Araştırma Projeleri 1. Astragalus diphtherites Fenzl var. diphtherites ve Astragalus gymnalocepias Rech

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1 Unvan Adı Yrd.Doç.Dr. Cumali KESKİN Fakültesi: Sağlık Yüksekokulu Bölümü: Beslenme ve Diyetetik İletişim Adres: M.A.Ü. Sağlık Yüksekokulu, Diyarbakır Yolu 5. km, Kampüs, 47200, Mardin Telefon: Fax: YDS PUANI: Öğrenim Durumu Derece Alan Üniversite Yıl Lisans Biyoloji Dicle Üniversitesi Y. Lisans Biyoloji Dicle Üniversitesi/Fen Bilimleri Enstitüsü Doktora Biyoloji Dicle Üniversitesi/Fen Bilimleri Enstitüsü Yayınlar Araştırma Projeleri 1. Astragalus diphtherites Fenzl var. diphtherites ve Astragalus gymnalocepias Rech (Fabaceae) Taksonlarının Farklı Polariteye Sahip Çözücüler ile Hazırlanan Özütlerinin Antioksidan ve Antimikrobiyal Özelliklerinin Araştırılması, Dicle Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü, DÜBAP , Projede Araştırmacı, Mayıs 2007-Mart 2010.

2 2. Bölgemizde yayılış gösteren bazı Nepeta (Lamiaceae) ve Hyoscyamus (Solanaceae) türlerinin yağ asidi kompozisyonlarının belirlenmesi ve farklı çözücü sistemleri ile elde edilen özütlerinin biyolojik aktivitelerinin araştırılması, Mardin Artuklu Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü, MAÜBAP/SYO/2011/11, Projede Yürütücü, Haziran 2011-Haziran İn vivo ve İn vitro Yetiştirilen Sakız Ağacı (Pistacia lentiscus L.) Genotiplerinin Yağ asidi ve Sekonder Metabolit İçeriklerinin Belirlenmesi, DUBAP-12-FF-104, Projede Araştırmacı, Haziran 2012-Haziran Hypericum perforatum (Sarı kantaron) bitkisinin çiçek, meyve ve tohumlarından farklı çözücülerle elde edilen özütlerinin in vitro koşullarda hücre kültürü ortamından genotoksisite ve oksidatif durum üzerine etkilerinin araştırılması, Mardin Artuklu Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü, MAÜ-BAP 12 SYO 04, Projede Yürütücü, Şubat 2013-Eylül Mardin ilinde yeni doğum yapmış annelerin sütlerinde total yağ asidi içeriğinin incelenmesi. Mardin Artuklu Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü, MAÜ-BAP 12 SYO 03, Projede Araştırmacı, Aralık 2012-Eylül Mardin ve Çevresinde Yenilebilen Şapkalı Mantarların Besinsel İçeriklerinin ve Biyolojik Aktivitelerinin Araştırılması. Mardin Artuklu Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü, MAÜ-BAP XX SYO XX, Projede Araştırmacı, Kasım 2014-Kasım Mardin Dargeçit Ilısu (Germ-i Ab Köyü) Kaplıcalarından Termofilik Bakteri İzolasyonu ve Ticari Öneme Sahip β-galaktozidaz ve α- Amilaz Enzimlerinin Üretimi. Mardin Artuklu Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü, MAÜ- BAP-15-SHMYO-01, Projede Araştırmacı, Ocak 2015-Ocak 2017.

