INOVITA: First 9 Months Project Activities/Developments

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1 INOVITA: First 9 Months Project Activities/Developments Prof. Dr. Cengizhan Öztürk Boğaziçi University, Institute of Biomedical Engineering IP Universities (16-18 May, 2012) Panel 6 Yaşam Bilimleri ve Teknolojileri İstanbul İşbirliği Platformu Projesi (İnovita), İstanbul Kalkınma Ajansı Bilgi Odaklı Ekonomik Kalkınma Mali Destek Programı kapsamında İstanbul Kalkınma Ajansı (İSTKA) tarafından desteklenmiştir. Bu kitapçıktaki tüm içerik ile ilgili tek sorumluluk, ortaklara ve katılımcılara ait olup, İSTKA veya T.C. Kalkınma Bakanlığı nın görüşlerini yansıtmamaktadır. Yaşam Bilimleri ve Teknolojileri İstanbul İşbirliği Platformu Projesi İstanbul Kalkınma Ajansı, Bilgi Odaklı Ekonomik Kalkınma Mali Destek Programı kapsamında İstanbul Kalkınma Ajansı tarafından desteklenmiştir.

2 As we Start, Brief Landscape in Turkey Public Sector (Ministry of Health) is very active, but very problematic, payments through social security system is being overhauled. Uncertaintities: Turkish FDA (Medical Device Agency), Purchase Guaranteed R&D Project Contracts, Health Technology Free-Trade Zones, Extreme Mass Purchasing by the Government (device, drugs, services)... Our first priority is not to loose our reference/scientific identity within the government as Boğaziçi University (if someone asks!). As inovita, we stand equidistant to all projects, promote the innovation in life sciences and technologies in general, but we facilitate the promising ideas/projects towards products, keeping an eye always on the priorities of life science sector in Turkey. There is currently no established IDE-like (premarket evaluation, approval) mechanisms in Turkey, we need to to solve this urgently. Boğaziçi University: Scientific, Technology and Innovation Education should be side-by-side. We need to restructure our current R&D infrastructure and how we utilize it

3 Center for Life Sciences and Technologies and Inovita has triggered and leading current efforts for the, Kandilli Campus (Rasathane) Science and Technology Park (Transformation) Project cooperating with other universitesies, and partners from industry and government to include the necessary infrasturcture for translational research projects in Life Sciences and Health Technologies. TAM BME LifeSci/İnovita

4 Brief Info About Inovita Project Prof. Dr. Cengizhan Öztürk Boğaziçi University, Institute of Biomedical Engineering Yaşam Bilimleri ve Teknolojileri İstanbul İşbirliği Platformu Projesi İstanbul Kalkınma Ajansı, Bilgi Odaklı Ekonomik Kalkınma Mali Destek Programı kapsamında İstanbul Kalkınma Ajansı tarafından desteklenmiştir.

5 As we start... Our aim is to facilitate the transformation of the scientific research and technological development activities within universities and companies in life sciences (and health technologies) towards a real economic value for the region.

6 İnovita (Istanbul Platform for Life Sciences and Technologies) Partners (in expansion phase!): Sabancı University (SU NUM) İstanbul University Boğaziçi University Started July 2011, funded By İstanbul Development Agency (ISTKA), only initial 12 month funding is secured.

7 Our Mission (Communication) increase the dialog between universites, government, industry, public and private institutions, (Environment) we bring people together in focused events to facilitate collaborations (Infrastructure) we aim to provide lab and support spaces for collaborative projects (Support) we aim to provide support services to project teams in education, capacity building, technical consultancy, technology transfer, intellectual property ; either in house or via efffective referral to its supporting partners. (Sustainability) plan to make this platform a long-term instutition.

