XXXIII. Ulusal Hematoloji Kongresi

XXXIII. Ulusal Hematoloji Kongresi 6-9 Ekim 007 Sheraton Otel - Ankara TURKISH JOURNAL of HEMATOLOGY Supplement Vol. 4 No:4 007 Türk Hematoloji Derne i

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967 TURKISH JOURNAL OF HEMATOLOGY The Official Journal of the Turkish Society of Hematology Formerly known as New Istanbul Contribution to Clinical Science established by Prof. Dr. E. Frank in 95 ISSN: 00-7777 Editor-in-Chief Aytemiz Gürgey Co-Editor Hamdi Akan Associate Editors Mutlu Arat Reyhan Diz Küçükkaya Mehmet Ertem Hale Ören Mehmet Ali Özcan Teoman Soysal Past Editors Erich Frank Orhan Ulutin Hamdi Akan Senior Advisory Board Orhan Ulutin Yücel Tangün Osman İlhan Language Editor Corrine Can Editorial Secretary İpek Durusu Graphic Design and Publication Services BAYT Ltd. Şti., Ankara, Türkiye Tel. +90 4 0 6 E-mail: info@bayt.com.tr Printed at Miki Matbaacılık San. Tic. Ltd. Şti. Matbaacılar Sitesi 560. Sk. No. 7 İvedik, Ankara Tel. +90 95 8 Cover Picture: Gültekin Serbest (006) Gültekin Serbest Collection Turkish Society of Hematology President: Muhit Özcan General Secretary: Mutlu Arat Vice President: M. Nejat Akar Research Secretary: G. Hayri Özsan Treasurer: N. Mustafa Yenerel Member: Mustafa Çetin Member: Savaş Kansoy International Review Board Nejat Akar (Türkiye) Serhan Alkan (USA) Çiğdem Altay (Türkiye) Andrea Bacigalupo (Italy) Ernest Beutler (USA) Ayhan Çavdar (Türkiye) Ahmet Doğan (USA) Jawed Fareed (USA) Gösta Gahrton (Sweden) Dieter Hoelzer (Germany) Marilyn Manco-Johnson ( USA) Andreas Josting (Germany) Emin Kansu (Türkiye) Winfried Kern (Germany) Nigel Key (USA) Abdullah Kutlar (USA) Ghulam Mufti (UK) Gerassimos A. Pangalis (Greece) Santiago Pavlovsky (Argentina) Antonio Piga (Italy) Ananda Prasad (USA) Orhan Sezer (Germany) Nüket Tüzüner (Türkiye) Catherine Verfaillie (USA) Claudio Viscoli (Italy) TURKISH JOURNAL OF HEMATOLOGY, Official Journal of Turkish Society of Hematology is published quarterly, in one volume per year. Dates of issue are the first day of March, June, October and December. All postage is sent by surface mail unless otherwise indicated. Contact Information Editorial Correspondence should be addressed to Prof. Dr. Aytemiz Gürgey Editor-in-Chief Hacettepe University Faculty of Medicine Pediatric Hematology Department 0600 Sıhhiye, Ankara/TURKEY Tel No : +90 05 4 7 Fax No: +90 05 4 7 E-mail: agurgey@hacettepe.edu.tr All other inquiries should be addressed to TURKISH JOURNAL OF HEMATOLOGY Editorial Office Sancak Mahallesi, Turan Gunes Bulvari 94. Sok. No:8, 06550 Cankaya Ankara/TURKEY Tel No : +90 490 98 97 Fax No: +90 490 98 68 E-mail: infotjh@thd.org.tr Web address: www.onlinedergi.com/hematology Correspondence regarding permission to reproduce any part of the journal should be addressed to Editorial Office of Turkish Journal of Hematology. For all advertising materials please contact Editorial Office. Publication of an advertisement in TURKISH JOURNAL OF HEMATOLOGY does not imply endorsement of its claims by the Turkish Society of Hematology or by the editors or publisher of the Journal. Aims and Scope Turkish Journal of Hematology is an international journal publishing credible peer-reviewed original and review articles in the field of general hematology, including oncology, pathology, biology, clinical research and epidemiology. [The Turkish Journal of Hematology is a nonprofit scientific peerreviewed journal. ISSN: 00-7777.] Indexed in EMBASE (EXCERPTA MEDICA), CHEMICAL ABSTRACTS, SCOPUS Printed in Turkey Printed on acid free paper Sahibi Türk Hematoloji Derneği adına Muhit Özcan Sorumlu Yazı İşleri Müdürü Aytemiz Gürgey Yayın yeri Türk Hematoloji Derneği, Türk Ocağı Cad. No:7/6 Cağaloğlu - Eminönü - İstanbul Üç ayda bir yayımlanan yerel bilimsel dergidir. Baskı Tarihi:?????? 007

XXXII. Ulusal Hematoloji Kongresi KONGRE BA KANI Muhit ÖZCAN KONGRE SEKRETER Mutlu ARAT TÜRK HEMATOLOJ DERNE YÖNET M KURULU Ba kan: Muhit ÖZCAN Sayman: N. Mustafa YENEREL II. Ba kan: M. Nejat AKAR Üye: Mustafa ÇET N Genel Sekreter: Mutlu ARAT Üye: Sava KANSOY Ara tırma Sekreteri: G. Hayri ÖZSAN B LD R ÖZETLER DE ERLEND RME KURULU Ahmet Muzaffer DEM R smet AYDO DU Seçkin ÇA IRGAN Atilla YALÇIN Akif YE L PEK Kaan KAVAKLI Sema ANAK Ayhan DÖNMEZ Ali U ur URAL Klara DALVA Semra PAYDA Ay en Timur A AO LU Ay egül ÜNÜVAR Lebriz Yüksel SOYCAN Serdar Bedii OMAY Aytemiz GÜRGEY Beyhan DURAK Levent ÜNDAR Tansu S PAH Ba ak Oyan ULUÇ Burhan FERHANO LU Leyla A AO LU Teoman SOYSAL Bülent ANTMEN Can BO A Mahmut TÖBÜ Türker ÇET N Bülent ESER Cengiz BEYAN Mehmet Ali ÖZCAN U ur ÖZBEK Emel ÜNAL Dilek YAZMAN Mehmet ERTEM Yahya BÜYÜKA IK Ercüment OVALI Fahir ÖZKALEMKA Melih AKTAN Yener KOÇ Erol AYYILDIZ Ferit AVCU Meral BEKSAÇ Yusuf ÖZKUL Evren ÖZDEM R Fevzi ALTUNTA Mine HEK MG L Yücel TANGÜN Mehmet TURGUT Görgün AKPEK Muhit ÖZCAN Zafer GÜLBA Nurdan TAÇYILDIZ Gülsan Sucak TÜRKÖZÜ Murat TOMBULO LU Zahit BOLAMAN Özden P K N Gülsüm ÖZET Mustafa ÇETIN Cem AKIN Pervin TOPÇUO LU Günhan GÜRMAN Mustafa ÇETINER Ezogelin OFLAZO LU Sami S. KARTI Güray SAYDAM Mustafa YENEREL Ömer YILMAZ Selim Akif YAVUZ Gürhan KADIKÖYLÜ Mutlu ARAT Bülent ÖZPOLAT Sema KARAKU Hakan GÖKER Nejat AKAR Ça la AKAY Sevgi Be ı ık KALAYO LU Hakan ÖZDO U Osman LHAN Evin GÜLBAHÇE Ülkü ERGENE Hale ÖREN Osman ÖZCEBE Ahmet ÖZTÜRK Volkan HAZAR Hamdi AKAN Önder ARSLAN Ajlan TÜKÜN Zafer BA LAR Hayri ÖZSAN Reyhan Diz KÜÇÜKKAYA Alp CAN brahim C. HAZNEDARO LU Rıdvan AL Alpay AZAP Türk Hematoloji Derne i, Bildiri Özetleri De erlendirme Kurulu na, verdi i destek için te ekkür eder. 4

