Adı Soyadı: Elif Damla Arısan Doğum Tarihi: 22 Mart 1977 Öğrenim Durumu: ÖZGEÇMİŞ VE ESERLER LİSTESİ Derece Bölüm/Program Üniversite Yıl Lisans Biyoloji Öğretmenliği Marmara Üniversitesi 1999 Y. Lisans Tıbbi Biyoloji ve Genetik Marmara Üniversitesi 2003 Doktora Biyolojik Bilimler ve Sabancı Üniversitesi 2009 Hayat boyu eğitim programı Biyomühendislik Tıp Fakültesi, Küresel Eğitim Programı, Kanser Biyolojisi ve Terapotikleri Harvard Üniversitesi Yüksek Lisans Tez Başlığı (özeti ekte) ve Tez Danışman(lar)ı: 2016-2017 Farklı tip ve evrelerdeki lösemilerde poliamin biyosentez ve katabolizma mekanizmasının incelenmesi Prof. Dr. Beyazıt Çırakoğlu Doktora Tezi/S.Yeterlik Çalışması/Tıpta Uzmanlık Tezi Başlığı (özeti ekte) ve Danışman(lar)ı : Molecular mechanism of drug induced apoptosis and chemoresistance in estrogen receptor alpha +/- breast cancer cell lines: MCF-7 and MDA-MB-231 Prof. Dr. S. Hüveyda Başağa Görevler: Görev Unvanı Arş.Gör. Arş.Gör. Uzman Öğrt. Gör. Arş. Gör Öğrt. Gör. Görev Yeri Fen Fakültesi, Biyoloji Bölümü, Botanik ABD, İstanbul Üniversitesi Fen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, Haliç Üniversitesi Fen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, Haliç Üniversitesi Fen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, Haliç Üniversitesi Fen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, İstanbul Kültür Üniversitesi Fen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, İstanbul Kültür Üniversitesi Yıl 1999-2001 2001-2003 2003-2004 2004-2006 2006-2008 2008-2010 1
Yard.Doç. Doç Fen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, İstanbul Kültür Üniversitesi Fen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, İstanbul Kültür Üniversitesi 2010-2012 2012- Yönetilen Yüksek Lisans Tezleri : Pelin Özfiliz, Eş danışman İstanbul Teknik Üniversitesi, Moleküler Biyoloji ve Genetik Yüksek Lisans Programı Özge Berrak, İstanbul Kültür Üniversitesi, Moleküler Biyoloji ve Genetik Yüksek Lisans Programı Çağrı Gümüşkaptan, İstanbul Kültür Üniversitesi, Moleküler Biyoloji ve Genetik Yüksek Lisans Programı Şenay Dursun, İstanbul Kültür Üniversitesi, Moleküler Biyoloji ve Genetik Yüksek Lisans Programı Ayça Ece Nezir, İstanbul Kültür Üniversitesi, Moleküler Biyoloji ve Genetik Yüksek Lisans Programı Yönetilen Doktora Tezleri/Sanatta Yeterlik Çalışmaları : Özge Berrak, Yeditepe Üniversitesi, Fen Bilimleri enstitüsü eş danışmanlık Pelin Özfiliz, İstanbul Teknik Üniversitesi, Fen Bilimleri enstitüsü, eş danışmanlık Projelerde Yaptığı Görevler : 1. Obezite tedavisinde kullanılan orlistat ın prostat kanseri PC3 ve PNT1A hücre hatlarında AMPKa hedefi ile ilişkili global protein düzeylerinin 2d-DIGE yöntemi ile tanımlanması, 116Z804 TÜBİTAK 1002, Yürütücü 2. European Molecular Biology Organization (EMBO) Networking Grant for COST-GENiE BM1408, Tubitak Proje No: 115Z037 (Araştırmacı) 3. Epibrassinolid ve(ya) roskovitin in potansiyel GSK3b inhibitörü olarak Caenorhabditis elegans modelinde moleküler hedeflerinin terapotik açıdan incelenmesi (COST Action BM1408 (GENIE), Proje no: 115Z037, 2015-2018, Araştırmacı) 4. Epibrassinolidle Tetiklenen Hücre Ölümünün Endoplazmik Retikulum Stresi İle İlişkisinin Kolon Kanseri Hücre Hatlarında Araştırılması (3001-TÜBİTAK Başlangıç Ar-Ge Projeleri Destekleme Programı, 113Z845, 2014-2016, Araştırmacı) 2
5. Curcumin in terapotik etkinliğinin otokrin büyüme hormonu sinyal yolağı aracılığı ile farklı meme kanseri hücrelerinde poliamin metabolizması irdelenerek incelenmesi (1001-TÜBİTAK KBAG- Proje No: 113Z791, 2014-2017, Araştırmacı) 6. Kolon Karsinoma Hücrelerinde Epibrassinolid Tarafından Tetiklenen Apoptotik Süreçte Poliaminlerin Rolü (TÜBITAK, Hızlı Destek Projesi, 212T168, 2013-2014 Bursiyer) 7. Farklı Prostat Kanseri Hücre Hatlarında Epibrassinolidle Tetiklenen Apoptotik Süreçte Poliaminlerin Rollerinin Araştırılması (Doktora Tezi, İstanbul Üniversitesi BAP Projesi, 20958, 2012-2014, Araştırmacı) 8. CDK Inhibitörü Roskovitin Tarafından Tetiklenen Apoptotik Yolakta Poliamin Katabolizmasının Rolünün LNCaP, DU145 Ve PC3 Prostat Kanseri Hücre Hatlarında İncelenmesi (TÜBİTAK 1002, Hızlı Destek Projesi, 210T107, 2010-2011 Araştırmacı) 9. Cdk Inhibitörü Purvalanolün (CYC 202) Meme Kanseri Hücrelerindeki (MCF-7) Etkisinin Apoptotik Sinyal Molekülleri ve Poliamin Parametreleri Ile Araştırılması (İstanbul Kültür Üniversitesi, Arastırmacı, 2009-2010) 10. Cdk Inhibitörü Roskovitinin (CYC 202) Meme Kanseri Hücrelerindeki (MCF-7) Etkisinin Apoptotik Sinyal Molekülleri ve Poliamin Parametreleri ile Araştırılması (İstanbul Kültür Üniversitesi, Araştırmacı, 2008-2009) 11. 01.03.2011-01.03.2012- Cdk Inhibitörü Roskovitin Tarafından Tetiklenen Apoptotik Yolakta Poliamin Katabolizmasının Rolünün LNCaP, DU145 Ve PC3 Prostat Kanseri Hücre Hatlarında Incelenmesi (TBAG Hızlı Destek, Proje Yürütücüsü) KARİYER TÜBİTAK Projesi, 36 ay 12. 01.01.2006-01.01.2007- Human prostate specific glandular kalikrein 2 and entothelial nitric oxide synthase gene polymorphism: Modelling in Turkish prostate cancer patients (Terry Fox Araştırma Desteği, Proje Yürütücüsü) Diğer Projeler TÜBİTAK 1512 Programı BİGG destekleri İTU Teknokent Çekirdek üyeliği, DAPGenomics mirna Hunters programı Sertifikalar: KOSGEB Uygulamalı Girişimcilik Eğitimi Duke Üniversitesi online Sinir Bilim 3
İdari Görevler : 2017- İstanbul Kültür Üniversitesi, Teknoloji ve Proje Destek Birimi Koordinatörü 2016- İstanbul Kültür Üniversitesi, Kalite Komisyonu Üyesi 2012-2017 İstanbul Kültür Üniversitesi, Proje Geliştirme ve Koordinasyon Birimi Koordinatörü 2012- İstanbul Kültür Üniversitesi, Moleküler Biyoloji ve Genetik Bölümü, Bölüm Başkan Yardımcısı 2010-2012 İstanbul Kültür Üniversitesi, Avrupa Birliği Çerçeve Projeleri, LEAR kişisi 2007- İstanbul Kültür Üniversitesi, Moleküler Biyoloji ve Genetik Bölümü ERASMUS koordinatörü 2005-2006 HÜSEM Genel kurul üyesi 2005-2006 Haliç Üniversitesi, Fen-Edebiyat Fakültesi Genel Sekreteri 2004-2006 Haliç Üniversitesi, Fen Bilimleri Enstitüsü Genel Sekreteri Bilimsel Kuruluşlara Üyelikler: 2010- Moleküler Kanser Araştırmaları Derneği 2006-2008 European Cell Death Organization 2006-2009 European Urological Association Ödüller : 2016 H2020 Eşik üstü ödülü 2016- İstanbul Kültür Üniversitesi, Akademik Başarı Ödülü 2015- İstanbul Kültür Üniversitesi, Akademik Başarı Ödülü 2014- İstanbul Kültür Üniversitesi, Akademik Başarı Ödülü 2013- İstanbul Kültür Üniversitesi, Akademik Başarı Ödülü 2012- İstanbul Kültür Üniversitesi, Akademik Başarı Ödülü 4
