Page 1 of 24. Curriculum Vitae. 1. Name Surname: ZEYNEP NARCİN UNSAL. Contact information

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1 Curriculum Vitae 1. Name Surname: ZEYNEP NARCİN UNSAL Contact information Address: Istanbul Kultur University, Faculty of Science and Literature, Department of Moleculşar Biology and Genetics Atakoy Campus, Bakirkoy-Istanbul Phone: Date of Birth: November 3, Title: Prof. Dr. 4. Education: Degree Field University Year Bachelor Biology Istanbul University 1971 Master Doctorate Plant Physiology Istanbul University 1977 Post Graduate Plant Physiology Yale University (ABD) Academic Titles Title Department University Year/Period Assistant Biology Istanbul Professor University Associate Biology Istanbul Professor University Professor Biology Istanbul University Page 1 of 24

2 6. Graduate Theses Supervised 6.1 Master Theses 6.2 Doctorate Theses DENİZ COŞKUN, The Role of Polyamines induced by epibrassinolide during the apoptotic process at HCT 116 and HT 29 colon carcinoma cell lines. February HAKAN COKSUER Investigation of the different biomarkers indifferent types of gynecological cancers SEMİN MERVE ALOĞLU the investigation on the therapeutic importance of bohemine in rate prostate cell lines by different biomarkers MEHMET ALİ TÜFEKÇİ The effect of Meta-topolin ve olomicine on cell cycle and polyamine relations (2003). NEVAL AKTAN The effect of lead stress on polyamine content in Helianthus annuus plants 1994 ZEPÜR ZEHİR The investigation of cotyledon senescence in horizontal Helianthus annuus seedlings PINAR OBAKAN The investigation of the role of polyamines induced by epibrassinolide during the apoptotic process in different prostate cancer cell lines Publications 7.1 Articles published in peer reviewed international journals 1. Elif Damla Arisan, Yunus Akkoç*, Kaan Gencer Akyüz*, Ezgi Melek Kerman*, Pinar Obakan, Ajda Çoker-Gürkan, Narçin Palavan Ünsal, Polyamines modulate roscovitine-induced cell death decision as autophagy or apoptosis in MCF-7 and MDA-MB-231 breast cancer cells, Molecular Medicine Reports, (Araştırma makalesi, Baskıda). 2. Ajda Coker Gurkan, Deniz Coskun, E. Damla Arisan, Pinar Obakan, Özer Soylu, Narcin Palavan Unsal. Fetuin-A 742 (C/T) and 766 (C/G) polymorphic sitesare associated with increasing risk of myocardial infarction in older patients ( 40 years of age). Molecular Medicine Reports, (Araştırma makalesi, Baskıda). 3. Ajda Çoker-Gürkan, Elif Damla Arisan, Pinar Obakan, Pelin Özfiliz, Betsi Köse, Güven Bıçkıcı, Narçin Palavan Ünsal, Roscovitine finalized autophagy later than apoptosis by downregulating of Bcl-2 in HeLa cells, Molecular Medicine Reports, Mol Med Rep Mar;11(3): doi: /mmr Epub 2014 Nov 7. (Araştırma Makalesi). Page 2 of 24

3 4. Ajda Çoker-Gürkan, Elif Damla Arisan, Pınar Obakan, Narçin Palavan Ünsal, Lack of functional p53 renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon cancer cells, Amino Acids Jan;47(1): doi: /s Epub 2014 Oct 14. (Araştırma Makalesi). 5. Pinar Obakan, Elif Damla Arisan, Ajda Çoker-Gürkan, Narçin Palavan Ünsal, Epibrassinolide- Induced Apoptosis Regardless of p53 Expression via Activating Polyamine Catabolic Machinery, a Common Target for Androgen Sensitive and Insensitive Prostate Cancer Cells, Prostate Dec;74(16): doi: /pros Epub 2014 Sep 11. (Araştırma Makalesi). 6. Ajda Çoker-Gürkan, Elif Damla Arisan, Pınar Obakan, Esin Güvenir, Narçin Palavan Ünsal, Inhibition of autophagy by 3-MA potentiates purvalanol-induced apoptosis in Bax deficient HCT 116 colon cancer cells, Exp Cell Res Oct 15;328(1): doi: /j.yexcr Epub 2014 Aug 1. (Araştırma Makalesi). 7. Pinar Obakan, Gizem Alkurt, Betsi Köse, Ajda Çoker Gürkan, Elif Damla Arısan, Deniz Coşkun, Zeynep Narçin Ünsal. Downregulation of c-myc mediated ODC expression after purvalanol treatment is under control of upstream MAPK signaling axis in MCF-7 breast cancer cells Turk. J. Biol., 38, (2014), Pelin Ozfiliz, Elif Damla Arisan, Ajda Coker, Pınar Obakan, Tugce Eralp, Gizem Doganay-Dinler, Narcin Palavan-Unsal, Bag-1L mediated chemoresistance mechanism through preventing downregulation of Mcl-1 and c-raf by heat shock proteins in HeLa cells, Asian Pac J Cancer Prev 2014 ;15(11): (Araştırma Makalesi). 9. Pinar Obakan, Pelin Ozfiliz, Elif Damla Arisan, Ajda Çoker-Gürkan, Narcin Palavan Ünsal, Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells, Mol Biol Rep Jan;41(1): doi: /s Epub 2013 Nov 5. (Araştırma Makalesi). 10. Elif Damla Arisan, P. Obakan, A. Çoker-Gürkan, A. Calcabrini, E. Agostinelli, N. Palavan Ünsal, CDK inhibitors induce mitochondria-mediated apoptosis through the activation of polyamine catabolic pathway in LNCaP, DU145 and PC3 prostate cancer cells. Curr Pharm Des. 2014;20(2): (Araştırma Makalesi). 11. A. Çoker-Gürkan, S. Arısan, E.D. Arısan, N. Palavan Ünsal, Lack of evidence for the association of ornithine decarboxylase (+316 G>A), spermidine/spermine acetyl transferase ( 1415 T>C) gene polymorphisms with calcium oxalate stone disease, Biomed Rep Jan;2(1): Epub 2013 Oct 21. (Araştırma Makalesi) Page 3 of 24

