 6. Ceylan-Isik A, Erdogan-Tulmac OB, Ari N, Ozansoy G. Effects of 17β-estradiol treatment on tissue Antioxidant Status of ovariectomized and diabetic rats. 43 rd Annual Meeting of European Association for the Study of Diabetes, Diabetologia p281-282. September 17-21, 2007. AMSTERDAM, HOLLAND (oral presantation). 7. C Karasu, B Cimen, A Ceylan, M Stefek. Tissue myeloperoxidase & adenosine deaminase activities in diabetic rats treated with stobadine & vitamine. 19 th International Diabetes Federation (IDF), Diabetic Medicine 23 (suppl 4) p482. December 3-7, 2006. CAPE TOWN-SOUTH AFRICA. 8. Ceylan-Isik A, Erdogan-Tulmac OB, Ari N, Ozansoy G. Effects of 17β-estradiol treatment on vaascular reactivity of ovariectomized and diabetic rats. 42 nd Annual Meeting of European Association for the Study of Diabetes, Diabetologia 49 (suppl 1) p754-755. September 14-17, 2006. COPENHAGEN&MALMO-DENMARK-SWEDEN (oral presantation). 4
9. Ulusoylar S, Ceylan-Isik A, Ari N, Ozansoy G. Effects of chronically low-dose fluvastatin treatment in STZ-induced diabeic rats on vascular reactivity of aorta. IX. International Symposium on Atherosclerosis, Atherosclerosis Suppl 7 (3) p569. June 18-22, 2006. ROME-ITALY. 10. Ari N, Sahilli M, Ceylan-Isik A, Ozansoy G. Effect of high dose insulin therapy in type 2 diabeic rats on vascular reactivity of aorta. European Congress of Endocrinology, Abstract Book p310. September 3-7, 2005. GOTEBORG-SWEDEN. 11. Ceylan-Isik A, Erdogan-Tulmac OB, Ari N, Ugur M, Ozansoy G. Effects of 17β-estradiol treatment on calcium regulation of aortae from streptozotocin-induced diabetic ovariectomized rats. European Congress of Endocrinology, Abstract Book p135-136. September 3-7, 2005. GOTEBORG-SWEDEN. 12. G Ozansoy, A Ceylan-Işık, N Arı. Direct Effects of Simvastatin on Vascular Smooth Muscle Responsiveness of Diabetic Rats: Role of Calcium Mobilization. 40 th Annual Meeting of European Association for the Study of Diabetes, Diabetologia (suppl 1) September 5-9, 2004. MUNICH- GERMANY (oral presantation). 13. Ari N, Sahilli M, Ceylan-Isik A, Karasu-Yilmaz C. A lack of acute synergistic interaction between insulin and pioglitazone on vasodepressor responses in aorta from type 2 diabetic rats. 40 th Annual Meeting of European Association for the Study of Diabetes, Diabetolgia (suppl 1) September 5-9, 2004. MUNICH- GERMANY (oral presantation). 14. Ç Karasu, N Türközkan, A Ceylan, B Çimen, N Arı, M Stefek. Comparison of Stobadine and Vitamine E Treatments on Kidney Na +, K + -ATPase activity, HbA1c and systolic blood pressure of chronically Diabetic Rats. 18 th Annual Meeting of International Diabetes Federation, Diabetes & Metabolism (suppl 1) p303. August 24-29, 2003. PARIS-FRANCE (oral presantation). 15. N Arı, AM Irat, A Ceylan, Ç Karasu: Alteration of K ATP Channel Function In Internal Mammary Artery from Patients with Type 2 Diabetes. 18 th Annual Meeting of The International Diabetes Federation, Diabetologia Abstract Volume p390. August 24-29, 2003. PARIS-FRANCE (oral presantation). 16. A Ceylan, Ç Karasu, B Gönül, E Öz, N Arı, G Ozansoy: Effects of Simvastatin Treatment on Cardiac Performance in Streptozotocin-Induced Diabetic Rats. 18 th Annual Meeting of The International Diabetes Federation. Diabetologia Abstract Volume p364. August 24-29, 2003. PARIS-FRANCE (oral presantation). 