CURRICULUM VITAE. F. Çiğdem Doğulu, MD, PhD Associate Professor of Neurology

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1 CURRICULUM VITAE F. Çiğdem Doğulu, MD, PhD Associate Professor of Neurology Birth Date : June 24, 1965 Birth place : Bingöl, TURKEY Work Address : Acıbadem Bursa Hospital Neurology Clinic Fatih Sultan Mehmet Bulvarı Sümer Sk 1 Nilüfer BURSA / TURKEY Education: Phone: Fax: Institution and Location Degree Year Field of Study Uludag University School of Medicine, MD 1988 Medicine Bursa, TURKEY Hacettepe University, Ankara, TURKEY PhD 2002 Clinical Neuroscience (Neuro-Ophthalmology) Academical Titles & Responsibilities: 1989 to 1990: Resident in Neurology, Haseki Hospital, İstanbul, TURKEY 1990 to 1991: Resident in Neurology, Gazi University School of Medicine, Ankara, TURKEY 1992 to 1997: Resident in Neurology, Hacettepe University School of Medicine, Ankara, TURKEY April 1995 to July 1995: Research Fellow in Human Mitochondrial DNA Lab, Beth Israel Hospital, Harvard Medical School, Boston, MA, USA 1997 to 2002: PhD Student in Clinical Neuroscience (Neuro-Ophthalmology) at Hacettepe University, Institute of Neurological Sciences and Psychiatry, Ankara, TURKEY April 6, 2001: ECFMG Certificate May 2001 to December 2001: Clinical fellow in Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, MD, USA

2 December 2001 to January 2008 : Clinical fellow in Laboratory of Clinical Genomics, National Institute of Child Health and Human Development, National Institutes of Health, MD, USA October 17, 2007: Associate Professorship in Neurology, TURKEY March 2008 to October 2008: Founder, MERT Life Sciences, Inc., Bethesda, MD, USA December 22, 2008 to present: Attending Neurologist, Acıbadem Bursa Hospital, BURSA, TURKEY Membered Societies: Hacettepe Nöroloji Derneği Türk Nöroloji Derneği Beyin Damar Hastalıkları Derneği Turkish American Scientists and Scholars Association (TASSA) Honored Prizes: 1995 NATO Science Fellowship Award and participation in a collaborative study; Mt DNA Analysis in the Turkish Leber s Hereditary Optic Neuropathy (LHON) Population at Harvard Medical School, Beth Israel Hospital, Department of Neurology, Human Mitochondrial DNA Laboratory. April 21, 2003: Department of Health and Human Services, NIH, NICHD Staff Recognition Award May 2, 2004: Department of Health and Human Services, NIH, NICHD Staff Recognition Award September 27, 2006: State of Maryland, Medical Licensure by Conceded Eminence March 4, 2007: Department of Health and Human Services, NIH, NICHD Cash Award RB Patent Applications: METHOD EVOLVED FOR RECOGNITION OF THROMBOPHILIA (MERT) Institution: National Institutes of Health, NICHD Inventors: Cigdem F. Dogulu MD, PhD, Owen M. Rennert MD, Wai-Yee Chan PhD Institution: National Institutes of Health, NICHD NIH (DHHS) Reference No. E /0-US-03 United States Patent Application No This approach uses genomic DNA microarray technology to detect an individual s overall genetic susceptibility to venous thrombosis by screening of all currently possible 143 venous thrombosis associated recurrent mutations and polymorphisms in eight different genes and links the microarray data directly to the combined likelihood ratio for the panel of venous thrombosis associated susceptibility genes and applicable to diverse ethnic populations METHOD EVOLVED FOR RECOGNITION AND TESTING OF AGE RELATED MACULAR DEGENERATION (MERT-ARMD)

