ÖZGEÇMİŞ I. BİREYSEL BİLGİLER Adı Arzu Zeynep Soyadı KARABAY İetişim adresi Biyokimya Anabilim Dalı Tandoğan 06100, ANKARA Telefon 0312-2033059 e-posta akarabay@ankara.edu.tr zeynepkarabay@yahoo.com II. EĞİTİMİ 2005-2012 Biyokimya Anabilim Dalı (Doktora) Doktora tez döneminde, Madrid Complutense Üniversitesi Eczacılık Fakültesi, Farmakoloji Departmanı nda Prof. Dr. Beatriz de las Heras Polo nun denetiminde, 3 ay süreli AB HAYATBOYU ÖĞRENME/ERASMUS bursu (1/5/2008-31/7/2008) 2001-2004 Biyokimya Anabilim Dalı (Yüksek Lisans) 1997-2002 (Lisans) 1989-1996 Konya Meram Anadolu Lisesi III. BİLİMSEL YAYIN LİSTESİ SCIENCE CITATION INDEX (SCI) KAPSAMINDA YER ALAN ÖZGÜN MAKALELER Koc A, Ozkan T, Karabay AZ, Sunguroglu A, Aktan F. Cell Biochem Funct. 2011, 9(8):679-85. Effect of L-carnitine on the synthesis of nitric oxide in RAW 264 7 murine macrophage cell line.
A. Selen GURKAN, Arzu Z. KARABAY, Zeliha BUYUKBINGOL, Erdem BUYUKBINGOL, Synthesis and effects of some novel tetrahydronaphthalene derivatives on proliferation and nitric oxide production in lipopolysaccharide activated Raw264.7 macrophages, Eur. J. Med. Chem., accepted for publication, 2010. A. Selen GURKAN, Arzu KARABAY, Zeliha BUYUKBINGOL, Adeboye ADEJARE, Erdem BUYUKBINGOL, Syntheses of Novel Indole Lipoic Acid Derivatives and Their Antioxidant Effects on Lipid Peroxidation, Arch. Pharm. Chem. Life Sci., 338, 67-73 (2005). Karabay AZ, Koc A, Gurkan-Alp AS, Buyukbingol Z, Buyukbingol E. Inhibitory effects of indole α-lipoic acid derivatives on nitric oxide production in LPS/IFNγ activated RAW 264.7 macrophages. Cell Biochem Funct. 2015 Apr;33(3):121-7. Karabay AZ, Aktan F, Sunguroğlu A, Buyukbingol Z.Methylsulfonylmethane modulates apoptosis of LPS/IFN-γ-activated RAW 264.7 macrophage-like cells by targeting p53, Bax, Bcl-2, cytochrome c and PARP proteins. Immunopharmacol Immunotoxicol. 2014 Dec;36(6):379-89. HAKEMLİ ULUSAL DERGİLERDE YER ALAN ÖZGÜN MAKALELER Effects of glucosamine on LPS/IFN- γ induced RAW 264.7 macrophage apoptosis Arzu Zeynep Karabay, Aslı Koç, Tülin Özkan, Asuman Sunguroğlu, Fügen Aktan, Zeliha Büyükbingöl, Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2012, 65 (1) DOI: 10.1501/Tıpfak_000000802 Effect of taurine on hydrogen peroxide production in lipopolysaccharide induced RAW 264.7 macrophage cells. Arzu Z. Karabay, Aslı Koç, Tülin Özkan, Zeliha Büyükbingöl, Asuman Sunguroğlu, Fügen Aktan. FABAD J. Pharm. Sci., 33, 187-192, 2008. BİLDiRiLER ULUSLARARASI BİLİMSEL TOPLANTILARDA SUNULAN VE BİLDİRİ KİTABINDA BASILAN BİLDİRİLER: 1. Karabay, AZ; Buyukbingol, Z Probable antioxidant effects of tryptophan on streptozotocin diabetic rats., 31st Febs Congress Molecules in Health and Disease 24-29 June 2006/İstanbul-Turkey 2. Özkan T, Karabay ZA, Koç A, Karadag A, Aydos S, Çalıskan E, Öztürk G, Ilgaz SN, Yükselen I, Sunguroglu A. Wheatgrass extract increases proliferation of RAW 264.7 macrophages induced by hydrogen peroxide (H2O2) or lipopolysaccharide (LPS) International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Geneva(CICG) 16-20 August 2009.