17. C Karasu, G Ayvaz, E Akbay, N Ulusu, F Toruner, A Ceylan. Effects of rosiglitazone treatment on pentose phosphat pathway and glutathione dependent enzymes in kidney of high fat fed rats. North American Association for the Study of Diabetes Annual Meeting, Obesity Research (vol 11) p463. October 11-15, 2003. FLORIDA-USA. 18. A Ceylan, Ç Karasu, N Arı, M Stefek. Stobadine Regulates Vascular Reactivity and Blood Pressure Via The Effects on Calcium Channels in Chronically Diabetic Rat Aorta. 12 th International Congress on Cardiovascular Pharmacotherapy, Abstract Book p May 7-10, 2003. BARCELONA-SPAIN. 19. Ari N, İrat AM, Ceylan A, Karasu-Yılmaz Ç. Rosiglitazone has no effect on K ATP channel opener relaxations in human internal mammary. 3 th International Symposium on PPARs: From Basic Science to Clinical Applications, Abstract Book p34. March 19-22, 2003. FLORANCE- ITALY. 5
20. A Ceylan, G Ozansoy, F Aktan, Ç Karasu. Effects of Simvastatin on Endothelial Dysfunction and Biochemical Markers of Oxidative Stress in Diabetic Rat Aorta. 38 th Annual Meeting of European Association for the Study of Diabetes, Diabetologia Abstract Volume p400. September 1-5, 2002. BUDAPEST-HUNGARY (oral presantation). 21. Ç Karasu, A Avcı, O Canbolat, M Bali, G Ozansoy, A Ceylan, N Arı, M Stefek. Comperative Effects of Stobadine and Vitamine E Treatments on Oxidative Stress Markers in Heart and Kidney of STZinduced Diabetic Rats. 11 th Meeting of The Society for Free Radical Research International. Free Radical Biology&Medicine, Abstract book p188. July 16-20, 2002. PARIS-FRANCE. 22. A Ceylan, T Hünkar, G Ozansoy, T Söylemezoğlu, N Renda, Ç Karasu. Effects of Treatment with Cod Liver Oil On Oxidative Stress, Vascular Reactivity and Cardiac Performance in Streptozotocin- Diabetic Rats. 2 nd International Meeting on Free Radicals in Health and Disease: The Role of Antioxidants in the Regulation of Chronic Diseases, Abstract Book p98. May 8-12, 2002. ISTANBUL- TURKEY (oral presantation). 23. A Ceylan, Ç Karasu, T Hünkar, B Can, C Güven, F Aktan, G Ozansoy. Effects of Simvastatin Treatment on Antioxidant Status and Ultrastructure Of Diabetic Rat Myocardium. 2 nd International Meeting on Free Radicals in Health and Disease: The Role of Antioxidants in The Regulation of Chronic Diseases, Abstract Book p36. May 8-12, 2002. ISTANBUL-TURKEY (oral presantation). 7.4. Yazılan uluslararası kitaplar veya kitaplarda bölümler - 7.5. Ulusal hakemli dergilerde yayınlanan makaleler 1. N. Arı, A. Ceylan-Işık, C. Karasu. Yaşlanma ve İleri Glikozillenme Son Ürünleri. Türkiye Klinikleri Dergisi (Özel Sayı) 2008. Derleme. 2. A. Ceylan-Işık, Ö.B. Erdoğan-Tulmaç, F. Aktan, N. Arı, G. Ozansoy. Östrojen Yerine Koyma Tedavisinin Overektomili ve Overektomili-Diyabetik Sıçanlarda Doku Lipid Peroksidasyonu ve Antioksidan Enzim Aktiviteleri Üzerine Etkisi. Dicle Üniversitesi Tıp Fakültesi Dergisi. 2007, 34: 275-282 (doktora tez çalışmasından üretilmiştir). 3. A.M. İrat, A. Ceylan-Işık. HMG-KoA Redüktaz İnhibitörlerinin Pleiotropik Etkileri. Ankara Üniversitesi Eczacılık Fakültesi Dergisi. 2006, 35: 197-206. Derleme. 7.6. Ulusal bilimsel toplantılarda sunulan ve bildiri kitabında basılan bildiriler 1. Ellen Thompson, Asli F. Ceylan-Isik, Nair Sreejayan, Jun Ren. The Role of the Apelin Receptors in Obesity-induced Cardiac Dysfunction. Woming Undergraduate Research Day, March 2010. WYOMING, USA. 2. Asli F. Ceylan-Isik, Nair Sreejayan, Jun Ren. Apelin Receptor Silencing Attenuates Apoptosis in H9c2 cells. IDeA Networks of Biomedical Research Excellence (INBRE) Meeting, April 2010, WYOMING, USA. 6