3 8. Sıçanlarda Siklofosfamid nedenli hemotoksisite üzerine Hypericum triquetrifolium Turra bitkisinin olası koruyucu etkisi. Mardin Artuklu Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü, MAÜ-BAP-15-SHMYO-01, Projede Araştırmacı. Bitiş tarihi Mard n ve Çevres nde Yerleş m Alanlarının Dışında ve Yerleşim Alanlarına Yakın Bölgelerde Yetişen Meyve Ağaçlarının Çiçek, Meyve ve Yaprak Kısımlarından Elde Edilen Özütlerin Uçucu Bileşen, Ağır Metal ve Pestisit Kalıntı Miktarlarının Belirlenmesi. Mardin Artuklu Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü, MAÜ-BAP-16-SYO-13, Projede Yürütücü, (Devam Ediyor) 10. Mardin İlinde Satılan Gıdalarda Dioksin PCB ve Dioksin Benzeri PCB Tayini. Mardin Artuklu Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü, MAÜ-BAP-16- SHYO-03, Projede araştırmacı Diğer Projeler 1. Mardin Artuklu Üniversitesi Merkezi Laboratuar Projesi, DPT, Proje Yürütücüsü, Temmuz 2010-Temmuz Uluslararası Hakemli Dergilerde Yayımlanan Makaleler A1. Özen HÇ, Başhan M, Toker Z, Keskin C. 3-hydroxy fatty acids from the flowers of Hypericum lysimachioides var. lysimachioides, Turkish Journal of Chemistry 28(2), , A2. Özen HÇ, Başhan M, Keskin C, Toker Z. Fatty acid and 3-hydroxy fatty acid composition of two Hypericum species from Turkey, European Journal of Lipid Science and Technology 106(1), 68-70, 2004.

4 A3. Toker Z, Keskin C. Composition of Essential Oil of Carthamus glaucus Bieb. subsp. glaucus. Asian Journal of Chemistry, 20 (2), , A4. Keskin C, Kaçar S. Fatty acid composition of root and shoot samples of some Astragalus L. (Fabaceae) taxa growing in the east and southeast of Turkey. Turkish Journal of Biology. 37, , A5. Keskin C, Kişin E, Yavuz M. Trace Metal Determination in the Medicinal Plant Hyoscyamus (Solanaceae) by Inductively Coupled Plasma Optical Emission Spectrometry. Atomic Spectroscopy. 35(5), , A6. Ö. F. Akdemir, E. Tilkat, C. Keskin, A. Onay, V. Kızmaz, H. Yıldırım, M. Başhan. Determination of the Fatty Acid Composition of the Fruits, Resins and Different Organs of Lentisk [Pistacia lentiscus L.]. Journal of Essential Oil Bearing Plants, 18(5): , DOI: / X A7. Necmettin Aktepe, Abdurrahim Kocyigit, Yunus Yukselten, Abdullah Taskin, Cumali Keskin, Hakim Celik. Increased DNA Damage and Oxidative Stress among Silver Jewellery Workers. Biol Trace Elem Res. 164(2): , DOI: /s A8. Cumali Keskin. Antioxidant, anticancer, anticholinesterase activities of flower, fruit and seed extracts of Hypericum amblysepalum HOCHST. Asian Pac J Cancer Prev, 16 (7), , A9. Cumali Keskin, Murat Yavuz, Semra Kaçar. Determination of fatty acid compositions of total lipid, phospholipid and triacylglycerol fractions of aboveground parts of four species of the genus Hyoscyamus. Chemistry Reseach Journal. 1(5): 1-8, 2016.

