ÖZGEÇMİŞ. ODTÜ Biyoloji Bölümü Biyoteknoloji Araştırma Ünitesi. 06531Ankara. TELEFON 312 2105195 FAKS 312 2101326 E-MAIL gurdal@metu.edu.

ÖZGEÇMİŞ 1. GENEL DÜZENLEME TARİHİ 22.04.2002 SOYADI, ADI YAZIŞMA ADRESİ Alaeddinoğlu N.Gürdal ODTÜ Biyoloji Bölümü Biyoteknoloji Araştırma Ünitesi 06531Ankara TELEFON 312 2105195 FAKS 312 2101326 E-MAIL gurdal@metu.edu.tr 2. EĞİTİM ÖĞRENİ M DÖNEMİ DERECE ÜNİVERSİTE ÖĞRENİM ALANI 1963-1967 B.Sc Hacettepe Üniversitesi Tıp Fakültesi Tıbbi Teknoloji 1971-1976 Ph.D Reading Üniversitesi Mikrobiyal Genetik 1982 Doçentlik ODTÜ Mikrobiyal Genetik 1988 Profesör ODTÜ Moleküler Genetik 3. AKADEMİK DENEYİM GÖREV DÖNEMİ ÜNVAN BÖLÜM ÜNİVERSİTE 1967-1968 Asistan H.Ü.Tıp Fak.Hast.Klinik Patoloji Hacettepe Üniversitesi 1970-1971 Asistan Yüksek İhtisas Hast.Bakteriyoloji Lab. Sağlık Bakanlığı 1971-1976 Doktora Eğitimi Mikrobiyoloji Reading Üniversitesi (İngiltere) 1976-1977 Öğ.Gör. Biyolojik Bilimler ODTÜ 1978-1982 Y.Doç.Dr Biyolojik Bilimler ODTÜ 1985-1988 Doç.Dr Biyoloji ODTÜ 1988-2002 Prof.Dr. Biyoloji ODTÜ 4. YÖNETİM DENEYİMİ GÖREV DÖNEMİ YÖNETİM GÖREVİ KURULUŞ 1977-1978 Bölüm Bşk.Yrd Biyolojik Bilimler Bl. ODTÜ 1979-1982 Böl.Bşk. Biyolojik Bilimler Bl. ODTÜ 1985-1988 Böl.Bşk.Yrd. Biyoloji Bl. ODTÜ 1997-2000 Böl.Bşk. Biyoloji Bl. ODTÜ 1

5. DANIŞMANLIK DENEYİMİ GÖREV DÖNEMİ DANIŞMANLIK KONUSU KURULUŞ 1995-1998 Fermentasyon Teknolojisi Sifar İlaç San. İstanbul 1996-1999 Fermentasyon Teknolojisi Orba Kimyasal Sanayi, İstanbul 2000-2003 Pestisit geliştirme Delta Tarım&kim.San.Tic.A.Ş. 2004- Ortopedik malzeme geliştirme Fame-Med, Ortopro A.Ş. 6. Seçilmiş Yayınlar 1. Kitap/Rapor Microbiology Laboratory Notes, N.G.Alaeddinoğlu, METU-Ankara. 1978 N.G.Alaeddinoğlu: E.coli K-12 de Kromozomal Tobramycin Dirençliliği (dissertation for associate professorship). Submitted to METU., Ankara. 1981. Endüstride Genetik Mühendisliği: Endüstriyel Mikrobiyoloji (Ed:E.T.Çetin) Istanbul Tıp Fak.Vakfı. 123. 1982. Industrial Aspects of Biochemistry and Genetics (Eds: N.G.Alaeddinoğlu., A.L. Demain., G. Lancini). Plenum Press. Series A: Life Sciences Vol. 87.1985. General Microbiology Manual (N.G. Alaeddinoğlu., S.Kocabıyık) METU- Ankara. 1988. Konjugasyon, Bakteri plazmidleri. Türk Mikrobiyoloji Cemiyeti Yayınları, 14 (Ed: K.Töreci), 37-45.1990 Plazmidlerin genetik mühendisliğindeki yeri. Türk Mikrobiyoloji Cemiyeti Yayınları, 14 (Ed: K.Töreci), 79-84.1990. Fen Bilimleri 1. Milli Eğitim Bakanlığı Yayınları (93. 34. 0002-1208): N. G.Alaeddinoğlu., M.Özbakan., S.Özkar., I.Özkan., F.Sharif. Milli Basım Sanayii A.fi. Istanbul. 1993-1994. Fen Bilimleri 2. Milli Eğitim Bakanlığı Yayınları (93. 34. 0002-1223): N. G.Alaeddinoğlu., M.Özbakan., S.Özkar., I.Özkan. Milli Basım Sanayii A.fi. Istanbul. 1993-1994. Fen Bilimleri 1(Öğretmen El Kitabı). Milli Eğitim Bakanlığı Yayınları (95.34.4.0002.1459): N.G.Alaeddinoğlu., M.Özbakan., S.Özkar., I.Özkan. Milli Basım Sanayii A.fi. Istanbul. 1995. Fen Bilimleri 2(Öğretmen El Kitabı). Milli Eğitim Bakanlığı Yayınları (95.34.4.0002.1460): N.G.Alaeddinoğlu., M.Özbakan., S.Özkar., I.Özkan. Milli Basım Sanayii A.fi. Istanbul. 1995. Mikroorganizma Genetiği 1999. Temel ve Klinik Mikrobiyoloji (Ed: Şemsettin Ustaçelebi) Güneş Kitabevi Ltd.Şti.(975-7467-77-4).Sayfa 71-81. 2. Araştırma makaleleri N.G.Alaeddinoğlu (1976)Genetical analysis of variation in the ability to utilize sucrose in strains of E.coli (Ph.D. Thesis submitted to the University of Reading.,UK). N.G.Alaeddinoğlu(1978) Chromosomal genes related to the antibiotic resistance factor in E.coli; investigation of sucrose fermentation. Microbiology Bulletin, 12.,2. N.G.Alaeddinoğlu, H.P. Charles (1979) Transfer of a gene for sucrose utilization into E.coli K- 12 and consequent failure of expression of genes for D-serine utilization., J.Gen.Microbiol, 47. N.G.Alaeddinoğlu(1982) Genetic analysis of raffinose fermentation in E.coli and investigation of the relationship with K88 antigen. Microbiology Bulletin, 16: 21-32. 2