3 Institution: National Institutes of Health, NICHD, USA Inventors: Cigdem F. Dogulu MD, PhD, Owen M. Rennert MD, Wai-Yee Chan PhD NIH (DHHS) Reference No. E /0-US-07 United States Patent Application No This approach uses genomic DNA microarray technology to detect an individual s overall genetic susceptibility to Age Related Macular Degeneration by screening of 105 mutations and polymorphisms in all currently known Age Related Macular Degeneration-associated sixteen different genes and links the microarray data directly to the combined likelihood ratio for the panel of Age Related Macular Degeneration associated susceptibility genes. METHOD EVOLVED FOR RECOGNITION AND TESTING OF ISCHEMIC STROKE (MERT-IS) Institution: MERT Life Sciences, Inc, Bethesda, MD, USA Inventor: Cigdem F. Dogulu MD, PhD U.S. Provisional Appl. No. 61/087,495 This approach uses genomic DNA microarray technology to detect an individual s overall genetic susceptibility to Ischemic Stroke by screening of 30 mutations and polymorphisms in all currently known Ischemic Stroke-associated fifteen different genes and links the microarray data directly to the combined likelihood ratio for the panel of Ischemic Stroke associated susceptibility genes and applicable to diverse ethnic populations. Publications: Invited Lectures and Conferences: Doğulu Ç.F. DNA Chips and Future Genomic Neurology. 43. Ulusal Nöroloji Kongresi, Antalya, Doğulu Ç.F. Pseudotumor cerebri, İkinci Rumeli Nöropsikiyatri Günleri, NÖBİVA III. Trakya Sempozyumu, NÖROOFTALMOLOJİ, Mart 2009, Çorlu, Tekirdağ. Book Chapter: Doğulu Ç.F. Herediter Optik Noropatiler. Nöro-oftalmoloji El Kitabı. Editorler; O dwyer PA, Kansu T, Torun N.Gunes Tıp Kitabevleri, Ankara, sayfa: 89-94, Articles: 1. Dogulu CF, Ciger A, Saygı S, Yalaz K, Renda Y: Atypical EEG findings in subacute sclerosing panencephalitis. Clin Electroencephalogr 26:193-9, Dogulu CF, Kansu T, Karabudak R: Alexia without agraphia in MS. J Neurol Neurosurg Psychiatry 61:528, Dogulu CF, Kansu T: Upside-down reversal of vision in multiple-sclerosis. J Neurol 244:461, Unal I, Dogulu CF, Saygı S, Fırat M, Ruacan S, Karabudak R: Multiphasic Disseminated Encephalomyelitis: A four year folllow-up. Eur Neurol 43:55-58, 2000.

4 5. Yemisci M, Dogulu CF, Kansu T, Saatci I, Ozgen T: Tethered brain. Case illustration. J Neurosurg 93:146, Tezer I, Dogulu CF, Kansu T: Isolated inferior rectus palsy as a result of paramedian thalamopeduncular infarction. J Neuroophthalmol 20:154-5, Dogulu CF, Kansu T, Kadayifcilar S: The role of IgM isotype anticardiolipin antibodies in occlusive ocular vascular disease: report of two cases with primary antiphospholipid antibody syndrome. Eye 14:789-90, Arsava EM, Uluc K, Kansu T, Dogulu CF, Soylemezoglu F, Selekler K: Granulomatous hypophysitis and bilateral optic neuropathy. J Neuroophthalmol 21:34-6, Dogulu CF, Kansu T, Seyrantepe V, Ozguc M, Topaloglu H, Johns DR: Mitochondrial DNA analysis in the Turkish Leber s hereditary optic neuropathy population Eye 15:183-8, Kansu T, Dogulu CF, Erbengi A: How much brain is necessary for vision? Eur J Neurol 8; , Yemisci M, Dogulu CF, Kansu T, Kanpolat Y: Trochlear nerve palsy as a complication of trigeminal radiofrequency rhizolysis. Neuroophthalmol 24;485-7, Karabudak R, Dogulu CF, Nurlu G, Simsek H, Saatci I: Central nervous system demyelination in familial Mediterranean fever: is it a coincidence? Eur J Neurol 10;327-8, Acaroglu G, Kansu T, Dogulu CF: Visual recovery patterns in children with Leber s hereditary optic neuropathy. Int Ophthalmol 24: , Dogulu CF, Kansu T, Leung MY, Baxendale V, Wu SM, Ozguc M, Chan WY, Rennert OM: Evidence for genetic susceptibility to thrombosis in idiopathic intracranial hypertension. Thromb Res 111;389-95, Dogulu CF, Tsilou E, Rubin B, FitzGibbon EJ, Kaiser-Kupper MI, Rennert OM, Gahl WA: Idiopathic Intracranial Hypertension in Cystinosis. J Pediatr 145: 673-8, Sener S, Dogulu FC, Demirhan N. An uncommon cause of hip pain: isolated gluteal deep venous thrombosis associated with prolonged seated immobility. Turkish Journal of Thoracic and Cardiovascular Surgery 21; , Presentations: 1. Doğulu Ç.F., Karabudak R., Durguner M., ve Sarıbaş O., An unusual case presentation: multiple sclerosis like white matter lesions in a patient with bradikinetic-rigid syndrome, 1994 Meeting of the European Federation of Neurological Societies, Poznan, Polonya, Doğulu Ç.F., Kansu T., ve Karabudak R., Unusual Ocular Findings in Multiple Sclerosis, 1994 Meeting of the European Federation of Neurological Societies, Poznan, Polonya, Doğulu Ç.F., Karabudak R., Verşevsha Y., Saygı S., ve Sarıbaş O., Relapsing Acute Disseminated Encephalomyelitis: Neuroimaging findings, 1994 Meeting of the European Federation of Neurological Societies, Poznan, Polonya, Johns D.R., Doğulu Ç.F., Kansu T., Seyrantepe V., Özgüç M., ve Topaloğlu H., Mitochondrial DNA Analysis in the Turkish LHON Population, 49 th Annual Meeting of American Academy of Neurology, Boston, A.B.D., Ünal I., Doğulu Ç.F., Saygı S., Karabudak R., ve Ruacan Ş., Multiphasic Disseminated Encephalomyelitis presenting as large tumor-like lesion and response to