2011- İstanbul Kültür Üniversitesi, Akademik Başarı Ödülü 2010- İstanbul Kültür Üniversitesi, Akademik Başarı Ödülü 2009- İstanbul Kültür Üniversiesi Akademik Başarı Ödülü 2009- Sabancı Üniversitesi, Dr. Gürsel Sönmez Araştırma Ödülü 2008- İstanbul Kültür Üniversiesi Akademik Başarı Ödülü 2007- TÜBİTAK Bilimsel Yayınları Teşvik Ödülü-157051 2007- TÜBİTAK Bilimsel Yayınları Teşvik Ödülü-157050 2007- İstanbul Kültür Üniversitesi Akademik Başarı Ödülü, 2006- Avrupa Üroloji Kongresi, katılım ve ziyaret bursu 2001- İstanbul Üniversitesi BEKADEP proje desteği-b-429/13042000 Verdiği lisans ve lisansüstü düzeydeki dersler: Lisans Genel Biyoloji II Genel Biyoloji Laboratuvarı II Moleküler Mikrobiyoloji Lisansüstü Biyolojik sistemlerde serbest radikaller Hücre siklusu ve apoptoz 2D- ve 3D hücre kültürü Moleküler Mikrobiyoloji Laboratuvarı Moleküler Biyoloji Teknikleri II Kök Hücre Biyolojisi Nutrigenomik Moleküler Evrim Biyoinformatik Doku Mühendisliği Epigenetiğe Giriş Moleküler Kanser Biyolojisi II 5
ESERLER A. Uluslararası hakemli dergilerde yayımlanan makaleler : 1. Obakan-Yerlikaya P, Arisan ED, Coker-Gurkan A, et al. Calreticulin is a fine tuning molecule in epibrassinolide-induced apoptosis through activating endoplasmic reticulum stress in colon cancer cells. Molecular Carcinogenesis. 2017 Jan 23. doi: 10.1002/mc.22616. (Araştırma makalesi) 2. Zeynep Akyol, Ajda Çoker-Gürkan, Elif Damla Arisan, Pınar Obakan-Yerlikaya, Narçin Palavan-Ünsal. DENSpm overcame Bcl-2 mediated resistance against Paclitaxel treatment in MCF-7 breast cancer cells via activating polyamine catabolic machinery. Biomedicine & Pharmacotherapy. doi.org/10.1016/j.biopha.2016.11.016, 2016 (Araştırma makalesi) 3. Ozge Berrak, Elif Damla Arisan, Pinar Obakan-Yerlikaya, Ajda Coker-Gürkan, Narçin Palavan-Unsal. mtor is a fine tuning molecule in CDK inhibitors-induced distinct cell death mechanisms via PI3K/AKT/mTOR signaling axis in prostate cancer cells. Apoptosis. DOI: 10.1007/s10495-016-1275-9, 2016. (Araştırma makalesi) 4. Özge Berrak, Yunus Akkoç, Elif Damla Arısan, Ajda Çoker-Gürkan, Pınar Obakan- Yerlikaya, Narçin Palavan-Ünsal. The inhibition of PI3K and NFKB promoted curcumin-induced cell cycle arrest at G2/M via altering polyamine metabolism in Bcl-2 overexpressing MCF-7 breast cancer cells. Biomedicine & Pharmacotherapy, 77: 150 160, 2016. (Araştırma makalesi) 5. Obakan P, Barrero C, Coker-Gurkan A, Arisan ED, Merali S, Palavan-Unsal N. SILAC-based mass spectrometry analysis reveals that epibrassinolide induces apoptosis via activating endoplasmic reticulum stress in prostate cancer cells PLOS One, 10(9):e0135788. doi: 10.1371/journal.pone.0135788.), 2015 (Araştırma Makalesi) 6. Deniz Coskun*, Pinar Obakan*, Elif Damla Arisan, Ajda Çoker-Gürkan, Narçin Palavan- Ünsal Epibrassinolide alters PI3K/MAPK signaling axis via activating Foxo3a- induced mitochondria-mediated apoptosis in colon cancer cells Experimental Cell Research, DOI: 10.1016/j.yexcr.2015.08.015, 2015 (Araştırma Makalesi) 7. Ozfiliz P, Kizilboga T, Demir S, Alkurt G, Palavan-Unsal N, Arisan ED, Dinler-Doganay G. Bag-1 promotes cell survival through c-myc-mediated ODC upregulation that is not preferred under apoptotic stimuli in MCF-7 cells. Cell Biochem Funct. 2015 Jul;33(5):293-307. doi: 10.1002/cbf.3114. Epub 2015 Jul 15. 6
8. Coker-Gurkan A, Arisan ED, Obakan P, Akalin K, Ozbey U, Palavan-Unsal Purvalanol induces endoplasmic reticulum stress mediated apoptosis and autophagy in a time dependent manner in HCT116 colon cancer cells Oncology Reports. Jun;33(6):2761-70, 2015 (Araştırma Makalesi) 9. Obakan P, Yildirim S, Ozturk MB, Berrak O, Coker-Gurkan A, Arisan ED, Palavan- Unsal N. CDK inhibitors-induced SSAT expression requires NFĸB and PPARƔ in MCF-7 breast cancer cells. Turkish Journal of Biology (DOI: BIY-1501-18, 2015) (Araştıma Makalesi) 10. Yunus Akkoç, Ozge Berrak, Pinar Obakan, Ajda Çoker-Gürkan, Elif Damla Arisan, Narçin Palavan Ünsal, Inhibition of PI3K signaling triggered apoptotic potential of curcumin which, is hindered by Bcl-2 through activation of autophagy in MCF-7 cells, Biomedicine & Pharmacotherapy, 2015 Apr;71:161-71, 2015 (Araştırma Makalesi) 11. Çoker-Gürkan A, Arisan ED, Obakan P, Palavan-Unsal N. Lack of functional p53 renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon cancer cells. Amino Acids. 47(1):87-100, 2015 (Araştırma Makalesi) 12. Coker-Gurkan A, Arisan ED, Obakan P, Ozfiliz P, Kose B, Bickici G, Palavan-Unsal N. Roscovitine-treated HeLa cells finalize autophagy later than apoptosis by downregulating Bcl 2. Mol Med Rep. 11(3):1968-74, 2015 (Araştırma Makalesi) 13. Elif Damla Arisan, Yunus Akkoç*, Kaan Gencer Akyüz*, Ezgi Melek Kerman*, Pinar Obakan, Ajda Çoker-Gürkan, Narçin Palavan Ünsal, Polyamines modulate roscovitineinduced cell death decision as autophagy or apoptosis in MCF-7 and MDA-MB-231 breast cancer cells, Mol Med Rep. 2015 Feb 4. doi: 10.3892/mmr.2015.3303). (Araştırma makalesi) 14. Pinar Obakan, Elif Damla Arisan, Ajda Çoker-Gürkan, Narçin Palavan Ünsal. Epibrassinolide induced apoptosis regardless of p53 expression via activating polyamine catabolic machinery, a common target for androgen sensitive and insensitive prostate cancer cells The Prostate, 74(16):1622-33, 2014 (Araştırma Makalesi) 15. Pinar Obakan, Gizem Alkurt, Betsi Köse, Ajda Çoker Gürkan, Elif Damla Arısan, Deniz Coşkun, Zeynep Narçin Ünsal. Downregulation of c-myc mediated ODC expression after purvalanol treatment is under control of upstream MAPK signaling axis in MCF-7 breast cancer cells, Turkish Journal of Biology (special issue Cancer: normal cells reply to a deadly fate) 38: 867-879, 2014 (Araştıma Makalesi) 7