8 Activities Partner Search Meeting (4 October 2011) Sectoral Expectation & Competetiveness Analysis in Life Sciences(done?) Developing Communication Strategies, Public Relations (ongoing) Management Structure of the Platform (ongoing) Events to Foster New Collaborative Joint Projects (main focus) Educational Activities, Seminars and Workshops: In Vivo Medical Device Technologies Workshop, 16 December 2011 (done) Personalized Diagnosis and Treatment in the Genomics Era Workshop, January 2012 (done) Drug Technologies Workshop, (in planning) Nanotechnology and Food Sector (in planning, in May)

9 Cooperation with Industry and Project Kickoff/Partners Meeting 4 October 2011,@ İTO Cemile Sultan Tesisleri, Istanbul

10 Cooperation with Industry and Project Kickoff/Partners Meeting 4 October 2011,@ İTO Cemile Sultan Tesisleri, Istanbul

11 Participation in National Conferences (TıpTekno 2011) İnovita: Where do we start? October 2011, Antalya Ela Resort Hotel

12 Weekly Seminars

13 Weekly Seminars

14 Weekly Seminars

15 In vivo Medical Device Workshop, 16 December Boğaziçi University Kandilli Campus

16 Monthly Patent Meeting with an Expert Patent Toplantısı Değerlendirme Tablosu KİŞİ A KİŞİ B KİŞİ C KİŞİ D YAPILACAKLAR Gizlilik sözleşmesi gelecek Uluslar arası patent başvurusu düşünülüyor Patent veri tabanı araştırması gerekli Teknik bir başvuru formu hazırlanacak Buluş detaylı bir şekilde yazılacak. Çizimler yapılacak ve bunlarla tarifname yazımına geçilecek. İNOVİTADAN BEKLENTİLER Fikri hakların korunması sürecinde mevcut destekler hakkında bilgilendirme Fikri hakların korunması sürecinde mevcut destekler hakkında bilgilendirme Başvuru takibi, gerektiği yerde mali destek, Ankara Patent ile koordinasyonun sürmesi Patent başvuru sürecinde desteğin devam etmesi ANKARA PATENT BÜROSU (İSTANBUL) DEĞERLENDİRME 5 Adet buluştan 4'ünün patent ile korunabileceği düşünülüyor. Gizlilik sözleşmesi gönderildi. Buluş bildirim formları bekleniyor. Buluşa ilişkin detaylar açıklanmadı; patent alım süreci hakkında bilgi verildi. Buluş bildirim formları bekleniyor. Ortaya henüz bir ürün çıkmadığı için sadece patent alım süreciyle ve desteklerle ilgili bilgi verildi. Buluş bildirim formu bekleniyor. Buluş henüz fikir aşamasında olduğu için patent ile korunamaz. Buluşa ilişkin teknik ayrıntılar hazırlandıktan sonra başvuru yapılabilir. Patent Danışmanı: Kenan Doğan, Ankara Patent Ofisi

17 Inovita Partners Prof. Dr. Cengizhan Öztürk Boğaziçi University, Institute of Biomedical Engineering Yaşam Bilimleri ve Teknolojileri İstanbul İşbirliği Platformu Projesi İstanbul Kalkınma Ajansı, Bilgi Odaklı Ekonomik Kalkınma Mali Destek Programı kapsamında İstanbul Kalkınma Ajansı tarafından desteklenmiştir.

18 İnovita Partners: Sabancı University (SU NUM) İstanbul University Boğaziçi University

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20 50 Milyon TL investment, 7,368 m 2 modern building (with LEED ve BREEAM sertificate) 800 m 2 Clean Room (100 Class), 1,500 m 2 multidisiplinary labs ve 2400 m 2 support space: Mikro-Nano Lab, Molekuler Biology, Material Characterization, Nanoelektronics- Nanomagnetism, Micro-Nano Fluidics, Energy Systems, Nano Packaging, Electron Microskopi ve Spectroskopi, 3D Mikro Prototip, Tissue ve Regenerative Engineering Lab Multi-wavelength Confocal Microscope MultiBeam SEM-FIB Gas and Mass spectrometer High Resolution TEM ICP-MS Electron Beam Lithography Plasma Deposition Genome Sequencer

21 İnovita Partners: Sabancı University (SU NUM) İstanbul University Boğaziçi University

22 İnovita Partners: Sabancı University (SU NUM) İstanbul University Boğaziçi University ( BU LifeSci )

23 Life Sciences Resaerch Center A modular, interdisciplinary Center for Life Sciences and Technologies has been established within Bogaziçi University in It has been recognized as one of university s top strategic priorities. An initial infrastructure money has been secured from National Planning Agency (DPT) for 3(+2) years. It is ongoing, total budget around 10 Million USD.

