SARS Associated Corona Virus (SCV)

Transkript

1 975 Konu 114 SARS Associated Corona Virus (SCV) $\GÕQ06$56$VVRFLDWHG&RURQD9LUXV6&9(G&HQJL]0ÕVÕUOÕJLO$\GÕQ7ÕSYHGLúKHNLPOL LQGH genel ve özel Mikrobiyoloji. Konu 114. Sa:975-* QHú\D\ÕQHYL$QNDUD *(1(/g=(//ø./(5 %X KDVWDOÕN \ÕOÕQÕQ LNLQFL \DUÕVÕQGD X]DNGR X $V\D GD JULSDO LQIHNVL\RQ JLEL RUWD\D oõnpõúwõu 6ROXQXP \HWPH]OL L VHEHEL\OH O POH VRQXoODQDQ YDND VD\ÕVÕ KHU JHoHQ D\JLGHUHNDUWPÕúWÕU%XKDVWDOÕ DVHUWDNXWVROXQXPVHQGURPXDQODPÕQD JHOHQ6HYHUH$FXWH5HVSLUDWRU\6\QGURPH6$56LVPLYHULOPLúWLU &'& YH ' Q\D VD OÕN UJ W QH LON UDSRUODU dlq +RQJ.RQJ.DQDGD øqgrqh]\d)lolslqohu6lqjdsxu7d\odqgyh9lhwqdp GDQJHOPLúWLU\ÕOÕúXEDWÕQGD KDVWDOÕN WDP RODUDN WDQÕPODQDELOPLúWLU 'DKD VRQUD øqjlowhuh 6ORYHQ\D $PHULND $OPDQ\D GDQYDNDUDSRUODUÕJHOPLúWLU-Nisan- WH ONHGHWHVSLWHGLOPLúNHQ- 0D\ÕV-WDULKLQHNDGDUWRSODP ONHGHQYDNDUDSRUODUÕELOGLULOPLúWLU HastalDUÕQ or X - \Dú DUDVÕQGDGÕU \DúÕQ DOWÕQGD VDGHFH ELUNDo YDND YDUGÕU +DVWDODU DUDVÕQGD FLQVL\HW D\ÕUÕPÕ WHVSLW HGLOHPHPLúWLU %XQDUD PHQHUNHN KDVWDODUÕQRUDQÕFLYDUÕQGDGÕU (7.(1ø (OGHNL ELOJLOHUH J UH6$56KDVWDOÕ ÕQÕQ HWNHQL NRURQDYLUXV 7RU VXúXGXU%X virusa SARS-DVVRFLDWHG&RURQD9LUXV6&9LVPLYHULOPLúWLU'L HUNRURQDYLUXVODUJLEL 80-QPE \ NO QGHSOHRPRUILNVIHULNYH\DHOLSVúHNOLQGHKHOLNDOVLPHWULGHGLU < ]H\LQGHNL oõnõqwõodu SHSORPHU QP JHQLúOL LQGH QP X]XQOX XQGDGÕU 7HN VDUPDO51$VÕYDUGÕUdHYUHVLQGH-QPNDOÕQOÕ ÕQGDOLSLWELU]DUÕEXOXQXU6&9µQX izole edip Macaca fascicularis PD\PXQODUÕQD KDVWDOÕ Õ EXODúWÕUPDN P PN Q ROPXúWXU Bu virusun ED]oLIWOLNJHQRPXQXQVHNDQVÕWHVSLWHGLOPLúWLUWDQe ORF 2SHQ5HDGLQJ)UDPHXFXEXOXQPDNWDGÕU%XUDGDQDQODúÕOGÕ ÕQDJ UHL\LELOLQHQKHU iki koronavirus genomuna (HCoV-OC43 ve HCoV-229E) orta seviyede bir benzerlik göstermektedir (300 nükleotitten %50-NDGDUÕEHQ]HPHNWHGLU 6$56 KDVWDVÕQÕQ VROXQXP VÕYÕODUÕQGDQ KXPDQ PHWDSQHXPRYLUXV L]ROH HGLOPLúWLU %X GXUXPGD