16. Ajda Çoker-Gürkan, Elif Damla Arisan, Pinar Obakan, Esin Güvenir, Narçin Palavan Ünsal, Inhibition of autophagy by 3-MA potentiates purvalanol-induced apoptosis in Bax deficient HCT 116 colon cancer cells. Experimental Cell Research, 328(1):87-98, 2014 (Araştırma Makalesi) 17. Ajda Coker Gurkan, Deniz Coskun, E. Damla Arisan, Pinar Obakan, Baris Gungor, Narcin Palavan Unsal. Fetuin-A 742 (C/T) and 766 (C/G) polymorphic sitesare associated with increasing risk of myocardial infarction in older patients ( 40 years of age). Molecular Medicine Reports, 2015 Mar 20. doi: 10.3892/mmr.2015.3521. (Araştırma makalesi) 18. E. D. Arisan, P. Obakan, A. Çoker-Gürkan, A. Calcabrini, E. Agostinelli, N. Palavan Ünsal, CDK inhibitors induce mitochondria-mediated apoptosis through the activation of polyamine catabolic pathway in LNCaP, DU145 and PC3 prostate cancer cells. Current Pharmaceutical Design, 20: 180-188 (9), 2014 (Araştırma Makalesi) 19. Ozfiliz P, Arisan ED, Coker A, Obakan P, Eralp T, Doganay-Dinler G, Palavan-Unsal N. Bag-1L mediated chemoresistance mechanism through preventing downregulation of Mcl-1 and c-raf by heat shock proteins in HeLa cells. Asian Pacific Journal of Cancer Prevention, 2014; 15(11):4475-82 (Araştırma Makalesi) 20. P. Obakan, P. Ozfiliz, E.D. Arısan, A. Çoker-Gürkan, N. Palavan Ünsal, Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells, Molecular Biology Reports, 41(1):145-54, 2014 (Araştırma Makalesi). 21. P.Obakan, E.D. Arisan, A. Calcabrini, E. Agostinelli, S. Bolkent, N. Palavan-Unsal. Activation of Polyamine Catabolic Enzymes Involved in Diverse Responses Against Epibrassinolide-induced Apoptosis in LNCaP and DU145 Prostate Cancer Cell Lines, Amino Acids, 46(3):553-64, 2014 (Araştırma Makalesi) 22. Çoker-Gurkan, E. D. Arisan, P. Obakan, N. Palavan-Ünsal, Inhibition of polyamine oxidase prevented cyclin dependent kinase inhibitor-induced apoptosis in HCT116 colon carcinoma cells Apoptosis, 18(12):1536-47, 2013 (Araştırma Makalesi) 23. E. D. Arisan, P. Obakan, A. Çoker-Gürkan, A. Calcabrini, E. Agostinelli, N. Palavan Ünsal, CDK inhibitors induce mitochondria-mediated apoptosis through the activation of polyamine catabolic pathway in LNCaP, DU145 and PC3 prostate cancer cells. Current Pharmacological Design, 2013 8
24. A. Çoker-Gurkan, S. Arisan, E. D. Arisan, N.C. Sönmez, N. Palavan-Ünsal, Association between IL-1RN VNTR,IL-1 _ 511 and IL-6 ( 174, 572, 597) Gene Polymorphisms and Urolithiasis Urologia Internationalis, 2013 (Kabul edildi, Araştırma Makalesi) 25. A.Çoker, E.D. Arısan, Narcin Palavan-Unsal, "Silencing of polyamine catabolic key enzyme SSAT prevented CDK inhibitors induced apoptosis in Caco-2 colon cancer cells", Molecular Medicine Reports (ISI), 1037-1042 pp., 2012, DOI: 10.3892/mmr.2012.768 26. E. D. Arısan, A. Coker, P. Obakan, N. Palavan-Unsal, "Inhibition of ornithine decarboxylase altered the roscovitine-induced mitochondria mediated apoptosis in MCF- 7 breast cancer cells", Molecular Medicine Reports (ISI), 5(5):1323-9, 2012 (Araştırma Makalesi) 27. E.D.Arisan, A.Coker, N.Palavan-Unsal, "Polyamine depletion enhances the roscovitineinduced apoptosis through the activation of mitochondria in HCT116 colon carcinoma cells", Amino Acids (ISI), 2011, DOI: 10.1007/s00726-011-1040-x (Araştırma Makalesi) 28. S.Akyuz, A.E.Ozel, K.Balci, T.Akyuz, A.Coker, E.D.Arisan, N.Palavan-Unsal, A.Ozalpan, "Raman micro-spectroscopic analysis of cultured HCT116 colon cancer cells in the presence of roscovitine", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy A (ISI), 1540 1547 pp., 2011, DOI: 10.1016/j.saa.2011.01.046 (Araştırma Makalesi) 29. S.Akyuz, A.E.Ozel, K.Balci, T.Akyuz, A.Coker, E.D.Arisan, N.Palavan-Unsal, A.Ozalpan, "Raman micro-spectroscopic investigation of the interaction of cultured HCT116 colon cancer cells with alpha- difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase." Journal of Molecular Structure (ISI) 319-323 pp., 2011, DOI: 10.1016/j.molstruc.2011.01.04 (Araştırma Makalesi) 30. E.D.Arisan, O.Kutuk, T.Tezil, C.Bodur, D.Telci, H.Basaga, "Small inhibitor of Bcl-2, HA14-1, enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells", Breast Cancer Research and Treatment (ISI), 271-281 pp., 2010, DOI: 10.1007/s10549-009-0343-z (Araştırma Makalesi) 31. O.Kutuk, E.D.Arisan, T.Tezil, H.Basaga, "Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation", Carcinogenesis (ISI), 1517-1527 pp., 2009, DOI: 10.1093/carcin/bgp165 (Araştırma Makalesi) 32. N.Palavan-Unsal, D.Arisan, "Nitric oxide signalling in plants", Botanical Reviews (ISI), 203-229 pp., 2009, DOI: 10.1007/s12229-009-9031-2 (Derleme) 9
33. E.D.Arisan, S.Arisan, G.Atis, N.Palavan-Unsal, E.Ergenekon, "Adiponectin serum levels in prostate cancer patients", Urologia Internationalis (ISI), 203-208 pp., 2009, DOI: 10.1159/000200801 (Araştırma Makalesi) 34. N.Palavan-Ünsal, E.D.Arisan, S.Terzioğlu, "Polyamines in tea processing", International Journal of Food Sciences and Nutrition (ISI), 309-316 pp., 2007, DOI: 10.1080/09637480701228476 (Araştırma Makalesi) 35..Palavan-Unsal, E.D.Arisan, "Distribution of peroxidase activity and polyamine pattern of Heliotropium europeum in potassium deficiency conditions", International Journal of Environment and Pollution (ISI), 435-441 pp., 2007, DOI: 10.1504/IJEP.2007.014230 (Araştırma Makalesi) 36. N.Palavan-Unsal, S.M.Aloglu-Senturk, D.Arisan, "Polyamines and prostate cancer", Experimental Oncology, 1-9 pp., 2006 (Araştırma Makalesi) 37. S.Arisan, E.D.Buyuktuncer, N.Palavan-Unsal, T.Caskurlu, O.O.Çakır, E.Ergenekon, "Increased expression of EZH2, a polycomb group protein, in bladder carcinoma", Urologia internationalis (ISI), 252-257 pp., 2005, DOI: 10.1159/000087804 38. S.Arisan, T.Caskurlu, S.Guney, N.C.Sonmez, B.Keles, E.D.Buyuktuncer, E.Ergenekon, "The prognostic importance of e-cadherin and p53 gene expression in transitional bladder carcinoma patients", International Urology and Nephrology (ISI), 485-492 pp., 2005, DOI: 10.1007/s11255-005-0919-4 (Araştırma Makalesi) 39. N. Palavan-Unsal, D. Buyuktuncer, A. Efe, "Polyamine contents in Plantago species exhibiting different allergic significance", Biotechnology and Biotechnological Equipment, 96-100 pp., 2004 40. S.Cag, N.Palavan-Unsal, D.Buyuktuncer, "Comparison of the effect of meta-topolin and other cytokinins on chlorophyll and protein contents and peroxidase activity in cucumber cotyledons", Israel Journal of Plant Sciences (ISI), 261-265 pp., 2003, DOI: 10.1560/216M-053D-12UX-5DBQA B. Uluslararası bilimsel toplantılarda sunulan ve bildiri kitabında (Proceedings) basılan bildiriler : 1. Kaan Adacan, Pinar Obakan Yerlikaya, Elif Damla Arisan, Ajda Coker-Gurkan, Narcin Palavan-Unsal. Epibrassinolide controls polyamine levels to induce autophagy in Mouse Embryonic Fibroblasts, 4th International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives, September 4-9, 2016, Rome-Italy 10
