Derece Bölüm/Program Üniversite Yıl. Y. Lisans Tıp Fakültesi Osmangazi Üniversitesi, Tıp Fakültesi. Docentlik Tıbbi Genetik 2012

Transkript

1 ÖZGEÇMİŞ VE ESERLER LİSTESİ ÖZGEÇMİŞ Adı Soyadı: Ahmet Okay ÇAĞLAYAN Öğrenim Durumu: Derece Bölüm/Program Üniversite Yıl Y. Lisans Tıp Fakültesi Osmangazi Üniversitesi, Tıp Fakültesi 2001 Doktora/S.Yeterlik/ Tıpta Uzmanlık Tıbbi Genetik Erciyes Üniversitesi, Tıp Fakültesi 2007 Docentlik Tıbbi Genetik 2012 Görevler: Görev Unvanı Görev Yeri Yıl Dr. Ar. Gör. Erciyes Üniversitesi, Tıp Fakültesi Uz. Dr. Kayseri Eğitim ve Araştırma Hastanesi Doktora Sonrası Arastırmacı Dr. Yale Üniversitesi Öğretim Görevlisi Yale Üniversitesi Doç. Dr. İstanbul Bilim Üniversitesi Bilimsel Kuruluşlara Üyelikler : 2015 American Association for Science and Technology 2008 European Biotechnology Thematic Network Association 2007 Türkiye Diabet, Obezite ve Beslenme Derneği 2006 Tıbbi Genetik Derneği Editöryal Hizmetler Halen Editorial Board, Austin Journal of Autism and Related Disorders Halen Editorial Board, Austin Journal of Clinical Neurology Halen Editorial Board, Journal of Genomes and Exomes Halen Associate Editor, Frontiers in Child and Neurodevelopmental Psychiatry Assistant Editor, Journal of Pediatric Neurology Co-Editor, Türkiye Tıbbi Genetik Derneği Bülteni 1

2 ARAŞTIRMA MAKALELERİ (SCI DERGİLERDE) Dundar, M., O. Caglayan, C. Saatci, H. Karaca, M. Baskol, S. Tahiri, Y. Ozkul, How the I1307K Adenomatous Polyposis Coli Gene Variant Contributes in the Assessment of Risk of Colorectal Cancer, but not Stomach Cancer, in a Turkish Population, Cancer Genet. Cytogenet., 2007;177: Eggermann, T., E. Meyer, O. Caglayan, M. Dundar, N. Schönherr, ICR1 epimutations in 11p15 are restricted to patients with Silver-Russell syndrome features, J. Pediatr. Endocrinol. Metab., 2008;21: Saatci, C, Y. Ozkul, S. Tahiri, A.O. Caglayan, A.B. Turhan, M. Dundar, The effect of maras powder on DNA methylation and micronucleus formation in human buccal tissue, J. Toxicol. Environ. Health. A., 2008;71: Unger, S., F. Antoniazzi, M. Brugnara, Y. Alanay, A. Caglayan, K. Lachlan, S. Ikegawa, G. Nishimura, B. Zabel, J. Spranger, A. Superti-Furga, Clinical and radiographic delineation of odontochondrodysplasia, Am. J. Med. Genet. A., 2008;146: Dundar, M., K. Erkilic, M. Agun, A.O. Caglayan, P. Comeglio, G. Matyas, A.H. Child, Scoliosis, blindness and arachnodactyly in a large Turkish Family: Is it new syndrome?, Genet. Couns., 2008;19: Tanriverdi, F., S. Taheri, H. Ulutabanca, A.O. Caglayan, Y. Ozkul, M. Dundar, A. Selcuklu, K. Unluhizarci, F.F. Casanueva, F. Kelestimur, Apolipoprotein E3/E3 genotype decreases the risk of pituitary dysfunction after traumatic brain injury due to various causes: preliminary data, J. Neurotrauma, 2008;25: Yalcin, A.A., N. Kalay, A.O. Caglayan, F. Kayaalti, M. Duran, I. Ozdogru, M.T. Inanc, A. Dogan, E. Basar, A. Oguzhan, The Relationship between Slow Coronary Flow and Angiotensin Converting Enzyme and ATIIR1 Gene Polymorphisms, J. Natl. Med. Assoc., 2009;101: Saatci, C., A.O. Caglayan, Y. Ozkul, S. Tahiri, A.B. Turhan, M. Dundar, Detection of p16 promotor hypermethylation in "Maras powder" and tobacco users, Cancer Epidemiology, 2009;33: Caglayan, O., N. Kalay, C. Saatci, A. Yalcın, H. Akalın, M. Dundar, Lack of Association of the Glu298Asp Polymorphism of Endothelial Nitric Oxide Synthase with Coronary Slow Flow in the Turkish Population, Canadian J. Cardiology, 2009;25: e Kalay, N., A.O. Caglayan, H. Akkaya, I. Ozdogru, A. Dogan, M.T. Inanc, M.G. Kaya, A. Ergin, R. Topsakal, N.K. Eryol, A. Oguzhan, M.Dundar, The Relation Between The Acute Aortic 2