4 12. P.Obakan, E.D. Arisan, A. Calcabrini, E. Agostinelli, S. Bolkent, N. Palavan-Unsal. Activation of Polyamine Catabolic Enzymes Involved in Diverse Responses Against Epibrassinolide-induced Apoptosis in LNCaP and DU145 Prostate Cancer Cell Lines, Amino Acids, 2014 Mar;46(3): (Araştırma Makalesi) 13. A. Çoker-Gurkan, E. D. Arisan, P. Obakan, N. Palavan-Ünsal, Inhibition of polyamine oxidase prevented cyclin dependent kinase inhibitor-induced apoptosis in HCT116 colon carcinoma cells Apoptosis Dec;18(12): doi: /s (Araştırma Makalesi). 14. Çoker-Gurkan, S. Arisan, E. D. Arisan, N.C. Sönmez, N. Palavan-Ünsal, Association between IL-1RN VNTR, IL and IL-6 ( 174, 572, 597) Gene Polymorphisms and Urolithiasis Urol Int. 2013;91(2): doi: / Epub 2013 Jan 26. (Araştırma Makalesi) 15. A.Çoker, E.D. Arısan, Narcin Palavan-Unsal, " Silencing of the polyamine catabolic key enzyme SSAT prevents CDK inhibitor-induced apoptosis in Caco-2 colon cancer cells", Mol Med Rep Apr;5(4): doi: /mmr Epub 2012 Jan 30. (Araştırma Makalesi) 16. E. D. Arısan, A.Coker, P.Obakan, N.Palavan-Unsal, "Inhibition of ornithine decarboxylase altered the roscovitine-induced mitochondria mediated apoptosis in MCF-7 breast cancer cells", Mol Med Rep May;5(5): doi: /mmr Epub 2012 Feb 13. (Araştırma Makalesi) 17. E.D.Arisan, A.Coker, N.Palavan-Unsal, "Polyamine depletion enhances the roscovitine-induced apoptosis through the activation of mitochondria in HCT116 colon carcinoma cells", Amino Acids Feb;42(2-3): doi: /s x. Epub 2011 Aug 2. (Araştırma Makalesi) 18. S.Akyuz, A.E.Ozel, K.Balci, T.Akyuz, A.Coker, E.D.Arisan, N.Palavan-Unsal, A.Ozalpan, "Raman micro-spectroscopic analysis of cultured HCT116 colon cancer cells in the presence of roscovitine",spectrochim Acta A Mol Biomol Spectrosc May;78(5): doi: /j.saa Epub 2011 Feb 2. (Araştırma Makalesi) 19. S.Akyuz, A.E.Ozel, K.Balci, T.Akyuz, A.Coker, E.D.Arisan, N.Palavan-Unsal, A.Ozalpan, "Raman micro-spectroscopic investigation of the interaction of cultured HCT116 colon cancer cells with alpha- difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase." Journal of Molecular Structure (Impact Factor: 1.6). 01/2011; 993(1): DOI: /j.molstruc (Araştırma Makalesi) 20. K. Balci, Y. Akkaya, S. Akyuz and N. Palavan-Unsal. DFT and MP2 based quantummechanical calculations and a theoretical vibrational spectroscopic investigation on roscovitine, a potential drug to treat cancers. Journal of Raman Spectroscopy, 42: , 2011, (Araştırma Makalesi) Page 4 of 24

5 21. Narcin Palavan-Unsal and Elif Damla Arisan. Nitric Oxide Signalling in Plants. Botanical Review, 75: , Elif Damla Arisan, Serdar Arisan, Gökhan Atuş, Narçin Palavan-Unsal, Erbil Ergenekon. Serum adipocytokine levels in prostate cancer patients. Urologia Internationalis. 82: , 2009, (Araştırma Makalesi). 23. Unal M, Tufekci MA, Palavan-Unsal N. Effects of polyamines and polyaminebiosynthetic inhibitors on mitotic activity of Allium cepa root tips. Acta Biologica Hungarica, 59:93-102, 2008, (Araştırma Makalesi). 24. Narcin Palavan-Ünsal, Elif Damla Arısan and Salih Terzioğlu Polyamines in tea processing. International Journal of Food Sciences and Nutrition. 58: , 2007, (Araştırma Makalesi). 25. Narçin Palavan-Ünsal and Elif Damla Arısan. Distribution of peroxidase activity and polyamine pattern of Heliotropium europeum in potassium deficiency conditions. Int. J. Environment and Pollution, Vol. 29: , 2007, (Araştırma Makalesi). 26. Narcin Palavan-Unsal, Semin Merve Aloglu-Senturk, Elif Damla Arısan, The function of polyamine metabolism in prostate cancer. Experimental Oncology, 28:1-6, 2006, (Araştırma Makalesi). 27. Elif Damla Arısan, Serdar Arisan, MC Kiremit, Hatice Tigli, T Çaskurlu, Narçin Palavan-Unsal ve E Ergenekon Manganase superoxide dismutase polymorphism in chronic pelvic pain syndrome patients Prostate Cancer and Prostatic Diseases 2006, 1 6, (Araştırma Makalesi). 28. Serdar Arısan, Elif Damla Büyüktunçer, Narcin Palavan Ünsal, Turhan Çaşkurlu, Ömer Onur Çakır, Erbil Ergenekon. Increased expression of EZH2, a polycomb group protein, in bladder carcinoma. Urol. Int., 75: , 2005, (Araştırma Makalesi). 29. Meral Unal, Narcin Palavan-Unsal ve Isil Ismailoglu, The effect of putrescine and difluoromethylornithine on cell division activity of wheat in different ploidy level. Caryologia, 58, 1:15-20, 2005, (Araştırma Makalesi). 30. Elif Damla Büyüktuncer ve Narçin Palavan-Ünsal, Future molecular markers in childhood acute leukemias: Polyamines. Turkish J. of Cancer, 34:5-10, 2004, (Araştırma Makalesi). 31. Narçın Palavan-Ünsal, Elif Damla Buyuktuncer ve Asuman Efe, Polyamine and protein profiles of Plantago species exhibiting different allergic significance. Biotechnol and Biotechnol. Eq., 18: , 2004, (Araştırma Makalesi). 32. Serap Çağ, Narçın Palavan-Ünsal ve Elif Damla Büyüktuncer, Comparison of the effect of metatopolin and other cytokinins on chlorophyll and protein contents and peroxidase activity in cucumber cotyledons. Israel Journal of Plant Sciences, 51: , 2003, (Araştırma Makalesi). Page 5 of 24

6 33. Asım Kadıoğlu, Rabia Turgut, Narçın Palavan-Ünsal ve N Saruhan, Effect of polyamines on leaf rolling in Ctenanthe setosa. Israeli Journal of Plant Sciences, 50:19-23, 2002, (Araştırma Makalesi). 34. Meral Ünal, Narçın Palavan-Ünsal ve Mehmet Ali Tüfekçi, Role of putrescine and its biosynthetic inhibitor on seed germination, root elongation and mitosis in Hordeum vulgare L. Bull. Pure and Applied Sciences, 21B: 33-38, 2002, (Araştırma Makalesi). 35. Narçın Palavan-Ünsal, Serap Çağ ve Ergül Çetin, Growth responses of excised radish cotyledons to meta-topolin. Canadian J. Plant Sci, 82: , 2002, (Araştırma Makalesi). 36. Narçın Palavan-Ünsal, Ergül Çetin ve Asım Kadıoğlu, Boron stress affects peroxidase activity. Plant Peroxidases Newsletter, 15: 37-44, 2000, (Araştırma Makalesi). 37. Ergül Çetin, Cansev Yıldırım, Narçın Palavan-Ünsal ve Meral Ünal, Effect of spermine and cyclohexylamine on in vitro pollen germination and tube growth in Helianthus annuus. Canadian Journal of Plant Science, 80: , 2000, (Araştırma Makalesi). 38. Narçın Palavan-Ünsal, Stimulation of diamine oxidase and peroxidase activities in potassium deficiency conditions in chick-pea stems. Plant Peroxidases Newsletter 11: 13-18, 1998, (Araştırma Makalesi). 39. Palavan-Ünsal, N. Stress and polyamine metabolism. Bulg. J. Plant Physiol., 21: 3-14, 1995, (Araştırma Makalesi). 40. Z. Zehir-Delibaşoğlu ve Narçın Palavan-Ünsal, Effect of gravity on senescence and polyamine content of Helianthus annuus cotyledons. Phytochemistry, 35: , 1994, (Araştırma Makalesi). 41. Nermin Gözükırmızı, Şule Arı, Güler Oraler, Okatan, Y. ve Narçın Palavan-Ünsal, Callus induction. Plant regeneration and chromosomal variations in barley. Acta Bot. Neerl., 39 (4): , 1990,(Araştırma Makalesi). 42. Palavan-Ünsal, N., Zehir, Z. and Sağlam, S. Inhibition of alpha-amylase release from germinating wheat embryos by abscisic acid and cyclohexylammonium. In: Polyamines and ethylene: Biochemistry, Physiology and Interactions. H.E.Flores, R.N. Arteca, J.C. Shannon, Eds. American Society of plant Physiologists, Proceedings 5th annual Penn state symposium in plant physiology, pp May 17-19, 1990, (Araştırma Makalesi). 43. Narçın Palavan-Ünsal. Polyamine metabolism in the roots of Phaseolus vulgaris. Interaction of the inhibitors of polyamine biosynthesis with putrescine in growth and polyamine biosynthesis (doçentlik tezi). Plant and Cell Physiol., 28: , 1987, (Araştırma Makalesi). Page 6 of 24