2. Pinar Obakan, Elif Damla Arisan, Ajda Coker-Gurkan, Narcin Palavan-Unsal. Epibrassinolide Induced Apoptosis via Endoplasmic Reticulum Stress Regardless of p53 Expression in Prostate Cancer Cells, International Conference on Prostate Cancer, June 22-24, 2015, Florida, USA 3. Elif Damla Arisan, Çağri Gümüşkaptan, Özge Berrak, Pinar Obakan, Ajda Coker- Gurkan, Narcin Palavan Ünsal, Roscovitine treatment inhibited cell proliferation and induced apoptosis via modulating activity of Stat3 and Foxo1 under control of Akt in LNCaP prostate cancer cells, International Conference on Prostate Cancer, 22-24 June 2015, Florida USA. (Davetli konuşmacı) 4. K. Adacan, P. Obakan, E. D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal, EBR induced autophagy in colon carcinoma cell lines, 40th FEBS Congress, The Biochemical Basis of Life, P09-015, p:110, 4-9 July, 2015, Berlin, Germany. 5. O. Berrak, E. D. Arısan, P. Obakan, A. Coker Gurkan, N. Palavan Unsal Investigation the potential role of FoxO members in the purvalanol and roscovitine- induced autophagy in LNCaP and DU 145 prostate cancer cells, 40th FEBS Congress, The Biochemical Basis of Life, LB-081, p:383, 4-9 July, 2015, Berlin, Germany. 6. U. Ozbey, P. Obakan, E. D. Arisan, A. Coker Gurkan, N. Palavan-Unsal, EBR promotes p53 independent apoptosis in colon carcinoma cell lines, 40th FEBS Congress, The Biochemical Basis of Life, P11-028, p:227, 4-9 July, 2015, Berlin, Germany. 7. M. Celik, A. Coker Gurkan, E. Damla Arisan, P. Obakan, N. Palavan Unsal, Curcumin induced-apoptotic cell death in GH overexpressed MDA-MB-231 breast cancer in time dependent manner, 40th FEBS Congress, The Biochemical Basis of Life, P15-126, p:273, 4-9 July, 2015, Berlin, Germany. 8. Berna Somuncu*, Pinar Obakan, Ajda Coker-Gurkan, Elif Damla Arisan, Narcin Palavan Unsal, Endoplasmic reticulum stress induced both intrinsic/extrinsic pathway of apoptosis following epibrassinolide treatment in colon cancer cells 3rd AntiCancer Agent Development Congress, PP-011, p: 68, 18-19 Mayıs 2015, İzmir, Türkiye. 9. Busra Alper*, Ajda Coker-Gurkan, Elif Damla Arisan, Pınar Obakan, Narcin Palavan Unsal, The role of autocrine GH expression in the diferuloylmethane inducedapoptotic cell death in T47D breast cancer cells 3rd AntiCancer Agent Development Congress, PP-017, p:74, 18-19 Mayıs 2015, İzmir, Turkey. 10. Didem Baran*, Pinar Obakan, Ajda Coker-Gurkan, Elif Damla Arisan, Narcin Palavan- Unsal, Epibrassinolide-induced endoplasmic reticulum stress activated extrinsic 11
pathway of apoptosis in HCT116 Bax-/- colon carcinoma cell lines 3rd AntiCancer Agent Development Congress, PP-025, p: 82, 18-19 Mayıs 2015, İzmir, Turkey. 11. Gizem Damla Yalcın*, Elif Damla Arısan, Ajda Coker-Gurkan, Pınar Obakan, Deniz Coskun, Narcin Palavan-Unsal, Cox-2 inhibitor ibuprofen induced apoptosis via altering different signalling routes in HT-29 and DLD-1 colon cancer cells, 3rd AntiCancer Agent Development Congress, PP-054, p: 111, 18-19 Mayıs 2015, İzmir, Turkey. 12. Gulnihal Bozdag*, Elif Damla Arısan, Pınar Obakan, Ajda Coker-Gurkan, Deniz Coskun, Narcin Palavan-Unsal, NSAIDs, ibuprofen and diclofenac induced apoptosis via altering MAPKs and de novo protein synthesis regardless of COX-2 expression in SW480 colon cancer cells, 3rd AntiCancer Agent Development Congress, PP-059, p: 116, 18-19 Mayıs 2015, İzmir, Turkey. 13. Harbiye Hacıbektasoglu*, E. Damla Arisan, Ozge Berrak, Cagrı Gumuskaptan, Ajda Coker-Gurkan, Pınar Obakan, Narcin Palavan-Unsal, Investigation the role of CDK inhibitors on ER stress-mediated apoptosis in LNCaP prostate cancer cells, 3rd AntiCancer Agent Development Congress, PP-063, p: 120, 18-19 Mayıs 2015, İzmir, Turkey. 14. Sevilay Acar*, Ozge Berrak, Cagrı Gumuskaptan, Pınar Obakan, Ajda Coker-Gurkan, E. Damla Arısan, Forced Bcl-2 expression induced prevented roscovitine inducedautophagy via in PC3 cells 3rd AntiCancer Agent Development Congress, PP-112, p: 169, 18-19 Mayıs 2015, İzmir, Turkey. 15. Sinem Kadıoglu*, Ajda Coker-Gurkan, Merve Celik, Pınar Obakan, Elif Damla Arısan, Determination of Growth hormone (GH) and GH Releasing Hormone (GHRH) expression profile in breast cancer cell lines with different HER2/PR/ER genotype, 3rd AntiCancer Agent Development Congress, PP-114, p: 171, 18-19 Mayıs 2015, İzmir, Turkey. 16. Tugce Demirel*, Ajda Coker-Gurkan, Pınar Obakan, Elif Damla Arisan, Narcin Palavan Unsal, NF-κB and PPAR-" mediated diferuloylmethane induced apoptotic cell death in MCF-7 breast cancer cells in time dependent manner, 3rd AntiCancer Agent Development Congress, PP-121, p: 178, 18-19 Mayıs 2015, İzmir, Turkey. 17. Tugce Dogruel*, Ozge Berrak*, Elif Damla Arısan, Pınar Obakan, Ajda Coker Gurkan, Narcın Palavan Unsal, Purvalanol and roscovitine exert their apoptotic effect differently in terms of mtor downstream signalling route, 3rd AntiCancer Agent Development Congress, PP-123, p: 180, 18-19 Mayıs 2015, İzmir, Turkey. 12
18. Utku Ozbey*, Deniz Coskun, Pinar Obakan, Ajda Coker-Gurkan, Elif Damla Arisan, Narcin Palavan Unsal, Epibrassinolide induces p53-independent apoptosis in colon cancer cell lines, 3rd AntiCancer Agent Development Congress, PP-124, p: 181, 18-19 Mayıs 2015, İzmir, Turkey. 19. Zehragul Ergul*, Elif Damla Arisan, Deniz Coskun, Ajda Coker-Gurkan, Pınar Obakan, Narcin Palavan-Unsal, Non-steroidal anti-inflammatory drugs; ibuprofen and diclofenac are potent apoptotic inducers, which are altered PI3K/AKT/MAPK signalling axis in HCT 116 colon cancer cells 3rd AntiCancer Agent Development Congress, PP-131, p: 188, 18-19 Mayıs 2015, İzmir, Turkey. 20. Elif Damla Arisan, Özge Berrak, Pinar Obakan, Ajda Coker-Gurkan, Narcin Palavan- Unsal. mtor signaling alters cell fate following inhibition of cyclin-dependent kinases due to androgen receptor status in prostate cancer cells, International Journal of Molecular Medecine, The 19th World Congress on Advances in Oncology and 17th International Symposium on Molecular Medecine, 9-11 October 2014, Athens, Greece. 21. P. Obakan, E.D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal. Endoplasmic reticulum stress is involved in EBR-induced autophagy in colon cancer cell lines, First Joint Meeting of Nordic, Spanish & French Autophagy Networks, 15-18 September, 2014, Toulouse, France. (Poster sunumu) 22. Ajda Coker-Gürkan, Elif Damla Arisan, Pinar Obakan, Narcin Palavan-Unsal. Inhibition of autophagy enhanced DENSpm induced-apoptotic cell death in HCT 116 colon cancer cells, First Joint Meeting of Nordic, Spanish & French Autophagy Networks, 15-18 September, 2014, Toulouse, France. 