Önsöz De erli Meslekta larım, Gururluyuz. Derne imiz 40. yılını dolduruyor. Türkiye nin en köklü geçmi e sahip bilim derneklerinden olan Türk Hematoloji Derne i, 40. yılında. Ulusal Kongresini gerçekle tiriyor. On yıllara ayrı önem verilir; biz de böyle yaptık. Bu altın yılımızı iki uluslararası kongre ve iki kursla süsleyip, ulusal kongreyle de taçlandırıyoruz. Camiamızı yine dopdolu bir kongreye davet ediyoruz. lk basamak kursu, mezuniyet sonrası e itim oturumları, sözlü ve poster sunuları standart; bunun üzeri ise zengin bir bilimsel gösteri. JACIE ve PROMISE kursları, hukuk ve hematoloji oturumu, Türkçe ve hematoloji oturumu, endüstri ile ili kiler oturumları ve nükleer tehditlere kar ı yapılması gerekenler oturumu gerçekten büyük ilgi toplayacak kanısındayım. THD, geleneksel ödüllerini bu kongrede de hak edenlere teslim edecek. Gençlere özel önem veriyor ve onları kongreye ayrıca davet ediyoruz. Yurt dı ında ya ayan genç Türk bilim insanlarını bu ulusal kongremizde de gururla dinleyece iz. Kongre sırasında Ata mıza yürüyüp, ulusal hematoloji camiamızın ula tı ı ça da uygarlık düzeyini ona anlataca ız. Tüm üyelerimizi Anıtkabir ziyaretine davet ediyorum. çinde yer almaktan büyük mutluluk duydu um bu camia ile 40. ya ımızda Ankara da bulu mak dile iyle... Prof. Dr. Muhit Özcan THD Ba kanı 5

967 TURKISH JOURNAL OF HEMATOLOGY The Official Journal of the Turkish Society of Hematology Instructions for Authors The Turkish Journal of Hematology accepts invited review articles, research articles, brief reports, case reports, letters to the editor, and images in Hematology on subjects within the scope of hematology, on the condition that they have not been previously published elsewhere. All papers are subject to editorial revision for purpose of conformity to the style adopted by the Journal. Manuscripts should in general not exceed 0 typewritten pages for original articles or reviews and 7 typewritten pages for case reports, including all tables, figures and illustrations. Preparation of Manuscript Each of the following sections of the manuscript should be typed on separate pages. Title Page should include (in Turkish when possible): (a) title of the article in a concise but informative style, (b) first name, middle initial, last name of each author, (c) name of department(s) and institution(s) to which the work should be attributed, (d) name and address of author responsible for correspondence for the manuscript, (e) name and address of author to whom requests for reprints should be addressed, (f) source(s) of support in the form of grants, equipments, drugs, etc., and (h) short running title of no more than 40 characters. Authorship: Each author should have participated sufficiently in the work to take public responsibility for the content. Any part of an article critical to its main conclusions must be the responsibility of at least one author. Abstract and Key Words: The second page should include an Abstract which does not exceed 500 characters. For manuscripts sent from Turkey, a title and abstract in Turkish are required. The abstract should state the purpose of the study or investigation, basic procedures, methods, main findings, specific data, statistical significance and the principal conclusions. Provide to 5 key words below the abstract to assist indexers. Use terms from the Medical Subject Headings List of Index Medicus (www.nlm.nih.gov/ mesh/mbrowser.html) The text should be divided into sections with headings as follows: Introduction, Materials and Methods, Results and Discussion. Other types of articles such as case reports, reviews, perspectives and editorials will be published according to uniform requirements. Introduction: State the purpose of the article and summarize the rationale for the study. Materials and Methods: Describe your selection of the observational or experimental subjects clearly. Identify the methods and procedures in sufficient detail to allow other workers to reproduce the results. Give references to established methods (including statistical methods), provide references and brief modified methods, give reasons for using them and evaluate their limitations. Identify all drugs and chemicals used, including generic name(s), dose(s) and route(s) of administration. Statistics: Describe statistical methods in enough detail to enable a knowledgeable reader with access to the original data to verify the reported results. Give details about randomization, describe treatment complications, give number of observations, and specify any computer program used. Ethics: When reporting experiments on human subjects indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation. Do not use patient names, initials, or hospital numbers, especially in any illustrative material. Results: Present your results in logical sequence in the text, tables and illustrations. Do not repeat in the text all the data in the tables or illustrations; emphasize or summarize only important observations. Discussion: Emphasize the new and important aspects of the study and the conclusions that follow them. Link the conclusions with the goals of the study but avoid unqualified statements and conclusions not completely supported by your data. Acknowledgements: On a separate page after the completion of the Discussion section, one or more statements should mention, if necessary, (a) contributions that require acknowledgement but do not justify authorship, (b) any technical help, and (c) financial and material support, specifying the nature of the support. References: Identify references in text, tables and legends by Arabic numerals in parentheses. Number references consecutively in the order in which they are first mentioned in the text. The titles of the journals should be abbreviated according to the style used in 6