7 44. Narçın Palavan-Ünsal, Goren, R. ve Galston, A.W. Effects of some growth regulators on polyamine biosynthetic enzymes in etiolated pea seedlings. Plant and Cell Physiol., 25: , 1984, (Araştırma Makalesi). 45. Narçın Palavan-Ünsal ve Arthur W Galston. Polyamine biosynthesis and titer during various developmental stages of Phaseolus vulgaris. Physiol. Plant. 55: , 1982, (Araştırma Makalesi). 46. Goren, R., Narçın Palavan-Ünsal, Flores, H. ve Galston, A.W. Changes in polyamine titer in etiolated pea seedlings following red light treatment. Plant and Cell Physiol., 23: 19-26, 1982, (Araştırma Makalesi). 47. Goren, R., Narçın Palavan-Ünsal ve Galston, A.W. Separating phytochrome effects on arginine decarboxylase activity from its effect on growth. J.Plant Growth., 1: 61-73, 1982, (Araştırma Makalesi). 7.2 Papers delivered in international conferences and printed as proceedings 1. Ajda Coker-Gurkan, Elif Damla Arisan, Pinar Obakan, Narcin Palavan-Unsal, Inhibition of autophagy enhanced DENSpm induced-apoptotic cell death in HCT 116 colon cancer cells, International Autophagy Conferences: First Joint Meeting: Nordic, Spanish & French Autophagy Networks, P39, p:77, Eylül 2014, Toulouse-Fransa. 2. E. Damla Arisan, Ozge Berrak, Pinar Obakan, Ajda Coker-Gürkan, Narcin Palavan Unsal, The combination of rapamycin with CDK inhibitors; purvalanol and roscovitine induces autophagy by modulating different mtor complexes in DU 145 prostate cancer cells International Autophagy Conferences: First Joint Meeting: Nordic, Spanish & French Autophagy Networks, P6, p:100, Eylül 2014, Toulouse-Fransa. 3. Ajda Coker-Gürkan, Elif Damla Arisan, Pinar Obakan, Yunus Akkoc, Narcin Palavan Unsal, Silencing of Atg-7 increased therapeutic efficiency of Curcumin, which activated both autophagy and apoptosis in MCF-7wt breast cancer cells, International Autophagy Conferences: First Joint Meeting: Nordic, Spanish & French Autophagy Networks, P47, p:81, Eylül 2014, Toulouse- Fransa. 4. Pinar Obakan, E. Damla Arisan, Ajda Coker Gurkan, Narcin Palavan Unsal, ER stress involved in EBR-induced apoptosis in colon carcinoma cell lines International Autophagy Conferences: First Joint Meeting: Nordic, Spanish & French Autophagy Networks, P11, p:63, Eylül 2014, Toulouse-Fransa. 5. Elif Damla Arısan, Özge Berrak, Pinar Obakan, Ajda Çoker-Gürkan, Narcin Palavan-Unsal mtor inhibisyonunun androjen bağımlı ve bağımsız prostat kanseri hücrelerinde yeni CDK Page 7 of 24

8 inhibitörlerinin terapötik özelliklerini arttırması EACR Sponsored 2nd Anticancer Agents Congress& 5th Multidisciplinary Cancer Research Congress, Nisan 2014, Bodrum, Türkiye.(Invited speaker: Damla Arısan) 6. Ajda Çoker-Gürkan, Kübra Akalın, Utku Özbey, Elif Damla Arısan, Pınar Obakan, Narçin Palavan- Ünsal, Induction of Endoplasmic Reticulum (ER) stress-mediated apoptosis and autophagy by Purvalanol in HCT 116 colon cancer cells EACR Sponsored 2nd Anticancer Agents Congress& 5th Mutlidisciplinary Cancer Research Congress, PP13, Sayfa: 99, Nisan 2014, Bodrum, Türkiye. (Poster presentation: Ajda Çoker-Gürkan) 7. P. Obakan, E.D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal, ER stress is involved in Epibrassinolide-induced apoptotic cell death EACR Sponsored 2nd Anticancer Agents Congress& 5th Mutlidisciplinary Cancer Research Congress, PP61, Sayfa: 147, Nisan 2014, Bodrum, Türkiye. (Poster presentation: Pınar Obakan) 8. Deniz Coskun, Pınar Obakan, Elif Damla Arisan, Ajda Çoker Gürkan, Narcin Palavan- Unsal, Epibrassinolide-induced Apoptosis is Modulated by AKT-FOXO3a Signaling Pathway, EACR Sponsored 2nd Anticancer Agents Congress& 5th Mutlidisciplinary Cancer Research Congress, PP24, Sayfa: 110, Nisan 2014, Bodrum, Türkiye. (Poster presentation) 9. Özge Berrak, Elif Damla Arisan, Pinar Obakan, Ajda Çoker-Gürkan, Narcin Palavan-Unsal, The combination of rapamycin with purvalanol and roscovitine induces autophagy through PI3K/AKT and Ras/Raf/Erk pathways regulation in DU 145 prostate cancer cells EACR Sponsored 2nd Anticancer Agents Congress& 5th Mutlidisciplinary Cancer Research Congress, PP57, Sayfa: 143, Nisan 2014, Bodrum, Türkiye. (Poster presentation: Özge Berrak)) 10. Pelin Özfiliz, Elif Damla Arısan, Pınar Obakan, Ajda Çoker-Gürkan, Gizem Dinler Doğanay, Narçin Palavan Ünsal, Silencing of Bag-1 enhanced the cisplatin or paclitaxel- induced apoptosis via regulating PI3K, Akt and MAPK signaling axis in MCF-7 breast cancer cells EACR Sponsored 2nd Anticancer Agents Congress& 5th Mutlidisciplinary Cancer Research Congress, PP59, Sayfa: 145, Nisan 2014, Bodrum, Türkiye. (Poster presentation: Pelin Özfiliz)) 11. D. Coşkun, P. Obakan, ED Arisan, AC Gürkan, NP Ünsal. Epibrassinolide induced apoptotic cell death in HCT 116 and HT29 colon carcinoma cells. 1st International Congress of the Molecular Biology Association of Turkey November, 2012, Istanbul, p. 64, (Poster presentation Deniz Coşkun). 12. P.Obakan, ED Arisan, S. Bolkent, NP Ünsal. Epibrassinolide induces apoptosis by targeting polyamine catabolism in LNCaP prostate cancer cells. 1st International Congress of the Page 8 of 24