S.Kocabıyık., N.G Alaeddinoğlu (1985) Enrichment of whey in nitrogen by fermentation. Doğa Dergisi A2, 5 74. G.Aykut., V. N.Hasırcı., N.G.Alaeddinoğlu (1985) Invertase activity in entrapped yeast cells in: Industrial Aspects of Biochemistry and Genetics (Eds: N.G Alaeddinoğlu., A.L. Demain., G.Lancini) Plenum.NATO-ASI Series A:87 pp. 171. S.Kocabıyık., N.G.Alaeddinoğlu(1987) Epidemiological aspects of enzyme mediated aminoglycoside resistance. Hacettepe Medical Journal :20, 3: 185-199. N.G.Alaeddinoğlu., S.Kocabıyık (1987) Plasmid mediated enzymatic detoxification of aminoglycoside antibiotics in clinical isolates of Gram(-) bacilli. Proceedings of 15th Inter. Cong Chem. (Eds: B.Berkarda.,H.P. Kuemmerle). Ecomed, 760-762, Germany. S.Kocabıyık., E. Akalın., N.G. Alaeddinoğlu (1987) Aminoglycoside resistance profiles of the gentamycin resistant strains of Enterobacteriaceae and Pseudomonas. Proceedings of 15th Inter. Cong. Chem. (Eds: B.Berkarda.,H.P. Kuemmerle). Ecomed, 777-779, Germany. M.D.Hilton., N.G. Alaeddinoğlu., A.L.Demain (1988) Bacillus subtilis mutant deficient in the ability to produce the dipeptide antibiotic bacilysin: Isolation and mapping of the mutation. J. Bacteriol. 170, 2. M.D.Hilton., N.G. Alaeddinoğlu., A.L.Demain (1988) Synthesis of bacilysin by Bacillus subtilis from prephanate of the aromatic amino acid pathway. J.Bacteriol. 170, 1. F.A.Sharif, N.G. Alaeddinoğlu (1988) A rapid, simple method for staining of the crystal protein of Bacillus thuringiensis. J. Ind. Microbiol. 3, 227. G.Aykut., V.N. Hasırcı., N.G Alaeddinoğlu (1988) Immobilization of yeast cells in acrylamide gel matrix. Biomaterials, 169. S.Kocabıyık., N.G. Alaeddinoğlu (1989) Analysis of plasmid mediating ANT(2") and ACC(3- II) based gentamycin resistance in clinical isolates of Enterobacteriaceae. International Journal of Medical Microbiol. 271. S.Kocabıyık., N.G.Alaeddinoğlu (1988) Determination of aminoglycoside modification enzymes by "MIC ratio" method and its comparison with radioactive assay. Hacettepe Medical Journal, 21, 3, 145-156. S.Kocabıyık., E. Akalın, N.G. Alaeddinoğlu (1989) Aminoglycoside resistance profiles of the gentamycin resistant Enterobacteriaceae and Pseudomonas strains. lnternational Journal of Experimantal and Clinical Chemotherapy; 2: 2, 118. G.Özcengiz., N.G Alaeddinoğlu (1988) Microbial removal of sulfur compounds from Turkish Çanakkale Çan lignites, Doğa Dergisi 12, 2. A.Güven., M. Özbilgen., N.G. Alaeddinoğlu (1989) Activity loss kinetics of freeze-dried lactic acid starter cultures. Enzyme and Microb. Technol. 1, 11. S.Kocabıyık., N.G. Alaeddinoğlu (1989) Cross resistance patterns for aminoglycosides and non-aminoglycosides among clinical strains. Doğa Dergisi, Series A2, 13(1),35. M.Kriechbaum., H.J. Hielmann., F.J. Wientjes., M. Hahn., Jany., H.G. Gassen., F. Sharif., N.G Alaeddinoğlu (1989). Cloning and DNA sequence analysis of the glucose oxidase gene from A.niger. NRRL-3. FEBS Letters, 225, 1. G.Özcengiz., N.G.Alaeddinoğlu and A.L. Demain.(1990). Regulation of biosynthesis of bacilysin by Bacillus subtilis. J. Indust. Microbiol. 6: 91-100. A.Başalp., G.Özcengiz., N.G.Alaeddinoğlu (1990). A rapid plate test for screening of hyperproducer mutants of alkaline serine protease Turkish J.Biochem.15: 19-25. K.Adwan., S.Kocabıyık., N.G. Alaeddinoğlu (1990). Effect of Drug Usage on Aminoglycoside Susceptibilities of Pseudomonas aeruginosa Isolates. Int. J.Experiment. Clin.Chemother.3, (3),179-183. G.Özcengiz., N.G.Alaeddinoğlu (1990). Dipeptide Antibiotic Bacilysin: Isolation and Kinetics of Biosynthesis. Doğa-Türk Biyoloji Dergisi, 14:114-124. G.Özcengiz., N.G.Alaeddinoğlu (1991).Bacilysin production and sporulation in Bacillus subtilis. Current Microbiology, 23:61-64. N.G.Alaeddinoğlu (1991).Aminoglikozit antibiyotik direnclilikte plazmitlerle taşınan enzimler: Antibiyotik kullanımında stratejiler 3.Ulusal İnfeksiyon Hastalıkları Kongre Kitabı (Ed: E.Tümbay., A.Tuncer., Z.Zilmi) 236-247. G.Özcengiz., N.GAlaeddinoğlu (1991). Bacilysin production in relation to sporulation in B. subtilis. Doğa-Türk Biyoloji Dergisi, 15: 85-93. 3