5 A10. Cumali Keskin, Necmettin Aktepe, Yunus Yukselten, Asuman Sunguroglu, Mehmet Boga. In vitro Antioxidant, Cytotoxic, Cholinesterase Inhibitory Activities and Anti-Genotoxic Effects of Hypericum retusum Aucher Flowers, Fruits and Seeds Methanol Extracts in Human Mononuclear Leukocytes. Iranian Journal of Pharmaceutical Research (2017), 16 (1): A11. Investigations of in vitro Antioxidant Activities, Elemental Compositions and Lipid Constituents of Acanthus dioscoridis L. var. dioscoridis L. as a Medicinal Plant. Iğdır University Journal of the Institute of Science and Technology. (2017) 7(2): A12. Astragalus diphtherites FENZL var. diphtherites ve Astragalus gymnalopecias RECH. FIL in gövde ve kök kısımlarından farklı çözücüler ile elde edilen özütlerin invitro antioksidan ve antimikrobiyal özelliklerinin belirlenmesi. Kahramanmaraş Sütçü İmam Üniversitesi Doğa Bilimleri Dergisi. (2018) 21(3): Sunulan ve/veya Basılan Bildiriler Sözlü Bildiriler 1. A. Selçuk Ertekin, Cumali Keskin. Ömeryan (Mardin) Bölgesinin Nadir ve Endemik Bitkileri, Uluslar arası Ömerli/Ömeran ve Çevresi Sempozyumu, Mayıs 2011, Mardin, Türkiye. 2. Yükselten Y, Koçyiğit A, Aksoy N, Aktepe N, Taşkın A, Keskin C. Isırgan Otu (Urtica Diocia L.) ve Isırgan Tohumu (Fructus Urtica Piluliferea) Ekstraktlarının Hücre Kültürü Ortamında Genotoksisite ve Oksidatif Durum Üzerine Etkilerinin Araştırılması. 10. Ulusal Tıbbi Genetik Kongresi, Aralık 2012, Bursa, Türkiye.

6 3. Keskin C, Acay H, Aktepe N. Hypericum retusum bitkisinin farklı kısımlarından elde edilen özütlerin anti-kanser ve antikolinesteraz aktiviteleri. 22. Ulusal Biyoloji Kongresi, Haziran 2014, Eskişehir, Türkiye. 4. Songül Çetik, Cumali Keskin, Adnan Ayhancı. Protective Effect of Hypericum triquetrifolium Turra. on Cyclophosphamide-Induced Myelotoxicity and Hemotoxicity in Rat. 7th European Congress of Pharmacology, June, 2016, İstanbul, TURKEY. 5. Songül Çetik, Cumali Keskin, Adnan Ayhancı. Protective effect of Hypericum triquetrifolium Turra. on Cyclophosphamide induced hepatotoxicity in rat. 3rd World Congress on Pharmacology, August, 2016 Birmingham, UK. 6. Songül Çetik, Cumali Keskin, Adnan Ayhancı. Protective Effect of Hypericum triquetrifolium Turra. on Cyclophosphamide Induced Cardiotoxicity in Rat. 2nd International Conference on Clinical Trials and Therapeutic Drug Monitoring, August, 2016, Philadelphia, USA. 7. Cumali Keskin, Songül Çetik, Adnan Ayhancı. Hypericum triquetrifolium'un sıçanlarda oluşturulmuş Siklofosfamid nedenli nefrotoksisite üzerine olası koruyucu etkileri. 23. Ulusal Biyoloji Kongresi. 5-9 Eylül, 2016, Gaziantep, Türkiye. 8. Nurhayat Kayar, Songül Çetik, Cumali Keskin, Ahmet Musmul, Mustafa Cengiz, Özgün Teksoy, Senanur Can, Yaprak Özge Yıldırım, Gülçin Telvim, Adnan Ayhancı. Antikanser Tedavide Siklofosfamid Nedenli Akut Akciğer Hasarına Karşı Hypericum triquetrifolium Turra Ham Ekstresinin Koruyucu Etkileri. 23. Ulusal Biyoloji Kongresi. 5-9 Eylül, 2016, Gaziantep, Türkiye.