9 Molecular Biology Association of Turkey November, 2012, Istanbul, p. 82, (Poster presentation: Pınar Obakan). 13. O. Berrak, Y. Akkoç, ED Arisan, P. Obakan, AC Gürkan, NP Ünsal. Effect of CDK inhibitors and rapamycin combination on autophagy with status of AR expression on androgen dependent LNCaP and androgen independent DU145 prostate cancer cells. 1st International Congress of the Molecular Biology Association of Turkey November, 2012, Istanbul, p. 62, (Poster presentation: Özge Berrak). 14. Y. Akkoç, ED Arisan, AC Gürkan, P. Obakan, NP Ünsal. Understanding the role of Bcl-2 in curcumin induced autophagic/apoptotic cell death mechanism in MCF-7 and MDA-MB-231 breast cancer cells.1st International Congress of the Molecular Biology Association of Turkey November, 2012, Istanbul, p. 55, (Poster presentation: Yunus Akkoç) Yunus Akkoc, Merve Çelik, Pınar Obakan, Ajda Çoker Gürkan, E.Damla Arisan and Narçin Palavan-Ünsal, The functional role of Bcl-2 in the regulation of curcumin induced autophagic/apoptotic cell death in MCF-7 breast cancer cells. Conference on Apoptosis and Cancer, Cambridge, UK, June , ( Poster presentation: Yunus Akkoç) 16. Elif Damla Arısan, Pınar Obakan, Özge Berrak, NarçinPalavan-Ünsal, Cyclin Dependent Kinases Exert their Apoptotic Potential by Acting on mtor Mediated Energy Signaling Cascade in the Presence of Activated Polyamine Catabolism in LNCap, DU145 and PC3 Prostate Cancer Cells. International Congress on Polyamines Biological and Clinical Perspectives 2-7 September, Istanbul, L20, p.54, 2012, (Oral presentation: Narçın Palavan Ünsal). 17. Ajda Çoker Gürkan, Pınar Obakan, Elif Damla Arısan, Annarica Calcabrini, Enzo Agostinelli, Narçin Palavan-Ünsal, The Effect of Polyamine Catabolism Products on CDK Inhibitors-Induced on HCT116 wt and Bax -/- Colon Carcinoma Apoptotic Cell Death International Congress on Polyamines Biological and Clinical Perspectives 2-7 September, Istanbu, P15, p.126, 2012, (Poster presentation: Ajda Çoker Gürkan). 18. Ajda Çoker Gürkan, Elif Damla Arısan, Narçin Palavan-Ünsal, Which is the Most Prominent Cellular Decision Against CDK Inhibitors in the Presence of Modulated Polyamine Pool? Autophagy or Apoptosis, International Congress on Polyamines Biological and Clinical Perspectives 2-7 September, Istanbul, P16, p.127, 2012 (Poster presentation: Damla Arisan). 19. Betsi Köse, Gizem Alkurt, Ajda Çoker Gürkan, Elif Damla Arısan, Pınar Obakan, Narçin Palavan- Ünsal, ODC is a Mediator of the Purvalanol-A-Induced Apoptotic Signaling via the p38 Mitogen- Activated Protein Kinase Pathway in MCF-7 Breast Cancer Cells, International Congress on Poster presentation: Betsi Köse-Gizem Alkurt). Page 9 of 24

10 20. Deniz Coşkun, Pınar Obakan, Elif Damla Arısan, Ajda Çoker Gürkan, Narçin Palavan-Ünsal The Potential Role of Polyamines in EBR-Induced Apoptotic Cell Death in HCT116 Colon Carcinoma Cells. International Congress on Polyamines Biological and Clinical Perspectives 2-7 September, Istanbul, P20, p.134, 2012, (Poster presentation: Deniz Çoşkun). 21. Halime İlhan, Ajda Çoker Gürkan, Pınar Obakan, Elif Damla Arısan, Narçin Palavan-Ünsal, Timing is Critical in the Decision of Apoptosis or Autophagy by N1, N11- Diethylnorspermine (DENSpm) treatment in HCT116 Colon Cancer Cells, International Congress on Polyamines Biological and Clinical Perspectives 2-7 September, Istanbul, P24, p.142, 2012, (Poster presentation: Halime İlhan). 22. Onur Irmak, Elif Damla Arısan, Ajda Çoker-Gürkan, Pınar Obakan, Narçin Palavan-Ünsal, The Role of Polyamine Catabolic Enzymes in Cisplatin-Induced Apoptotic Cell Death, in MCF-7 Cells. International Congress on Polyamines Biological and Clinical Perspectives 2-7. September, Istanbul, P29, p.151, 2012, (Poster presentation: Onur Irmak). 23. P. Obakan, Elif Damla Arısan, A. Calcabrini, E. Agostinelli, Ş. Bolkent, Narçin Palavan- Ünsal, Epibrassinolide Targets Polyamine Catabolism and Triggers Apoptosis in LNCaP, DU145 and PC3 Cell Lines. International Congress on Polyamines Biological and Clinical Perspectives 2-7. September, Istanbul, P31, p.153, 2012, (Poster presentation: Pınar Obakan). 24. S. Akyüz, T. Akyüz1, P. Obakan, E. D. Arısan, Ş. Bolkent, N. Palavan-Ünsal, FTIR Spectroscopic Investigation of the Effects of Polyamine Oxidase Inhibitor MDL on the Interaction of Epibrassinolide with Cultured LNCaP Prostate Cancer Cells. International Congress on Polyamines Biological and Clinical Perspectives 2-7. September, Istanbul, P32, p.154, 2012, (Poster presentation: Sevim Akyüz). 25. Şeyma Yıldırım, Mert Burak Özturk, Elif Damla Arısan, Pınar Obakan, Ajda Çoker- Gürkan, Narçin Palavan-Ünsal, PPAR is the Critical Upstream Factor in Cyclin-Dependent Kinase Inhibitors Roscovitine and Purvalanol A- Induced SSAT Upregulation in MCF-7 Cells. International Congress on Polyamines Biological and Clinical Perspectives 2-7. September, Istanbul, P33, p.156, 2012, (Poster presentation:şeyma Yıldırım, Mert Burak Özturk). 26. Zeynep Akyol, Ajda Çoker-Gürkan, Elif Damla Arısan, Narçin Palavan-Ünsal, N1, N11- Diethylnorspermine (DENSpm) Modulates the Paclitaxel-Induced Apoptosis in MCF-7 wt and Bcl- 2 Overexpressing Breast Cancer Cells. International Congress on Polyamines Biological and Clinical Perspectives 2-7. September, Istanbul, P39, p.168, 2012, (Poster presentation: Zeynep Akyol). Page 10 of 24