3 dissection and The Angiotensin Converting Enzyme Gene Polymorphism, The Tohoku Journal of Experimental Medicine, 2009;219: Saatci, C., A.O. Caglayan, I. Kocyigit, H. Akalin, L.G. Kaynar, F. Altuntas, B. Eser, M. Demir, M. Cetin, Y. Ozkul, No Significant Expression of WT1 Gene In Multiple Myeloma Patients At Diagnosis: Is WT1 Gene Expression Useful Marker In Multiple Myeloma?, Hematology, 2010;15(1): Caglayan, A.O., I. Ozyazgan, F. Demiryilmaz, M.T. Ozgun, Are Heterochromatin Polymorphisms Affect Recurrent Miscarriage?: Cytogenetic Results of 336 Patients With Recurrent Spontaneous Abortions in Middle Anatolia in Turkey, Journal of Obstetrics and Gynecology Research, 2010;36(4): Caglayan, A.O., I. Ozyazgan, F. Demiryilmaz, H. Gumus, MEFV Gene Compound Heterozygous Mutations In Familial Mediterranean Fever Phenotype: A Retrospective Clinical and Molecular Study, Nephrology Dialysis Transplantation, 2010;25(8): Bahi-Buisson, N., Poirier, K., Boddaert, N., Fallet-Bianco, C., Specchio, N., Bertini, E., Caglayan, O., Lascelles, K., Elie, C., Rambaud, J., Baulac, M., An, I., Dias, P., des Portes, V., Moutard, M.L., Soufflet, C., El Maleh, M., Beldjord, C., Villard, L., Chelly, J. GPR56-related bilateral frontoparietal polymicrogyria: further evidence for an overlap with the cobblestone complex., Brain, 2010;133(11): Bilgüvar, K., Oztürk, A.K., Louvi, A., Kwan, K.Y., Choi, M., Tatli, B., Yalnizoğlu, D., Tüysüz, B., Cağlayan, A.O., Gökben, S., Kaymakçalan, H., Barak, T., Bakircioğlu, M., Yasuno, K., Ho, W., Sanders, S., Zhu, Y., Yilmaz, S., Dinçer, A., Johnson, M.H., Bronen, R.A., Koçer, N., Per, H., Mane, S., Pamir, M.N., Yalçinkaya, C., Kumandaş, S., Topçu, M., Ozmen, M., Sestan, N., Lifton, R.P., State, M.W., Günel, M. Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations., Nature, 2010;467(7312): Bakircioglu, M., O.P. Carvalho, M. Khurshid, J.J. Cox, B. Tuysuz, T. Barak, S. Yilmaz, O. Caglayan, A. Dincer, A.K. Nicholas, O. Quarrell, K. Springell, G. Karbani, S. Malik, C. Gannon, E. Sheridan, M. Crosier, S.N. Lisgo, S. Lindsay, K. Bilguvar, F. Gergely, M. Gunel, C.G. Woods, The Essential Role of Centrosomal NDE1 in Human Cerebral Cortex Neurogenesis, Am. J. Hum. Genet., 2011;88(5):