7 9. Senanur Can, Varol Sahintürk, Songül Çetik, Cumali Keskin, Özgün Teksoy, Adnan Ayhancı. Protective effects of Hypericum triquetrifolium Turra upon chemotherapy-induced testicular toxicity in rats. I. International Congress on Medicinal and Aromatic Plants Natural and Healthy Life May, 2017, Konya, Türkiye. 10. Songül Çetik, Cumali Keskin, Cemil Demir, Adnan Ayhancı. Hypericum triquetrifolium Turra. against cyclophosphamide-induced hemorrhagic cystitis in rats. 10 th International conference on cancer stem cells and oncology research. June 26-28, 2017, London, UK. 11. Cumali Keskin. Investigations of in vitro Antioxidant Activities, Elemental Compositions and Lipid Constituents of Asphodeline damascena (Boiss.) Baker subsp. gigantea as an Endemic Medicinal Plant. 4. Ulusal Botanik Kongresi. 6-9 Temmuz, 2017, Afyon, Türkiye. 12. Hilal Acay, Cumali Keskin, Semra Kaçar. Mardin, Türkiye de doğal olarak yetişen yenilebilen yabani mantar Morchella conica nın besinsel kalitesi ve biyoaktif özelliklerinin değerlendirilmesi. II. Ulusal Uygulamalı Biyolojik Bilimler Kongresi Temmuz, 2017, Afyon, Türkiye. 13. Hilal Acay, Semra Kacar, Abdurrahman Dündar, Cumali Keskin. Assessment of the antimicrobial, antioxidant and cytotoxic activities of the wild edible mushroom Pleurotus eryngii from Hakkari, Turkey. Intrenational Science and Technology Conference. July 17-19, 2017, Berlin, Germany. Poster bildiriler 1. Keskin C, Bashan M, Ozen HC., Hypericum scabrum L. nin total yağ asidi miktarı ve yağ asidi bileşenleri, XVI. Ulusal Biyoloji Kongresi, 6-7 Eylül 2002, Malatya, Türkiye.

8 2. Keskin C, Yavuz M, Özen HC, Farklı Polariteye Sahip Çözücülerle Astragalus gymnalocepias Rech Bitkisinin Gövde Kısmından Elde Edilen Ekstraktların Antioksidan ve Antimikrobiyal Aktivitelerinin Araştırılması. 24. Ulusal Kimya Kongresi, 29 Haziran-02 Temmuz, 2010, Zonguldak, Türkiye. 3. Yavuz M, Keskin C, Özen HC, Astragalus gymnalocepias Rech Bitkisinin Kök Kısmının in Vitro Antioksidan ve Antimikrobiyal Aktivitesinin Araştırılması. 24. Ulusal Kimya Kongresi, 29 Haziran-02 Temmuz, 2010, Zonguldak, Türkiye. 4. Necmettin Aktepe, Abdurrahim Kocyigit, Abdullah Taskin, Yunus Yükselten, Cumali Keskin, Hakim Çelik. Evaluation of Lymphocyte DNA Damage and Oxidative Status in Silver Jewelry Workers, 4th International Congress on Cell Membranes and Oxidative Stress: Focus on Calcium Signaling and TRP Channels Volume 4, Number 1, June 2012, Isparta, Turkey. 5. Acay H, Keskin C, Kaçar S. Effect of agro-industrial wastes on production of laccase in submerged cultures of some wild mushrooms. 15 th European Congreess on Biotechnology, September 2012, İstanbul, Turkey. 6. Keskin C. Anti-cancer and anticholinesterase activities on different parts of Hypericum amblysepalum. 3rd. International Molecular Biology and Biotechnology Congress, June 2-6, 2014, Sarajevo, Bosnia and Herzegovina. 7. Ö.F. Akdemir, V. Kızmaz, C. Keskin, M. Başhan, A. Onay. Comparision of the fatty acid composition of the different organs of Pistachia lentiscus L. regenerants produced in vitro. Balkan Agricultural Congress, 8-11 September 2014, Edirne, Turkey. 8. Abdurrahman Dundar, Cumali Keskin, Ersin Kilinc, Sadin Ozdemir, Veysi Okumus. Solid Phase Extraction Based on the Use of Helvella crispa as a