11 27. Yunus Akkoç, Gencer Kaan Akyüz, Ezgi Melek Kerman, Elif Damla Arısan, Ajda Çoker- Gürkan, Pınar Obakan, Narçin Palavan-Ünsal, Potential Role of Polyamines in Roscovitine-Induced Autophagic/Apoptotic Cell Death in MCF-7 and MDA-MB-231 Breast Cancer Cells.International Congress on Polyamines Biological and Clinical Perspectives 2-7. September, Istanbul, P41, p.170, 2012 (Poster presentation: Yunus Akkoç). 28. Özge Berrak, Elif Damla Arısan, Pınar Obakan and Narçin Palavan-Ünsal, Investigation of possible role of mtor in CDK inhibitors induced apoptotic cell death in LNCap, DU145 and PC3 prostate cancer cells.international Graduate Student Immunology Congress, Harvard University, Boston, April 27-28, 2012, (Poster presentation: Özge Berrak). 29. E.D. Arısan, P. Obakan, N. Palavan-Unsal. CDK inhibitors induced apoptosis and activated polyamine catabolic pathway in androgen dependent LNCaP (p53 wt), DU145 (p53 wt) and PC3 (p53 null) prostate cancer cells Congress on Biogenic Amines: Biochemical, Physiological and Clinical Perspectives (Trento, Italy) September, 2011, (Poster presentation: Damla Arısan). 30. P. Obakan, E.D. Arisan, S. Bolkent, N. Palavan-Unsal, 24-Epibrassinolide induces SSAT and causes caspase-dependent apoptosis in different prostate cancer cell lines. Congress on Biogenic Amines: Biochemical, Physiological and Clinical Perspectives (Trento, Italy) September, 2011, (Poster presentation: Pınar Obakan). 31. A. Coker, E.D. Arisan, N. Palavan-Ünsal, Roscovitine modulated autophagic cell death related to polyamine metabolism in HCT-116 cells Congress on Biogenic Amines: Biochemical, Physiological and Clinical Perspectives (Trento, Italy) September, 2011, (Poster presentation: AJDA Çoker). 32. A. Çoker, S. Arısan, D. Coşkun, A. Yavuz, E.D. Arısan, N.C. Sönmez, N. Palavan-Ünsal, Investigation of Fetuin-a single nucleotide gene polymorphism in urinary stone disease patients. IV. International Congress on Molecular Medicine, p.67, June 2011, (Poster presentation: Deniz Çoşkun). 33. S. Akyuz, A. E. Ozel, K. Balci, T. Akyuz, A. Coker, E. D. Arisan, N. Palavan-Unsal, A. Ozalpan. Micro Raman spectroscopic investigation of the interaction of cultured HCT116 colon cancer cells with alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase. EUCMOS 30th European congress on molecular spectroscopy with GISR 2010, PS2-21, pp.107, 2010, (Poster presentation: Sevim Akyüz). 34. K. Balci, Y. Akkaya, S. Akyuz, N. Palavan-Unsal. An IR and Raman spectroscopic investigation on a- difluoromethylornithine (DFMO), a potential target as chemotherapeutic agent. EUCMOS Page 11 of 24

12 30th European congress on molecular spectroscopy with GISR 2010, PS2-38, pp (Poster presentation: Sevim Akyüz) 35. N. Palavan-Unsal, E.D. Arisan, P. Obakan, A. Coker and I. Ozdemir, Cyclin Dependent Kinase Inhibitors Modulates Polyamine Metabolism in MDA-MB-231 Cells. 2nd International Conference on the Role of Polyamines and their Analogs in Cancer and other Diseases 1-6 December, 2010, Sapienza University of Roma Italy, L39, pp.131 (Oral presentation: Narçın Palavan Ünsal) 36. Arisan ED, Obakan P, Coker A and Palavan-Unsal N. Investigation of purvalanol-induced apoptosis in MCF-7 breast cancer cell lines. 2nd International Conference on the Role of Polyamines and their Analogs in Cancer and other Diseases 1-6 December, 2010, Sapienza University of Roma Italy, p17, pp.193 (Poster presentation: Damla Arısan). 37. Obakan P, Arisan ED, Palavan-Unsal N and Coker A., Combined treatment of Roscovitine and DFMO induced caspase dependent-apoptosis in MCF-7"cells. "2nd International Conference on the Role of Polyamines and their Analogs in Cancer and other Diseases 1-6 December, 2010, Sapienza University of Roma Italy, L39, p.131, P22, pp.205, (Poster presentation: Pınar Obakan). 38. Coker A. Arisan ED, Palavan-Unsal N. Modulation of catabolic pathway in ROSC treated Caco-2 cells. "2nd International Conference on the Role of Polyamines and their Analogs in Cancer and other Diseases 1-6 December, 2010, Sapienza University of Roma Italy, p19, p.131, P22, pp.199, (Seçili Poster Sunum: Ajda Çoker) 39. Arisan E.D., Palavan-Unsal, N. and Obakan P. Investigation of roscovitine (CYC202)- induced apoptosis related with polyamine metabolism in MCF-7 human breast cancer cell line. IUBMB LIFE, 61: 370, 2009 (Poster presentation: Pınar Obakan). 40. S. Akyuz, A. E. Ozel, K. Balci, T. Akyuz, A. Coker, E. D. Arisan, N. Palavan-Unsal, A. Ozalpan. Micro Raman spectroscopic investigation of the interaction of cultured HCT116 colon cancer cells with roscovitine. 5th International Conference on Vibrational Spectroscopy (ICAVS5) (12-17 July 2009) (Poster presentation: Sevim Akyüz) 41. K. Balcı, Y. Akkaya, S. Akyuz, N. Palavan-Unsal.Quantum chemical calculations and vibrational spectral investigation of roscovitine, a potential drug to treat cancers. 5th International Conference on Vibrational Spectroscopy (ICAVS5) (12-17 July 2009) (Poster presentation: Sevim Akyüz) 42. Çoker A., Arısan E.D., Palavan-Unsal N. The involvement of polyamines in Seliciclib Induced Apoptosis and ROS Generation in HCT116 Colon Carcinoma Cells. Joint 4th Eortic Page 12 of 24

13 Pathobiology Group Annual Meeting and 1st International Multidisciplinary Cancer Research Congress May, Antalya-Turkey. P.13, 2009, (Poster presentation: Ajda Çoker). 43. Palavan-Ünsal N and Arisan ED., a-difluoromethylornithine Sensitize the Rat Prostate Cancer Cells Against Olomoucine II and Bohemine Treatment. TASSA 2008 Annual Conference, April 11-13, Innovation as Driver for Social Transformation and Economic Growth. Harvard Medical School, Boston, USA Mehmet Ali Tufekci, Narcin Palavan-Unsal, Nezih Hekim, Damla Arisan, Tuğsan Tezil. Phytotoxicity of hydrogen peroxide: Comparison of phytotoxic response in in vitro and in vivo, XV FESPB Congress, 17-21, July, 2006, Lyon, France. (Poster presentation: Narcin Unsal) 45. Narcin Palavan-Unsal, Nezih Hekim, Mehmet Ali Tufekci.Benzene induces programmed cell death features in cultured Arabidopsis thaliana cells in dose-dependent manner, XV FESPB Congress, 17-21, July, 2006, Lyon, France. (Poster presentation: Narcin Unsal) 46. Serdar Arısan, Damla Buyuktuncer, Murat Can Kiremitci, Turhan Çaşkurlu, Narcin Palavan- Ünsal and Erbil Ergenekon MNSOD and IL-10 polymorphisms in chronic pelvic pain syndrome patients, European Association of Urology, Annual EAU Congress, Paris, France 5-8 April, Narcin Palavan Unsal, Semin Merve Aloglu, Mehmet Ali Tüfekci, Damla Arısan,Miroslav Strnad, Libor Havlicek, Marek Zatloukal and Mustafa Djamgoz. Effects of olomoucine II on ODC and Bax mrna levels in rat prostate cancer cell lines. P 223, 13th Euroconference on Apoptosis, 1-4 October, Budapest, Hungary.2005.( Poster presentation: Narcin Unsal) 48. Narcin Palavan Unsal, Semin Merve Aloglu, Mehmet Ali Tüfekci, Damla Arısan, Miroslav Strnad, Libor Havlicek, Marek Zatloukal and Mustafa Djamgoz, Suppression of ODC and Bax mrna levels in bohemine threated rat prostate cancer cell lines. P 4, 13th Euroconference on Apoptosis, 1-4 October, Budapest, Hungary Elif Damla Buyuktuncer, Serdar Arisan, Murat Can Kiremitci, Hatice Tigli, Narcin Palavan Unsal, Turhan Caskurlu, Erbil Ergenekon.Mn-SOD polymorphism in chronic pelvic pain syndrome patients. AUA San Antonio Elif Damla Buyuktuncer, Serdar Arısan, Hatice Tığlı, Turhan Çaşkurlu, Ayhan Dalkılınç, Narcin Palavan Unsal, Erbil Ergenekon.Frequency of PSA-mRNA bearing cells in the peripheral blood of patients after prostate biopsy. Advances in Molecular Medicine suppl. Vol 1: 422 (P082), Tüfekçi, Mehmet Ali, Ünal, M and Palavan-Ünsal N. The effect of olomoucine on polyamine content and mitosis in root tips of Allium cepa 14th FESPP Congress August 23-27, 2004 Cracow- Poland. Page 13 of 24