3. Machender R. Kandadi, Asli F. Ceylan-Isik, Jun Ren, Nair Sreejayan. Tauroursodeoxycholic Acid Inhibits Obesity-induced Apoptosis in Liver. Western Region COBRE-INBRE Scientific Conference, September 2009. MONTANA, USA. 4. Yinan Hua, Asli F. Ceylan Isik, Jun Ren and Nair Sreejayan. ER-Stress Up-regulates Proteintyrosine Phosphatase-1B in Obesity. Western Region COBRE-INBRE Scientific Conference, September 2009. MONTANA, USA. 5. Asli F. Ceylan-Isik, Jun Ren, Nair Sreejayan. Tauroursodeoxycholic Acid Alleviates Insulin resistance and Endoplasmic Reticulum Stress Induced by Palmitate, Western Region COBRE- INBRE Scientific Conference, September 2009. MONTANA, USA. 6. Asli F. Ceylan-Isik, Subat Turdi, Feng Dong and Jun Ren. Cardiomyocyte-Specific Endothelin A Receptor Knockout Alleviates Aging-Induced Cardiac Remodeling and Myocardial Contractile Dysfunction. IIç Antıagıng and Aestetıc Medicine Congress, October 2009. İZMIR, TURKEY. 7. N.N. Ulusu, M. Sahilli, A. Ceylan, Ç. Karasu. The Comperative Activities of Glucose-6-Phosphate Dehydrogenase, 6-Phosphogluconate Dehydrogenase, Glutathion-S-Transferase on Brain in Long and Short Term Streptozotocin Induced Diabetic Rats. National Nerve Sciences. March 16-20, 2002. ESKİŞEHİR-TURKEY. 7.7. Diğer yayınlar - 8. Projeler Araştırıcı olarak görev yaptığı projeler: American Heart Association ve University of Wyoming (USA) tarafından desteklenen The Chemical Chaperon Tauroursodeoxycholic acid Alleviates Cardiac Contractile Dysfunction in Obesity - araştırıcı (2008-). Heart Association ve University of Wyoming (USA) tarafından desteklenen ER-Stress Up-regulates Protein-tyrosine Phosphatase-1B in Obesity - araştırıcı (2008-). Ankara Üniversitesi Araştırma Fonu tarından desteklenen (2005.08.03.053) Diyabetik Farelerde Gelişen Ventrikül Miyosit Disfonksiyonu Üzerine Statin Tedavisinin Etkileri - araştırıcı (2005-2008). National Institute of Health, American Diabetes Association, American Heart Association Pasific Mountain Affiliate ve University of Wyoming (USA) tarafından desteklenen Contractile dysfunction in obesity -araştırıcı (2004-2005). National Institute of Health, American Diabetes Association, American Heart Association Pasific Mountain Affiliate ve University of Wyoming (USA) tarafından desteklenen Cardiac dysfunction in diabetes mellitus: Role of Ca 2+ cyscling proteins -araştırıcı (2004-2005). National Institute of Health (USA) tarafından desteklenen Gender influence in diabetic heart diseases - araştırıcı (2004-2005). TÜBİTAK tarafından desteklenen Antioxidants and Aldose Reductase Blockade in Prevention of Late Diabetic Complications: Study on New Pyrıdoindole Derivatives adlı joint project -araştırıcı (2004-2007). 7