5 intravenous gammaglobulin theraphy, 14 th Congress of the European Committee for Treatment and Research in Multiple Sclerosis, Stockholm, İsveç, Dogulu CF, Kansu T, Leung MY, Baxendale V, Wu SM, Ozguc M, Chan WY, Rennert OM. Evidence for genetic susceptibility to thrombosis in idiopathic intracranial hypertension, 52 nd Annual Meeting of American Society of Human Genetics, Baltimore, A.B.D., Articles in Turkish: 1. Kıratlı H., Kansu T., ve Doğulu Ç.F., Psödotümör Serebri Tedavisinde Optik Sinir Kılıfı Fenestrasyonu, Türk Nöroşirürji Dergisi, 8,10-14 (1998). 2. Doğulu Ç.F., Temporal Arterit (Dev Hücreli Arterit), Hacettepe Dişhekimliği Dergisi, 23(3-4), (1999). Presentations in Turkish: 1. Baysal A.İ., Doğulu Ç.F., ve Doğulu F., Kortikal körlük: Vaka sunumu, 26. Ulusal Nöroloji Kongresi, İstanbul, Baysal A.İ., Doğulu Ç.F., ve Doğulu F., Ilginç bir paradoksal kinezi vakası, 26. Ulusal Nöroloji Kongresi, Istanbul, Baysal A.İ., Doğulu Ç.F., ve Doğulu F., Unilateral frontal infarkta bağlı akinetik mutizm vakası, 26. Ulusal Nöroloji Kongresi, Istanbul, Baysal A.İ., Doğulu Ç.F., ve Doğulu F., Meme ve akciğer kanserine bağlı Millard- Gubler ve Gradenigo sendromu, 26. Ulusal Nöroloji Kongresi, Istanbul, Ciğer A., Doğulu Ç.F., Saygı S., Renda Y., ve Yalaz K., Subakut Sklerozan Panensefalit de EEG Bulguları, 29. Ulusal Nöroloji Kongresi, İstanbul, Ertem E., Doğulu Ç.F., ve Sarıbaş O., Bir demans nedeni olark VİTB12 yetmezliği, 29. Ulusal Nöroloji Kongresi, İstanbul, Doğulu Ç.F., Saygı S., Saka E., Sarıbaş O., ve Özcebe O.I., Nöroakantositoz: olgu sunumu, 30. Ulusal Nöroloji Kongresi, Adana, Doğulu Ç.F., Kayahan K., Tan E., ve Sarıbaş O., Karnitin-Palmitoil Transferaz Eksikliği: Vaka Takdimi, 30. Ulusal Nöroloji Kongresi, Adana, Doğulu Ç.F., Saygı S., Saka E., Karabudak R., ve Sarıbaş O., Bir Meningovasküler Nörosifiliz olgusu: MRG ile takibi, 30. Ulusal Nöroloji Kongresi, Adana, Doğulu Ç.F., Kansu T., ve Karabudak R., Multipl Skleroz da nadir göz bulguları, Multipl Skleroz Sempozyumu, İstanbul, Doğulu Ç.F., Kansu T., Seyrantepe V., Özgüç M., ve Johns D.R., 9804 nükleotid pozisyonunda mutasyon taşıyan 4. Leber in Herediter Optik Nöropatisi (LHON) vakası ve ailesinde yapılan moleküler genetik çalışma, 32. Ulusal Nöroloji Kongresi, İstanbul, Doğulu Ç.F., Gürgey A., ve Sarıbaş O., Leiden mutasyonuna bağlı APC rezistansının Genç İnmedeki Rolü; Vaka Sunumu, 34. Ulusal Nöroloji Kongresi, Bursa, Genç S., Doğulu Ç.F., ve Karabudak R., Monofazik ve polifazik dissemine ensefalomiyelit: Klinik ve kranial MRG, 34. Ulusal Nöroloji Kongresi, Bursa, 1998.

6 14. Tezer F.İ., Doğulu Ç.F., ve Kansu T., İzole İnferior Rektus Paralizisi, 35. Ulusal Nöroloji Kongresi, Kuşadası, Kurt.T, Doğulu Ç.F., ve Kansu T., Konjenital Horizontal Bakış Felci, Skolyoz ve Arnold-Chiari Malformasyonu, 35. Ulusal Nöroloji Kongresi, Kuşadası, Doğulu Ç.F., ve Kansu T., Okluziv Oküler Hastalıkta IgM Antikardiolipin Antikorlarının Rolü, 35. Ulusal Nöroloji Kongresi, Kuşadası, Yemişçi M., Doğulu Ç.F., Kansu T., ve Kanpolat Y., Trigeminal Radyofrekans Termoregülasyon Tedavisinin Bir Komplikasyonu olarak İzole Troklear Sinir Felci, 36. Ulusal Nöroloji Kongresi, İstanbul, 2000.