Timuçin AVŞAR (PhD) (July 2015)

CURRICULUM VITAE 1. Name Surname : Timuçin AVŞAR Timuçin AVŞAR (PhD) (July 2015) Address Phone E-Mail : Göktürk mah. Istanbul Cad. Telekom Sok. Arcadium 1 No:18 Eyüp İstanbul : 0533 731 4937 : timucinavsar@gmail.com 2. Date of Birth : 30.05.1986 3. Title : Molecular Biologist and Geneticist 4.Öğrenim Durumu : Degree Programme University Year Bachelor Molecular Biology and 2003 - Genetics 2007 Bachelor (Erasmus) Moleculare Biotechnologie Technische Universitaet Muenchen 2005-2006 Molecular Biology, Graduate (Masters 2007 - Genetics and Degree) 2009 Biotechnology Graduate (PhD) Molecular Biology, Genetics and Biotechnology 5. Academic Titles Molecular Biologist and Geneticist (PhD) Molecular Neuroscientist 6. Yönetilen Yüksek Lisans ve Doktora Tezleri 2009-2013 6.1. Master Thesis Institute of Life Sciences Thesis Title: Protein Biomarkers Of Multiple Sclerosis; Studies Of Cerebrospinal Fluids From Clinically Different Subtypes of Multiple Sclerosis Patients 6.2. PhD Thesis Institute of Life Sciences Thesis Title: Investigation of Molecular Pathways and Biomarkers in Multiple Sclerosis Clinical Subtypes 7. Publications

7.1. Internationally reviewed and indexed journal articles 1. Avsar, T., Korkmaz, D., Tütüncü, M., Demirci, N. O., Saip, S., Kamasak, M., Siva A. & Turanli, E. T. (2012). Protein biomarkers for multiple sclerosis: semi-quantitative analysis of cerebrospinal fluid candidate protein biomarkers in different forms of multiple sclerosis. Multiple Sclerosis Journal, 18(8), 1081-1091. 2. Yener, U., Avsar, T., Akgün, E., Şeker, A., Bayri, Y., & Kılıç, T. (2012). Assessment of antiangiogenic effect of imatinib mesylate on vestibular schwannoma tumors using in vivo corneal angiogenesis assay: Laboratory investigation. Journal of neurosurgery, 117(4), 697-704. 3. Özkan, A., Biçer, A., Avşar, T., Şeker, A., Toktaş, Z. O., Bozkurt, S. U. & Kılıç, T. (2012). Temporal expression analysis of angiogenesis-related genes in brain development. Vascular cell, 4(1), 1-9. 4. Karal-Yilmaz, O., Ozkan, A., Akgun, E., Kukut, M., Baysal, K., Avsar, T., & Kilic, T. (2013). Controlled release of imatinib mesylate from PLGA microspheres inhibit craniopharyngioma mediated angiogenesis. Journal of Materials Science: Materials in Medicine, 24(1), 147-153. 5. Clark, V. E., Erson-Omay, E. Z., Serin, A., Yin, J., Cotney, J., Özduman, K., Avsar T et. al. & Günel, M. (2013). Genomic analysis of non-nf2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Science, 339(6123), 1077-1080. 6. Yener, U., Avsar, T., Akgun, E., Seker, A., Bayri, Y., & Kilic, T. (2013). Angiogenesis RESPONSE. Journal of Neurosurgery, 119(5), 1353-1353. 7. Kılıç, K., Avsar, T., Akgün, E., Özkan, A., Toktaş, Z. O., Şeker, A., & Kılıç, T. (2013). Gamma Knife Radiosurgery Inhibits Angiogenesis of Meningiomas: In Vivo Rat Corneal Assay. World neurosurgery, 80(5), 598-604. 8. Villar, L. M., Casanova, B., Ouamara, N., Comabella, M., Jalili, F., Leppert, D., Avsar T. & Bar Or, A. (2014). Immunoglobulin M oligoclonal bands: Biomarker of targetable inflammation in primary progressive multiple sclerosis. Annals of neurology, 76(2), 231-240. 9. Ceylan, D., Tatarlı, N., Avsar, T., Arslanhan, A., Bozkurt, S. U., Bağcı, P., & Kilic, T. (2014). In vivo effect of pregnancy on angiogenesis potential of arteriovenous malformation tissue samples: an experimental study. Journal of neurosurgical sciences. 10. Kuhle, J., Disanto, G., Dobson, R., Adiutori, R., Bianchi, L., Topping, J., Avsar T et. al. & Martínez, A. D. (2015). Conversion from clinically isolated syndrome to multiple sclerosis: a large multicentre study. Multiple Sclerosis Journal, 1352458514568827. 11. Avsar, T., Durası, İ. M., Uygunoğlu, U., Tütüncü, M., Demirci, N. O., Saip, S., Siva A & Turanlı, E. T. (2015). CSF Proteomics Identifies Specific and Shared Pathways for Multiple Sclerosis Clinical Subtypes. PLoS ONE. e0122045. 12. Atabay, K. D., Yildiz, M. T., Avsar, T., Karabay, A., & Kiliç, T. (2015). Knockdown of Pin1 leads to reduced angiogenic potential and tumorigenicity in glioblastoma cells. Oncology Letters. Online publication. 7.2. Publications in Proceedings and International Congress Abstract Books 1. Avsar, T., Yener, U., & Akgun, E. (2011). Abstract A30: Investigation of imatinib mesylate effect on vestibular schwannoma tumor by using in vivo corneal angiogenesis model. Cancer Prevention Research, 4(10 Supplement), A30-A30.