23. E. Damla Arisan, Ozge Berrak, Pinar Obakan, Ajda Coker-Gurkan, Narcin Palavan Unsal. The combination of rapamycin with CDK inhibitors; purvalanol and roscovitine induces autophagy by modulating different mtor complexes in DU 145 prostate cancer cells, First Joint Meeting of Nordic, Spanish & French Autophagy Networks, 15-18 September, 2014, Toulouse, France. 24. Ajda Coker-Gürkan, Elif Damla Arisan, Pinar Obakan, Yunus Akkoc, Narcin Palavan- Unsal. Silencing of Atg-7 increased therapeutic efficiency of Curcumin, which activated both autophagy and apoptosis in MCF-7 wt breast cancer cells, First Joint Meeting of Nordic, Spanish & French Autophagy Networks, 15-18 September, 2014, Toulouse, France. 25. P. Obakan, E.D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal, ER stress is involved in Epibrassinolide-induced apoptotic cell death EACR Sponsored 2nd Anticancer Agents 13
Congress& 5th Mutlidisciplinary Cancer Research Congress, PP61, Sayfa: 147, 23-27 Nisan 2014, Bodrum, Türkiye, (Seçili Poster-Sözlü Sunum). 26..Ajda Çoker-Gürkan, Kübra Akalın, Utku Özbey, Elif Damla Arısan, Pınar Obakan, Narçin Palavan-Ünsal, Induction of Endoplasmic Reticulum (ER) stress-mediated apoptosis and autophagy by Purvalanol in HCT 116 colon cancer cells EACR Sponsored 2nd Anticancer Agents Congress& 5th Mutlidisciplinary Cancer Research Congress, PP13, Sayfa: 99, 23-27 Nisan 2014, Bodrum, Türkiye. 27. Deniz Coskun, Pınar Obakan, Elif Damla Arisan, Ajda Çoker Gürkan, Narcin Palavan- Unsal, Epibrassinolide-induced Apoptosis is Modulated by AKT-FOXO3a Signaling Pathway, EACR Sponsored 2nd Anticancer Agents Congress& 5th Mutlidisciplinary Cancer Research Congress, PP24, Sayfa: 110, 23-27 Nisan 2014, Bodrum, Türkiye. 28. Özge Berrak, Elif Damla Arisan, Pinar Obakan, Ajda Çoker-Gürkan, Narcin Palavan- Unsal, The combination of rapamycin with purvalanol and roscovitine induces autophagy through PI3K/AKT and Ras/Raf/Erk pathways regulation in DU 145 prostate cancer cells EACR Sponsored 2nd Anticancer Agents Congress& 5th Mutlidisciplinary Cancer Research Congress, PP57, Sayfa: 143, 23-27 Nisan 2014, Bodrum, Türkiye. 29. Pelin Özfiliz, Elif Damla Arısan, Pınar Obakan, Ajda Çoker-Gürkan, Gizem Dinler Doğanay, Narcin Palavan Ünsal, Silencing of Bag-1 enhanced the cisplatin or paclitaxelinduced apoptosis via regulating PI3K, Akt and MAPK signaling axis in MCF-7 breast cancer cells EACR Sponsored 2nd Anticancer Agents Congress& 5th Mutlidisciplinary Cancer Research Congress, PP59, Sayfa: 145, 23-27 Nisan 2014, Bodrum, Türkiye. 30. P. Obakan, E.D. Arisan, S. Bolkent, N. Palavan-Unsal. Epibrassinolide Induces Apoptosis by Targetting Polyamine Catabolism in LNCaP Prostate Cancer Cells, First International Congress of the Molecular Biology Association of Turkey, 23-24 November 2012, Istanbul-TURKEY. 31. O. Berrak, Y. Akkoc, P. Obakan, E.D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal. Effects of CDK Inhibitors and Rapamycin Combination on Autophagy With The Status of AR expression on Androgen Dependent LNCaP and Androgen Independent DU145 Prostate Cancer Cells, First International Congress of the Molecular Biology Association of Turkey, 23-24 November 2012, Istanbul-TURKEY. 32. D. Coskun, P. Obakan, E.D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal. Epibrassinolide Induced Apoptotic Cell Death in HCT116 and HT29 Colon Carcinoma cells, First International Congress of the Molecular Biology Association of Turkey, 23-24 November 2012, Istanbul-TURKEY. 14
33. Y. Akkoc, E.D. Arisan, A. Coker-Gurkan, P. Obakan, N. Palavan-Unsal. Understanding the Role of Bcl-2 in Curcumin induced Autophagic/Apoptotic Cell Death Mechanism in MCF-7 and MDA-MB-231 Breast Cancer Cells, First International Congress of the Molecular Biology Association of Turkey, 23-24 November 2012, Istanbul-TURKEY. 34. H. Ilhan, A. Coker-Gurkan, E.D. Arisan, P. Obakan, N. Palavan Unsal. N. Diethylnorspermine (DENSpm) Induced Apoptosis in SW480 Colon Cancer Cells, First International Congress of the Molecular Biology Association of Turkey, 23-24 November 2012, Istanbul-TURKEY. 35. P. Obakan, E.D. Arisan, A. Calcabrini, E. Agostinelli, S. Bolkent, N. Palavan-Unsal. Epibrassinolide Targets Polyamine Catabolism and Triggers Apoptosis in LNCaP, DU145 and PC3 Cell Lines. International Congress on Polyamines: Biological and Clinical Perspectives, 2-7 September 2012, Istanbul-TURKEY. (Seçili poster sözlü sunum) 36. S. Akyuz, T. Akyuz, P. Obakan, E.D. Arisan, S. Bolkent, N. Palavan-Unsal. FTIR Spectroscopic Investigation of The Effects of Polyamine Oxidase Inhibitor MDL 72527 on The Interaction of Epibrassinolide With Cultured LNCaP Prostate Cancer Cells. International Congress on Polyamines: Biological and Clinical Perspectives, 2-7 September 2012, Istanbul-TURKEY. 37. S. Yildirim, M.B. Ozturk, E.D. Arisan, P. Obakan, A. Coker-Gurkan, N. Palavan-Unsal. PPARγ is the Critical Upstream Factor in Cyclin-Dependent Kinase Inhibitors Roscovitine and Purvalanol A- Induced SSAT Upregulation in MCF-7 Cells. International Congress on Polyamines: Biological and Clinical Perspectives, 2-7 September 2012, Istanbul-TURKEY. 38. A. Coker-Gurkan, P. Obakan, E.D. Arisan, A. Calcabrini, E. Agostinelli, N. Palavan- Unsal. The Effect of Polyamine Catabolism Products on CDK Inhibitors-Induced on HCT116 wt and Bax -/- Colon Carcinoma Apoptotic Cell Death. International Congress on Polyamines: Biological and Clinical Perspectives, 2-7 September 2012, Istanbul- TURKEY. 39. B. Kose, G. Alkurt, A. Coker-Gurkan, E.D. Arisan, P. Obakan, N. Palavan-Unsal. ODC is a Mediator of the Purvalanol A-Induced Apoptotic Signaling via the p38 Mitogen- Activated Protein Kinase Pathway in MCF-7 Breast Cancer Cells. International Congress on Polyamines: Biological and Clinical Perspectives, 2-7 September 2012, Istanbul- TURKEY. 15