PHWDSQHXPRYLUXV XQ ELU NR-LQIHNW U P ROGX X YH\D 6$56 KDVWDOÕ ÕQÕQEXLNLYLUXVXQELUOLNWHOL LLOHPLPH\GDQDoÕNWÕ Õ\ROXQGDGH LúLNJ U úohu YDUGÕU SINIFLANDIRMASI: $VOÕQGD Coronaviridae IDPLO\DVÕQGD \HU DODQ YLUXVODUÕQ E \ N or XQOX X VDGHFH KD\YDQGD KDVWDOÕN \DSDU %XQODUÕQ LoHULVLQGH LQVDQGD VROXQXP \ROX KDVWDOÕ ÕQDVHEHSRODQ+XPDQUHVSLUDWRU\&RURQD9LUXV+&9µXQUKLQRYLUXVODUJLEL VWVROXQXP\ROXQGDKDVWDOÕN\DSDELOGL L QFHGHQELOLQL\RUGX\ÕOÕQGD7\UHOYH %\QRHD\UÕFD\ÕOÕQGD+DPUHYH3URFNQRZEXYLUXVXVR XNDOJÕQOÕ ÕEHOLUWLOHUL RODQ LQVDQÕQ QD]RIDULQJHDO \ÕNDPD VX\XQGDQ L]ROH HGHUHN J Q OO LQVDQODUD X\JXODPÕú YH EX LQVDQODUGD VR XN DOJÕQOÕ ÕQD EHQ]HU ELU KDVWDOÕN ROXúWXUPD\Õ EDúDUPÕúODUGÕ%XYLUXVODUDVÕUDVÕ\OD%YH(LVPLQLYHUPLúOHUGL GHWDQH

2 976 GDKD NRURQDYLUXV WHVSLW HGLOPLúWLU <HQL EXOXQDQODUÕQ or X VÕoDQGD YH NXúODUGD SQ PRQL\DSDELOGL LLoLQYH OG U F ROPDGÕ ÕLoLQ ]HULQGH\HWHULQFHGXUXOPDPÕúWÕ 6&9LVHPXKWHPHOHQEXYLUXVODUGDQELUWDQHVLQLQVSRQWDQPXWDV\RQJHoLUPLú ELUIRUPXGXU%L\RORMLNVDYDúDPDFÕ\ODJHQHWLNP KHQGLVOHULWDUDIÕQGDQ\DUDWÕOGÕ ÕQD GDLUV \OHQWLOHUGHYDUGÕU $17ø-(1<$3,6,h5(7ø/0(6ø SCV viryonun kapsitindeki M(pro) antijeni, konak dokuda replikasyon IDDOL\HWOHULQL \ QHWHQ ELU SURWHLQD]GÕU GL HU LVPL &/SUR GXU 9LUXVXQ D\UÕFD KHPDJO WLQLQOHULYDUGÕU%XKHPDJO WLQLQOHU0\[RYLUXVODUGDROGX XJLELHULWURVLWOHUGHQ NHQGLOL LQGHQD\UÕOPD]ODU Transmissible gastroenteritis virus (TGEV) un M(pro) antijeni ile SCV un 0SURDQWLMHQLDUDVÕQGDPROHN OHUELUEHQ]HUOLNYDUGÕU%XVHEHSOH7*(9LQIHNVL\RQX geçirenlerin anti-6&9dqwlnruxwdúõpdoduõp PN QG U &RURQDYLULGDHIDPLO\DVÕQGDNLYLUXVODUIDUNOÕDQWLMHQLNJXUXEDD\UÕOÕUODUg]J O RODUDN 6&9 XQ KDQJL DQWLMHQLN JXUXS LoHULVLQH \HUOHúWLULOHFH L KHQ ] NHVLQOLN ND]DQPDPÕúWÕUDPDKHUELUJXUXSLoLQGH\HUDODQNRURQDYLUXVODUGL HUJXUXEXQ \HOHUL LOH odusud] UHDNVL\RQ YHUHELOPHNWHGLU %X ]HOOLN NRURQDYLUXV WHúKLV NLWOerinin SCV WDQÕVÕQGDNXOODQÕOPDVÕNROD\OÕ ÕQÕJHWLULU Koronaviruslar, insan embriyonu trekae organ kültüründe, bebek fare EH\QLQGHWHNWDEDNDOÕGRNXN OW UOHULQGH UHWLOHELOLU6&9LoLQHQX\JXQYDVDW9HUR( hücre kültürüdür. 