2. Avsar, T., Atabay, K. D., Mehmet, Y. T., Kilic, T., & Karabay, A. K. (2011). Abstract A31: Effects of Pin1 inhibition on tumorigenicity of glioblastoma multiforme. Cancer Prevention Research, 4(10 Supplement), A31-A31. 3. Avsar, T., Akgun, E., Yılmaz, O. K., Küküt, M., Baysal, K., Bayir, Y.,... & Kilic, T. (2011). Abstract B48: Inhibition of recurrence of craniopharyngiomas with imatinib mesylate-loaded poly (lactide-co-glycolide)(plga) microspheres. Cancer Prevention Research, 4(10 Supplement), B48-B48. 4. Ayranci, G., Avsar, T., Seker, A., Kilic, T., & Bozkurt, S. (2012). Leptin and leptin receptor expression in pituitary adenomas. In VIRCHOWS ARCHIV (Vol. 461, pp. S81-S82). 233 Sprıng St, New York, Ny 10013 USA: Springer. 5. Avsar, T., Uygunoglu, U., Tutuncu, M., Demirci, N. O., Saip, S., Siva, A., & Turanli, E. T. (2012, October). Proteomic analysis: identification of candidate protein biomarkers in the CSF and serum samples of patients with clinically different multiple sclerosis subtypes. In Multiple Sclerosis Journal (Vol. 18, pp. 263-264). 1 Olıvers Yard, 55 Cıty Road, London Ec1y 1sp, England: Sage Publications Ltd. 6. Avsar T, Uygunoğlu U, Tütüncü M, Demirci NO, Saip S, Siva A and Turanlı ET, (2012). Proteomic Analysis: Identification of candidate protein biomarkers in the CSF and serum samples of patients with clinically different multiple sclerosis subtypes. 28th Congress of the European Comittee For Treatment and Research in Multiple Sclerosis (ECTRIMS), 10 14.10. Lyon, France, Poster Presentation 7. Avsar T, Durası IM, Saip S, O. OU, Siva A and Turanlı ET, (2012) Disease Specific Pathway Analysis in Multiple Sclerosis. American Society of Human Genetics, Annual Meeting, 6-10.11., San Francisco, USA, Poster Prensentation 8. Avşar T, Terzioğlu G, Çelikyapı G, Bozkurt SU, Demirel GY, Siva A, Altuğ T and Turanlı ET. (2012) CXCR4 (Chemokine Receptor) Expression Analysis In Chronic Cuprizone Model of Multiple Sclerosis By Quantitative Real Time PCR. American Society of Human Genetics, Annual Meeting, 6-10.11.2012, San Francisco, USA, Poster Prensentation 9. Kuhle, J., Dobson, R., Bestwick, J. P., Topping, J., Dalla Costa, G., Khademi, M., Avsar T. & Brassat, D. (2013, October). Multivariate clinically isolated syndrome (CIS) risk factor study: towards individual prognosis and treatment indication in CIS. In Multiple Sclerosis Journal (Vol. 19, No. 11, pp. 33-34). 1 Olivers Yard, 55 City Road, London Ec1y 1sp, England: Sage Publications Ltd. 10. Avsar, T., Durasi, İ., Uygunoglu, U., Tutuncu, M., Demirci, N., Saipoglu, S.,... & Turanli, E. (2015). Proteomic Analysis in CSF Identified Subtype Specific and Shared Molecular Pathways for Multiple Sclerosis Clinical Phenotypes (P5. 216). Neurology, 84(14 Supplement), P5-216. 7.3. Book Chapters 1. Eda Tahir Turanli, Timucin Avsar, Uğur Uygunoğlu, Orhun H. Kantarci, Aksel Siva. (2015). General Methods in Biomarker Research and their Applications, Biomarkers for Phase Switches in Multiple Sclerosis, ISBN: 978-94-007-7695-1. 2. Timuçin Avşar, Uğur Uygunoğlu Aksel Siva ve Eda Tahir Turanlı, (2013) Temel ve Klinik Nöroimmunoloji, Multipl Sklerozda Biyobelirteçlerin Tanı ve Prognozdaki Önemi, ISBN: 3872003, 2013

