A.Fuat Kalyoncu Bilimsel Araştırmalar Çalıştayı Kasım 2017 İstanbul

Transkript

1 A.Fuat Kalyoncu Bilimsel Araştırmalar Çalıştayı Kasım 2017 İstanbul

2 TTD MYK Üyelerinden sevgi ve selamlar.

3 A.Fuat Kalyoncu Astım Araştırmaları Çalıştayı Mart 2017 Düzce

4 Resim şu anda görüntülenemiyor. Bilim Bilim, endüstrileşmenin ve onun getirdiği zenginliğin ana kaynağıdır. Bilim ve ona bağlı artı değer için uygun koşullar geliştirmek, batı toplumları yönetim sistemlerinin temelini oluşturmaktadır. Ticaret %10-30 Know how % Orijinal buluş & patent % kazandırıyor 15 gr eritropoetin TL ( TL den=2000 otomobil)

5 Lokman Hekim, Hipokrat tan onun, büyük bir kıskançlıkla koruduğu tıbbi sırları ele geçirmeyi başarır. Hipokrat da Yunan tıp bilgisi meşalesinin Doğu ya kaptırılmasından dolayı duyduğu üzüntü yüzünden ölür (Sayılı A. Ortaçağ islam dünyasında yüksek öğrenim ve medrese, 2002). İlk üniversite nerede? Doğuda medreselerin ortaya çıkması 11.yy Özsel olarak teoloji ve hukuk okulları Tarih, fen, felsefe ve seküler bilimlerin müfredat mücadelesi ile dolu. Bilgiye ulaşmada üst tabakadan olma gerekliliği İcazet: bireysel belge Vakıflarla içiçe, hayır kurumu temelinde işliyor. Batıda üniversitelerin ortaya çıkması 13.yy Özsel olarak teoloji ve hukuk okulları Zamanla fen, felsefe ve laik bilim giriyor Bilgiye ulaşmada üst tabakadan olma gerekliliği Licentia docendi: diploma Öğrenci ve hoca loncalarının gelişmesiyle ortaya çıkan sağlam örgütlenmiş loncalar. Bilimde batının öne geçmesi, Endülüs Emevilerinin yıkılması ve batıda eksperimental analitik düşüncenin, dinden bağımsız yapılabilmesinden sonra olmuştur. Bilimin gelişmesi için gereken en önemli şey, özgür düşünce ortamıdır.

6 Cumhuriyet döneminde bilimin mottosu: Kültür, Cumhuriyetin temelidir yılında yayınlanan Maarif-i Umumiye Nizamnamesi -İstanbul Darülfünun-u Şahane Kuruluş : 7 adet doktoralı hoca, Sadece biri araştırmacı -Okuma-yazma oranı %7 erkeklerde (subay ve gayrımüslim), kadınlar %0.4 (3 şehirde), Tevhid-i Tedrisat Kanunu. Türkiye de kadınlar eşit eğitim hakkı na sahip oluyor üniversite reformu -Yurtdışına öğrenci gönderiliyor arası Nazi rejiminden kaçan 1202 bilimadamı, doktor ve sanatçı geliyor! -Ankara Üniversitesi Aslında 1925 Hukuk Mektebi ile başlayan bir sürece sahip.

7 Türk Toraks Derneği Çalışma Grupları Tüm Çalışma Grupları, TTD için önemlidir, Derneğimiz bürokrasisi için şubeler ve Çalışma Grupları önemlidir, Dernek başkanlarının hepsi bu gruplarda çalışmış kişilerdir, TTD bünyesinde birçok yurtdışı araştırma makalesi olan araştırma yapılmıştır, Göğüs Hastalıkları alanında birçok araştırma, kitap, makale, toplantı, rapor, çalıştay vs. TTD, esasen bu Çalışma Gruplarının bir çok projesini destekledi, destekliyor, Bir çok rehber yayınlandı. Sempozyumlar, kurslar, il toplantıları Dünya günleri kutlamaları, halk için eğitim materyalleri, kitapçıklar, filmler, afişler Ulusal ve uluslararası işbirlikleri önemli (örneğin GARD, MECOR, ERS, ATS vs). Bilim alanında çalıştay düzenlenmesi ender, dernekler arasında tek tük, Yapılamayanlar..