3. Karabay ZA,Özkan T, Koç A, Büyükbingöl Z, Sunguroglu A. Effects of MSM (methylsulfonylmethane) on SNP (sodium nitroprusside) and H2O2 (hydrogen peroxide) induced RAW 264.7 macrophages International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Geneva(CICG) 16-20 August 2009. 4. Aydos S, Ozkan T, Karabay AZ, Koc A, Karadag A, Altinok B, Sunguroglu A.Wheatgrass juice reduces nitric oxide production in LPS induced raw 264.7 cells. Molecular Medicine(IUBMB Life), 5-8 May 2006, İstanbul. 5. Koc A, Karabay AZ, Ozkan T, Karadag A, Sunguroglu A, Aktan F, Buyukbingol Z. Effect of L-carnitine on NO production in lipopolysaccharide induced RAW 264.7 cells. Molecular Medicine(IUBMB Life), 5-8 May 2006, İstanbul. 6. Arzu Zeynep Karabay, Asli Akinci, Tulin Ozkan, Asuman Sunguroglu, Fugen Aktan, Zeliha Buyukbingol. Effect of methylsulfonylmethane on proliferation and nitric oxide production in LPS activated RAW 264.7 cells 34th FEBS Congress. Life's Molecular Interactions. July 4-9, 2009, Prague, Czech Republic. 7. Tulin Ozkan, Filiz Bakar, Arzu Zeynep Karabay, Asli Akinci, Buket Altinok, Aynur Karadag, Sena Aydos, Asuman Sunguroglu. Wheatgrass extract effects lipid peroxidation levels in human promyelocytic leukemia cell line HL-60 34th FEBS Congress. Life's Molecular Interactions. July 4-9, 2009, Prague, Czech Republic. 8. Asli Akinci, Arzu Karabay, Tulin Özkan, Asuman Sunguroglu, Fugen Aktan. The effect of LPS incubation periods on nitric oxide levels in RAW 264.7 macrophage cell line 34th FEBS Congress. Life's Molecular Interactions. July 4-9, 2009, Prague, Czech Republic. 9. Effect of methylsulfonylmethane on LPS-IFN-gamma induced RAW 264.7 macrophage apoptosis Karabay, AZ; Ozkan, T; Koc, A, et al. 35th Congress of the Federation-of-European-Biochemical-Societies, Date: JUN 26-JUL 01, 2010 Gothenburg SWEDEN FEBS JOURNAL Volume: 277 Pages: 57-57 Published: 2010 10. NF-kappaB activation and complex control of NOS2 gene promoter in K562 imatinib mesylate resistant CML cell line Ozkan, T; Karadag, A; Altinok, B, Karabay AZ, Koc A, Bozkurt S, Aydos S, Sunguroglu A. Conference Information: 35th Congress of the Federation-of-European-Biochemical-Societies, Date: JUN 26-JUL 01, 2010 Gothenburg SWEDEN FEBS JOURNAL Volume: 277 Pages: 147-147 Published: 2010 11. Effect of wnt3a or lithium chloride preconditioning on nitric oxide production in RAW264.7 macrophages and K562 leukemic cell line Karabay, AZ; Ozkan, T; Koc, A, Karadag A Altinok B, Buyukbingol Z, Sunguroglu A. Conference Information: 35th Congress of the Federation-of-European-Biochemical- Societies, Date: JUN 26-JUL 01, 2010 Gothenburg SWEDEN FEBS JOURNAL Volume: 277 Pages: 147-148 Published: 2010
12. Effect of L-carnitine on the synthesis of nitric oxide in RAW 264 murine macrophage cell line Koc, A.; Ozkan, T.; Karabay, A. Z.; et al. CELL BIOCHEMISTRY AND FUNCTION Volume: 29 Issue: 8 Pages: 679-685, 2011. 13. Effects of methylsulfonylmethane on viability of HCT-116 cell line Karabay, A. Z; Ozkan, T.; Koc, A.; et al. 22. IUBMB Congress/37th FEBS Congress, Seville, SEP 04-09, 2012. 14. Effect of methylsulfonylmethane on inos gene methylation in macrophages Buyukbingol, Z.; Karabay, A. Z.; Ozkan, T.; et al. 22nd IUBMB Congress/37th FEBS Congress Location: Seville, SPAIN Date: SEP 04-09, 2012 15. Karabay AZ, Koc A, Gurkan-Alp AS, Buyukbingol Z, Buyukbingol E. Effects of indole α-lipoic acid derivatives on nitric oxide production in LPS/IFN-γ activated RAW 264.7 macrophages FEBS-EMBO 2014 Conference. 30 Ağustos-4 Eylül 2014 Paris-Fransa 16. Karabay AZ, Koc A, Buyukbingol Z. Effect of microenvironment on Imatinib resistance of K562 cells. FEBS Congress. Berlin, Germany 4-9 Temmuz, 2015. IV. PROJE VE BENZERİ ÇALIŞMALAR Projenin Konusu Destekleyen/Projedeki görevi Başlangıç / Bitiş Tarihleri Metilsülfonilmetan (MSM), kondroitin sülfat ve glukozaminin LPS/IFN-gamma (lipopolisakkarit/interferon-gamma) ile indüklenmiş RAW 264.7 makrofaj hücre serisinde apoptoz ve inos (indüklenebilen nitrik oksit sentaz) gen metilasyonu üzerine etkileri TÜBİTAK/Bursiyer 15 Ekim 2010-15 Ekim 2011 Projenin Adı Destekleyen Projedeki Görevi Başlangıç/Bitiş Tarihleri
Beta-katenin, Nükleer faktör kappa B ve Akirin Proteinlerinin Birliktelikleri ve Kronik Myeloid Lösemide İmatinib Direncindeki Rolleri TÜBİTAK Araştırıcı 15 Ekim 2011-15 Ekim 2013