G.Özcengiz., N.G.Alaeddinoğlu (1991). Bacilysin production by B. subtilis: Effects of bacilysin, ph and temperature., Folia Microbiology, 36-6. G.Özcengiz., N.G.Alaeddinoğlu., A.L.Demain (1992).Control by nitrogenous compounds of bacilysin production. In: Recent advances in Biotechnology. NA TO-ASl Series E. Vol.210. Plenum Publishing Co.pp.489-490. G.Özcengiz.,O.Zarrinabadi., N.G.Alaeddinoğlu (1992). Metal-binding proteins from Kluyveromyces spp. ln: Recent Advances in Biotechnology. NATO-ASl Series E. Vol.210. Plenum Publishing Co. pp.491-492. A.Başalp., G.Özcengiz., N.G.Alaeddinoğlu (1992). Changes in patterns of alkaline serine protease and bacilysin formation caused by common effectors of sporulation in B. subtilis 168., Current Microbiology, 24(3):129-135. K.Adwan., S.Kocabıyık., N.G. Alaeddinoğlu (1992) Evaluation of plasmid DNA and the protein profiles as epidemiologic tools in Pseudomonas aeruginosa. lnt. J. Experimental and Clinical Chemother. 5(1). 37-40. Sharif.F., N.G. Alaeddinoğlu (1992) Expression and over production of glucose oxidase in Aspergillus niger. Appl. Microbiol.Biotechnol. 38(1), 115-116. N.G.Alaeddinoğlu (1992) Safety aspects of biotechnology. In: Recent Advances in Pharmaceutical and Industrial Biotechnology (Eds: A. A.Hinçal, S.Kaş,). pp. 224-238, Editions de Sante. A.Yazgan.,G.Özcengiz.,N.G.Alaeddinoğlu (1993).Studies on metal resistance systems. Biological Trace Element Research.Vol.38: 117-127. K.M.Adwan.,S.Kocabıyık.,N.G.Alaeddinoğlu (1993). Evaluation of multiple drug resistance in clinical isolates of Pseudomonas aeruginosa. lnt. J.Experimental and Clinical Chemother. 6,1: 1-5. P.Afkhami., G.Özcengiz., N.G.Alaeddinoğlu (1993). Plasmid patterns of B.thuringiensis 81 and its crystal negative mutants. Biotechnology Letters, Vol.15, 12: 1247-1253. N.G.Alaeddinoğlu (1993).Biochemical and genetical aspects of aminoglycoside and β-lactam antibiotic resistance among the clinical isolates of P.aeruginosa. 12th Int. Meeting of European Culture Coll. Org.Abstr.Book: pp.1-6. Y.Arıca., F.A.Sharif, N.G.Alaeddinoğlu, N.Hasırcı., V.N.Hasırcı (1993). Covalent immobilization of A.niger on phema membrane: application to continuous flow reactors.j. Chem. Tech. Biotechnology, 58; 281-285. P.Afkhami., G.Özcengiz., N.G.Alaeddinoğlu (1993). Production of Lepidoptera-specific crystal protein by a local isolate of Bacillus thuringiensis. Biotechnology Letters, Vol.15, 12:1253-1259. Adwan.K., N.G. Alaeddinoğlu (1994) Mechanism of aminoglycoside, β-lactam and Quinolone antibiotic resistance in Pseudomonas aeruginosa Isolated from Turkey and Jordan. lnt.j.experimental and Clinical Chemother. 7: 2 C.Halıcıgil., G.Özcengiz., N.G.Alaeddinoğlu (1994) Delta endotoksinin üretici organizmada sporlanma ve jerminasyon üzerine etkileri. Tr.J.Biology.18: 243-250. P.Afkhami.,C.Halıcıgil.,G.Özcengiz., N.G.Alaeddinoğlu (1994).Biochemical and Molecular Characterization of Crystal Protein-Negative Mutants of Bacillus thuringiensis. ECB6 Proceedings of 6th European Congress on Biotechnol. (Ed:L.Alberghina, L.Frontali, P.Sensi., Elsevier Sa. B.V.)1081-1083. P.Afkhami., C.Halicigil., G. Ozcengiz and N.G.Alaeddinoglu (1994). Molecular and biochemical characterization of crystal protein-negative mutants of Bacillus thrungiensis. Progress in Biotechnology. 6:1081-1084. N.Asgari., F.A.Sharif., M.Y.Özden and N.G.Alaeddinoğlu (1995). Bacterial Utilization of Purified Temik. Process Biochemistry Vol. 30, 2: 183-187. Y.Arıca.,V.N.Hasırcı.,N.G.Alaeddinoğlu (1995) Covalent Immobilization of α-amylase onto phema Microspheres: Preparation and Application to Fixed Bed Reactor.Biomaterials 16, 10: 761-768. F.A.Sharif., N.G.Alaeddinoğlu (1995) Gene cloning and Protoplast Transformation in Aspergillus niger: Tr.J. Biology 19: 209-215. V.Hasırcı., Y.Arıca., N.G.Alaeddinoğlu., C.Halıcıgil., R.M.Wilkins., R.B.Cain (1995). Bacterial degradation and controlled release of Aldicarb; Proceed. Intern. Symp. Control. Rel.Bioact.Mater: 22, Controlled Release Society,Inc. 4

S.Bayarı., F.Severcan., I.Gürsel.,V.Hasırcı., N.G.Alaeddinoğlu (1998). The FTIR Studies of the Poly (3-hydroxybutyrate) and Poly (3- hydroxybutyrate-co-3-hydroxyvalerate); New Biomedical Materials, pp 58-64. IOS Press, United Kingdom. M.Y.Arıca., N.G.Alaeddinoğlu and V.Hasırcı (1998) Immobilization of glucoamylase onto activated phema/egdma microspheres: properties and application to a packed-bed reactor; Enzyme and Microbial Technology 22:152-157. V.Hasırcı., I.Gürsel., F.Türesin., G.Yiğitel., F.Korkusuz and N.G.Alaeddinoğlu (1998) Microbial polyhydroxyalkanoates as biodegradable drug release materials. In: Biomedical Science and Technology Recent Developments in the Pharmaceutical and Medical Sciences (Ed; A.A.Hıncal., H.S.Kas)., pp.183-189.plenum Press.NewYork and London. İ.Gürsel and N.G.Alaeddinoğlu (1998) Bacterial polyhydroxyalkanoates: Biosynthesis, screening and characterisation. In: Biomedical Science and Technology Recent Developments in the Pharmaceutical and Medical Sciences (Ed; A.A.Hıncal., H.S.Kas)., pp.81-89.plenum Press.NewYork and London. V.Hasırcı., I.Gürsel., F.Türesin., G.Yiğitel., F.Korkusuz and N.G.Alaeddinoğlu (1998) Microbial polyhydroxyalkanoates as biodegradable drug release materials. In: Biomedical Science and Technology Recent Developments in the Pharmaceutical and Medical Sciences (Ed; A.A.Hıncal., H.S.Kas)., pp.183-189.plenum Press.NewYork and London. E.E.Yıldız., G.