14 52. Unsal Palavan N, Ozalpan A, Aloglu M,Strnad M, Havlicek L, Zatloukal M, Djamgoz M. Investigation of therapeutic importance of cycline dependent kinase inhibitors by different biomarkers in rat prostate cell lines. Cell cycle senescence, apoptosis and cancer, Haziran, 2004, Glasgow Scotland 53. Damla Buyuktuncer, Beyazıt Çırakoğlu, Narçın Palavan-Ünsal, AtillaÖzalpan and Kürşat Özdilli. Polyamine profiles in the peripheral blood leucocytes of childhood acute lymphoblastic leukemia patients Biochemical Society Meeting 678, Polyamines and their Role in Human Disease. Abstract book, p.35, December 2002, Imperial Collage, London. 54. Palavan-Ünsal N., Atak Ç., Büyüktuncer D., Özdilli K. Role of meta-topolin in tissue culture of Arabidopsis thaliana.1st Eurasia Congress on Molecular Biotechnology. p. 48, October Trabzon, Turkey. 55. Palavan-Ünsal N., Çağ S., Büyüktuncer D. Comparison of the effect of different cytokinins on chlorophyll, protein content and peroxidase activity.17th International Conference on Plant Growth Substances. 101, 1-6 July Brno, Czech Republic. 56. Ünal M., Palavan-Ünsal N., Tüfekçi M.A. Role of putrescine and its biosynthetic inhibitor on seed germination, root elongation and mitosis in Hordeum vulgare L. XX.Congress of the Scandinavian Society for Plant Physiology. 32, June Roros, Norway. 57. Palavan-Ünsal N., Çağ S., Çetin E.Retardation senescence by meta-topolin in wheat leaves. II. Stimulation of peroxidase activity, nitrogen content and their relation with polyamines. XIIth Congress of the Federation of European Societies of Plant Physiology August, Budapest, Hungary. 38(Suppl.): S04-05L 58. Palavan-Ünsal N., Çağ S., Çetin E.Growth responses of meta-topolin excised radih cotyledones. XIIth Congress of the Federation of European Societies of Plant Physiology August, Budapest, Hungary. 38(Suppl.): S04-06L 59. Palavan-Ünsal N., Çağ S., Buyuktuncer D.Retardation of senescence by meta-topolin in wheat leaves. I. Inhibition of protease activity and chlorophyll loss. XIIth Congress of the Federation of European Societies of Plant Physiology August, Budapest, Hungary. 38 (Suppl.):S04-12L 60. Palavan-Ünsal, N.Distribution of peroxidase activity and polyamine pattern in Heliotropium europeum in potassium deficiency conditions. Second Balkan Botanical Congress, May-14-18, Abstract book p Kadıoğlu, A., Palavan-Ünsal, N., Turgut, R. and Ayaz, F.A. Effect of polyamines on leaf rolling in Ctenanthe setosa. Second Balkan Botanical Congress, May-14-18, Abstract book p Page 14 of 24

15 62. Palavan-Ünsal, N. Tissue distribution of peroxidase in Heliotropium europeum seedlings. Second Balkan Botanical Congress, May-14-18, Abstract book p Narçin Palavan-Unsal, Ergül Çetin and Asım Kadıoğlu Boron stress affects the peroxidase activity. Bulgarian Journal of Plant Physiology, 11th FESPP Congress, 7-11 September, Varna, Bulgaria, Special Issue S 16-03, p 266, Ergül Çetin, Cansev Yıldırım, Narçin Palavan-Ünsal and Meral Ünal The effect of spermine and cyclohexylamine on in vitro polen germination and tube growth in Helianthus annuus, Bulgarian Journal of Plant Physiology, Special Issue S 01-23, p 19, Palavan-Unsal, N. Stimulation of DAO and POD activities in potassium deficiency conditions in chick pea stems. 10 th FESPB Congress, 9-13 September, Firense, Italy, Plant Physiology and Biochemistry, Suppl., S 18-20, Aktan, N. and Palavan-Unsal, N.The effect of lead on polyamine content in Helianthus annuus plants. 9th FESPB Congress, Brno, Czech Republic, Biologia Plantarum, Suppl., 36: 1701, Palavan-Unsal, N., Zehir, Z. and Önder, N. The effect of gravity and horizontal clinostat on polyamine content in Helianthus annuus hypocotyls, 8th Congress of FESPB, Antwerpen, Belgium, Physiologia Plantarum, Suppl. 85(3), 164, Zehir, Z. and Palavan, N. Effect of unilateral gravity on senescence and polyamine content in the cotyledons of Helianthus annuus seedlings. Plant Physiol. Suppl., 99: 817, Palavan-Unsal, N., Çağ, S., Zehir, Z. and Okatan, Y. The investigation of seed-induced senescence in non-monocarpic Gleditschia pods. Plant Physiol. Suppl., 96: 1017, Palavan-Unsal, N., Zehir, Z. and Sağlam, S.Detection of abscisic acid and difluoromethylornithine inhibited α-amylase release from wheat embryos. Plant Physiol. Suppl., 93: 857, Gözükırmızı, N., Arı, Ş., Oraler, G., Okatan, Y., Palavan, N. A comparative study on callus induction plant regeneration and chromosomal variations from different explants of barley.international Conference.The impact of biotechnology in agriculture July, Amiens, France, Po.Vo. 8, Palavan, N. The relation between polyamine biosynthesis with root growth in Phaseolus vulgaris. Plant Physiol., Suppl., 69: 118, USA Goren, R., Palavan, N., Flores, H. and Galston, A.W. Polyamines in Plants: Phytochrome control of polyamine biosynthesis and titer in etiolated pea seedlings. Plant Physiol., Suppl., 67: 132, USA, Palavan, N. and Galston, A.W.Polyamines in Plants: Activities of biosynthetic enzymes during flower development in Phaseolus vulgaris. Plant Physiol., Suppl., 67: 11, USA, Page 15 of 24