4 Caglayan, A.O, M. Dundar, F. Tanriverdi, N. A. Baysal, K. Unluhizarci, Y. Ozkul, M. Borlu, C. Batukan, F. Kelestimur, Can Decreased Aromatase and 5-alpha reductase expressions can be responsible for idiopathic hirsutism?, Fertil. Steril. 2011;96(2): Barak, T., K.Y. Kwan, A. Louvi, V. Demirbilek, S. Saygı, B. Tüysüz, M. Choi, H. Boyacı, K. Doerschner, Y. Zhu, H. Kaymakçalan, S. Yılmaz, M. Bakırcıoğlu, A.O. Cağlayan, A.K. Oztürk, K. Yasuno, W.J. Brunken, E. Atalar, C. Yalçınkaya, A. Dinçer, R.A. Bronen, S. Mane, T. Ozçelik, R.P. Lifton, N. Sestan, K. Bilgüvar, M. Günel, Recessive LAMC3 mutations cause malformations of occipital cortical development, Nat. Genet., 2011;43(6): Kalb, S., A.O. Caglayan, A. Degerliyurt, S. Schmid, S. Ceylaner, G. Utermann, N. Hatipoglu, K. Hinderhofer, H. Rehder, S. Kurtoglu, G. Ceylaner, J. Zschocke, M. Witsch-Baumgartner, High Frequency of p.thr93met in Smith-Lemli-Opitz Syndrome Patients in Turkey, Clin. Genet., 2012;81(6): Bilguvar, K., N.K. Tyagi, C. Ozkara, B. Tuysuz, M. Bakircioglu, M. Choi, S. Delil, A.O. Caglayan, J.F. Baranoski, O. Erturk, C. Yalcinkaya, M. Karacorlu, A. Dincer, M.H. Johnson, S. Mane, S.S. Chandra, A. Louvi, T.J. Boggon, R.P. Lifton, A.L. Horwich, M. Gunel. Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration, PNAS, 2013;110(9): Clark, V.E., E.Z. Erson-Omay, A. Serin, J. Yin, J. Cotney, K. Ozduman, T. Avşar J. Li, P.B. Murray, O. Henegariu, S. Yilmaz, J.M. Günel, G. Carrión-Grant, B. Yilmaz, C. Grady, B. Tanrikulu, M. Bakircioğlu, H. Kaymakçalan, A.O. Caglayan, L. Sencar, E. Ceyhun, A.F. Atik, Y. Bayri, H. Bai, L.E. Kolb, R.M. Hebert, S.B. Omay, K. Mishra-Gorur, M. Choi, J.D. Overton, E.C. Holland, S. Mane, M.W. State, K. Bilgüvar, J.M. Baehring, P.H. Gutin, J.M. Piepmeier, A. Vortmeyer, C.W. Brennan, M.N. Pamir, T. Kiliç, R.P. Lifton, J.P. Noonan, K. Yasuno, M. Günel. Genomic analysis of non-nf2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO, Science, 2013;339(6123): Radmanesh, F.,* Caglayan A.O.,* L.J. Silhavy, C. Yilmaz, V. Cantagrel, T. Omar, B. Rosti, H. Kaymakcalan, S. Gabriel, M. Li, N. Šestan, K. Bilguvar, W.B. Dobyns, M.S. Zaki, M. Gunel, J.G. Gleeson, Mutations in LAMB1 Cause Cobblestone Brain Malformation without Muscular or Ocular Abnormalities, Am. J. Hum. Genet., 2013;92(3):