9 Fungal Biomass for the Preconcentrations of Pb and Al by ICP-OES. The 6th Congress of European Microbiologists, June, 2015, Maastricht, Netherlands. 9. Cumali Keskin, Murat Yavuz, Abdurrahman Dündar, Ersin Kılınç. Antimicrobial properties on different solvent extracts of four Hyoscyamus species from Turkey. The 6 th Congress of European Microbiologists, June, 2015, Maastricht, Netherlands. 10. Necmettin Aktepe, Cumali Keskin, Yunus Yukselten, Asuman Sunguroglu. Hydrogen Peroxide-Induced Oxidative Damage in Human Mononuclear Leukocyte: The Anti-Genotoxic Effects of H. perforatum Extract on DNA Damage. 40 th FEBS Congress-The Biochemical Basis of Life, 4-9 July, 2015, Berlin, Germany. 11. Keskin C, Yavuz M, Kaçar S. Acanthus dioscoridis L. var. dioscoridis in total yağ asidi, fosfolipit ve triaçilgliserol kompozisyonlarının belirlenmesi. Ulusal Botanik Kongresi, Ekim 2014, Antalya, Türkiye. 12. Cumali Keskin, Necmettin Aktepe, Yunus Yükselten, Asuman Sunguroğlu. The Antioxidant and Anti-Genotoxic Effects of Hypericum amblysepalum HOCHST. 3 rd Anticancer Agent Development Congress, May, 2015, İzmir, Turkey. 13. Necmettin Aktepe, Cumali Keskin, Yunus Yukselten, Asuman Sunguroglu. The Antioxidant and Anti-genotoxic Effects of Hypericum retusum Aucher Methanol Extracts in Human Mononuclear Leukocyte. V. International Congress of Molecular Medicine, May, 2015, İzmir, Turkey.

10 Yönetilen Yüksek Lisans Tezleri 1. AKDEMIR ÖMER FARUK, (2013). In vivo ve in vitro sartlarda yetistirilen Pistacia lentiscus L. (sakız ağacı)' nin yağ asidi ve uçucu yağ içeriklerinin belirlenmesi, Dicle Üniversitesi/Fen Bilimleri Enstitüsü/Biyoloji Anabilim Dalı. Editörü Olunan Uluslararası Hakemli Dergiler 1. Journal of Advances in Plant Biology (Editor) 2. EC Nutrition (Editor) Uluslararası Hakemli Dergilerde Yapılan Hakemlikler 1. Isolation of Plant Growth Promoting Bacteria from Sugarcane (Saccharum officinarum L.) Rhizosphere of Wonji-Shoa Sugar Estate and Farmers Landraces of Ethiopia. African Journal of Microbiology Research. Manuscript ID: AJMR/ /7196 (2014). 2. Protective Effect of Carvacrol Against Oxidative Stres and Heart Injury in Cyclophosphamide Induced Cardiotoxicity in Rat. Brazilian Archives of Biology and Technology. Manuscript ID: BABT (2015). 3. Seasonal Variations on the Fatty Acid Composition of Phospholipid and Triacylglycerol in gonad and liver of Mastacembelus simack. Journal of the American Oil Chemists' Society. Manuscript ID: JAOCS (2015). 4. Syringic Acid Preconditioning Improves Kidney Ischemia-Reperfusion. International Journal of Urology. Manuscript ID: IJU (2015). 5. Unusual alkaloids of the highland species Astragalus cryptanthus Wedd. (Fabaceae). Natural Product Research. Manuscript ID: GNPL (2015).