24 Motivation Recent global trends in Health Care: Personalized Medicine Minimal Invasive Diagnosis and Treatment In the near future: Information technology based drug and treatment design and more need for specialized animal research centers all around the world Pressure to decrease the halth care costs (less hospital stays) A more comrehensive sytem based aproach is needed to biological systems 24

25 BU LifeSci Center National Center Open to all relevant projects from Boğaziçi University or from outside Focus on solutions and applications Dissemination Activities will not be neglected Become a part of International Networks and Collaborations.

26 Why Boğaziçi? A multidisciplinary, young, academic team: (BME, EE, CHE, CHEM, MBG, PSYCH) Turkey s first Institute of Biomedical Engineering (1983) Applied engineering and industry collaboration focus stated firmly within its renewed R&D strategy Matching support by the university BME bldg, TAM, Vivarium,

27 Center Labs Microsytem Based Medical Device Development Laboratory (Clean Room) Cengizhan Öztürk (BME) Animal Center (Vivarium) Burak Güçlü, (BME) - Nesrin Özören (MBG) Smart Drug Development Laboratory (SmartDrug) Rana Sanyal, (Chem) Biological System Research Laboratory (BioSys) Betül Kırdar, (Chem Eng.) Computational Biology and Bioinformatics (CompBio) Türkan Haliloğlu (Chem Eng.) 27

28 Medical Dev. Vivarium Physics EE Psychology Computer Eng. BME MBG Biosys Chemical Eng. Chemistry Pharmaceutic Technology CompBio Smart Drug Sanayi Araştırmacı Yetiştirme Programı

29 VIVARIUM (on main campus) Rat, Mice, rabbit, birds, zebra fish, drosophilia. Routin animal care, diagnosis and treatment. Small interventions, lab tests and surgical operations

30 Smart Drug Lab: (Rana Amitav Sanyal) Nanomaterials for Life Sciences Drug Delivery Systems Makromolekuler Structures Hydrojels Metal-Nonmetal nanoparticules

31 Smart Drug Lab: (Rana Amitav Sanyal) Nanomaterials for Life Sciences Surface Applications Cardiovascular Stents Ortophedic implants Thin Films for Biochips Fibers

32 Microsystem Based Medical Device Development Center (Clean Room) Cengizhan Ozturk, Biomedical Engineering Institute Yaşam Bilimleri ve Teknolojileri İstanbul İşbirliği Platformu Projesi İstanbul Kalkınma Ajansı, Bilgi Odaklı Ekonomik Kalkınma Mali Destek Programı kapsamında İstanbul Kalkınma Ajansı tarafından desteklenmiştir. 32

33 Motivation (1) Medical interventions are increasingly done via minimally invasive methods. Customized smart treatments are delivered locally, using image guidance, using increasingly smaller devices (eg: endoscopes or endovascular catheters). Implanted medical devices are also getting more smaller, but much more smarter. They are utilized in diverse medical applications (e.g.: cancer, neural and cardiovascular diseases) 33

34 Motivation (2) Turkey has importing almost all of its high-tech medical devices. Turkey currently has no reference laboratory or strategic plan for the development and testing of the next generation clinical grade medical microdevices (catheters, sensors, etc.) Bogazici University, with its current strengths of micro electro-optics and biomedical engineering are well positioned to place a role. Advantages: Better funding opportunity, bigger national and international scientific impact. While trying to catch up with the current technology, actively develop the next generation to play a bigger role in the future. Help/guide national medical device industry 34

35 Aim Develop clinical grade next generation catheters, smart implantable microsystems (sensors, stimulators, drug delivery systems, all integrated) for specific medical applications

36 Current Team Biomedical Engineering Cengizhan Ozturk, Ata Akın, Murat Gülsoy Electrical and Electronics Engineering Senol Mutlu, Arda Yalcinkaya, Günhan Dündar, Burak Acar, Kıvanç Mıhçak Chemistry Rana Sanyal, Amitav Sanyal External Academicians Engineering (Koc, Bilkent, ODTU); Istanbul University Medical Faculty (Neuroscience, Cardiovascular Surgery, Interventional Radiology&Cardiology) Industrial Partners (Alvimedica, York) International Partners/Supporters (JHU, Siemens, NHLBI) 36