16 75. Goren, R., Palavan, N., Flores, H. and Galston, A.W. Polyamines in Plants: Phytochrome control of polyamine biosynthesis and titer in etiolated pea seedlings. Northeastern Section American Society of Plant Physiologists.Annual meeting, May 1-2, USA, Palavan, N. and Galston, A.W.Polyamine in Plants: Activities of biosynthetic enzymes during flower development in Phaseolus vulgaris. Northeastern Section American Society of Plant Physiologists.Annual meeting, May 1-2, USA, Books and sections in books published internationally 1. Palavan-Ünsal, N.,(Editör), eisbn: , 2010, Mechanism of Lansdscape Rehabilitation and Sustainability, Authors: Kefeli V and Blum W. (Bentham Publishing) 2. Özalpan, A.,Palavan-Ünsal, N. (2008),(Editor), Genomic Applications,Istanbul Kultur University Publication. 3. Narçin Palavan-Ünsal, Plant Physiology, Auxins: Growth Hormone (Chapter 19.)(Plant Physiology, Taiz and Zeiger, (Chapter 19 Translation), Palme Publication, Narçin Palavan-Ünsal, Plant Hormones Manual, ISBN: 3001 DK ,Halic University Publication 5. Narçin Palavan-Ünsal, 1993, Plant Growth Substances, Istanbul University Publication 6. Narçin Palavan-Ünsal, 1990, General Biology-Botany Manual, Istanbul University Publication Ekim 2006 Journal of Cell and Molecular Biology, Associate Editor (5 Volume, 10 Issue). 8. Advances in Molecular Biology Associate Editor, 2006, 2007, 2008, 2009 (3 Volume 6 Issue). 7.4 Articles published in peer reviewed national journals 1. Narcin Palavan-Unsal and E. Damla Arısan. Evidences for the presence of caspase-like activities in plants. Marmara Üniversitesi Fen Bilimleri Dergisi, 23: Arısan ED and Palavan-Ünsal N. Resveratrol: Chemoprevention with red wine. Advances in Molecular Biology, 1: 13 22, Arısan ED, Arısan S, Kiremit MC, Palavan-Ünsal N, Ergenekon E. Antioxidant enzyme profile in chronic pelvic pain syndrome patients. Advances in Molecular Biology, 1: 41 46, Narçin Palavan-Ünsal, Elif Damla Büyüktuncer and Mehmet Ali Tüfekçi. Programmed cell death in plants. Journal of Cell and Molecular Biology, 4: 9 23, Page 16 of 24

17 5. Palavan-Unsal, S., Cag, S. ve Cetin, E., The role of meta-topolin in senescence of wheat leaf segments. Journal of Cell and Molecular Biology 3: 23-31, İsmailoğlu, I., Ünal, M. ve Palavan-Ünsal, N. Effects of spermidine, spermine and cyclohexylamine on mitotic activity of 2X, 4X and 6X wheats. Journal of Cell and Molecular Biology. 3: 83-88, Duman İ, Arisan S, Büyüktunçer, Çaşkurlu T, Sönmez C, Palavan-Unsal N. Apoptosis detection by TUNEL assay in BPH patients. Journal of Cell and Molecular Biology 3: , Çağ S ve Palavan-Ünsal N The effect of meta-topolin on protein profile in radish cotyledons. Journal of Cell and Molecular Biology. 2: 31-34, Palavan-Ünsal, N., Çağ, S., Çetin, E. and Büyüktunçer, D. Retardation of senescence by metatopolin in wheat leaves. Journal of Cell and Molecular Biology. 1: , Palavan-Ünsal, N., Çotuk, A. and Kalaç-Martini, Y. a-difluoromethylornithine inhibits the growth of fungus Macrophomina phaseoli. Turkish Journal of Botany, 26: 43-46, Narçin Palavan-Ünsal. Bitkilerde stres ve poliaminler. Bitkilerde Stres Fizyolojisinin Moleküler Temelleri Semineri Kitabı. E.Ü.Ziraat Fakültesi, EBİLTEM, p , Palavan-Ünsal, N. Hızlı Büyüme ve Kanserde Poliaminler. Doğa Bilim Dergisi, C 14, S 1, 1-19, Palavan-Ünsal, N. Bitkilerdefotomorfogenez ve fotoreseptörler. Doğa Bilim Dergisi, C 12, S 1, 58-70, Palavan-Ünsal, N. Bitki steroidleri ve Fizyolojik İşlevleri. Doğa Bilim Dergisi, Seri. A 2, C 8, S , Palavan-Ünsal, N. Poliamin Biyosentez ve Mekanizması. Doğa Bilim Dergisi, Ser. 2,C 8, S 2, , Palavan-Ünsal, N. Lastik ağacı: Guayule. Bilim ve Teknik Dergisi, Sayı: 183: 36-38, Palavan, N. Çiçeklenme Fizyolojisi. Doğa Bilim Dergisi, C 4: 73-84, Palavan The effects of some growth regulators on flowering, estrogen content and growth. Ist. Univ. Fen fak. Mec. Sei B 45: 43-62, Papers delivered at national conferences and printed as proceedings 7.6 Other publications 1. A. Coker-Gurkan, E. D. Arisan, H. İlhan, P. Obakan, N. Palavan-Unsal, Inhibition of Cellular Autophagic Responses against N1, N11-Diethylnorspermine (DENSpm) Enhanced Apoptosis Page 17 of 24

18 in HCT116 and SW480 Colon Cancer Cells, Haziran 2013, Waterville Valley, Amerika (Poster presentation: Ajda Çoker Gürkan) 2. E. D. Arısan, M.B Öztürk, A. Çoker-Gürkan, P. Obakan, N. Palavan-Ünsal, Ibuprofen induced apoptosis through c-myc sifgnaling pathway related to polyamines in p53 null PC3 cells, Haziran 2013, Waterville Valley, Amerika (Poster presentation: Damla Arısan) 3. D. Coskun, P. Obakan, E.D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal, The Potential Role of Polyamines in Epibrassinolide-Induced Apoptotic Cell Death in HCT116 and HT29 Colon Carcinoma Cells, Haziran 2013, Waterville Valley, Amerika (Poster presentation: Narçın Palavan Ünsal). 4. O. Berrak, E.D. Arisan, P. Obakan, A. Coker- Gurkan, N. Palavan-Unsal, Co-treatment of rapamycin prevented activation of polyamine oxidase and apoptosis via triggering autophagy after CDK inhibitor treatment in LNCaP cells, Haziran 2013, Waterville Valley, Amerika (Poster presentation: Özge Berrak) 5. Y. Akkoç, E.D. Arisan, P. Obakan, A. Çoker-Gürkan, N. Palavan-Ünsal, Co-treatment of PI3K inhibitor and curcumin overcomes Bcl-2 mediated drug-resistance in MCF-7 breast cancer cells via activating SSAT, Haziran 2013, Waterville Valley, Amerika (Poster presentation: Yunus Akkoç) 6. N. Palavan-Unsal, A. Coker, E. D. Arisan, Alterations in Apoptotic and Polyamine Catabolic Pathway in HCT-116wt and HCT-116 Puma -/- Cell Lines Treated with Cdk Inhibitors. Gordon Research Seminar and Gordon Research Conference, Polyamines in Cell Metabolism. June Waterville Valley NH (USA). 7. E.D. Arisan, P. Obakan, A. Çoker, N. Palavan-Ünsal, Roscovitine induced apoptosis and activated polyamine catabolic pathway in LNCap, DU145 and PC3 prostate cancer cell lines. Gordon Research Seminar and Gordon Research Conference, Polyamines in Cell Metabolism June Waterville Valley NH (USA). (Oral presentation) 8. P. Obakan, E.D. Arısan, S. Bolkent, N. Palavan-Ünsal. Epibrassinolide induced apoptosis by modulating polyamine catabolic pathway in different prostate cancer cell lines. Gordon Research Seminar and Gordon Research Conference, Polyamines in Cell Metabolism. June 18-24, Waterville Valley NH (USA) (Poster presentation) 9. A.Coker, E.D.Arisan, N. Palavan-Unsal, Alterations in Apoptotic and Polyamine Catabolic Pathway in HCT-116wt and HCT-116 Bax -/- Cell Lines Treated with Cdk Inhibitors. Gordon Page 18 of 24