40. D. Coskun, P. Obakan, E.D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal. The Potential Role of Polyamines in EBR-Induced Apoptotic Cell Death in HCT116 Colon Carcinoma Cells. International Congress on Polyamines: Biological and Clinical Perspectives, 2-7 September 2012, Istanbul-TURKEY. 41. H. Ilhan, A. Coker-Gurkan, P. Obakan, E.D. Arisan, N. Palavan-Unsal. Timing is Critical in the Decision of Apoptosis or Autophagy by N1, N11-Diethylnorspermine (DENSpm) treatment in HCT116 Colon Cancer Cells. International Congress on Polyamines: Biological and Clinical Perspectives, 2-7 September 2012, Istanbul-TURKEY. 42. O. Irmak, E.D. Arisan, A. Coker-Gurkan, P. Obakan, N. Palavan-Unsal. The Role of Polyamine Catabolic Enzymes in Cisplatin-Induced Apoptotic Cell Death in MCF-7 Cells. International Congress on Polyamines: Biological and Clinical Perspectives, 2-7 September 2012, Istanbul-TURKEY. 43. E. D. Arisan, O. Berrak, P. Obakan, N. Palavan-Unsal. Cyclin Dependent Kinases Exert Their Apoptotic Potential By Acting on mtormediated Energy Signaling Cascade In The Presence Of Activated Polyamine Catabolism in LNCap, DU145 and PC3 Prostate Cancer Cells. International Congress on Polyamines: Biological and Clinical Perspectives, 2-7 September 2012, Istanbul-TURKEY. 44. Y. Akkoc, M. Celik, P. Obakan, A. Coker-Gurkan, E.D. Arisan, N. Palavan-Unsal. The Functional Role of Bcl-2 in the Regulation of Curcumin-Induced Autophagy/ Apoptotic Cell Death in MCF-7 Breast Cancer Cells. Apoptosis and Cancer, 14-15 June 2012,Cambridge- UK. 45. S.Katrinli, P.Ozfiliz, E.D.Arisan, G.Dinler-Doganay. Identification of Bag-1 interacting partners from MCF-7 human breast cancer cell lines, 4th International Congress of Molecular Medicine, 80-81 pp., 27-30 Haziran, Istanbul-Türkiye, 2011 (Poster sunum: S. Katrinli) 46. P. Obakan, E.D. Arisan, S. Bolkent, N. Palavan-Unsal. 24-Epibrassinolide Induces SSAT and Causes Caspase-Dependent Apoptosis In Different Prostate Cancer Cell Lines. Biogenic Amines: Biochemical, Physiological and Clinical Perspectives, September 21 25, 2011 Alberè di Tenna (Trento), ITALY. (Seçili poster sözlü sunum) 47. A.Coker, E.D.Arisan, N.Palavan-Unsal. Roscovitine modulated autophagic cell death related to polyamine metabolism in HCT-116 colon cancer cells. International Congress on Biogenic Amines: Biochemical, Physiological and Clinical Perspectives. 48 pp. 21 25 Eylül, Alberè di Tenna (Trento), İtalya, 2011 (Seçili poster sözlü sunum: A. Coker) 16
48. A.Coker, S.Arisan, D.Coskun, A.Yavuz, E.D.Arisan, N.C.Sonmez, N.Palavan-Unsal. Investigation of Fetuin-A SNP in urinary stone disease patients 4th International Congress of Molecular Medicine, 67pp., 27-30 Haziran, Istanbul-Türkiye, 2011 (Poster sunum: D. Coskun) 49. N. Palavan-Unsal, E.D. Arisan, P. Obakan, A. Coker, I. Ozdemir. Cyclin Dependent Kinase Inhibitors Modulates Polyamine Metabolism in MDA-MB-231 Cells, 2nd International Conference on the Role of Polyamines and their Analogs in Cancer and other Diseases, 1-6 December, 2010, Sapienza University of Roma, ITALY. 50. E.D. Arisan, P. Obakan, A. Coker, N. Palavan-Unsal. Investigation Of Purvalanol- Induced Apoptosis In MCF-7 Breast Cancer Cell Lines. 2nd International Conference on the Role of Polyamines and their Analogs in Cancer and other Diseases, 1-6 December, 2010, Sapienza University of Roma, ITALY. 51. N.Palavan-Unsal, E.D.Arisan, P.Obakan, A.Coker, I.Ozdemir. Cyclin dependent kinase inhibitors modulates polyamine metabolism in MDA-MB-231 cells. "2nd International Conference on the Role of Polyamines and their Analogs in Cancer and other Diseases 1-6 Aralık, Sapienza University of Roma, İtalya, 131 pp., 2010 (Sözlü sunum: N. Palavan Ünsal) 52. A.Coker, E.D.Arisan, N.Palavan-Unsal. Modulation of catabolic pathway in ROSC treated Caco-2 cells. "2nd International Conference on the Role of Polyamines and their Analogs in Cancer and other Diseases 199 pp., 1-6 Aralık, Sapienza University of Roma, İtalya, 2010 (Sözlü sunum: A. Coker) 53. S.Akyuz, A.E.Ozel, K.Balci, T.Akyuz, A.Coker, E.D.Arisan, N.Palavan-Unsal, A.Ozalpan. Micro Raman spectroscopic investigation of the interaction of cultured HCT116 colon cancer cells with alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase. EUCMOS 30th European congress on molecular spectroscopy with GISR, Floransa, İtalya, PS2-21, 107 pp., 2010 (Sözlü sunum: S. Akyuz) 54. P. Obakan, E.D. Arisan, N. Palavan-Unsal, A. Coker. Combined Treatment of Roscovitine and DFMO Induced Caspase Dependent Apoptosis in MCF-7 cells. 2nd International Conference on the Role of Polyamines and their Analogs in Cancer and other Diseases, 1-6 December, 2010, Sapienza University of Roma, ITALY. (Seçili poster sözlü sunum) 55. E.D. Arisan, N. Palavan-Unsal, P. Obakan. Investigation of Roscovitine (CYC202)- Induced Apoptosis Related With Polyamine Metabolism in MCF-7 Human Breast Cancer 17
Cell Line. IUBMB LIFE, 61: 370, 2009. III. Congress of Molecular Medicine, From Cell to Bedside, 5-8 May 2009, Harbiye Military Museum, Istanbul, Turkey. 56. A.Coker, E.D.Arisan, N.Palavan-Unsal. The involvement of polyamines in seliciclib induced apoptosis and ROS generation in HCT116 colon carcinoma cells. Joint 4th EORTC Pathobiology Group Annual Meeting and 1st Internationally Multidisciplinary Cancer Research Congress. P13, Antalya-Turkey, 2009 (Poster sunum: A. Coker) 57. E.D.Arisan, N.Palavan-Unsal, A.Coker. Investigation of roscovitine (CYC202) induced apoptosis related with polyamine metabolism in MCF-7 human breast cancer cell line. 3rd International Congress of Molecular Medicine, İstanbul, Türkiye, IUBMB Life. Vol:63 (3), P164, 2009 (Poster sunum: P. Obakan) 58. S.Akyuz, A.E.Ozel, K.Balci, T.Akyuz, A.Coker, E.D.Arisan, N.Palavan-Unsal, A.Ozalpan. Micro raman spectroscopic investigation of the interaction of cultured HCT116 colon cancer cells with roscovitine. 5th International Conference on Vibrational Spectroscopy (ICAVS5), 31 pp., Melbourne, Avustralya, 12-17 Temmuz, 2009 (Sözlü sunum: S. Akyuz) 59. E.D.Arisan, O.Kutuk, A.Verim, H.Basaga. Molecular mechanism of paclitaxel-induced apoptosis in ER+/- breast cancer cell lines: MCF-7 and MDA-MB-231. 31st FEBS Congress, İstanbul, Türkiye, FEBS Journal, 273: 51-52 Suppl. 1, 2006 (Sözlü sunum: E.D.Arisan) 60. M.A.Tufekci, N.Palavan-Unsal, N.Hekim, D.Arisan, T.Tezil. Phytotoxicity of Hydrogen peroxide: Comparison of phytotoxic response in vitro and in vivo. XV. FESPB Congress, RAS02-121 172 pp., 17-21 Temmuz, Lyon-France, 2006 (Poster sunum: M.A.Tüfekçi) 61. S.Arisan, E.D.Buyuktuncer, M.C.Kiremit, T.Caskurlu, N.Palavan-Unsal, E.Ergenekon. MnSOD and IL-10 polymorphisms in chronic pelvic pain syndrome patients. European Urological Congress, 901 pp., 4-8 Nisan, Paris, Fransa, 2006 (Sözlü sunum: E.D. Buyuktuncer) 62. N.Palavan-Unsal, S.M.Aloglu, M.A.Tufekci, E.D.Buyuktuncer, M.Strnad, L.Havlicek, M.Zatloukal, M.Djamgoz. Effects of olomoucine II on ODC and Bax mrna levels in rat protate cancer cell lines, P-223 pp., 13th Euroconference on Apoptosis Survival on the Danube, 1-4 Ekim, Budapeşte, Macaristan, 2005 (Poster sunum: S.M.Aloglu) 63. N.Palavan-Unsal, S.M.Aloglu, M.A.Tufekci, E.D.Buyuktuncer, M.Strnad, L.Havlicek, M.Zatloukal, M.Djamgoz. Suppression of ODC and Bax mrna levels in bohemine treated rat prostate cancer cell lines, P-4 pp., 13th Euroconference on Apoptosis Survival on the Danube, 1-4 Ekim, Budapeşte, Macaristan, 2005 (Poster sunum: M.A.Tufekci) 18