11 6. MSPD extraction method for Tropane alkaloid detection in cultured and collected Hyoscyamus reticulatus plants. Agricultural Science Research Journal. Manuscript ID: ARJ (2015). 7. Gene-Eden-VIR: A Potential Natural Treatment for Cervical Cancer". Journal of Cervical Cancer. Manuscript ID: JCC (2016). 8. Comparative study of lipid and fatty acid profile in muscle tissue of male and female Silurus triostegus. Journal of Food Science and Technology. Manuscript ID: JFST-D (2016). 9. A novel thermostable raw starch hydrolyzing α-amylase produced by newly isolated Bacillus mojavensis: Purification, characterization and usage in starch industries. Brazilian Archives of Biology and Technology. Manuscript ID: BABT (2016). 10. Detection of food consumption in type 2 diabetic patients with a previous cardiovascular event before and after an education program: a pilot study. EC Nutrition Journal. ECNU-17-RA-286 (2017). 11. Analysis of fatty acid composition and physico-chemical characteristic of Trigonella Foenum-Graecum Linn ripe seed by gas liquid chromatography. Sky Journal of Biochemistry Research. SJBR (2017). 12. Punica granatum L. suppresses colon cancer through down regulation of Wnt/β-catenin in rat model. Brazilian Journal of Pharmacognosy. Manuscript ID: BJP_2017_147. (2017). 13. Cholinesterase Inhibitory Activity of Some Semi-Rigid Spiro Heterocycles: POM analyses and crystalline structure of pharmacophore site. Mini-

12 Reviews in Medicinal Chemistry. Manuscript ID: BSPMRMC (2017). Atıf Alan Makaleler A1: Özen HÇ, Başhan M, Toker Z, Keskin C. 3-hydroxy fatty acids from the flowers of Hypericum lysimachioides var. lysimachioides, Turkish Journal of Chemistry 28(2), , RAPD and FAME analyses of Astragalus species growing in eastern Anatolia region of Turkey. Biochemical Systematics and Ecology. 34: 5, , FAME and RAPD analysis of selected Vicia taxa from eastern Anatolia, Turkey. Annales Botanici Fennici. 43: 4, , Interspecific variability of RAPD and fatty acid composition of some pomegranate cultivars (Punica granatum L.) growing in Southern Anatolia Region in Turkey. Biochemical Systematics and Ecology. 35: 11, , The comparison of persimmon genotypes (Diospyros kaki Thunb.) by using RAPD and FAME data. Romanian Biotechnological Letters. 13: 4, , Comparison of Sea Buckthorn Genotypes (Hippophae rhamnoides L.) Based on RAPD and FAME Data. Turkish Journal of Agricultural Forestry. 32, , Phenotypic and Genetic Variation of Some Salvia Species Grown in Eastern Anatolia Region of Turkey. Asian Journal of Chemistry. 20:5, , Phenotypic and genetic variation among Astragalus species from Turkey. Romanian Biotechnological Letters. 14: 2, , 2009.

13 8. Concentrations of medium-chain 2- and 3-hydroxy fatty acids in foodstuffs. Food Chemistry. 114: , Biochemical and Molecular Characterization of Some Centaurea Species Growing in the Eastern Anatolia Region of Turkey. Biochemical Genetics. 47:850, Phenotypic and genotypic diversity among Astragalus species growing in eastern Anatolia region of Turkey. Bangladesh Journal of Botany. 39:1, 1-7, Morphological and phytochemical diversity among Hypericum species of the Mediterranean Basin. Medicinal and Aromatic Plant Science and Biotechnology. 5(Special Issue 1): 14 28, Aktivitas Anticendawan Zat Ekstraktif Faloak (Sterculia comosa Wallich) (Antifungal Activity of Faloak (Sterculia comosa Wallich) Extractives). Journal of Tropical Wood Science and Technology. 10:1, 60-65, Antioxidant, Anticancer and Anticholinesterase Activities of Flower, Fruit and Seed Extracts of Hypericum amblysepalum HOCHST. Asian Pasific Journal of Cancer Preventation. 16:7, , Genetic diversity and relationships detected by ISSR and RAPD analysis among Aethionema species growing in Eastern Anatolia (Turkey). Comptes Rendus Biologies. 339: 3 4, , Acetyl-3-[(3R)-hydroxyfatty acyl]glycerols: Lipid Compounds from Euphrasia rostkoviana Hayne and E. tetraquetra (Bréb.) Arrond. Chemistry and Biodiversity.13:5, , 2016.