7.4. National Peer Reviewed Publications 7.5. National Scientific Meeting Abstracts 1. Avşar T, Turanli E, Pusuluk O, Yanikkaya GD, Saip S, Altıntaş A, Sav A, Siva A, Establishment of Multiple Sclerosis Cuprizone Mouse Model. IX. International Attended, National Medical Biology and Genetics Congress. 23-27 October, 2007, Antalya, Turkey, Poster Presentation. 2. Avşar T, Turanli ET, Tütüncü M, Siva A; Protein Biomarkers for Multiple Sclerosis: Analysis of cerebrospinal fluid candidate protein biomarkers in different forms of multiple sclerosis X. National Medical Biology and Genetics Congress, 28 31 October 2009: Bodrum, Muğla, Turkey, Poster presentation. 3. Genç A, Avşar T, Bozkurt SU, Karabağlı P, Şeker A, Bayri Y, Konya D, Kılıç T, The importance of Gamma Knife Radiosurgery in the treatment of Central Neurocytomas. Nervous System Surgery Society VI. Scientific Congress, 28-31 Ekim 2010, Marmaris Muğla, Turkey, Poster presentation. 4. Tural S, Avşar T, Bozkurt SU, Şeker A, Bayri Y, Konya D, Özek M, Kılıç T, The importance of Gamma Knife Radiosurgery in the treatment of optic gliomas. Nervous System Surgery Society VI. Scientific Congress, 28-31 Ekim 2010, Marmaris Muğla, Turkey, Poster presentation 5. Yilmaz OK, Ozkan A, Akgun E, Kukut M, Baysal K, Avşar T, Kilic T, Inhibition of Recurrence of Craniopharyngiomas with Imatinib Mesylate-Loaded Poly(Lactide-Co-Glycolide) (PLGA) Microspheres. Turkish Neurosurgery Society, 25. Scientific Congress, 22-26 April Belek, Antalya, Turkey 2011, Poster Presetation. 6. Kılıç K, Akgün E, Avşar T, Özkan A, Toktaş ZO, Şeker A, Bayri Y, Konya D, Kılıç T, Gamma- Knife Radiosurgery Inhibits Meningioma Induced Angiogenesis: Dose Escalation by Corneal Angiogenesis. Turkish Neurosurgery Society, 25. Scientific Congress, 22-26 April Belek, Antalya, Turkey 2011, Oral Presetation. 7. Yener U, Avşar T, Bozkurt SU, Şeker A, Bayri Y, Konya D, Özek M, Kılıç T, Investigation Of Imatinib Mesylate Effect On Vestibular Schwannoma Tumor By Using In Vivo Corneal Angiogenesis Model. Turkish Neurosurgery Society, 25. Scientific Congress, 22-26 April Belek, Antalya, Turkey 2011, Oral Presetation. 8. Avsar T, Uygunoğlu U, Tütüncü M, Demirci ON, Saip S, Siva A, Turanli ET, (2012) Proteom study in clinically different subtypes of multiple sclerosis, by using CSF and Serum samples: Subtype specific protein biomarker identification. National Neurology Congress, Antalya, Turkey, Oral Presentation 7.6 Other Publications 1. Avsar T, Siva A, Altug T and Turanli ET, (2011) Neuro-Degeneration and Inflammation Based Animal Models of Multiple Sclerosis, Turkish Immunology Journal. 2. Avsar T, Tütüncü M, Demirci NO, Saip S, Siva A and Turanlı ET, Proteomic Analysis In The CSF and Serum Pool of Clinically Different Multiple Sclerosis Patients, Turkey Clinical Medical Sciences Journal Supplement [Türkiye Klinik Tıp Bilimleri Dergisi], December 2011, Vol:31 No:6, p:173. 3. Avsar T, Bozkurt SU, Demirel GY, Saip S, Altıntaş A, Siva A, Altuğ T and Turanli ET, (2011).