Index Medicus; consult List of Journals Indexed in Index Medicus. Include among the references any papers accepted but not yet published, designating the journal and followed by in press. Articles in Journals. Lists all authors Halpern SD, Ubel PA, Caplan AL. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 00;47:84-7.. Organization as author Diabetes Prevention Program Research Group. Hypertension, insulin, and proinsulin in participants with impaired glucose tolerance. Hypertension. 00;40(5):679-86.. No author given st century heart solution may have a sting in the tail. BMJ. 00;5(757):84. 4. Article not in English (Note: NLM translates the title into English, encloses the translation in square brackets, and adds an abbreviated language designator.) Ellingsen AE, Wilhelmsen I. Sykdomsangst blant medisin- og jusstudenter. Tidsskr Nor Laegeforen. 00;(8):785-7. 5. Volume with supplement Geraud G, Spierings EL, Keywood C. Tolerability and safety of frovatriptan with short- and longterm use for treatment of migraine and in comparison with sumatriptan. Headache. 00;4 Suppl : S9-9. 6. Issue with supplement Glauser TA. Integrating clinical trial data into clinical practice. Neurology. 00;58( Suppl 7):S6-. 7. CD-ROM Anderson SC, Poulsen KB. Anderson s electronic atlas of hematology [CD-ROM]. Philadelphia: Lippincott Williams & Wilkins; 00. 8. Journal article on the Internet Abood S. Quality improvement initiative in nursing homes: the ANA acts in an advisory role. Am J Nurs [serial on the Internet]. 00 Jun [cited 00 Aug ];0(6):[about p.]. Available from: http://www.nursingworld.org/ajn/00/june/ Wawatch.htm 9. Homepage/Web site Cancer-Pain.org [homepage on the Internet]. New York: Association of Cancer Online Resources, Inc.; c000-0 [updated 00 May 6; cited 00 Jul 9]. Available from: http://www. cancer-pain.org/. 0. Part of a homepage/web site American Medical Association [homepage on the Internet]. Chicago: The Association; c995-00 [updated 00 Aug ; cited 00 Aug ]. AMA Office of Group Practice Liaison; [about screens]. Available from: http://www.ama-assn.org/ama/ pub/category/76.html. Database on the Internet Open database: Who s Certified [database on the Internet]. Evanston (IL): The American Board of Medical Specialists. c000 - [cited 00 Mar 8]. Available from: http://www.abms.org/newsearch.asp Closed database: Jablonski S. Online Multiple Congential Anomaly/Mental Retardation (MCA/MR) Syndromes [database on the Internet]. Bethesda (MD): National Library of Medicine (US). c999 [updated 00 Nov 0; cited 00 Aug ]. Available from: http://www.nlm.nih.gov/mesh/jablonski/syndrome_title.html Tables Type each table on a separate sheet. Number tables consecutively in the order of appearance in the text and supply a brief title for each. Give each column a short or abbreviated heading. Place explanatory statistical measures of variations such as standard deviation or standard error of mean. Be sure that each table is cited in the text. Illustrations Figures should be professionally drawn and photographed. Please send sharp, glossy, black and white photographic prints, usually 9 x cm. Affix a label to the back of each figure indicating the number of the figure, first author's name and top of the figure. Type legends for illustrations double-spaced, starting on a separate page with Arabic numerals corresponding to the illustrations. Explain the internal scale and identify method of staining. Units of Measurement Measurements should be reported in the metric system in terms of the International System of Units (SI). Consult SI Unit Conversion Guide, New England Journal of Medicine Books 99, when necessary. Abbreviations and Symbols Use only standard abbreviations. Avoid abbreviations in the title and abstract. The full term for which an abbreviation stands should precede its first use in the text unless it is a standard abbreviation. 7

EMEKL L E AYRILAN ÜYELER M Z Studies in Genetics Prof. Dr. Gündüz GEDİKOĞLU and Our Children Leukemia Foundation Education Dr. Gediko lu had his high school education in Isik Lisesi (Istanbul) and thereafter, he entered the Istanbul Faculty of Medicine in Istanbul University. After obtaining the medical doctor degree, he did his military service in the Field Officer School of the Sixth Army in Smyrna; and he had the first position while finishing the military service. He was accepted to the Baylor University in Houston to perform a residency in pediatrics. He did his subspecialty in Pediatric Hematology and Oncology in St. Paul Hospital and in the Wadley Research Center. He was accepted into the Cardiff University to perform research in genetics with the grand of the British Council. He transferred his experience in Cardiff to perform research in Istanbul Faculty of Medicine. Heterochromasy in Human Chromosomes Until 966, existence of the heterochromatic regions in the chromosomes was well known in plants and animals, yet there was no information regarding to their presence in human chromosomes. First in 966, Dr. Gediko lu observed such regions in chromosomes of a -years old Caucasian male bearing Wilson disease independent of the disease and published these observations in Lancet. New Observations in Kartagener s Disease In 9, Kartagener described a new syndrome comprised of a symptoms trio of dextrocardia, bronchiectasis and sinusitis; and therefore, this syndrome is named as Kartagener s triad or syndrome. New research confirmed that this disease phenotype may associate with multiple chromosomal regions. Most frequently, the dynein axonemal intermediate chain protein locus (9p-p) exerts mutations; yet 5p and 9q anomalies are also linked with the similar disease phenotypes. In 967, Dr. Gediko lu described new findings in a sibling born from nephew-parents with Kartagener symptoms. While documenting the existence of fibrocystic lung disease in both patients, and the eosinophilic infiltration in the sinonasal epithelium as a novel finding; he also described isolated green color blindness (deuteranopia) in one of the siblings and published these clinical data again in Lancet (). Isolated color blindness could be the first sign of degenerative eye diseases with progressive rode-cone injury (64) and one gene causing one of such diseases, the retinitis pigmentosa is localized also in 9q similar to the gene of Kartagener s (65, 66). Only very recently, it is found that the motile flagellum and the immotile sensory cilia can bear the same structural proteins (67); and in 00 Kartagener s syndrome-accompanying retinitis pigmentosa is described (68). 9

Chromosomal abnormalities and Large Y Chromosomes in Thalassemia Major Dr. Gediko lu was the first investigator observing that abnormally large Y chromosomes are found with greater frequency in the caryotypes of thalassemia major-bearing patients (4, 5, 6, 7). In one thalassemia family reported by Dr. Gediko lu, there were two thalassemia major cases, and one thalassemia minor case and only the disease phenotype-carrying patients had large Y anomaly (6). There are no genes related to the hemoglobin metabolism and there exist many repeating nonsense sequences on that chromosome; thus, for many years these findings lacked any relevant explanation. Much later than these studies, it is established that the thalassemia-accompanying Y chromosome abnormalities are related with the African origin and migration pattern of the disease (). Clinical Cytogenetic Studies of Dr. Gediko lu Klinefelter syndrome with the rare XXXXY (n-49) chromosome-constitution as the ninth reported case at the world (7), Mongolismus-Turner combination (8), minor deletions in the long arm of the chromosomes in Mongolismus (9) were detected first in Turkey with caryotype research of Dr. Gediko lu. Dominance of the Blood Group type 0 in duodenal ulcer and and the accompanying existence of the minor chromosome breakages despite the normal caryotype (0), normal chromosomal patterning in the Blackfan-Diamond anemia (0), and the extensive chromatid breakage and the existence of achromatic regions in Fanconi anemia () were again reported by Dr. Gediko lu as fruits of his genetics research. Usage of Diazepam in Neonatal Tetanosis First in 964, Hendrickse proposed usage of diazepam in the treatment of neonatal tetanosis; yet until 97, the mortality ratio of neonatal tetanosis remained as high as around 90%. Dr. Gediko lu performed a research on that disease, in which he selected six newborn and two six years old patients as the investigation group and nine newborns and one six years old patients as the control group. He treated intensively both the investigation and the control group patients with heterologous tetanosis antitoxin + chlorpromazine + phenobarbitone + meprobamat; and added diazepam treatment (9 mg/kg) only to the therapy of the investigation group, which was at the early experimental stage for this indication on that years. Generalized spasticity, trismus, risus sardonicus, opisthotonus, sucking and swelling difficulties were at their latest stages in both groups before the treatment. The children, who were only treated with the standart treatment did not survive, yet all the investigation group children returned to their health in six to thirthy days (). Dr. Gediko lu underlined that diazepam exerted a profound inhibition on the general rigidity, spasm and convulsions, which was accompanied with a sedation and without any respiratory depression. Thus, according to his controlledstudy design, he proposed that diazepam acted via on motor neuron decharge, and published these results again in Lancet (). Roentgenological Studies on Pediatric Hematologic Diseases with Friedrich Reimann Dr. Gediko lu joined the research of Friedrich Reimann on roentgen studies of pediatric diseases. Together they described the metopismus in iron deficiency anemia (4), and firstly described panzer skull sign due to enlargement of cranial bones in compensatory hematopoesis of thalassemia major (5, 6). 0