64. E.D.Buyuktuncer, S.Arisan, M.C.Kiremit, H.Tigli, N.Palavan-Unsal, T.Caskurlu, E.Ergenekon. MN-SOD polymorphism in chronic pelvic pain syndrome patients. AUA Annual Meeting, Journal of Urology, 173: 115 pp., San Antonio-USA, 2005 (Poster sunum: E.D.Buyuktuncer) 65. E.D.Buyuktuncer, B.Cirakoglu, N.Palavan-Unsal, A.Ozalpan, K.Ozdilli. Polyamine profiles in the peripheral blood leucocytes of childhood acute lymphoblastic leukemia patients, Biochemical Society Meeting 678, Polyamines and their Role in Human Disease. Abstract book, 35 pp., 16-18 Aralık, Imperial College, London-England, 2002 (Poster sunum: E.D.Buyuktuncer) 66. N.Palavan-Unsal, C.Atak, D.Buyuktuncer, K.Ozdilli. Role of meta-topolin in tissue culture of Arabidopsis thaliana. 1st Eurasia Congress on Molecular Biotechnology. 48 pp., 17-20 October, Trabzon, Turkey, 2001 (Poster sunum: D.Buyuktuncer) 67. N.Palavan-Unsal, S.Cag, E.D.Buyuktuncer. Comparison of the effect of different cytokinins on chlorophyll, protein content and peroxidase activity. 17th International Conference on Plant Growth Substances. 101 pp., 1-6 Temmuz, Brno, Czech Republic, 2001 (Poster sunum: E.D.Buyuktuncer) 68. N.Palavan-Unsal, S.Cag, E.Cetin, E.D.Buyuktuncer. Retardation of Senescence by meta- Topolin in wheat leaves. I. Inhibition of protease activity and chlorophyll loss. 12th Plant Physiology and Biochemistry Congress. S04-12, 38 pp., Budapeşte, Macaristan, Ağustos, 2000 (Poster sunum: E.D.Buyuktuncer) C. Yazılan ulusal veya uluslararası kitaplar veya kitaplarda bölümler : Ulusal 1. A. Olgun, E. D. Arisan. Nukleik asit izolasyon yöntemleri, Genomik Uygulamalar (Editörler: A. Özalpan, N. Palavan-Unsal) 79-97 pp., 2008 (Kitap bölümü) 2. E. D. Arisan. Polimeraz zincir reaksiyonu yöntemi ile özgül DNA dizilerinin çoğaltımı, Genomik Uygulamalar (Editörler: A. Özalpan, N. Palavan-Unsal) 99-109 pp., 2008 (Kitap bölümü) 3. E.D.Arisan, A. Elmaslar. Gerçek zamanlı kantitatif polimeraz zincir reaksiyonu (real time PCR veya qpcr). Genomik Uygulamalar (Editörler: A. Özalpan, N. Palavan-Unsal) 110-114 pp., 2008 (Kitap bölümü) Uluslararası 19
1. Arisan ED, Obakan-Yerlikaya P, Coker-Gurkan A, Palavan-Unsal N. Aging related diseases and autophagy. Autophagy in Current Trends in Cellular Physiology and Pathology. 978-953-51-4815-9. Editor: Nikolai Gorbunov, Intech, 2016. 2. Obakan-Yerlikaya P, Arisan ED, Coker-Gurkan A, Palavan-Unsal N. Breast cancer and flavonoids as treatment strategy. Breast Cancer. ISBN 978-953-51-4947-7. Editor: Phuc Van Pham, Intech, 2016. 3. Elif Damla Arısan, Kanserde Baskılayıcı Faktörlerden Kaçış, Moleküler Kanser Biyolojisi, Editor: Yusuf Baran, baskıda, 2017 D. Ulusal hakemli dergilerde yayımlanan makaleler : 1. N.Palavan-Unsal, E.D.Arisan. Evidences for the presence of caspases in plants. Marmara Üniversitesi Fen Bilimleri Dergisi, 23(2): 57-69 pp., 2011 (Derleme) 2. E.D.Arisan, N.Palavan-Unsal. Therapeutical potential of mitochondrial reactive oxygen species in carcinogenesis. Advances in Molecular Biology, 1-2: 1-8 pp., 2009 (Derleme) 3. E.D.Arisan, N.Palavan-Unsal. Resveratrol: Chemoprevention with red wine. Advances in Molecular Biology, 1: 13 22 pp., 2007 (Derleme) 4. E.D.Arisan, S.Arisan, M.C.Kiremit, N.Palavan-Unsal, E.Ergenekon. Antioxidant enzyme profile in chronic pelvic pain syndrome patients. Advances in Molecular Biology, 1: 41 46 pp., 2007 (Araştırma Makalesi) 5. I.Duman, S.Arisan, E.D.Buyuktuncer, T.Caskurlu, N.C.Sonmez, N.Palavan-Unsal. Apoptosis detection by TUNEL assay in BPH patients. Journal of Cell and Molecular Biology. 3: 103-107 pp., 2004 (Araştırma Makalesi) 6. E.D.Buyuktuncer, N.Palavan-Unsal. Future molecular markers in childhood acute leukemias: Polyamines. Turkish J Of Cancer, 34:5-10 pp., 2004 (Derleme) 7. N.Palavan-Unsal, E.D.Buyuktuncer, M.A.Tufekci. Programmed Cell Death in Plants. Journal of Cell and Molecular Biology, 4(1): 9-23 pp., 2004 (Derleme) 8. S.Arisan, E.D.Buyuktuncer, K.Ozdilli. E-cadherin molecular mechanism in prostate cancer. J of Cell and Molecular Biology, 2: 57-64 pp., 2003 (Derleme) 9. N.Palavan-Unsal, S.Cag, E.Cetin, D.Buyuktuncer. Retardation of senescence by metatopolin in wheat leaves. Jour Cell Mol. Biol. 1: 101-108 pp., 2002 (Araştırma Makalesi) E. Ulusal bilimsel toplantılarda sunulan ve bildiri kitaplarında basılan bildiriler: 1. Elif Damla Arısan, Okan Akar, Özge Berrak, Pinar Obakan-Yerlikaya, Ajda Çoker-Gürkan ve Narçin Palavan-Ünsal, PC3 prostat kanseri hücrelerinde NSAIDler tarafından tetiklenen 20
ölüm mekanizmasında p53 ün rolü, 1. Kanser Zirvesi, İstinye Üniversitesi, 25-26 Mart 2017, İstanbul 2. 1st International Congress of Cell Death Research Society Turkey, May 4-7, 2016 3. Elif Damla Arısan: Cyclin dependent kinase inhibitors modulated different mtor signalling targets to induce autophagy/apoptosis in prostate cancer cells. The First Autophagy Symposium in Turkey" 22 October 2014 in Karaköy Minerva Han, Istanbul. 4. E.D.Buyuktuncer, S.Arisan, H.Tigli, T.Caskurlu, A.Dalkilinc, N.Palavan-Unsal, E.Ergenekon. Frequency of PSA-mRNA bearing cells in the peripheral blood of patients after prostate biopsy. 1. Ulusal Moleküler Tıp Kongresi. 