ÖZGEÇMİŞ Adı: Adresi: Website: Dr. Ayhan Sıtkı Demir, Prof. Orta Dogu Teknik Universitesi Fen Edebiyat Fakultesi, Kimya Bolumu 06531 Ankara Tel. (90) 312-2103242 Fax: (90) 312-2103200 E-Mail: asdemir@metu.edu.tr curie.chem.metu.edu.tr/~asdemir/ Egitim: Doktora: 1985, Organik Kimya, Biyokimya, Rheinische Friedrich Wilhelms Universitaet, Institut für Organische Chemie- Biochemie BONN Almanya (Derecesi: Auszeichnung)). Yuksek Lisans (Diplomarbeit) 1981 Organik Kimya, Rheinische Friedrich Wilhelms Universitaet, Institut für Organische Chemie- Biochemie BONN Almanya. Lisans: 1980, Kimya, Rheinische Friedrich Wilhelms Universitaet, Institut für Organische Chemie- Biochemie BONN Almanya. Mesleki Deneyimi 1993- Profesor, Orta Dogu Teknik Universitesi Fen Edebiyat Fakultesi Kimya Bolumu. Arastirma Konulari: Asimetrik Sentez, Biyolojik Aktif Maddelerin Optik saf sentezleri, Kiral amino asit sentezlerinde yeni yontemler, Biyoteknolojik yontemlerle aktif madde sentezleri, yeni homojen heterojen katalizorler. Mangan Asetat la yeni oksidasyon yontemleri, Antikanser ilac gelistirme ve uygulama yontemleri. 1999- Alexander von Humboldt Arastirma Bursiyeri, Biotechnologische Forschungszentrum Julich-Almanya, Biyoteknolojik yontemlerle aktif Madde sentezleri 1998- Misafir Profesor, University of Kentucky, College of Pharmacy, Pharmaceutical Biotechnology Laboratory, Yeni antikanser etkide Topoisomeraz I inhibitorleri ve uygulama teknolojileri. 1997 Fulbright Bursiyeri, University of Kentucky, College of Pharmacy, Advanced Science and Technology Center, Liphophilic Camptothecin for Cancer Treatment. 1996 CNRS(Fransa)- TUBITAK Bursu, Institut de Chimie des Substances Naturelles 1
CNRS Gif-Sur Yvette (Paris), A practical total synthesis of Taxol and simpler taxoid analogues. 1989-1995 (Haziran- Eylul) Nato Bursu University of Kentucky, Department of Chemistry, Antikanser dogal urun sentezleri 1990-1991 Alexander von Humboldt Bursiyeri, Rheinische Friedrich Wilhelms Universitaet, Institutfür Organische Chemie- Biochemie BONN Germany. Doğal ürün Sentezleri. 1987 Yardimci Docent, Docent, Orta Dogu Teknik Universitesi Fen Edebiyat Fakultesi Kimya Bolumu. 1986-1987 Arastirmaci, University of Kentucky, Department of Chemistry, Lucille Parker- Markey Cancer CenterLexington, KY, 40506, USA. Antikanser etkili dogal urun sentezleri,biomarker sentezleri, 1981-1985 Doktora Tezi, Rheinische Friedrich Wilhelms Universitaet, Institut für Organische Chemie- Biochemie BONN Almanya. Prof. Dieter Enders. Konu: Regio-, diastereo und enantioselektive C-C- verknüpfungen über metallierte dimethyl- und SAMP-/ RAMP- Hydrazone sowie enamine von 1,3- dicarbonylverbindungen. (Friedrich Ebert Bursiyeri) 1980-1981 Yuksek Lisans (Diplom Arbeit), Rheinische Friedrich Wilhelms Universitaet, Institut für Organische Chemie- Biochemie BONN Almanya. Prof. Dieter Enders. Konu: Regioselektive alkylierungen von cyclischen 1.3- diketonen über mono und polymetallierte dimethylhydrazonen. (Friedrich Ebert Bursiyeri) 1976-1980 Kimya Ögrenimi, Rheinische Friedrich Wilhelms Universitaet, Institut für Organische Chemie- Biochemie BONN Almanya, Friedrich Ebert Kurumu Bursiyeri) Üye Oldugu Kuruluslar Türkiye Bilimler Akademisi Asli Üyesi Editör Turkish Journal of Chemistry Member of Advisorial Board of Journal of Faculty of Pharmacy of Istanbul University Member of Advisorial Board of the Journal CLEAN- Soil, Air, Water (Wiley) Turkish Chemical Society American Chemical Society German Chemical Society American Association of Pharm. Scientist European fedaration of biotechnology Aldigi Burslar - Friedrich Ebert Foundation- Germany, Predoctoral Fellowship,1977-1985. - Alexander von Humboldt Fellowship, Germany 1990-1991 and 1999. 2