Molecular and Immune Physiopathologic Studies It was known that autoimmune hemolytic anemia can arise during the course of bacterial (typhus) and viral diseases (influenza-a, coxsackievirus A, measles, varicella); yet its arousal due to vaccinations or due to different ethiologies in the same patient was not well described until 967. On that year, Dr. Gediko lu described a six years old case of autoimmune hemolytic anemia (AHA) with spontaneous onset and well remission with prednisolone. In this case, the hemolytic anemia was recurred after diphtheria-tetanosis-typhus vaccination, and again underwent remission with prednisolone. This case was the first strong indication that vaccinations could trigger high anti-erythroid responses in AHA-prone patients, which could make Coombs test as high as 4+, and which was published in Lancet (8). Dr. Gediko lu described the first Turkish cases of the Waardenburg syndrome () and the congenital leukemia (), and established the first immune electrophoretic investigations of pediatric viral hepatitis in Turkey. In 977, when the studies on Vitamin E and oxidant stress theory are at the emerging stage, he described iron dependent pancreatic beta-cell damage () and the protective function of Vitamin E against this injury (4) in Turkish thalassemic patients. He published the first international report about type IV glycogenosis in Turkey (), and performed research on ferritin-iron metabolism relations in ferropenic children and in workers of iron industry (). He first indicated the antimicrobial function of ovalbumin (=conalbumin) in gastroenteritis (4). He first applied intravenous acyclovir prophylaxis against varicella infections in pediatric oncology patients (5), and monitored pediatric ITP cases in Turkey (6). Editorial Work on the Translation of the Nelson Pediatrics, and Preparation of the Clinical Sciences Series for the Turkish Pyhsicians Dr. Gediko lu was the first to achieve the Turkish translation editions of Nelson Pediatrics as three volumes in 978; while working as the translation editor for all volumes, he also was personally responsible to translate the sections of the area of pediatrics (5), hematology (6) and convulsive diseases (7). He was one of the editors of Clinical Sciences [:In Turkish] series of 940 pages published by Cerrahpa a Faculty of Medicine in 99, and wrote the sections of pediatric growth and endocrinology (8), newborn diseases (9) and pediatric hematology (0). Review Articles and Contributions to the International Medical Books Dr. Robert Speer, who was the director of clinical chemistry in the Wadley Research Institute, had reviewed the first 0 years of cancer chemotherapy with Dr. Gediko lu (). Dr. Gediko lu also published his original research in internationally-edited books, such as in the Progress in Antimicrobial and Anticancer Chemotherapy edited by Kuemmerle and printed in West Germany in 988. In this book, he published Anti-Anti D immunoglobulin usage in the Rh incompatibility, the relations of prognoses with FAB classification and findings of extramedullary leukemia in 4 ALL cases, and the chromosomal findings in leukemia (7, 8, 9, 40, 4). Establishment of the Hematology Oncology Section under the Pediatrics Department and the Achievement of the Tumor Council and the Days of Pediatrics as New Concepts in Turkish Medicine Dr. Gediko lu pioneered the development of the Hematology and Oncology section under the Pediatrics Department in the Istanbul Faculty of Medicine, and also worked as the Director of the Oncology Institute at the Istanbul University; at this period he first achieved the establishment of the tumor council and the days of pediatrics. First in 97, he subdivided the malignant and non-malignant blood diseases and pediatric genetic diseases into different sections and floors at the Pediatry Clinics of the Istanbul Faculty of Medicine.

Establishment of the Our Children Leukemia Foundation Due to the essential need of a special place for leukemia treatment, the donations of the charitable and the patients relatives were organized under the patronage of the reverend prime minister Turgut Ozal and his dear wife Semra Ozal, the reverend Istanbul governor Nevzat Ayaz and his dear wife Sacide Ayaz in 980. The desolate roof of the Pediatrics building was reconstructed as the sixth floor and allocated to the Our Children Leukemia Foundation. The Health Establishment of Our Children Leukemia Foundation serviced for all pediatric diseases with special emphasis to the hematological diseases, leukemias and solid tumors of the pediatric age; and it was founded at the th of April in 980 and gained nominal personage via official registration of the 5th Principal Juristical Court of Istanbul at the 0 th of July in 98. Hematological Unit, which was founded at 986 with 5-bed capacities, continued to give medical service at its 000 square-meter settlement until 989. Our Children Leukemia Foundation has established the most forefront therapeutic modality service by opening the Bone Marrow Transplantation Unit at 989 with one-patient and one-donor bed; and expanded its capacity to eight-patient and one-donor bed in 994. Clinical Achivements of the OCLF Our Children Leukemia Foundation continued to give high quality medical service at its 000 square-meter settlement on a 4h/65 day and non-stop (shift) basis until 00. OCLF continues to serve the stem cell-transplanted patients via performing their routine examinations until today. In a years period, 9 chemotherapeutical treatments and 99 marrow stem cell transplantations were achieved, including the first pediatric marrow transplantation of Turkey, in 986. The general success rate of marrow transplantations was 70%, which was a good ratio in comparison to the world standart of 7%. Between October 988 and April 00, OCLF was the first institution with 88 cases of marrow transplantation among the total 479 transplants in Turkey. At that period, the whole pediatric transplant record of the Hacettepe University remained at patients. Among the 9 children, who received chemotherapy in OCLF, 80% of them are alive and healthy today; and the success rate in ALL LG has reached to 89.4%, which is between 80% and 90% in the developed countries. Moreover, considering the cost-effectivity, both the chemotherapy and transplantation costs were 5-times lower OCLF in comparison to the developed Western countries. Our Children Leukemia Foundation is awarded by the Directorate of the Charitable Funds of the Turkish Government as the Best-Working Foundation of the Health Sector in 998. Our Children Leukemia Foundation is awarded as The Foundation with The Best Public-Communication by the Communication Faculty of the Istanbul University in 998. Our Children Leukemia Foundation has attended to the EBMT-00, which was held in Montreux between and 7th March of 00. Among the attended 99 abstracts, the abstract prepared by the psychologists and doctors of the Our Children Leukemia Foundation has won the first prize. International Professors and Institutions visiting OCLF & EBMT Congress of 000 under the OCLF patronage Prof. Donald Edward Thomas, Nobel laurate of physiology and medicine in 97, came to OCLF for a scientific visit with the invitation of Dr. Gediko lu; and the European Bone Marrow Transplantation Society s annual congress of 000 was established in Istanbul under the pa-