Özcengiz., B.İçgen and N.G.Alaeddinoğlu (1999) Assignment of biological Functions to Specific Plasmids in a Local İsolate of Rhizobium cicer ; Folio Microbiol. 44 (1), 55-58. M.Y.Arıca., C.Halıcıgil and N.G.Alaeddinoğlu, A.Denizli (1999) Studies of the affinity interaction of hydroxypyruvate reductase from Methylophilus spp.with Cibacron blue F 3 GAderived poly(hema-egdma) microspheres: partial purification and characterization. Process Biochemistry., 34, 375-381. F.N.Kök., M.Y.Arıca., C.Halıcıgil., N.G.Alaeddinoğlu and V.Hasırcı (1999) Biodegradation of Aldicarb in a packed Bed Reactor by Immobilized Methylosinus; Enzyme and Microbial Technology; 24: 291-296. F.N.Kök., R.M.Wilkins., R.B.Cains., M.Y.Arıca., N.G.Alaeddinoglu and V.Hasırcı (1999) Controlled release of aldicarb from lignin loaded ionotropic hyrdogel microspheres. J.Microencapsulation, 16(5).,613-623 M.Gürsel.,S.Tunca.,M.Özkan.,G.Özcengiz and N.G.Alaeddinoğlu (1999) Immunoadjuvant action of plasmid DNA in liposomes.vaccines.17 (11-12), pp 1376-1383. M.Salameh., G.Özcengiz., Ü. Atalay., G.Özbayoğlu and N.G.Alaeddinoğlu (1999).Enhanced recovery of silver from Artvin-Kafkasör ore by microbial treatment. Biohydrometallurgy and the environment toward the mining of the 21 st century,part A (Ed: R.Amils and A.Ballester). Elsevier. pp.493-499. M.Y.Arıca., S.Şenel.,A.Denizli.,S.Patır and N.G.Alaeddinoğlu (1999) İmmobilized invertase on the spacer arm attached PHEMA membrane: preparation and properties. J.Applied Polymer Science 75: (14) pp.1685-1692. Füsun Türesin, Zeynep Gümüşyazıcı, Fatma.N.Kök, İhsan Gürsel, N.Gürdal Alaeddinoğlu and Vasıf Hasırcı (2000). Biosynthesis of Polyhydroxybutyrate and its Copolymers and Their use in Controlled Drug release. Turk J Med Sci (30) pp.535-541. Z.Özdemir, G.Özbayoğlu, Ü.Atalay, G.Özcengiz and G.Alaeddinoğlu (2000). Effect of bacterial treatment on silver recovery from Artvin-Kafkasör ore. Mineral Processing on the verge of the 21 st Century.(Ed:G.Özbayoğlu et al).2000 Balkema, Rotterdam, 553-556. İhsanGürsel, Feza Korkusuz, Füsun Türesin, N. Gürdal Alaeddinoğlu and Vasıf Hasırcı (2001) Invivo application of biodegradable controlled antibiotic release systems for the treatment of implant-related osteomyelitis Biomaterials, Vol. 22 (1) pp.73-80. Yazgan, A., Özcengiz, G., Özcengiz, E., Kilinc, K., Marahiel, M. A. and Alaeddinoğlu, N. G. (2001). Bacilysin biosynthesis by a partially-purified enzyme fraction from Bacillus subtilis. Enzyme and Microb. Technol. 29: 400-406. 5

7. Ulusal/Uluslararası Bilimsel Toplantılar N.G. Alaeddinoğlu (1980) Genetic analysis of raffinose fermentation in E.coli. TÜBITAK. 7th Science Congress 6-10 October, Kuşadası. N.G. Alaeddinoğlu, M. Akman., M. Baykal (1980) Tobramycin resistance and its transfer using plasmids. Kükem National Congress., May 14-17 Istanbul (Abstract) Kükem Joumal,3, 1. N.G. Alaeddinoğlu, S. Sukan., S.Kocabıyık., Y. Arıca (1981) Potential use of side products in milk industry. Kükem 2.nd National Congress, "Special Issue", September 1981. Istanbul (Abstract). N.G.Alaeddinoğlu (1981) Genetical analysis of spontaneous resistance to tobramycin in E.coli K-12. First National Genetics Symposium (TUBITAK) December 2-5., Ankara (Abstract). N.G. Alaeddinoğlu (1981) Use of whey in Industry. SEGEM (State Department) December 14-22, Ankara. N.G Alaeddinoğlu (1982) Coal desulfurization by Thiobacilli. Biogeochemistry Symposium 7-8 June, Hacettepe University, Ankara. N.G.Alaeddinoğlu (1982) University-Industry collaboration. SEGEM (State Department) April 21, Ankara. N.G. Alaeddinoğlu (1982) Genetic engineering in industry. Kükem 2nd. National Congress 3-5 May, Istanbul. N.G. Alaeddinoğlu (1983) Sucrose inversion by entrapped yeast cells. NATO/ASI on "Industrial aspects of Biochemistry and Genetics", 4-14 September, Çeşme/ Izmir. N.G. Alaeddinoğlu (1983) Genetic Engineering. 