37 Overview of Medical Device Unit Clean Room (modular, multipurpose) GMP eligible We aim to produce clinical grade devices to go directly into animal testing Support Labs (outside clean room) Electronic/Optic Mechanical Design and Testing Chemical Wet Lab Storage Research Cubicles for Faculty and Students

38 Device Center 38

39 Device Center Lithography Room Yellow Room (36 m 2, ISO Class 6 Clean Room) 39

40 Device Center Dry Surface Chem. Lab (40 m 2, ISO Class 7 Clean Room) 40

41 Device Center Wet Surface Chem. Lab (30 m 2, ISO Class 7 Clean Room) 41

42 Device Center Medical Grade Metal Processing Laboratory (42 m 2, ISO Class 8 Clean Room) 42

43 Device Center Medical Device Production/Assembly Lab (72 m 2, ISO Class 7 Clean Room, GMP ye uygun) 43

44 Device Center 44

45 Potential Expansion Areas: Neuroscience & Neural Engineering: CogSci, CompEng, BME, MBG, Medical Device InVitro Diagnostics: Chem, Phy, ChemEng, EE, BME, MBG Vivarium Preclinical Imaging Center: BME, CompEng, EE, MBG SmartDrugs BioSys/ CompBio Bioinformatics (Phase 2): MBG, ChemEng, BME, CompEng, EE 45

46 Current Focus/ Challenges Yaşam Bilimleri ve Teknolojileri İstanbul İşbirliği Platformu Projesi İstanbul Kalkınma Ajansı, Bilgi Odaklı Ekonomik Kalkınma Mali Destek Programı kapsamında İstanbul Kalkınma Ajansı tarafından desteklenmiştir.

47 Industrial Ph.D. Program in Life Sciences and Technologies Big problem in Turkey. Started as a test program in Student, will get a scholarhip from a company, university gets research money from government Joint Thesis Student time could be shared between university and firm. Student could be fully employer at the start or at a critical milestone. Coordinator: Rana Sanyal (Kimya)

48 Rasathane Science and Technology Park Project Planning is at its full spead. Includes spaces for projects, spin-off and small company incubators. Referans labs for certification (CE), seperate project Larger firms are encouraged in nearby developmental areas around the campus

49 Center/Platform Business (Partnership) Model No model in Turkey for a Government University for University-Industry Partnership (joint space, people, budget) SAM inc. (SAM A.Ş., Eskişehir) is an exception Non Profit Status (de facto, gentleman s aggreement) Protokol with public university and subesquent share donation Aim: public universities can not manage a big infrasturucture We got interest letters from 6 firms We will form the company and negatiate with the university (Elections??) Why should a firm be a partner? Plan and utilize precompetition level reference labs jointly Participate actively in management and strategy of the center

50 Biyogirişimci Destek Programı (HayalET-İnovita işbirliği ile)

51 INOVITA Translational Research Portfolio BUVAK is our partner ( 2 February 2011, first projects are screened. We focus mostly on students and early ideas (students, scientific prototip, before any big initial funding or angel/venture/investor. Projects will be supported financially based on their timetable, only when they achieve their critical milestones. Coulter-inspired. Main focus is mentoring and guidance. We actually needed funds to start the program (government or private, all welcome). But we need a portfolia for the fund! We put aside 50,000 USD for the initial carrot (could expand to 100K). We also need a Program Director.

52 İnovita İnovita - Yaşam Bilimleri ve Teknolojileri İstanbul İşbirliği Platformu Tel: , Faks: , Prof. Dr. Cengizhan Öztürk cozturk@boun.edu.tr, cengizhan.ozturk@gmail.com Biyomedikal Mühendisliği Enstitüsü, ( Yaşam Bilimleri ve Teknolojileri UYGAR Merkezi ( Medical Imaging Laboratory (BUMIL, Boğaziçi Üniversitesi, Kandilli Kampüsü, TAM-BME Binası, TAM Çengelköy - İstanbul