14 16. Phytochemical analysis, antioxidant, antimicrobial, anticholinesterase and DNA protective effects of Hypericum capitatum var. capitatum extracts. South African Journal of Botany. 104, , Fatty acid composition and tocopherol content in four Tunisian Hypericum species: Hypericum perforatum, Hypericum tomentosum, Hypericum perfoliatum and Hypericum ericoides Ssp. Roberti. Arabian Journal of Chemistry. 10:2, , A2: Özen HÇ, Başhan M, Keskin C, Toker Z. Fatty acid and 3-hydroxy fatty acid composition of two Hypericum species from Turkey, European Journal of Lipid Science and Technology 106(1), 68-70, Morphological and Phytochemical Diversity among Hypericum Species of the Mediterranean Basin. Medicinal and Aromatic Plant Science and Biotechnology. 5: 1, 14 28, The Effect of Different Plant Hormones (PGRs) on Multiple Shoots of 'Hypericum retusum' Aucher. Plant Omics , Gas Chromatography/Electron-Capture Negative Ion Mass Spectrometry for the Quantitative Determination of 2- and 3-Hydroxy Fatty Acids in Bovine Milk Fat. Journal of Agricultural and Food Chemistry. 56:14, , Concentrations of medium-chain 2- and 3-hydroxy fatty acids in foodstuffs. Food Chemistry. 114: 3, , Highly selective and sensitive gas chromatography electron-capture negativeion mass spectrometry method for the indirect enantioselective identification of 2- and 3-hydroxy fatty acids in food and biological samples. Journal of Chromatography A. 1146: 2, , 2007.

15 6. Comparative Study on Hypericum triquetrifolium Turra Fatty Acids. Asian Journal of Plant Sciences. 6:2, , Fatty acid composition and tocopherol content in four Tunisian Hypericum species: Hypericum perforatum, Hypericum tomentosum, Hypericum perfoliatum and Hypericum ericoides Ssp. Roberti. Arabian Journal of Chemistry. 10:2, , Antioxidant, Anticancer and Anticholinesterase Activities of Flower, Fruit and Seed Extracts of Hypericum amblysepalum HOCHST. Asian Pasific Journal of Cancer Preventation. 16:7, , Konya çevresinde yetişen içilebilir bazı tıbbi bitkilerin yağ asit kompozisyonlarının belirlenmesi ve karşılaştırılması. Selçuk Üniversitesi, Yüksek Lisans Tezi, Konya, Antiproliferative hydroxy-fatty acids from the fodder legume Stylosanthes guianensis. Journal of Pharmaceutical and Biomedical Analysis. 141, , Phytochemical analysis, antioxidant, antimicrobial, anticholinesterase and DNA protective effects of Hypericum capitatum var. capitatum extracts. South African Journal of Botany. 104, , A4: Keskin C, Kaçar S. Fatty acid composition of root and shoot samples of some Astragalus L. (Fabaceae) taxa growing in the east and southeast of Turkey. Turkish Journal of Biology. 37, , Activity of Brassica napus and Perilla frutescens microsomal w-3 desaturases expressed in yeast (Saccharomyces cerevisiae). Turkish Journal of Biology, 37 (5), , 2014.