tronage of OCLF. Many other prestigious members of the international hematology community, including the inventors of the desferrioxamin (Prof. Pippard) and the gamma-globulin (Prof. Hitzick) were also among the visitors of the OCLF. Research Achivements of OCLF Dr. Gediko lu described OCLF experiences of Aclacinomycin-A efficacy in acute leukemia (0) and the prognostic factors of acute lmyphoblastic leukemia (). He also described intraspinal hemorrhage in Factor XIII-deficiency (), performed cost-effectivity analysis of meslocillin-amikacin combination of the febrile neutropenia in pediatric oncology (46); and published treatment experiences in Ewing sarcoma (4) and rhabdomyosarcoma (74). Growth and puberty properties in thalassemia major-bearing children were investigated (5) and the first marrow transplantation results for Turkish thalassemia patients were reported (45). The likely relations between the Ara-C and staphylococcus superantigens (8), gingival histopathology of the leukemia (9), and the dental health care to reduce the septicemia risk in ALL (40) were again fruits of the basic and clinical research established in OCLF. First in vitro chemosensitivity tests in pediatric leukemia from Turkey (4) and reports on FLAG-IDA regime in relapsed or worse prognosis leukemia (44) were also succeeded with the experiences of the OCLF. OCLF also provided data for international work groups to identify new gene loci related to Griscelli Disease (7). OCLF and Dr. Gediko lu also monitored and reported rare accompanying symptoms such as hemophagocytosis of Griscelli Disease in international congresses (75). OCLF group also treated rare childhood malignancies with great success. A seven years old boy with no immune deficiency, cardiac involvement of an aggressive Non-Hodgkin lymphoma and cerebral stroke was successfully treated via three cycles of BFM-90 B-cell NHL protocol, triple intrathecal therapy (Mtx, Ara-C, HydroCortisone), and subsequent autologous stem cell transplantation with BEAM preparation (7). Such cases pioneered and forced the treatment of rare pediatric cancers with dismal prognosis in Turkey. OCLF is the first institution gaining EBMT accreditation for allogeneic marrow transplantation in Turkey; and its successes were awarded with the Distinguished Service Award of the Turkish State. Microbiologic Investigations performed in OCLF lead to significant scientific data OCLF provided detailed microbiologic analysis and screening for all its patients, and careful examination and monitoring of patient specimens revealed many firsts for Turkey. Cyclospora infection, which was reported to cause human disease first in 979 in USA, was reported first in Turkey in a patient of OCLF (7). As a clinical microbiological research, fungal etiological agents were investigated retrospectively in stool samples of 80 patients followed in OCLF to compare fungal flora of pediatric healthy volunteers and immunosuppressed patients. As a significant finding, non-albicans Candida species were found to be significantly higher and C. glabrata more prevelant in patients than in controls, which could guide for anti-fungal treatment selections in immune compromised children (50). Hemoglobinopathy/Anemia Screening Center Dr. Gediko lu also founded a thalassemia/hemoglobinopathy screening center in the place of OCLF with the extension of the scope to fight another frequent hematologic disease in Turkey causing profound morbidity and mortality. For the analysis of the routine erythrocyte indices, a conventional cell counter (Counter Gen-S) was applied, whereas levels of HbA and HbF were screened via fully automated cation exchange HPLC system. By performing mass analyses in the

Marmara district of Turkey, the prevalence of Beta-Thalassemia trait was found to be as high as 9.8% in comparison to the previously reported % based on much fewer patient numbers. In this center, Dr. Gediko lu s team also performed dermatoglyphics-based genetic characterization of other frequent anemias such as the Fanconi disease; and again the results of these studies were published in the international congresses (69, 70). OCLF Contribution to the Education Doctors working in OCLF have achieved residency training in Bakirkoy Maternity Hospital, Okmeydani State Hospital, Goztepe Education Hospital, Taksim First Aid Hospital, Dicle Medical Faculty, Zeynep Kamil Hospital and Kartal State Hospital. During its active working years, OCLF has also given grands to 0 medical students throughout their education. Laboratories of Biochemistry, Microbiology, Bone Marrow Freezing and Transfer, Apheresis and Thrombopheresis, Blood and Blood Products-Irradiation, Color Doppler Ultrasonography and of X-ray were serving at the same complex for OCLF patients. Besides, Child Psychology Services and continuing primary school education were provided in the OCLF. Hospital Project of the OCLF With the experience, know-how and experienced staff serving more than 5 years, OCLF defined its biggest project as the realization of a hospital construction, which would serve for all pediatric diseases and provide enough space for all patients. By the sentence of the National Estate Directorate of the Ministry of Finance with the resolution number 49 at the 8th May of 998, the landed property with a 5 square-meter size in Sisli district of Istanbul is assigned to Our Children Leukemia Foundation for 9 years. The easement on the immovable property, which is also mentioned by the land deed of the Sisli s. Deed Registry Directorate at the September 4 th of 00, has become absolute via being registered to the deed in favor of our Foundation. The permission for the beginning of the construction is given by the 5676 th resolution of the General Directorate of the Charitable Foundations at the th of March in 00. Recent Awards and the Scientific Projects of Professor Gediko lu Dr. Gediko lu and OCLF always provided support for the young investigators in the clinical and molecular medicine area. DNA polymorphism-based chimerism analysis in marrow transplantation (6), oxidative DNA damage in leukemia (7), wt (4), AML/ETO (4), and TEL- AML- (47) oncogene expression analyses in leukemia were published as the products of the Turkish medicine via the support of the OCLF. OCLF-based clinical data provided publications until 005, which were giving important results regarding a comparison of autologous and allogeneic transplantation results in ALL at the first complete remission (49). Melvin Jones Fellowship Dr. Gediko lu was awarded with the prize of the Melvin Jones fellowship of the International Rotary Club. Melvin Jones Fellowship is one of the important prizes given to the persons, who achieved extraordinary service for the society. Lynda Mc Cartney, wife of Paul Mc Cartney from Beatles won the same prize with her campaign for cleaning the land mines. From the scientific community, Donald Roy Bergsma working on the retinitis pigmentosa and the refractive ophthalmologic surgery, Lloyd McCarney working on the cornea epithelium, Guiseppe Grimaldi working on the neuro-psychiatric research and the mathematician Frank B Allen were the previous award winning persons from different countries. 4