16-19 Nisan 2005. Advances in Molecular Medicine suppl. Vol 1: P082-422 pp., Istanbul 2005 (Poster sunum: E.D.Buyuktuncer) 5. N.Palavan-Unsal, S.M.Aloglu, M.A.Tufekci, E.D.Buyuktuncer, M.Strnad, L.Havlicek, M.Zatloukal, M.Djamgoz. Boheminin sıçan prostat kanseri hücre dizilerinde terapötik öneminin çeşitli biyomarkırlarla araştırılması, 76 pp. XXXI. Ulusal Fizyoloji Kongresi, 27-30 Eylül, Gaziantep, Türkiye, 2005 (Poster sunum: M.A.Tufekci) 6. A.Ozalpan, N.Palavan-Unsal, S.M.Aloglu, E.D.Buyuktuncer, S.Altun, M.Djamgoz, K.Ozdilli. Sıçan prostat kanseri hücre hatlarında Olomisinin poliamin düzeyinde etkisi, 160-161 pp., II. Klinik Biyokimya ve Kanser Sempozyumu, Bursa, Türkiye, 2004 (Poster sunum: S.M.Aloglu) 7. N.Palavan-Unsal, N.Hekim, C.Atak, M.A.Tufekci, O.Emiroglu, E.D.Buyuktuncer. Soya fasulyesi süspansiyon hücre kültürlerinde hidrojen peroksidin toksik etkilerinin apoptotik parametrelerle saptanması, 10 pp., V. National Environment and Ecology Congress, 5-8, Eylül, Bolu, Turkiye, 2004 (Poster sunum: M.A.Tufekci) 8. A.Ozalpan, N.Palavan-Unsal, S.M.Aloglu, E.D.Buyuktuncer, M.A. Tufekci, S. Altun, M. Djamgoz, K. Ozdilli. Prostat kanseri hücre hatlarında Olomisinin teröpatik öneminin poliamin biyomarkırları ile gösterilmesi, 203 pp. XV. Ulusal Kanser Kongresi, 23-27, Nisan, Kemer, Antalya, Türkiye, 2003 (Poster sunum: M.A.Tufekci) 9. N.Palavan-Unsal, A.Ozalpan, E.D.Buyuktuncer, K.Ozdilli. Olomisinin terapötik etkisinin ALL hücre hatlarında poliamin parametresi ile belirlenmesi. XV. Ulusal Kanser Kongresi bildiri özetleri kitabı 106 pp., 23-27 Nisan, Kemer, Antalya, Türkiye, 2003 (Poster sunum: E.D.Buyuktuncer) 10. S. Arisan, E.D.Buyuktuncer, T.Caskurlu, E.Ergenekon, N.Palavan-Unsal. Mesane Tümörlerinde Erken Moleküler Tanı. XV. Ulusal Kanser Kongresi bildiri özetleri kitabı 203 pp., 23-27 Nisan, Kemer, Antalya, Turkiye, 2003 (Poster sunum: E.D.Buyuktuncer) 21
11. N. Palavan-Unsal, E.D.Buyuktuncer. Biyogenik aminlerin gıdasal önemi. Tübitak- MAM I. Ulusal Gıda ve Beslenme Kongresi bildiri özetleri kitabı, 40 pp., 29 Eylül-1 Ekim, İstanbul, Türkiye, 2003 (Sözlu sunum: E.D.Buyuktuncer) F-Diğer yayınlar (Kongre bünyesinde özet bildiri kitabı basılmayan bildiriler) 1. Pinar Obakan, Kaan Adacan, Elif Damla Arisan, Ajda Coker-Gurkan, Narcin Palavan- Unsal. Polyamine metabolism is involved in EBR induced autophagy in DLD-1 and SW480 colon carcinoma cell lines Gordon Research Seminar: Role of Polyamines in Biology and Disease, June 13-14, 2015, Waterville Valley, NH, USA. 2. Ajda Çoker Gürkan, Elif Damla Arisan, Pinar Obakan, Merve Çelik, Narçın Palavan Ünsal. Curcumin induced apoptotic cell death by modulating ODC and SSAT expression via NF-KB and PAPR-γ in MCF-7 and MDA-MB231 breast cancer cells Gordon Research Seminar: Role of Polyamines in Biology and Disease, June 13-14, 2015, Waterville Valley, NH, USA 3. Elif Damla Arısan, Özge Berrak, Yunus Akkoç, Ajda Çoker Gürkan, Pınar Obakan, Narçın Palavan Ünsal. Curcumin inactivates IκB and alters NFκB signaling to increase polyamine catabolism in MCF-7 breast cancer cells Gordon Research Seminar: Role of Polyamines in Biology and Disease, June 13-14, 2015, Waterville Valley, NH, USA. 4. P. Obakan, E.D. Arisan, S. Bolkent, N. Palavan-Unsal. Understanding the roles of polyamines in EBR-induced autophagy, Gordon Research Conferences: Polyamines, Regulation and Role of Polyamines in Biology and Disease, June 16-21, 2013, Waterville Valley, NH, USA, and Gordon Research Seminars: Polyamines in Biology and Disease, June 15-16, 2013, Waterville Valley, NH, USA. (Sözlü sunum) 5. O. Berrak, E.D. Arisan, P. Obakan, A. Coker-Gurkan, N. Palavan-Unsal. Co-treatment of rapamycin prevented activation of polyamine oxidase and apoptosis via triggering autophagy after CDK inhibitor treatment in LNCaP cells, Gordon Research Conferences: Polyamines, Regulation and Role of Polyamines in Biology and Disease, June 16-21, 2013, Waterville Valley, NH, USA. 6. Y. Akkoc, E.D. Arisan, P. Obakan, A. Coker-Gurkan, N. Palavan-Unsal. N. Co-treatment of PI3K inhibitor and curcumin overcomes Bcl-2 mediated drug-resistance in MCF-7 breast cancer cells via activating SSAT, Gordon Research Conferences: Polyamines, Regulation and Role of Polyamines in Biology and Disease, June 16-21, 2013, Waterville Valley, NH, USA. 22
7. D. Coskun, P. Obakan, E.D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal. The Potential Role of Polyamines in Epibrassinolide-Induced Apoptotic Cell Death in HCT116 and HT29 Colon Carcinoma Cells, Gordon Research Conferences: Polyamines, Regulation and Role of Polyamines in Biology and Disease, June 16-21, 2013, Waterville Valley, NH, USA. 8. Coker-Gurkan, E.D. Arisan, H. Ilhan, P. Obakan, N. Palavan-Unsal. Inhibition of Cellular Autophagic Responses against N1, N11-Diethylnorspermine (DENSpm) Enhanced Apoptosis in HCT116 and SW480 Colon Cancer Cells, Gordon Research Conferences: Polyamines, Regulation and Role of Polyamines in Biology and Disease, June 16-21, 2013, Waterville Valley, NH, USA 9. O. Berrak, E.D. Arisan, P. Obakan, N. Palavan-Unsal. Investigation Of Possible Role of mtor in CDK Inhibitors Induced Apoptotic Cell Death in LNCaP, DU145 and PC3 Prostate Cancer Cell Lines. Graduate Student Immunology Congress, April 27-28, 2012, Harvard University, Boston, USA. 10. P. Obakan, P. Ozfiliz, E.D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal. Purvalanol A is a Strong Apoptotic Inducer via Activating Polyamine Catabolic Pathway in MCF-7 Estrogen Receptor + Breast Cancer Cells. EMBO Young Scientist Forum, 14-16 June 2012, Istanbul-TURKEY. 11. P.Obakan, E.D.Arisan, S.Bolkent, N.Palavan-Unsal. 24-Epibrassinolide induced apoptosis by modulating polyamine catabolic pathway in various prostate cancer cell lines. Gordon Research Conferences on Polyamines. Polyamine Genetics, Metabolism, Cellular Homeostasis and Drug Discovery. June 19-24 Waterville Valley, USA, 2011 12. E.D.Arisan, P.Obakan, N.Palavan-Unsal. Roscovitine induced apoptosis and activated polyamine catabolic pathway in LNCap, DU145 and PC3 prostate cancer cell lines. Gordon Research Conferences on Polyamines. Polyamine Genetics, Metabolism, Cellular Homeostasis and Drug Discovery. June 19-24, Waterville Valley, USA, 2011 13. N.Palavan-Unsal, E.D.Arisan, A.Coker. Alterations in Apoptotic and Polyamine Catabolic Pathway in HCT116wt and HCT116 Puma -/- Cell Lines Treated with Cdk Inhibitors Gordon Research Conferences on Polyamines. Polyamine Genetics, Metabolism, Cellular Homeostasis and Drug Discovery. June 19-24, Waterville Valley, USA, 2011 (Poster sunum: N. Palavan-Unsal) 14. A.Coker, N.Palavan-Unsal, E.D.Arisan. Gordon Research Conferences on Polyamines. Alterations in Apoptotic and Polyamine Catabolic Pathway in HCT116 wt and HCT116 Bax -/- Cell Lines Treated with Cdk Inhibitors. Polyamine Genetics, Metabolism, 23