'ø5(1d/ø/ø. dhyuhnrúxooduõqdgluhqfl RUWDPÕQQHPPLNWDUÕQD YHVÕFDNOÕ ÕQDED OÕGÕU.XUX RUWDPGD ]DPDQOD LQIHNWLYLWHVLQL ND\EHGHU 6R XNWD YH Y FXW VDOJÕODUÕQÕQ LoHULVLQGH daha uzun süre infektif kalabilir. 6&9 QXQ OLSLW ]DUIÕ EXOXQPDVÕ VHEHEL\OH DONRO YH HWHU JLEL OLSLW o ] Fülere IHYNDODGHGX\DUOÕGÕU $QWLVHSWLNOHUH GX\DUOÕGÕU $QWLW EHUN OR DQWLVHSWLNOHU YH KLSR LOH NÕVD V UHGH LQKLEH ROXU 'URSOHWOHU KDOLQGH KDYD\D NDUÕúWÕ ÕQGD DQWLVHSWLN X\JXODPDVÕ VSUH\ úhnolqghropdoõgõu'xydu]hplqyhnrqwdplqhpdwhu\doklsryh\ddonollü antiseptik solüsyonlar ile silinmelidir. <$37,ö,+$67$/,./$5 øqvdqgd YH PD\PXQGD 6$56 KDVWDOÕ Õ \DSWÕ Õ ELOLQPHNWHGLU $\QÕ DLOHGHNL GL HU YLUXVODUD EHQ]HU RODUDN KD\YDQGD SQ PRQL HWNHQL ROPDVÕ GD PXKWHPHOGLU +DVWDOÕN ED]Õ LQVDQODUGD VXENOLQLN VH\UHWPHNWHGLU %D]Õ LQVDQODUGD LVH OG U F RODELOPHNWHGLU %D ÕúÕNOÕN EÕUDNÕS EÕUDNPDGÕ Õ KHQ ] LQFHOHQPHPLúWLU 'X\DUOÕ ELUH\OHUGH ELOKDVVD GL\DEHWLNOHUGH SURJQR]XQ D ÕU VH\UHWPHVL P PN QG U % W Q YDNDODU D\QÕ VHUWOLNWH VH\UHWPH] $NFL HU EHOLUWLVL ELOH YHUPHGHQ L\LOHúHQ YDNDODU YDUGÕU.URQLNOHúWL LUDSRUHGLOPHPLúWLU3RUW UO NUDSRUHGLOPHPLúWLU %(/ø57ø/(5ø øqn EDV\RQ SHU\RGX - J QG U DPD J QH NDGDU X]D\DELOLU øqn EDV\RQ peryodu uzun olan vakalar daha hafif seyreder. 5DVWODQPDVÕNOÕ ÕQDJ UHLONNOLQLNEHOLUWLOHUL\ NVHNDWHú!ƒ&KX]XUVX]OXN KLVVL WLWUHPH ER D] \DQPDVÕ NV U N NDV D UÕVÕ EDú D UÕVÕ ELODWHUDO SQ PRQL VROXQXPXQ GHULQOL LQLQ NÕVDOPDVÕ YH\D ]RU QHIHV DOPD úhnolqghglu $OÕúÕODJHOPLú VROXQXP\ROXKDVWDOÕ ÕQDEHQ]HUEHlirtiler verir. ' N QW UHQDO JDVWURLQWHVWLQDO YH Q URORMLN EXOJXVX \RNWXU %D]Õ YDNDODUGD \ NVHNDWHúG QHPLQGHGL\DUHUDSRUHGLOPLúWLU

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