Establishment of the Halic University With the aim of giving a wider educational and medical service, and also according to the existing aims and principals written on the trust indenture with its legislative code 44 at the 4th January 998, Our Children Leukemia Foundation has founded the Halic University of the Turkish Republic with special emphasis to the Health Sciences Institute and to the Medical Faculty. T.C. [Turkish Republic]- Halic University establishment was heralded in the official gazete at the 8th of January in 998, and it has began its academical life at the th November of 998. Today, TC-Halic University is successfully continuing education with over 500 students and with an instructor/professor framework of 50 employees. At the establishment act of the Halic University, the following faculties or institutions have been mentioned: Medical Faculty, Faculty of Arts and Sciences, Faculty of Engineering, Business Faculty, Nursing High-School, Conservatoire, Physical education and Sports High-School, Health Sciences Institute, Social Sciences Institute and Natural Sciences Institute. Currently, the hospital project is ongoing to realize the Medical Faculty; all the other faculties and institutions are realized with a growing success every year. Resources. Hill JM, Gedikoglu G, Speer RJ. 0 years of chemotherapy in leukemia. Southern Medical Jour (Austin, Texas), 96. Gedikoglu G. Heterochromatic human chromosome. Lancet 7477: 67, 966. Baris I, Sayili S, Gedikoglu G. Kartagener syndrome complex. Lancet 75: 67, 967 4. Gedikoglu G. Chromosome studies in twelve cases of thalassemia major. Proceedings of the Vth Congress of the Asian Pacific Society of Hematology. pp., 969 5. Gedikoglu G. Grand Chromosome Y dans le syndrome Thalassemique. Arch de L Union Med Al 4 : 680-68, 97 6. Gedikoglu G. Large Y Syndrome in Thalassemia Major. Med Bull Istanbul 5 : 50-54, 97 7. Gedikoglu G. Talasemi major vakalarında kromozom bulguları. Hematoloji Mecm : 4-49, 97 8. Gedikoglu G, Cantez T. Hemolytic anemia relapses after immunization and pertussis. Lancet 759: 894-895, 967 9. Gedikoglu A, Ones U, Kurdoglu G. Viral hepatitis and hemolytic anemia. Tip Fak Mecm : 509-, 969 0. Gedikoglu G, Ones U, Savas G. Blackfan-Diamond Sendromu. Tip Fak Mecm 6: 67-6, 97. Gedikoglu G, Tanman F, Ones U, Tari M, Savas G, Kurdoglu G, Ertugrul T. Fanconi Anemisi. Tip Fak Mecm 6: 60-607, 97. Gedikoglu G, Yalcin I, Aygen A, Cakin I. Diazepam in tetanus. Lancet 786: 454, 97. Nagel RL. Beta-globin-gene haplotypes, mitochondrial DNA, the Y-chromosome: their impact on the genetic epidemiology of the major structural hemoglobinopathies. Cell Mol Biol (Noisy-le-grand) 50: 5-, 004 4. Reimann F, Gedikoglu G, Talasli U. Metopism in iron deficiency disease. A roentgenological investigation. Rofo 9: 46-9, 978 5. Reimann F, Gedikoglu G, Ulukutlu L, Celik E. The effect of changes in the bones of the skull due to Mediterranean anaemia on the shape of the skull and the formation of the cranial cavity. Rofo : 65-6, 979 6. Reimann F, Gedikoglu G, Celik E, Ulukutlu L, Kilicozlu I. Deformity of the skull vault due to hypertrophy of red marrow in cases of Anaemia. Rofo 5: 0-4, 98 7. Gedikoglu G. A very rare case of Klinefelter syndrome with XXXXY (n-49) chromosome constitution. Med Bull Istanbul 0: 6-44, 967 8. Gedikoglu G, Bedir O, Tezel G, Saka C, Kiryasi V. Turner ve Mongolismus kombinasyonu, Balkan Tıp Kongresi, 968 9. Gedikoglu AG, Gurson CT. Cytological characteristics of mongolism. Tip Fak Mecm. 0: 45-5, 967 0. Gedikoglu G, Sezer R. Duodenum ülseri vakalarında hematolojik ve sitogenetik bulgular. Tip Fak Mecm 6: 504-509, 97. Gedikoglu G, Ones U, Cantez T, Ercikan C, Ozcan H. Waardenburg Syndrome. Proceedings of the IXth Turkish Pediatrics Congress, 970 5