8 Desteklenen Bilimsel Projeler da 3 adet proje için ödenen miktar; TL 2010 da 5 adet proje için ödenen miktar; TL 2011 de 7 adet proje için ödenen miktar; TL 2012 de 3 adet proje için ödenen miktar; TL 2013 de 1 adet proje için ödenen miktar; TL adet proje için ödenen miktar: TL 2016 da 2 adet proje için ödenen miktar; TL de 4 adet proje için ayrılan miktar; TL (halen)

9 PARFAIT Dizisi Phenoturk çalışması Yıldız F, Mungan D, Gemicioglu B, Yorgancioglu A, Dursun B, Oner Erkekol F, Ogus C, Turktas H, Bogatekin G, Topcu F, Deveci F, Bayram H, Tor M, Kalyoncu AF. Asthma phenotypes in Turkey: a multicenter cross-sectional study in adult asthmatics; PHENOTURK study. Clin Respir J. 2017; 11(2): Metintaş S, Kurt E & PARFAIT Study Group. Geo-climate effects on asthma and allergic diseases in adults in Turkey: results of PARFAIT study. Int J Environ Health Res 2010; 20(3): Kurt E, Metintas S, Basyigit I, Bulut I, Coskun E, Dabak S, Deveci F, Fidan F, Kaynar H, Kunt Uzaslan E, Onbasi K, Ozkurt S, Pasaoglu Karakis G, Sahan S, Sahin U, Oguzulgen K, Yildiz F, Mungan D, Yorgancioglu A, Gemicioglu B, Fuat Kalyoncu A; PARFAIT Study of the Turkish Thoracic Society Asthma and Allergy Working Group. Prevalence and risk factors of allergies in Turkey (PARFAIT); result of a multicentre cross-sectional in adults. Eur Respir J Apr;33(4): Kurt E, Metintas S, Basyigit I, Bulut I, Coskun E, Dabak S, Deveci F, Fidan F, Kaynar H, Uzaslan EK, Onbasi K, Ozkurt S, Pasaoglu G, Sahan S, Sahin U, Oguzulgen K, Yildiz F, Mungan D, Yorgancioglu A, Gemicioglu B, Fuat Kalyoncu A; PARFAIT Study of Turkish Thoracic Society Asthma-Allergy Working Group. Prevalence and risk factors of allergies in Turkey: Result of a multicentric crosssectional study in children. Pediatr Allergy Immunol Nov;18(7):

10 Epidemiology and distribution of interstitial lung diseases in Turkey. Müsellim B, Okumuş G, Uzaslan E, Akgün M,Çetinkaya E, Turan O, Akkoçlu A, Hazar A, Kokturk N, Çalışır HC; Turkish Interstitial Lung Diseases Group. Clin Respir J Jan;8(1): There is very few data on the epidemiological features of interstitial lung diseases (ILD) in the literature. These studies on this subject suffer from limited number of patients. OBJECTIVE: The goal of this study was to evaluate the epidemiological features of ILD in Turkey. METHODS: Fifty-four investigators, 31 centres in 19 cities from six regions of Turkey, participated in the study. Two thousand two hundred forty-five newly diagnosed patients (51.8% females), led by Turkish Thoracic Society Clinical Problems Study Group, enrolled in this prospective study. RESULTS:The mean age was 51.8 ± 16.7 years. The mean age among males was 50.5 ± 18.6 years and 53.0 ± 14.6 years among females (P < 0.001). 23.8% of the cases had ILD with known causes, while 39.4% were in granulomatous group, 23.7% were idiopathic, and 4.4% were in the unclassified group. Overall, histopathologically confirmed diagnosis rate was 40.4%. Sarcoidosis was the most common disease (37%), whereas cases with idiopathic pulmonary fibrosis (IPF) constituted 19,9% of patients. 53% of the sarcoidosis patients were females, and the ratio reaches to 75% under 50 years of age (for this group, IPF ratio is %3). In contrast, sarcoidosis and IPF ratios were equal in males (25%). Sarcoidosis was 8% in men over 50, while IPF was %45. CONCLUSION: The overall incidence of ILD in Turkey was computed to be 25.8/100,000.

11 Epidemiological features of Turkish patients with sarcoidosis. Müsellim B, Kumbasar Ö, Öngen G, Cetinkaya E, Türker H, Uzaslan E, Yentürk E, Uzun O, Sağlam L, Çelik G, Okumuş G, Annakkaya AN, Altıay G, Tabak L,Şakar A, Kiter G, Erturan S, Türktaş H, Yalnız E, Akkoclu A,Öğüş C, Doğan OT, Özkan M, Aktogu S, Uzel I. Respir Med Jun;103(6): Epidemiological characteristics of sarcoidosis differ according to geographical distribution. The aim of our study was to disclose epidemiological characteristics in our country. The data was collected from investigators, who sent information on newly-diagnosed patients via internet. In 2 years 198 female and 95 male patients were enrolled to the study (f/m:2.08). Mean age of patients was 44+/-13 years (17-90). Mean age of male patients was 38+/-12 while mean age of female patients was 48+/-13 (p<0.001). 73.4% of patients were nonsmokers (85.4% of females; 48.4% of males; (p<0.001)). About 50% of our 293 patients were housewives. Familial sarcoidosis was found in 3 patients' first degree relatives. Estimated annual incidence of sarcoidosis for Turkey was calculated as 4 per 100,000 person. According to our study, 2/3 of sarcoidosis patients were women; mean age of patients was 45 and the disease began 10 years later in female patients. 80% of patients were nonsmokers; negative relation between sarcoidosis and smoking was evident especially in women. Familial sarcoidosis frequency was lower compared to other studies in the literature. There was no occupational exposure history in our patients. Our incidence rate, is similar with the results of other European studies.