3rd National Congress of Kükem, 5-7 September, Izmir. N.G. Alaeddinoğlu (1984) Mapping of tobramyan resistance gene. Microbial Breeding, 3-8 September, Spoleto, Italy. A.L. Demain., M. Sakayoh., M.D. Hilton.,N.G. Alaeddinoğlu (1985) Studies on bacilysin biosynthesis in B.subtilis. 17th FEBS Meeting, 1-7 August., Berlin (Abstract). N.G. Alaeddinoğlu (1986) Aminoglycoside antibiotic resistance. Antibiotic use in clinical practise. Hacettepe University, 20-22 May (Abstract). M.D. Hilton., N.G. Alaeddinoğlu., A.L. Demain (1986) Analysis of mutants of B.subtilis which fail to produce bacilysin. ASM. Annual Meeting, 23-28 March Washington D.C (Abstract). S.Kocabıyık., N.G. Alaeddinoğlu., E.Akalın (1986) Aminoglycoside resistance and its characterization among clinical isolates. Journal of Biochemistry XI, I, 98-99 (Abstract). S.Kocabıyık., N.G. Alaeddinoğlu (1986) Genetic and Biochemical analysis of resistance to aminoglycoside antibiotics. Kükem Journal, 9, 1,169 (Abstract). N.G. Alaeddinoğlu (1987) Biological Warfare Prep. Meeting, 31 March-15 April, Geneva, Switzerland (Scientific Representative of Ministry of Foreign Affairs -Turkey). N.G. Alaeddinoğlu (1987) A series of conferences on "Pollution caused by the use of sea water as coolant". 7-11 December., Iskenderun (2 Conferences). N.G. Alaeddinoğlu., F. Sharif (1987) A rapid and a simple method for staining the crystal protein of B.thuringiensis. 5th National Kükem Congress, 14-16 September, Ankara (Abstract). S.Kocabıyık., N.G. Alaeddinoğlu (1987) Plasmid mediated enzymatic detoxification of aminoglycoside antibiotics in clinical isolates. 15th Intemational Congress of Chemotherapy.,20-27 July.,Istanbul (Abstract). S.Kocabıyık.,E.Akalın, N.G. Alaeddinoğlu (1987) Aminoglycoside resistance profiles of the gentamicin resistant strains. 15 th Intemational Congress of Chemotherapy. July, 20-27.,Istanbul (Abstract). F.A.Sharif and N.G.Alaeddinoğlu (1987) Identification and genetic analysis of B.thuringiensis plasmids.j.biochem.12 (2) : 96. Turkish Biochemical Society. G.Özcengiz.,N.G.Alaeddinoğlu (1987) Basilisin biyosentezi ve düzenlenmesine ilişkin Çalışmalar.5.Ulusal KÜKEM Kongresi (Eylül 6-10)., Ankara (Kükem Dergisi,10 (2):90-91). 6

G. Özcengiz ve N.G. Alaeddinoğlu: "Bacilysin Biyosentezi ve Düzenlenmesine Ilişkin Çalışmalar." 5. Ulusal KÜKEM Kong. Ankara. Eylül 1987. F.A.Sharif, S.Kocabıyık, N.G.Alaeddinoğlu(1989) Isolation of glucose oxidase producing fungi and subsequent mutagenesis for non-producer strains. 9th National Congress of Biochemistry. November,19-23., Antalya (Abstract in Turkish J.Biochem.14.,3;182 ). G. Özcengiz ve N.G. Alaeddinoğlu: "Bacillus subtilis'de Bacilysin(Dipeptid Antibiyotik) Sentezinin Düzenlenmesi." 6. Ulusal KÜKEM Kong. Erzurum. Eylül 1989. N.G.Alaeddinoğlu(1990) Conjugation, 24th Turkish Microbiology Congress (Symp: Bacterial Plasmids). 26-28 June, Kayseri. N.G.Alaeddinoğlu. Ülkemizde Biyoteknolojik Çalışma potansiyeli (Panel) 21 Mayıs 1990, Ankara Üniversitesi Ziraat Fakültesi. N.G.Alaeddinoğlu(1990) The uses of plasmids in genetic engineering. 24th Turkish Microbiology Congress (Symp:Bacterial Plasmids).26-28 June, Kayseri. G. Özcengiz and N.G. Alaeddinoğlu: "A Role of Bacilysin in Sporulation of Its Producer Organism Bacillus subtilis." 119th Annual Meeting of Soc. Gen. Microbiol. Edinburg,U.K. April 1991. G. Özcengiz ve N.G. Alaeddinoğlu: "Ribozomal Olmayan Peptid Sentezi Üzerine Çalışmalar. 10. Ulusal Biyokimya Kong. Izmir. 1991. G. Özcengiz ve N.G. Alaeddinoğlu: "Saccharomyces cerevisiae ve Kluyveromyces marxianus'da Bakır ve Gümüş Direncinin Moleküler Mekanizmaları Üzerine Karşılaştırmalı bir Çalışma." 7. Ulusal KÜKEM Kong. Adana. 1991. Başalp., G. Özcengiz, ve N.G. Alaeddinoğlu: "Bacillus subtilis'de Sekonder Aktiviteler Arasındaki Etkileşimler." 7. Ulusal KÜKEM Kong. Adana. 1991. P.Afkhami, G.Özcengiz, N.G.Alaeddinoğlu(1992) Cry I tipi delta endotoksin üretiminin moleküler karakterizasonu ve optimizasyonu üzerine çalışmalar. 8. KÜKEM Kongresi (20-22 Eylül, Ankara), KÜKEM Dergisi 16(2): 122-123. Yazgan, G. Özcengiz, and N.G. Alaeddinoğlu: "Metal Uptake Profile and Growth Kinetics of Kluyveromyces marxianus." 16th Intern. Conf. on Yeast Genet. and Mol. Biol. Vienna, Austria. August 1992. P. Afkhami, G. Özcengiz, ve N.G. Alaeddinoğlu: "Kültür Ortamı ve Üreme Bacillus thuringiensis'de Plazmid Kalıpları ve Kristal Protein Sentezi Üzerine Etkileri." 