5 Novarino, G., Fenstermaker, A.G., Zaki, M.S., Hofree, M., Silhavy, J.L., Heiberg, A.D., Abdellateef, M., Rosti, B., Scott, E., Mansour, L., Masri, A., Kayserili, H., Al-Aama, J.Y., Abdel- Salam, G.M., Karminejad, A., Kara, M., Kara, B., Bozorgmehri, B., Ben-Omran, T., Mojahedi, F., Mahmoud, I.G., Bouslam, N., Bouhouche, A., Benomar, A., Hanein, S., Raymond, L., Forlani, S., Mascaro, M., Selim, L., Shehata, N., Al-Allawi, N., Bindu, P.S., Azam, M., Gunel, M., Caglayan, A., Bilguvar, K., Tolun, A., Issa, M.Y., Schroth, J., Spencer, E.G., Rosti, R.O., Akizu, N., Vaux, K.K., Johansen, A., Koh, A.A., Megahed, H., Durr, A., Brice, A., Stevanin, G., Gabriel, S.B., Ideker, T., Gleeson, J.G., Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders., Science, 2014;343(6170): Schaffer, A.E., Eggens, V.R., Caglayan, A.O., Reuter, M.S., Scott, E., Coufal, N.G., Silhavy, J.L., Xue, Y., Kayserili, H., Yasuno, K., Rostim R,O,, Abdellateef, M., Caglar, C., Kasher, P.R., Cazemier, J.L., Weterman, M.A., Cantagrel, V., Cai, N., Zweier, C., Altunoglu, U., Satkin, N.B., Aktar, F., Tuysuz, B., Yalcinkaya, C., Caksen, H., Bilguvar, K., Fu, X.D., Trotta, C.R., Gabriel, S., Reis, A., Gunel, M., Baas, F., Gleeson, J.G., CLP1 Founder Mutation Links trna Splicing and Maturation to Cerebellar Development and Neurodegeneration., Cell, 2014;157(3): Tüysüz, B., K. Bilguvar, N. Koçer, C. Yalçınkaya, O. Cağlayan, E. Gül, S. Sahin, S. Comu, M. Günel. Autosomal recessive spastic tetraplegia caused by AP4M1 and AP4B1 gene mutation: Expansion of the facial and neuroimaging features, Am J Med Genet A., 2014;164(7): Caglayan, A.O., J.F. Baranoski, F. Aktar., W. Han, B. Tuysuz, A. Guzel, B. Guclu, H. Kaymakcalan, B. Aktekin, G.T. Akgumus, P.B. Murray, E.Z. Erson-Omay, C. Caglar, M. Bakircioglu, Y.B. Sakalar, E. Guzel, N. Demir, O. Tuncer, S. Senturk, B. Ekici, F.J. Minja, N. Šestan, K. Yasuno, K. Bilguvar, H. Caksen, M. Gunel. Brain Malformations Associated with Knobloch Syndrome Review of Literature, Expanding Clinical Spectrum and Identification of Novel Mutations, Pediatric Neurology, 2014;51(6): e8. Mishra-Gorur K.,* Caglayan, A.O.,* A.E. Schaffer, C. Chabu, O. Henegariu, F. Vonhoff, G.T. Akgümüş, S. Nishimura, W. Han, S. Tu, B. Baran, H. Gümüş, C. Dilber, M.S. Zaki, H.A.A. Hossni, J-B Rivière, H. Kayserili, E.G. Spencer, R.Ö. Rosti, J. Schroth, H. Per, C. Çağlar, Ç. Çağlar, D. Dölen, J.F. Baranoski, S. Kumandaş, F.J. Minja, E.Z. Erson-Omay, S.M. Mane, R.P. Lifton, T. Xu, H. Keshishian, W.B. Dobyns, N.C. Chi, N. Šestan, A. Louvi, K. Bilgüvar, K. Yasuno, 5

6 J.G. Gleeson, M. Günel. Mutations in KATNB1 Cause Complex Cerebral Malformations by Disrupting Asymmetrically Dividing Neural Progenitors. 2014;84(6): Erson-Omay E.Z.,* Caglayan, A.O.,* N. Schultz, N. Weinhold, S.B. Omay, K. Ozduman, Y. Koksal, J. Li, A.S. Harmancı, V. Clark, G. Carrio n-grant, J. Baranoski, C. Caglar, T. Barak, S. Coskun, B. Baran, D. Kose, J. Sun, M. Bakırcıog lu, J.M. Gunel, M.N. Pamir, K. Mishra-Gorur, K. Bilguvar, K. Yasuno, A. Vortmeyer, A.J. Huttner, C. Sander, M. Gunel. Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis. Neuro-Oncology 2015; 0, 1 9, doi: /neuonc/nov027 *Co-first authorship KİTAP BÖLÜMLERİ Dundar, M. ve A.O. Çağlayan, Andreoli and Carpenter s Cecil Essentials of Medicine, ed. C.C.J. Carpenter, R.C. Griggs and I.J. Benjamin, 7th Edition, 2-15, Nobel Tıp, İstanbul, 2007 (Translation). Dündar, M. ve A. O. Çağlayan, Lomber Dejeneratif Disk Hastalığı, ed. R.K. Koç, Türk Neroşirürji Derneği Spinal ve Periferik Sinir Cerrahisi Grubu Yayınları No:8, Buluş Tasarım ve Matbaacılık, 16-28, Ankara, 2008 (Chapter of the book). Şanlıoğlu, S. ve A.O. Çağlayan, Gen Tedavisi, ed. M. Dündar, H. Bağış, Erciyes Üniversitesi Yayınları No:180, , Kayseri, 2010 (Chapter of the book). Çağlayan, A.O., J.F. Baranoski, A. Arzeno, Dysmorphology and Databases, Atlas of Dysmorphology and Diagnosis, ed. Munis Dundar, Erciyes University Publications No:197, , Kayseri, 2015 (Chapter of the book). 6