. Gedikoglu G, Ones U. Etude immunoelectrophoretique de l hepatite virale. Arch de L Union Med Balc 8 : 57-58, 970. Koc L, Gedikoglu G. Beta cell functions of pancreas in beta thalassemia. Proceedings of the IVth Meeting of the International Society of Hematology European and African Division, pp. 95, Istanbul, 977 4. Gedikoglu G, Sidal M, Koc L, Yesilbek T. Intracellular levels of cholesterol, lipid, and of erythrocyte and blood serum levels of alpha tocopherol in beta thalassemia has been studied and compared with changes in same cases before and after Vitamin E administrations. Proceedings of the IVth Meeting of the International Society of Hematology European and African Division, pp. 9, Istanbul, 977 5. Pediatrinin Sahası Bölüm Çevirisi ve Cilt Çeviri Editörlü ü, Nelson Çocuk Hastalıkları (Pediatri), Victor C Vaughan, R James McKay, I.- Cilt, Güven Kitabevi Yayınları, 978 6. Kan Hastalıkları Bölüm Çevirisi ve Cilt Çeviri Editörlü ü, Nelson Çocuk Hastalıkları (Pediatri), Victor C Vaughan, R James McKay, II.- Cilt, Güven Kitabevi Yayınları, 978 7. Konvülsif Hastalıklar Bölüm Çevirisi ve Cilt Çeviri Editörlü ü, Nelson Çocuk Hastalıkları (Pediatri), Victor C Vaughan, R James McKay, III.- Cilt, Güven Kitabevi Yayınları, 978 8. Büyüme Geli me ve Endokrinoloji ve Tüm Klinik Bilimler Ciltleri için Editöryal: Kazancigil A, Gedikoglu G, Bayraktar K: Klinik Bilimler III. Cilt, Cerrahpa a Tıp Kitabevi, 99 9. Yenido an ve Hastalıkları ve Tüm Klinik Bilimler Ciltleri için Editöryal: Kazancigil A, Gedikoglu G, Bayraktar K: Klinik Bilimler III. Cilt, Cerrahpa a Tıp Kitabevi, 99 0. Pediatrik Hematoloji ve Tüm Klinik Bilimler Ciltleri için Editöryal: Kazancigil A, Gedikoglu G, Bayraktar K: Klinik Bilimler III. Cilt, Cerrahpa a Tıp Kitabevi, 99. Gedikoglu G, Sidal M, Ozsarfati J, Koc L. Delux cas de glycogenose type IV. Resumes de La XVIIIIé Semaine L Union Medicale Balcanique, pp. 6, Sofia, 98. Gedikoglu G, Koc L, Baran F. Correlation of serum ferritin and lead levels in ferropenic children and lead industrial workers. Proceedings of the VIIth Meeting of the International Society of Hematology- European and African Division, pp.649, Barcelona, 98. Koc L, Gedikoglu G, Demirkol M, Kinay M. La leucemia congenitale. II congress e entente medical meditteraneenne et VII session des journes medicale balcaniques. 0-Aout 4-Septembre, Selanique, Grece, 98 4. Gedikoglu G, Devecioglu O, Koc L, Anak S, Ang O. Studies on the antimicrobial activity of conalbumin in gastroenteritis. Proceedings of the Second Congress of the Meditteranean Society of Therapy, pp. 5, 986 5. Gedikoglu G, Anak S, Koc L, Devecioglu O. Intravenous acyclovir therapy for VZV infections in immune compromised children with oncologic disease. XIX Semaine Medicale Balcanique Resumes I, pp 7, 986 6. Koc L, Devecioglu O, Gedikoglu G, Anak S. Idiopathic thrombocytopenic purpura (ITP) in childhood. Danubian League Against Thrombosis and Hemorrhagic Diseases. Pp. 08, Istanbul 985 7. Gedikoglu G, Bilgen H, Kaya G, Anak S. Anti-Anti D Immunoglobulins for the treatment of Rhesus Hemolytic Disease, in Ed. Kuemmerle HP. Progress in Antimicrobial and Anticancer Chemotherapy, pp. 5-6, 988 8. Gedikoglu G, Agaoglu L, Devecioglu O, Anak S, Saglam A. A randomized study on Antibiotic Combinations Used for the Empiric Treatment of 89 Neutropenic-febrile Children with Oncological Diseases, in Ed. Kuemmerle HP. Progress in Antimicrobial and Anticancer Chemotherapy, pp. 60-604, 988 9. Devecioglu O, Anak S, Agaoglu L, Kinay M, Celik A, Gedikoglu G. Extramedullary leukemia in 4 Acute Lymphoblastic Leukemia (ALL), in Ed. Kuemmerle HP. Progress in Antimicrobial and Anticancer Chemotherapy, pp. 660-66, 988 40. Gedikoglu G, Agaoglu L, Devecioglu O, Anak S, Kinay M. Relationship of FAB and prognostic groups with the Outcome of 4 acute lymphoblastic leukemia (ALL) cases admitted to Istanbul University in 98-986, in Ed. Kuemmerle HP. Progress in Antimicrobial and Anticancer Chemotherapy, pp. 666-667, 988 4. Alpay II, Gedikoglu G, Agaoglu L, Anak S, Devecioglu O. Chromosomal abnormalities in acute lymphoblastic leukemia (ALL), in Ed. Kuemmerle HP. Progress in Antimicrobial and Anticancer Chemotherapy, pp. 668-669, 988 4. Anak S, Devecioglu O, Agaoglu L, Zulfikar B, Ayan I, Atilgan N, Yalman N, Bilgen H, Kaya G, Gedikoglu G. A study of various antibiotic combinations for the empiric treatment of neutropenic febrile children. Bone Marrow Transplant. 4 Suppl : 04, 989 4. Gedikoglu G, Zulfikar B, Anak S, Ayan I, Tuzun B, Ozgenc S, Devecioglu O, Agaoglu L. Aclacinomycin-A in the treatment of childhood acute leukaemia. Bone Marrow Transplant 4 Suppl : 4, 989 44. Gedikoglu G. Prognostic factors and treatment of acute lymphoblastic leukaemia (ALL)- Istanbul experience. Bone Marrow Transplant 4 Suppl : 8, 989 6

45. Ugur S, Uzel N, Dundar K, Kaya U, Ayan I, Gedikoglu G. Intraspinal hemorrhage in a child with factor XIII deficiency. Pediatr Emerg Care 7: -, 99 46. Zulfikar B, Devecioglu O, Anak S, Ovali F, Gedikoglu G. The efficacy of mezlocillin-amikacin combination in febrile neutropenic children with oncologic disease. J Chemother : 50-4, 99 47. Zulfikar B, Gedikoglu G. Ewing s sarcoma: experience with cases. J Chemother 4: 50-5, 99 48. Saka N, Sukur M, Bundak R, Anak S, Neyzi O, Gedikoglu G. Growth and puberty in thalassemia major. J Pediatr Endocrinol Metab 8: 8-6, 995 49. Ozbek U, Vural B, Kalayoglu S, Soysal T, Bilgen H, Yavuz S, Anak S, Sargin D, Gedikoglu G, Ferhanoglu B, Akoglu T, Tangun Y, Ozcelik T. Evaluation of chimerism with DNA polymorphisms in bone marrow transplantation. Turk J Pediatr 9: 0-, 997 50. Senturker S, Karahalil B, Inal M, Yilmaz H, Muslumanoglu H, Gedikoglu G, Dizdaroglu M. Oxidative DNA base damage and antioxidant enzyme levels in childhood acute lymphoblastic leukemia. FEBS Lett 46: 86-90, 997 5. Savasan S, Warrier I, Can E, Can M, Gedikoglu G. «Reaction to cytarabine (Ara-C) treatment in patients with concurrent Staphylococcus aureus infection: a coalition between Ara-C and superantigens?». Med Pediatr Oncol 0: 6-4, 998 5. Genc A, Atalay T, Gedikoglu G, Zulfikar B, Kullu S. Leukemic children: clinical and histopathological gingival lesions. J Clin Pediatr Dent : 5-6, 998 5. Sepet E, Aytepe Z, Ozerkan AG, Yalman N, Guven Y, Anak S, Devecioglu O, Agaoglu L, Gedikoglu G. Acute lymphoblastic leukemia: dental health of children in maintenance therapy. J Clin Pediatr Dent : 57-60, 998 54. Karakas Z, Agaoglu L, Erdem S, Anak S, Hacibektasoglu A, Gedikoglu G. MTT assay for drug resistance in childhood acute leukemia and effect of cyclosporin and interferon. A preliminary report. Adv Exp Med Biol 457: 45-9, 999 55. Ozgen U, Anak S, Ozbek U, Sarper N, Eryilmaz E, Agaoglu L, Devecioglu O, Yalman N, Gedikoglu G. wt gene expression in childhood acute leukemias. Acta Haematol. 0: 9-0, 000 56. Sarper N, Ozbek U, Agaoglu L, Ozgen U, Eryilmaz E, Yalman N, Anak S, Devecioglu O, Gedikoglu G. Is AML/ETO gene expression a good prognostic factor in pediatric acute myeloblastic leukemia? Pediatr Hematol Oncol 7: 577-8, 000 57. Yalman N, Sarper N, Devecioglu O, Anak S, Eryilmaz E, Can M, Yenilmez H, Agaoglu L, Gedikoglu G. Fludarabine, cytarabine, G-CSF and idarubicin (FLAG-IDA) for the treatment of relapsed or poor risk childhood acute leukemia. Turk J Pediatr 4: 98-04, 000 58. Gedikoglu G. Bone marrow transplantation in thalassemia. Bone Marrow Transplant. 8 Suppl :S0, 00 59. Agaoglu L, Devecioglu O, Anak S, Karakas Z, Yalman N, Biner B, Eryilmaz E, Goksan B, Unuvar A, Agirbasli H, Can M, Bilgen H, Gedikoglu G. Cost-effectiveness of cefepime + netilmicin or ceftazidime + amikacin or meropenem monotherapy in febrile neutropenic children with malignancy in Turkey. J Chemother : 8-7, 00 60. Devecioglu O, Yalman N, Biner B, Anak S, Agaoglu L, Unuvar A, Sarper N, Gedikoglu G. Reactivation: a severe problem in familial hemophagocytic lymphohistiocytosis. Pediatr Int 44: 0-5, 00 6. Ozbek U, Sirma S, Agaoglu L, Yuksel L, Anak S, Yildiz I, Devecioglu O, Timur C, Meral A, Gedikoglu G. Prognostic significance of the TEL-AML fusion gene in pediatric acute lymphoblastic leukemia in Turkey. J Pediatr Hematol Oncol 5: 04-8, 00 6. Anak S, Saribeyoglu ET, Bilgen H, Unuvar A, Karakas Z, Devecioglu O, Agaoglu L, Gedikoglu G. Allogeneic versus autologous versus peripheral stem cell transplantation in CR pediatric AML patients: a single center experience. Pediatr Blood Cancer 44: 654-9, 005 6. Agirbasli H, Ozcan SA, Gedikoglu G. Fecal fungal flora of pediatric healthy volunteers and immunosuppressed patients. Mycopathologia 59: 55-0, 005 64. Mantyjarvi MI. Color vision defect as first symptom of progressive cone-rod dystrophy. J Clin Neuroophtalmol 0: 66-70, 990 65. Evans K, al-maghtheh M, Fitzke FW, Moore AT, Jay M, Inglehearn CF, Arden GB, Bird AC. Bimodal expressivity in dominant retinitis pigmentosa genetically linked to chromosome 9q. Br J Ophtalmol 79: 84-6, 995 66. Nakazawa M, Xu S, Gal A, Wada Y, Tamai M. Variable expressivity in a Japanese family with autosomal dominant retinitis pigmentosa closely linked to chromosome 9q. Arch Ophtalmol 4: 8-, 996 67. Whitehead JL, Wang SY, Bost-Usinger L, Hoang E, Frazer KA, Burnside B. Photoreceptor localization of the KIFA and KIFB subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina. Exp Eye Res 69: 49-50, 999 7