11. Ulusal Biyokimya Kong. Antalya. Ekim 1992. Yazgan, G. Özcengiz, ve N.G. Alaeddinoğlu: " Maya Hücrelerinde Ağır Metal Biriktirilmesi: Yüzeye Bağlanma ve Hücre Alınım Seviyeleri." 11. Ulusal Biyokimya Kong. Antalya. Ekim 1992. P. Afkhami, G. Özcengiz, and N.G. Alaeddinoğlu: "Studies on Parasporal Crystal Protein Production by Bacillus thuringiensis 81 and Isolation of Acrystaliferous Mutants. 6th Intern. Pharmaceut. Technol. Symp. Ankara, Turkey. September 1992. Halıcıgil, P. Afkhami, E. Erdal, G. Özcengiz, ve N.G. Alaeddinoğlu: "Bacillus thuringiensis'de Kristal Protein Üretemeyen Mutantların Biyokimyasal Özellikleri." 11. Ulusal Biyokimya Kong. Antalya. Ekim 1992. E. Erdal, B. G. Özcengiz, F.A. Sharif, ve N.G. Alaeddinoğlu: "Çeşitli Rhizobium cicer Suşları ile Nohut Bitkisinde (Cicer arientinum) Verimliliğin Arttırılması." 8. Ulusal KÜKEM Kong. Ankara.1993. Içgen, E. Erdal, G. Özcengiz, F.A. Sharif, ve N.G. Alaeddinoğlu: "Rhizobium Izolatlarının Özellikleri ve Plazmidlerinin Analizi." 8. Ulusal KÜKEM Kong. Ankara.1993. N.Asghari.,M.Y.Özden.,F.A.Sharif.,N.G.Alaeddinoğlu (1993).Microbial degradation of Temik Aldicarb.12th International Meeting of European Culture Collection Organisation, Istanbul.Congress Book of Abstracts: pp.22. F.A.Sharif.,N.G.Alaeddinoğlu (1993).Cloning of glucose oxidase gene from Aspergillus niger. 12th International Meeting of European Culture Collection Organisation, Istanbul.Congress Book of Abstracts.pp.23 F.A.Sharif., M.Y.Arıca.,N.G.Alaeddinoğlu.,V.Hasırcı(1993).Overproduction of glucose oxidase from Aspergillus niger and immobilization of overproducers and wild type strains. 12th International Meeting of European Culture Collection Organisation. Istanbul.Congress Book of Abstracts pp.24. 7

Halıcıgil, P. Afkhami, G. Özcengiz, and N.G. Alaeddinoğlu: "Biochemical and Molecular Characterization of Crystal Protein-Negative Mutants of Bacillus thuringiensis" 6th Intern. Cong. on Biotechnol. Firenze, Italy. June 1993. F.A.Sharif., M.Y.Arıca.,N.G.Alaeddinoğlu.,V.Hasırcı(1993). Aspergillus niger de glukoz oksidaz enzimi üretiminin artırılması, organizmanın tutuklanması ve hücre reaktörüne uygulanması.8 Kükem Kongresi.Kükem Dergisi, 16 (2): 4-5. P.Afkhami, G. Özcengiz, ve N.G. Alaeddinoğlu: "Cry I Tipi Delta-Endotoksin Üretiminin Moleküler Karakterizasyonu ve Optimizasyonu Üzerine Çalıþmalar." 8. Ulusal KÜKEM Kong. Ankara.1993. Erdal, G. Özcengiz, F.A. Sharif, and N.G. Alaeddinoğlu: "Chickpea-Rhizobium cicer Symbiosis: I.Screening and Characterization of Effective Strains." 7th Intern. Cong. of Bacteriol. Appl. Microbiol. Prague,Czech. Republic. July 1994. Içgen, G. Özcengiz, F.A. Sharif, and N.G. Alaeddinoğlu: "Chickpea-Rhizobium cicer Symbiosis: II.Competitiveness of Inoculants and Optimization of Nodulation Conditions." 7th Intern. Cong. of Bacteriol. Appl. Microbiol. Prague,Czech. Republic. July 1994. Özcengiz, Y. Tayanç, and N.G. Alaeddinoğlu: "Regulation of Delta Endotoxin Synthesis by Mineral Elements." 7th Intern. Cong. of Bacteriol. Appl. Microbiol. Prague,Czech. Republic. July 1994. P. Afkhami, G. Özcengiz, ve N.G. Alaeddinoğlu: "Bacillus thuringiensis 81'de cry IA Tipi Kristal Genlerinin Lokasyonu." 2. Ulusal Biyoteknoloji Semp. Ankara. Eylül 1994. E. Erdal, G. Özcengiz, F.A. Sharif, ve N.G. Alaeddinoğlu: "Rhizobium cicer' de Melanin Üretiminin Genetik Analizi." 2. Ulusal Biyoteknoloji Semp. Ankara. Eylül 1994. Içgen, G. Özcengiz, F.A. Sharif, ve N.G. Alaeddinoğlu: "Rhizobium cicer-nohut Simbiyozu: Bazı Parametrelerin Değerlendirilmesi." 2. Ulusal Biyoteknoloji Semp. Ankara. Eylül 1994. P. Afkhami, G. Özcengiz, and N.G. Alaeddinoğlu: " Localization of cry I A type crystal protein genes in a local isolate of Bacillus thuringiensis." 7th Intern. Cong. on Biotechnol. Nice, France. February 1995. V.Hasırcı.,Y.Arıca.,N.G.Alaeddinoğlu.,C.Halıcıgil.,R.M.Wilkins.,R.B.Cain: Bacterial Degradation and Controlled Release of Aldicarb Intern.Symp. Control.Rel.Mater.18-21 July, 1995,Ottawa, Canada C.Halıcıgil.,M.Y.Özden., F.A.Sharif., N.G.Alaeddinoğlu Bacterial Degradation of Aldicarb Industrial Microbiology and Biotechnology Symposium, 27-30 July 1995. Massachusetts Intitute of Technology, Cambridge, USA. Y.Tayanç.,G.