Investigation of Neuro-Inflammatory Parameters in the Cuprizone Mouse Model of Multiple Sclerosis, Turkey Clinical Medical Sciences Journal Supplement [Türkiye Klinik Tıp Bilimleri Dergisi], December 2011, Vol:31 No:6, p:173-174. 4. Terzioğlu G, Avsar T, Çakan G, Çelikyapı G, Bozkurt SU, Demirel GY, Siva A, Altuğ T and Turanli ET, (2011). Investigation of CXCR4 (Chemokıne Receptor) Gene Level In The Chronic Cuprizone Model By Quantitative Real Time PCR, Turkey Clinical Medical Sciences Journal Supplement [Türkiye Klinik Tıp Bilimleri Dergisi], December 2011, Vol:31 No:6, p:186. 5. Avsar T, Korkmaz D, Kamasak M, Siva A, Turanli ET, Analysis of Tau, MBP, MOG, NFL and GFAP protein from cerebrospinal fluids of clinically different multiple sclerosis patients using computational classification methods. In VIVO International Journal of Experimental and Clinical Pathophysiology and Drug Research, Vol:25, No: 3 pp.367-576 May June 201, p 5. 8.Projects 1. TÜBİTAK SBAG (2008 2009): Oral Liken Planus İmmunopatogenezinde Th1/Th2 Sitokin Profili, Sitotoksik T-Hücre Aktivasyonu ve Hücre Aktivasyonunda Rolü Olan Adezyon Molekülleri Ile Kemokin Reseptörlerinin Periferik Kan ve Doku Örneklerinde Değerlendirilmesi, - Researcher (Budget: 22691 TL) 2. TÜBİTAK SBAG 109S070 (2010 2013): Multipl Skleroz'da Proteomik Analizler: Farklı MS Klinik Alt Tiplerinin BOS ve Serum Örneklerinde Protein Belirteçlerinin Tanımlanması Bursiyer (Budget: 307038 TL) 3. Tarımsal Araştımalar Genel Müdürlüğü (TAGEM) (2013 2014) Süt ve Süt Ürünlerinde Sitokrom B Primerleri ile Tağşiş Tespitine Yönelik Kantitatif Polimeraz Zincir Reaksiyonu Kiti Geliştirilmesi Project Manager (Budget: 27758 TL) 4. Sanayi ve Ticaret Bakanlığı TEKNOGİRİŞİM Projesi (2013 2014) Multipl Skleroz Hastalığının Tanı ve Prognozunda Önemli Biyobelirteçlerin Kantitatif Analizlerine Yönelik Elisa Kiti Geliştirilmesi Project Manager (Budget: 99850 TL) 5. TÜBİTAK TEYDEB 9130074 (2014 2016) Hipertrofik Kardiyomyopati İle İlgili Mutasyonların Tespitine Yönelik Genetik Tarama Kiti Geliştirilmesi Project Manager (Budget: 623351 TL) 6. TÜBİTAK TEYDEB 9130074 (2014 2016) Yaygin Kalıtsal Hastalıklarının Taşıyıcılık Tespitine Yönelik Mutasyon Tarama Kiti Geliştirilmesi Project Manager (Budget: 713076 TL) 7. TÜBİTAK TEYDEB 9130074 (2014 2016) Kalitsal Periyodik Ateş Hastalıklarının Tespiti İçin Genetik Tanı Kiti Geliştirilmesi Project Manager 9. Awards 1. Ulusal Nöroloji Kongresi (2015), En İyi Sözel Poster Bildirisi 2. lik Ödülü 2. Türk Nöroşirurji Derneği 29. Bilimsel Kongresi, En iyi Sözel Poster Bildirisi 1. lik ödülü