19 Research Seminar and Gordon Research Conference, Polyamines in Cell Metabolism. June 18-24, Waterville Valley NH (USA). (Poster presentation) 10. Palavan Unsal N, Arısan E.D, Çoker A. Roscovitine induced apoptosis is enhanced by ODC inhibition in HCT116 colon carcinoma cells. Gordon Research Conferences on Polyamines. Polyamine Genetics, Metabolism, Cellular Homeostasis and Drug Discovery. June 21-26, 2009, Waterville Valley,USA 11. Arısan E.D, Palavan-Unsal N, Çoker A. ODC sirna sensitizes HCT116 colon carcinoma cells to roscovitine induced apoptosis. Gordon Research Conferences on Polyamines. Polyamine Genetics, Metabolism, Cellular Homeostasis and Drug Discovery. June 21-26, 2009 Waterville Valley, USA 12. Palavan-Ünsal, N Yarının Dünyası İçin Çözümler. Belgelerle Türk Tarihi Dergisi, 23: Projects directed and participated 1. Kolon Karsinoma hücrelerinde epibrassinolid tarafından tetiklenen apoptotik süreçte poliaminlerin rolü. (TUBITAK-212 T 168) 2014 Completed Project. 2. Cdk İnhibitörü Roskovitinin (CYC 200) Kolon Kanseri Hücrelerindeki (HCT116) Etkisinin Apoptotik Sinyal Molekülleri ve Poliamin Parametreleri ile Araştırılması [TUBİTAK T630] Completed Project. 3. CDK inhibitörü Roskovitin tarafından tetiklenen apoptotik yolakta poliamin katabolizmasının rolünün LNCap, DU145 ve PC3 prostat kanseri hücre hatlarında incelenmesi (TUBiTAK T107) Completed Project. 4. mtor İnhibitörü Rapamisin in CDK İnhibitörleri tarafından Tetiklenen Hücre Ölümü Mekanizmasındaki Potansiyel Rolünün Androjen Reseptörü Pozitif LNCaP ve Androjen Reseptörü negatif DU145 ve PC3 Proatat kanseri Hücrelerinde Araştırılması [TÜBİTAK KARİYER PROJESİ-112T433 ]Ongoing Project. 5. The effects of Bohemin, a new generation chemotherapeutic, on the diagnosis and treatment of prostate cancer (Terry Fox Cancer Research Society supported) Completed Project. 6. Farklı Prostat Kanseri Hücre Hatlarında Epibrassinolidle Tetiklenen Apoptotik Süreçte Poliaminlerin Rollerinin Araştırılması. Istanbul University Research Fund Supported Completed Project. Page 19 of 24

20 7. Farklı kolon ve prostat kanseri hücre hatlarında roskovitin ve purvalanolün flow sitometrik gösterimi (İstanbul Kültür University and ve Roma La Sapienza University Shared Project Completed) 8. Roscovitinin HCT 116 kolon kanseri hücrelerinde otofajik hücre ölümü ve poliamin metabolizması ilişkisi. Completed Project. 9. Böbrek taş hastalarında Fetuin-A gen polimorfizminin moleküler düzeyde incelenmesi (İstanbul Kültür Üniversitesi) Completed Project. 10. Böbrek taş hastalarında ODC 316 G/C gen polimorfizminin moleküler düzeyde incelenmesi ( İstanbul Kültür Üniversitesi ve Şişli Etfal Araştırma ve Eğitim Hastanesi) 11. Böbrek taş hastalarında SSAT -1415TC gen polimorfizminin moleküler düzeyde incelenmesi ( İstanbul Kültür Üniversitesi ve Şişli Etfal Araştırma ve Eğitim Hastanesi) 12. Sikline bağımlı kinaz inhibitörleri, roskovitin ve purvalanol'ün kimyasal yapılarının ve sitotoksik etkilerinin mikroraman spektroskopi ile araştırılması (İstanbul Kültür Üniversitesi) 13. Epibrassinolide'in HCT116 Puma -/- ve Bax-/- kolon kanseri hücre hatlarında apoptotik ve otofajijk etkilerinin gösterilmesi (YL. Tezi) (İstanbul Kültür Üniversitesi) 14. Denspm-paclıtaksel kombine terapisinin mcf-7 wt ve bcl-2+ hücre hatlarında etkisinin apoptotik parametreler ile araştırılması (yl. Tezi) (İstanbul Kültür Üniversitesi) 15. p53 ifadesinin PC3 (p53 null) prostat kanseri hücrelerinde klonlama vektörü ile kazandırılarak NSAID'lere cevap mekanizmasının araştırılması (İstanbul Kültür Üniversitesi) 16. Diklofenak (NSAID türevi) terapotik etkisinin SW480 ve DLD-1 kolon kanseri hücre hatlarında gösterilmesi (İstanbul Kültür Üniversitesi) 17. Curcumin'in AKT yolağının baskılanması yolu ile terapotik etkisinin MCF-7 WT ve BCL-2+ hücrelerde gösterimi (İstanbul Kültür Üniversitesi) 18. Rapamycin'in terapotik etkisinin anderogenden bağımsız prostat kanseri hücrelerinde araştırılması (İstanbul Kültür Üniversitesi) 19. Roscovitin ve Purvalanol HeLa serviks kanseri hücre hatlarında araştırılması (İstanbul Kültür Üniversitesi) 20. Roscovitine resistant prostat kanseri hücre hatlarının oluşturulması (İstanbul Kültür Üniversitesi) 21. Gossypol'ün (Bcl-2 inhibitörü) prostat kanserinde terapotik etkisinin araştırılması (İstanbul Kültür Üniversitesi) Page 20 of 24

21 22. CDK inhibitörlerinin MCF-7 ve MDA-MB-231 meme kanseri hücrelerinde terapotik etkisinin poliamin metabolizması ile ilişkili olarak gösterimi (İstanbul Kültür Üniversitesi) Completed Project. 23. DFT and MP2 based quantummechanical calculations and a theoretical vibrational spectroscopic investigation on roscovitine, a potential drug to treat cancers (İstanbul Kültür Üniversitesi) Completed Project. 24. Raman micro-spectroscopic investigation of the interaction of cultured HCT116 colon cancer cells with alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (İstanbul Kültür Üniversitesi) Completed Project. 25. Purvalanol'ün neden olduğu apoptotik hücre ölümünün otofaji ve endoplazmik retikulum stresi ile ilişkisinin HCT-116 kolon kanseri hücrelerinde araştırılması (TUBITAK öğrenci projesi) (2209, TUBITAK, Student Project) 26. Poliamin analoğu DENSpm in otofaji ve apoptoz üzerine etkilerinin doğal tip ve Bcl-2 aşırı ifadesi görülen MCF-7 meme kanseri hücrelerinde araştırılması (2209, TUBITAK, Student Project) 27. Bag-1 aşırı ifadesine sahip HeLa hücrelerinde Cisplatin in HSP-70 ve HSP-90 şaperonları ve Raf kinazlar üzerine etkisi (2209, TUBITAK, Student Project) 28. Roscovitine uygulanan MCF-7 ve MDA-MB-231 hücrelerinde poliamin metabolizmasının apoptotik ve otofajik hücre ölümü ile ilişkisi (2209, TUBITAK, Student Project) 29. MCF-7 ve MDA-MB-231 Meme Kanseri Hücre Hatlarında Sikline Bağımlı Kinaz İnhibitörleri Roskovitin ve Purvalanol Tarafından Tetiklenen Poliamin Katabolizması ve Apoptotik Düzenlemede NFkB nin Rolü (2209, TUBITAK, Student Project) 9. Administrative designations 1. Halic University, Head and Founder of the Molecular Biology and Genetics Department ( ) 2. Istanbul University Biotechnology and Genetics Engineering İstanbul Research and Application Center General Council Member 3. Istanbul University Radiobiology and Health Physics Research and Application Center General Council Member 10. Membership in scholarly institutions Page 21 of 24