- NATO Fellowship, 1987, 1989, 1993 (June-October) - Fulbright Fellowship 1997. - DAAD Fellowship (misafir prof.) 2000 Akademik Ilgi Alanlari Sentetik Organik Kimya, Biyoorganik Kimya, Ilac Sentezleri, yeni kiral ilac gelistirme, Yeni katalizorler ve aktif madde sentezlerine uygulamalari. Yeni oksidasyon reaksiyonlari ve ilac sentezlerine uygulamalari. Biyoteknolojik yontemlerle aktif madde sentezleri. Antikanser ilac gelistirme uygulama, biyobozunur polimerler ve antikanser ilac uygulamalarinda kullanimlari. Yayınlar: 142 Adet Toplam atıflar: 1423 Patentler: US,6,291,676,Sep.2001 US,6,897,200 May 2005 EU : 1297159, 2002 WO: 02002753, 200 US, 7 045334, 2006. 3
Dr. Ayhan Sıtkı Demir, Professor Address : Department of Chemistry, Middle East Technical University 06531 Ankara TURKEY Tel : (90) 312-2103242 (office) Fax: (90) 312-2101280 E-Mail: asdemir@metu.edu.tr Education - Ph. D. 1985 in Organic Chemistry (mit Auszeichnung), Rheinische Friedrich Wilhelms Universitaet, Institut fur Organische Chemie- Biochemie BONN Germany - M. S. 1981 in Organic Chemistry, Rheinische Friedrich Wilhelms Universitaet, Institut fur Organische Chemie- Biochemie BONN Germany. - B. S. 1980 in Chemistry, Rheinische Friedrich Wilhelms Universitaet, Institut fur Organische Chemie- Biochemie BONN Germany. 1993-present Professor for Organic Chemistry, Department of Chemistry, Biotechnology and Biochemistry division Middle East Technical University. Research topic Development of new methods for chiral synthesis of biological active compounds, drugs, drug intermediates,chiral synthesis of amino acids, aminophosphonic acids, Synthesis of bioactive compounds using biotechnological methods, enzyme catalyzed organic synthesis, new homogeneous and heterogeneous chiral catalysts. Selective oxidation reactions with Mn(OAc)3. Anticancer drugs Topoisomerase I inhibitors, Biodegradable polymers, Controlled release in cancer therapy Professional Experience 2003- Prof. Middle East Technical University 2000 (April-August) Distinguished Visiting Professor, Institut fur Organische Chemie, RWTH Aachen- Germany 1999 (January-September) Visiting Professor, Institute of Biotechnology, Research Center Juelich- Germany 1997-1998 Visiting Professor, University of Kentucky, College of Pharmacy, Advanced Science and Technology Commercialization Center, USA. 1996 (January-February)Visiting Professor,CNRS- TUBITAK Fellow, Institut de Chimie des Substances NaturellesCNRS Gif-Sur Yvette, FRANCE ' 1987-1993 Assistant and Associate Professor, Department of Chemistry, Middle East Technical University. 1990-1991 Research Associate, Rheinische Friedrich Wilhelms Universitaet, Institut fur Organische Chemie- Biochemie BONN Germany. 1986-1987 Research Associate, University of Kentucky, Department of Chemistry, Lexington, KY, 40506, USA. Membership (Professional Organizations) Assoc. Editor Turkish Journal of Chemistry Member of Advisorial Board of Journal of Faculty of Pharmacy of Istanbul University Member of Advisorial Board of the Journal CLEAN- Soil, Air, Water Turkish Academy of Science Turkish Chemical Society American Chemical Society German Chemical Society American Association of Pharm. Scientist European Fedaration of biotechnology Awards Friedrich Ebert Foundation- Germany, Predoctoral Fellowship,1977-1985. 4
Alexander von Humboldt Fellowship, Germany 1990-1991 and 1999. NATO Fellowship, 1987, 1989, 1993 (June-October) Fulbright Fellowship 1997. DAAD Fellowship 2000 (Temporary Teaching Assignments for highly qualified foreign academics at German Institutions of Higher Education) Turkish Chemical Society, Honorary Member Award 5