12 Pattern of lung cancer in Turkey, Goksel T, Akkoclu A; Turkish Thoracic Society, Lung and Pleural Malignancies Study Group. Respiration. 2002;69(3): Lung cancer is the most common neoplasm in Turkey, but there is not enough data on the characteristics of this mortal illness in our country. OBJECTIVES AND METHODS: The Turkish Thoracic Society, Lung and Pleural Malignancies Study Group (TTS-LPMSG) conducted a national retrospective hospital-based study to determine the pattern of lung cancer in Turkey. RESULTS: A total of 11,849 lung cancer patients were studied between 1994 and 1998, 90.4% were male and 9.6% were female. The majority of patients were smokers (77.9%) or ex-smokers (10.8%). The mean age at the time of diagnosis was 58.4 years (20-84) and 56.7% of the patients were aged between 46 and 65 years. The most common histological types were squamous cell (45.4%), small cell (SCLC; 20.5%) and adenocarcinoma (20.2%). The majority of patients with non-small-cell lung cancer were diagnosed with metastatic disease (40.4%). Of the patients with SCLC patients, 37.9% had limited stage disease and 62.7% extensive stage disease at diagnosis. CONCLUSION: The results of the largest data so far collected in Turkey show that the vast majority of patients with lung cancer are male, squamous cell is the most common histological type, and only a small proportion of patients are diagnosed at an early stage.

13 Pneumococcal and influenza vaccination status of hospitalized adults with community acquired pneumonia and the effects of vaccination on clinical presentation. Demirdöğen Cetinoğlu E 1, Uzaslan E 1, Sayıner A 2,Çilli A 3, Kılınc O 4,Şakar Coşkun A 5, Hazar A 6, Köktürk N 7, Filiz A 8, Polatlı M 9 ; TURCAP Study Group. Hum Vaccin Immunother Sep 2;13(9): BACKGROUND: Previous reports have shown that vaccination rates of adult at-risk populations are low in Turkey. There are differing reports with regards to the effectiveness of the influenza and the pneumococcal polysaccharide vaccine (PPSV23) on the clinical outcomes of community acquired pneumonia (CAP). The purpose of this study was to analyze the influenza (FV) and pneumococcal vaccination (PV) status, the factors that influence the receipt of influenza/pneumococcal vaccine and the effects of prior vaccination on the clinical outcomes in adults hospitalized with CAP. PATIENTS AND METHODS: Patients hospitalized with CAP between March 2009 and October 2013 and registered at the web-based Turkish Thoracic Society Pneumonia Database (TURCAP) were included in this multicentric, observational study. Of a total of 787 cases, data were analyzed for 466 patients for whom self-reported information on PV and FV was available. RESULTS: In this adult population with CAP, the vaccination rate with both the pneumococcal and influenza vaccines was found to be 6%. Prior FV was found to be the sole variable that was associated with the receipt of PV [OR 17.8, 95% CI (25-75: ), p < 0.001]. Conversely, being vaccinated with PPSV23 was the only predictor of receipt of FV [OR 18.1, 95% CI (25-75: ), p < 0.001]. Compared to the unvaccinated cases, the chest radiograms of the vaccinated patients revealed less consolidation. The latter also reported fatigue, muscle pain and gastrointestinal symptoms less frequently. Although there was a trend for lower 30-day mortality and for lower rates of intensive care unit (ICU) admission, these did not reach statistical significance. A pneumonia severity index (PSI) score 90, CURB-65 score 3 and multilobar involvement, but not the vaccination status, were identified as independent determinants of ICU admission. CONCLUSIONS: This study showed that, among patients hospitalized with CAP, the FV and/or PV rates are low. Prior vaccination does not appear to significantly affect the clinical outcomes.

14 Bilim Bilim gerçeği aramaktır. Bilimsel Bilgi: Gerçeklerin toplanması, düzenlenmesi ve yorumlanmasıdır. Bilim insanı olmak bir yaşam biçimidir. Dürüstlük Şeffaflık Evrensellik Adalet Erişilebilme.

15 Araştırma Etiği İyi Klinik Uygulamalar Hayvan deneyleri Helsinki

16 Çalıştayın amacı Akciğer Sağlığı alanında ülkemizin öncelikli alanlarını belirlemek Orta-uzun vadeli araştırma planlarını yapmak Kısa vadeli olarak, başvuran projelerin niteliğini artırmak

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