Özcengiz.,N.G.Alaeddinoğlu Control by Mineral Nutrients, ph, and Temperature of Crystal Protein Biosynthesis in Bacillus thuringiensis Industrial Microbiology and Biotechnology Symposium, 27-30 July 1995. Massachusetts Intitute of Technology, Cambridge, USA. Ozcengiz, G., Tayanc, Y. and Alaeddinoglu, N. G. 1995. Control by mineral nutrients, ph and temperature of crystal protein biosynthesis in Bacillus thuringiensis. Presented in "Symposium on Industrial Microbiology and Biotechnology" (27-30 July 1995, Cambridge, U.S.A.). Abstract Book. p. 24. Afkhami, P., Ozcengiz, G. and Alaeddinoglu, N. G. 1995. Characterization of plasmids harboring crystal protein genes in Bacillus thuringiensis 81. Presented in "7th European Congress on Biotechnology" (18-24 February, 1995, Nice, France). Abstract Book. Vol. 2, p.52. N.G.Alaeddinoğlu.1997.Biyolojik Silahlar NBC Savunma Sempozyumu (8-9 Mayıs, Küçükyalı, Istanbul, Türkiye) N.G.Alaeddinoğlu.1997.Biyoremediasyon (Açılış konferansı) 1.Kızılırmak fen Bilimleri Kongresi, 14-16 Mayıs. C.Halıcıgil., N.G.Alaeddinoğlu. 1997.Aldicarb biyotransformasyonu. 1.Kızılırmak fen Bilimleri Kongresi, 14-16 Mayıs. N.G.Alaeddinoğlu 1997.Bacterial Degradation of Carbamate Pesticides (Aldicarb in particular).oral presentation in ISEB 97 Meeting on Bioremediation; 24-27 September 1997, Leipzig, Germany. N.G.Alaeddinoğlu. Bacterial biosynthesis of PHB: Screening and characterization (Oral presentation) 4 th International Symposium on Biomedical Science and Technology (15-17 September, Istanbul, Turkey). 1997. 8

N.G.Alaeddinoğlu. Temel Bilimler ve Biyoteknoloji Biyoteknoloji ve Sağlık Sempozyumu 19 Aralık, 1997. Ankara. I.Gürsel., Z.Gümüşyazıcı., B.E.Dayanç., V.Hasırcı and N.G.Alaeddinoğlu. Bacterial production and screening of polyhydroxybutyrate (PHB). Presented in An International Symposium to Link Basic Science, Biotechnology and Industry (3-6 June, Münster, Germany). 1998. F.N.Kök., Y.Arıca., I.Gürsel.,V.Hasırcı and N.G.Alaeddinoğlu. Biosynthesis of Polyhydroxybutyrate and its copolymers by Alcaligenes latus. Presented in An International Symposium to Link Basic Science, Biotechnology and Industry (3-6 June, Münster, Germany). 1998. M.Y.Arıca.,C.Halıcıgil., A.Denizli., V.Hasırcı and N.G.Alaeddinoğlu..Studies of the affinity interaction of hydroxypyruvate reductase from Methylophilus spp. With cibacron blue F 3 GAderived phema microspheres; 8 th Int.Conf.on Polymer based Technology (June28-July3 Ma ale Hachamisha, Israel). 1998 Gürsel, M., Tunca, S., Özkan, M., Özcengiz, G., Alaeddinoğlu.N.G. Immunoadjuvant action of plasmid DNA in liposomes. 1st World Congress on Vaccines and Immunization 4-6 Mayıs 1998, Istanbul, Turkey Abstract sayfa 2-5. N.G.Alaeddinoğlu A novel screening method for bacterial PHB production(oral presantation). 3 rd Symposium on Industrial Microbiology and Biotechnology, 8-10 July, 1999. Gent (Belgium).Abstract L-14 M.Salameh., G.Özcengiz., Ü. Atalay., G.Özbayoğlu and N.G.Alaeddinoğlu. Enhanced recovery of silver from Artvin-Kafkasör ore by microbial treatment.international Biohydrometallurgy Symposium, Euroforum-Infantes., san Lorenzo de ElEscorial, Madrid (Spain). June 20-23,1999. M.Salameh., G.Özcengiz., Ü.Atalay., G.Özbayoğlu and N.G.Alaeddinoğlu. Bioleaching of silver from a limonite ore by using Aspegillus sp. 3 rd Symposium on Industrial Microbiology and Biotechnology, 8-10 July, 1999. Gent (Belgium).Abstract P7. 8. ÜYELİKLER ÜYELİK DÖNEMİ 1978- Asil üye ÜYELİK TÜRÜ KURULUŞ Society for General Microbiology (UK) 1978- Asil Üye Microbiological Society (Türkiye) 1982- Bilimsel Kurum Üyesi Turkish Journal of Biology (Türkiye) 1987- Asil Üye The Newyork Academy of Sciences (USA) 1977- Asil Üye KÜKEM (CultureCollection and Ind.Microbiol). Türkiye 9. ÖDÜLLER ÖDÜLÜN ADI ALINDIĞI KURULUŞ YILI Yurtdışı doktora bursu Milli Eğitim Bakanlığı 1971 En iyi Bilimsel Yayın Türk Mikrobiyoloji Derneği 1978 NATO ASI /Honör NATO 1983 NATO Scientific Collaboration Grant NATO 1986 9