Ankara Üniversitesi Araştırma Fonu tarından desteklenen (2001.08.03.031) Diyabetik Komplikasyonların Önlenmesinde Antioksidanlar:Piridoindol Türevi Stobadin Üzerinde Çalışmalar - araştırıcı (2001-2005). TÜBİTAK tarafından desteklenen (SBAG-2397) Diyabetin geç komplikasyonların önlenmesinde antioksidanlar ve aldoz redüktaz inhibisyonu: Yeni Piridoindol bileşikleri üzerine çalışmalar -araştırıcı (2001-2005). Yürütücü olarak görev yaptığı projeler: Wyoming INBRE Thematic Research Projects, WY, USA tarafindan desteklenen Role of Endothelin Receptor-1A (ET A ) in Obesity Associated Cardiac Dysfunction - yürütücü (2011-). American Heart Association, USA tarafından desteklenen Apelin Attenuates High Fat Diet-Induced Cardiac Dysfunction: Regulation of mir-133a by Apelin yürütücü (2011-). IDeA Networks of Biomedical Research Excellence, USA tarafından desteklenen Role of Apelin in High Fat Diet-Induced Cardiovascular Dysfunction -yardımcı baş araştırıcı (2009-). tarafından desteklenen Role of Estrogen Receptors in Endoplasmic Reticulum Stress-Induced Neurodegeneration Impact of mir-29a -yürütücü (2010-2011; güz). tarafından desteklenen Role of Apelin receptor (APJ) in obesity-induced heart dysfunction -yürütücü (2009-2010, bahar). National institute of Health (NIH) R-15 application, USA tarafından desteklenen Role of heat shock proteins in obesity-induced cardiovascular dysfunction -yürütücü (düzenleme aşamasında) tarafından desteklenen Gender is Potential Risk Factor for Tunicamycin-Induced Endoplasmic Reticulum Stress-Mediated Cardiac Dysfunction -yürütücü (2008-2009, yaz). tafından desteklenen Estrogen can modulate endoplasmic reticulum stress-induced signaling pathways in heart -yürütücü (2008-2009, bahar). tarafından desteklenen Tauroursodeoxycholic Acid Alleviates Obesity Associated Cardiac Dysfunction -yürütücü (2008-2009, güz). 9. İdari Görevler Yönetim Kurulu üyesi (School of Pharmacy, University of Wyoming, WY, USA). 10. Bilimsel ve Mesleki Kuruluşlara Üyelikler Türk Farmakoloji Derneği Türk Biyokimya Derneği Türk Eczacıları Birliği 2. Bölge Ankara Eczacı Odası European Association for the Study of Diabetes (EASD) 8
American Heart Association (AHA) Society for Free Radical Research 11. Ödüller BURSLAR American Heart Association (AHA, 2008-) National Instute of Health (DHHSNIHLC4013, 2004-2005) TÜBİTAK Bilim Adamı Yetiştirme Bursu (Doktora, 2001-2005) TÜBİTAK Bilim Adamı Yetiştirme Bursu (Yüksek Lisans, 1999-2000) Türk Eczacıları Birliği Öğrenim Bursu (Lisans, 1995-1998) ÖDÜLLER Stayment Grant and poster award (2007), European Association for the Study of Diabetes (EASD); 43 th Annual Meeting European Association for the Study of Diabetes. Stayment Grant and poster award (2006), European Association for the Study of Diabetes (EASD); 42 th Annual Meeting European Association for the Study of Diabetes. Stayment Grant and poster award (2003), European Association for the Study of Diabetes (EASD);18 th Annual Meeting of International Diabetes Federation. 12. Son iki yılda verdiğiniz lisans ve lisansüstü düzeydeki dersler için aşağıdaki tabloyu doldurunuz. Akademik Yıl Dönem Güz Haftalık Saati Öğrenci Dersin Adı Teorik Uygulama Sayısı Pharmacology 3 48 2009-2010 İlkbahar Biopharmaceutics and Pharmacokinetics 4 48 Güz Pharmacology 3 48 2010-2011 Biopharmaceutics and 4 47 Pharmacokinetics İlkbahar Advanced Cardiovascular 6 4 8 Pharmacology (PhD Course) Not: Açılmışsa, yaz döneminde verilen dersler de tabloya ilave edilecektir. 9