16 2. Phytochemistry, biological activities and economical uses of the genus Sterculia and the related genera: A review. Asian Pacific Journal of Tropical Disease, 6(6), , Antioxidant capacity and fatty acid composition of different parts of Adenocarpus complicatus (Fabaceae) from Turkey. Revista de biologia tropical, 62(1), , Fatty Acid Composition, Total Sugar Content and Anti-Diabetic Activity of Methanol and Water Extracts of Nine Different Fruit Tree Leaves Collected from Mediterranean Region of Turkey. International Journal of Food Properties, 18: , Novel three-dimensional cellulose produced from trunk of Astragalus gummifer (Fabaceae) tested for protein adsorption performance. Materials Science and Engineering C. 62, , Astragalus gummifer çiçeklerinin etanol özütünün PC-3 ve HUVECs üzerindeki biyolojik aktivitesi. Türk Doğa ve Fen Dergisi. 5(1), 12-18, Determination of fatty acid compositions of total lipid, phospholipid and triacylglycerol fractions of aboveground parts of four species of the genus Hyoscyamus. Chemistry Research Journal. 1(5), 1-8, Variations in the fatty acid compositions of the liver and gonad tissue of spiny eel (Mastacembelus mastacembelus) from Atatürk Dam Lake. Turkish Journal of Biochemistry A viewpoint toward medical plant of astragalus and its main characteristics, products and economical importance in Iran (Case study: Boldaji and lake Choghakhor in Chaharmahal and Bakhtiari Province. Tech J Engin & App Sci., 3 (S): , 2013.

17 10. Chapter Two - The Role of Plant Primary and Secondary Metabolites in Root- Herbivore Behaviour, Nutrition and Physiology. Advances in Insect Physiology. 45, 53-95, Fatty acids of Hippocratea africana root: antioxidant and antimicrobial activity. Int J Pharm Sci Res. 5(7): , doi: /IJPSR A5: Keskin C, Kişin E, Yavuz M. Trace Metal Determination in the Medicinal Plant Hyoscyamus (Solanaceae) by Inductively Coupled Plasma Optical Emission Spectrometry. Atomic Spectroscopy. 35(5), , Investigations of in vitro Antioxidant Activities, Elemental Compositions and Lipid Constituents of Acanthus dioscoridis L. var. dioscoridis L. as a Medicinal Plant. Iğdır Univ. J. Inst. Sci. & Tech. 7(2): 55-62, A6: Ö. F. Akdemir, E. Tilkat, C. Keskin, A. Onay, V. Kızmaz, H. Yıldırım, M. Başhan. Determination of the Fatty Acid Composition of the Fruits, Resins and Different Organs of Lentisk [Pistacia lentiscus L.]. Journal of Essential Oil Bearing Plants, 18(5): , DOI: / X An analytical approach from natural sources ob bioactive compounds to nutraceuticals and functional foods: Development of extraction, characterization and bioactivity evaluation strategies. Universidad de Granada. Departamento de Química Analítica. Tesis, A7: Necmettin Aktepe, Abdurrahim Kocyigit, Yunus Yukselten, Abdullah Taskin, Cumali Keskin, Hakim Celik. Increased DNA Damage and Oxidative Stress among Silver Jewellery Workers. Biol Trace Elem Res. 164(2): , 2015.

18 1. A re-assessment of the safety of silver in household water treatment: Rapid systematic review of mammalian in vivo genotoxicity studies. Environmental Health. 16: 66, 1-9, Evaluation of Relationship Between Lymphocyte DNA Damages and Blood Arsenic Levels in Silver Mining Workers using Alkaline Comet Assay. Marmara Pharmaceutical Journal. 21(3), , DOI: /marupj Investigation of in-vitro and in-vivo anti-oxidant effects of Matricaria chamomilla extract on rat model of ulcerative colitis. Anti-Cancer Drugs, 27:76, A8: Cumali Keskin. Antioxidant, anticancer, anticholinesterase activities of flower, fruit and seed extracts of Hypericum amblysepalum HOCHST. Asian Pac J Cancer Prev, 16 (7), , In-vitro antioxidant, cytotoxic, cholinesterase inhibitory activities and antigenotoxic effects of hypericum retusum aucher flowers, fruits and seeds methanol extracts in human mononuclear leukocytes. Iranian Journal of Pharmaceutical Research, 16 (1), , Effects of Hypericum Scabrum extract on anxiety and oxidative stress biomarkers in rats fed a long-term high-fat diet. Metabolic Brain Disease, 32 (2), , 2017.