Bilimsel Başarı Ödülü ODTÜ 2000 10. Yönettiği Araştırma Projeleri 1. TÜBITAK (TBAG 330):1978-1979 Genetic analysis of raffinose fermentation in E coli. 2. METU-Research fund:1979-1981.genetic analysis of chromosomal tobramycin resistance in E.coli K-12. 3. METU-Research fund: 1979-1982. Fermentation of whey for production of single cell protein. 4. METU-Research fund: 1979-1983. Bacterial desulfurization of Turkish lignites. 5. METU-Research fund:1981-1983. Polyacrylamide-entrapped yeast cells. 6. TÜBITAK (TBAG: 741): 1985-1987.Genetic characterization of aminoglycoside antibiotic resistance in clinical strains. 7. NATO Research Fund (in collaboration with Massachusetts Institute of Technology):1985-1987 on "Enzymatic synthesis of dipeptides". 8. TÜBITAK (TBAG: 810): 1986-1988. Studies on bacilysin biosynthesis and regulation. 9. BMFT (Germany): 1987/1990. Cloning of glucose oxidase genes in Aspergillus niger (in collaboration with Darmstadt University-Germany). 10. METU-Research fund(87.01.08.01): 1987-1988 "Hydrocarbon utilization by microorganisms in Jet-fuel". 11.TÜBITAK (KTC, AG-DPT-l): 1992-1994. Microbial degradation of chlorinated hydrocarbons. 12. TÜBITAK (TBAG-1048): 1992-1993. Production of high fuctose syrup in a reactor by enzymatic hydrolysis of starch. 13. DPT (AFP.01.08.DPT-12-K): 1989-1993. A new biotechnological approach in control of pesticides and herbicides ( Carbamates-aldicarb in particular). 14. DPT(AFP.01.09.DPT-12-K): 1994-1996. Production and development of Polyester films (membranes) of Microbial origin. 15. Nato/SFS Grant:1996-1998. The Production and application of microbial polyesters in the construction of biodegradable controlled antibiotic release systems and bone fracture repair rods (Mikrobiyal üretimden sorumlu). 16.DPT(AFP.01-08.DPT.98K122600).1997-2000 Mikrobiyal Kökenli Poliester Biyopolimerlerinin Biyoteknolojik Yöntemlerle üretimi. 17.AFP 1997-1999.Kristal protein genlerinin (cry I,II,IV) klonlanması ve uygulama için spesifik bir formülasyon geliştirilmesi 10

11.Yönettiği Tez Çalışmaları 1. Yüksek Lisans 1.Fermented ammoniated whey. 1982 (S.Kocabıyık) 2.Microbial desulfurization of coal. 1983 (G.Özcengiz) 3.Sucrose inversion by entrapped yeast cells. 1983 (G.Aykut) 4.Effects o freeze- drying on yogurt starter cultures. 1985 (A.Güven) 5.Identification and genetical analysis of Bacillus thuringiensis. 1987 (F. Sharif) 6.Isolation and characterization of alkaline protease in Bacillus subtilis. 1988 (A.Başoğlu) 7.The use of glucose isomerase in sugar industry: Properties and screening of the enzyme. 1989 (E.Usta) 8.Production of non-lactose milk by immobilized, β-galactosidase. 1989 (G.Balta) 9.Microbial utilization of chlorinated hydrocarbons. l991 (B.Aygün) 10.Crystal protein production and its genetic expression in a local isolate of B.thuringiensis. 1992 (P.Afkhami) 11.High fructose syrup production in a model reactor. 1993 (F.Halatçı) Co-advised by Dr. I.Eroğlu) 12.Microbial degradation of Aldicarb. 1993 (N.Asghari) 13.Studies on metal resistance system in Kluyveromyces marxianus 1993 (A.Yazgan) Co-advised. 14.Characterization of Various Rhizobium cicer Strains and Assessment of Their Symbiotic Effectiveness. 1994 (B.İçgen) Co-advised. 15.Physiological and Genetical Aspects of Rhizobium - Legume Symbiosis. 1994 (E. Erdal) Co-advised by Dr.G.Özcengiz. 16.Aldicarb biodegradation by soil bacteria.1995 (C.Halıcıgil) 17.Regulation of Delta-endotoxin biosynthesis and endospore formation in Bacillus thuringien 1995 (Y.Tayanç) Co-advised 18. Bacterial Colonization on Dental Implant Materials.1996 (G.Kahveci) 19. An optimization study on antidipteran (Cry IV-Type) toxin production. 1997 (M.Özkan) 20. Overproduction of neutral protease in Bacillus subtilis. 1997 (A.Günal). 21. Overproduction of α-amylase in Bacillus subtilis. 1997 (S.Tunca). 22. Microbial processing of Artvin-Kafkasör silver ore. 1999 (M.Salameh). 23. Bacterial PHB production.1999 (Z.Gümüşyazıcı). 11

24. Methomyl utilization by Metylothrophic bacteria.2001(d. Özaslan) 25.Hybridoma development:monoclonal antibody production in search for protein purificatio 2002 (G.Yücel). 2. Doktora l. A comparative study on the resistance to aminoglycoside antibiotics among strains of Enterobacteriaceae. 1986 (S.Kocabıyık) 2.Bacilysin regulation in Bacillus subtilis.1989 (G.Özcengiz) 3.Cloning of glucose oxidase gene(s) in A.niger. 1991 (F.Sharif) 4.Biochemical and Genetical aspects of aminoglycoside, B-lactam and quinolone antibiotic resistance among the clinical isolates of Pseudomonas aeruginosa.1992 (K.M. Adwan) 5.Cloning of crystal protein(δ-endotoxin) genes and development of expression vectors in Bacillus thuringiensis.1998 (P.Afkhami) 6.Genetical and Biochemical Basis of Aldicarb utilization in Methylosinus sp.2001 (C.Halıcıgil) 12