68. Ohga H, Suzuki T, Fujiwara H, Furutani A, Koga H. A case of immotile cilia syndrome accompanied by retinitis pigmentosa. Nippon Ganka Gakkai Zasshi 95: 795-80, 00 69. Gedikoglu G, Ridolfi F, Yalman N, Anak S, Kokrek A, Can M. The prevalence of B-thalassemia traits in Istanbul, Turkey: a preliminary study, P0-0444. Proceedings of the Fourth Congress of the European Hematology Association, Barcelona-Spain, June 9-, 999 70. Polat MH, Ridolfi F, Yalman N, Gedikoglu G. Dermatoglyphics features in Fanconia Anemia, P0-08. Proceedings of the Fourth Congress of the European Hematology Association, Barcelona-Spain, June 9-, 999 7. Buget E, Buyukbaba BO, Kirkoyun UH, Agirbasli H, Yalman N, Anak S, Can E, Gedikoglu G. The first diarrhea case in Turkey caused by Cyclospora cayetanensis. J Turks Mic Soc 0: 6-65, 000 [In Turkish] 7. Pastural E, Ersoy F, Yalman N, Wulffraat N, Grillo E, Ozkinay F, Tezcan I, Gedikoglu G, et al. Two genes are responsible for Griscelli syndrome at the same 5q locus. Genomics 6: 99-06, 000 7. Anak S, Sarper N, Yalman N, Guler N, Gedikoglu G. Malignant lymphoma with cardiac involvement: A case report. Med Bull Istanbul : -6, 998 74. Karakas Z, Agaoglu L, Biner B, Devecioglu O, Anak S, Yalman N, Unuvar A, Celik A, Gedikoglu G. Results of rhabdomyosarcoma treatment in a developing country. Acta Med Okayama 54: 7-77, 000 75. Yalman N, Sarper N, Unal E, Devecioglu O, Anak S, Gedikoglu G. Griscelli Syndrome presenting with hemophagocytosis. Proceedings of the Fourteenth Annual Meeting of the Histiocyte Society, Kyoto-Japan, 998 8

Sevgi GÖZDAŞOĞLU Do um tarihi ve yeri: 940 Bursa Tabiyeti: Mesle i: Üniversite E itimi: Türk Tıp Doktoru Ankara Üniversitesi Tıp Fakültesi, 957-96 Uzmanlık E itimi: 96-967 Ankara Üniversitesi, Çocuk Sa lı ı ve Hastalıkları Klini i nde Asistanlık 967-97 Pediatrik Hematoloji ve Onkoloji Departmanı nda Ba asistanlık Akademik Kariyer: 97 Pediatri Doçenti 980 Pediatri Profesörü 994-000 Ankara Üniversitesi Hematoloji ve Onkoloji Ara tırma Merkezi Ba kanı 995-999 TÜB TAK, Pediatrik Lösemi ve Lenfoma Ünitesi Ba kanı 000-006 Pediatrik Hematoloji Bilim Dalı Ba kanı Yayınları: Yabancı dilde yayın sayısı: 97 Uluslararası kongre özet sayısı: Türkçe yayın ve kongre özet sayısı: 00 den fazla Ulusal ve Uluslararası Dernek Üyelikleri:. Türk Hematoloji Derne i. Mediterranean Blood Club. International Society of Hematology 4. International Society of Pediatric Oncology 5. Türk Kemoterapi Derne i 6. European Society of Pediatric Hematology and Immunology 7. ASCO 8. EHA 9. Çocuk Sa lı ı ve Hastalıkları Ara tırma Vakfı 9

Prof. Dr. Gönül HİÇSÖNMEZ Prof. Dr. Gönül Hiçsönmez, 97 yılında Ka da do mu, 96 yılında Ankara Üniversitesi Tıp Fakültesi nden mezun olmu tur. Dr. Hiçsönmez, 965 yılında Hacettepe Üniversitesi Tıp Fakültesi nde, Çocuk Sa lı ı ve Hastalıkları Uzmanlık Derecesi ni almı, aynı fakültede 970 yılında doçentli e, 975 yılında profesörlü e yükselmi tir. 97-97 yılları arasında St. Jude Children s Cancer Research Hospital da çalı mı ve daha sonraki yıllarda, ya haddinden emekli oldu u 004 yılına kadar, çalı malarına Hacettepe Üniversitesi Tıp Fakültesi Pediatrik Hematoloji bölümünde devam etmi tir. Prof. Dr. Hiçsönmez, 978-979 hsan Do ramacı Bilim ödülü, 997-998 Hacettepe Bilim ödülü ve 999 TÜB TAK Bilim Ödülü nü almı tır. Ulusal ve Uluslararası çe itli derneklerin üyesi olup, halen, uzun yıllar emek verdi i Lösemili Çocuklara Yardım Tedavi ve Dayanı ma Derne i nin ba kanlık görevine devam etmektedir. Evli, iki çocu u vardır. 0