A growth factor is a naturally occurring substance capable of stimulating

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İbrahi̇m Metin
10 yıl önce
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1 BÜYÜME FAKTÖRLERİ

2 Büyüme faktörleri Polipeptid yapıda, endojen solubl faktörler Farklı nöronlar, farklı büyüme faktörleri için reseptör ekspresse ederler Hücrenin yaşamasını,gelişmesini, farklılaşmasını ve sinapsların stabilizasyonunu sağlarlar

3 A growth factor is a naturally occurring substance capable of stimulating cellular growth proliferation cellular differentiation. Stimulates cell cycle from G0 phase to G1 phase

4 Adrenomedullin (AM) Angiopoietin (Ang) Autocrine motility factor Bone morphogenetic proteins (BMPs) Brain-derived neurotrophic factor (BDNF) Epidermal growth factor (EGF) Erythropoietin (EPO) Fibroblast growth factor (FGF) Glial cell line-derived neurotrophic factor (GDNF) Granulocyte colony-stimulating factor (G-CSF) Granulocyte macrophage colony-stimulating factor (GM- CSF) Growth differentiation factor-9 (GDF9) Hepatocyte growth factor (HGF)

factor (FGF) Glial cell line-derived neurotrophic factor (GDNF) Granulocyte colony-stimulating factor (G-CSF)

5 Hepatoma-derived growth factor (HDGF) Insulin-like growth factor (IGF) Migration-stimulating factor Myostatin (GDF-8) Nerve growth factor (NGF) and other neurotrophins Platelet-derived growth factor (PDGF) Thrombopoietin (TPO) Transforming growth factor alpha(tgf-α) Transforming growth factor beta(tgf-β) Tumor_necrosis_factor-alpha(TNF-α) Vascular endothelial growth factor (VEGF) Wnt Signaling Pathway placental growth factor (PlGF) [(Foetal Bovine Somatotrophin)] (FBS)

Transforming growth factor alpha(tgf-α) Transforming growth factor beta(tgf-β) Tumor_necrosis_factor-alpha(TNF-α)

6 IL-1- Cofactor for IL-3 and IL-6. Activates T cells. IL-2- T-cell growth factor. Stimulates IL-1 synthesis. Activates B-cells and NK cells. IL-3- Stimulates production of all non-lymphoid cells. IL-4- Growth factor for activated B cells, resting T cells, and mast cells. IL-5- Induces differentiation of activated B cells and eosinophils. IL-6- Stimulates Ig synthesis. Growth factor for plasma cells. IL-7- Growth factor for pre-b cells.

IL-4- Growth factor for activated B cells, resting T cells, and mast cells.

7 Factor Principal Source Primary Activity Comments PDGF platelets, endothelial cells, placenta promotes proliferation of connective tissue, glial and smooth muscle cells two different protein chains form 3 distinct dimer forms; AA, AB and BB EGF submaxillary gland, Brunners gland promotes proliferation of mesenchymal, glial and epithelial cells TGF-α common in transformed cells may be important for normal wound healing related to EGF FGF wide range of cells; protein is associated with the ECM promotes proliferation of many cells; inhibits some stem cells; induces mesoderm to form in early embryos at least 18 family members, 5 distinct receptors NGF mast cells, eosinophils, bone marrow stromal cells, keratinocytes promotes neurite outgrowth and neural cell survival member of a family of proteins termed neurotrophins that promote proliferation and survival of neurons; neurotrophin receptors are a class of related proteins first identified as proto-oncogenes: TrkA

for normal wound healing related to EGF FGF wide range of cells; protein is associated with the ECM promotes proliferation of many cells; inhibits some stem cells; induces mesoderm to form in early

8 Factor Principal Source Primary Activity Comments Erythrop oietin kidney promotes proliferation and differentiation of erythrocytes TGF-β activated Th1 cells (Thelper) and natural killer (NK) cells anti-inflammatory (suppresses cytokine production and class II MHC expression), promotes wound healing, inhibits macrophage and lymphocyte proliferation at least 100 different family members IGF-1 primarily liver promotes proliferation of many cell types related to IGF-2 and proinsulin, also called somatomedin C IGF-2 variety of cells promotes proliferation of many cell types primarily of fetal origin related to IGF-1 and proinsulin

macrophage and lymphocyte proliferation at least 100 different family members IGF-1 primarily liver promotes proliferation of many cell types related to IGF-2

11 Neurotrophins Neurokines Fibroblast growth factors Transforming growth factor superfamily Epidermal growth factor superfamily Other growth factors Nerve growth factor (NGF) Brain-derived neurotrophic factor (BDNF) Neurotrophin 3 (NT3) Neurotrophin 4/5 (NT4/5) Ciliary neurotrophic factor (CNTF) Leukemia inhibitory factor (LIF) Interleukin 6 (IL-6) Cardiotrophin 1 (CT-1) FGF-1 FGF-2 Transforming growth factors (TGF ) Bone morphogenetic factors (BMPs) Glial-derived neurotrophic factor (GDNF) Neurturin Epidermal growth factor (EGF) Transforming growth factor (TGF ) Neuregilins Platelet-derived growth factor (PDGF) Insulin-like growth factor I (IGF-I)

(LIF) Interleukin 6 (IL-6) Cardiotrophin 1 (CT-1) FGF-1 FGF-2 Transforming growth factors (TGF ) Bone morphogenetic factors (BMPs) Glial-derived neurotrophic

13 Nörotrofinler Nöron yaşamı ve ölümü Sinaps stabilizasyonu ve eliminasyonu Büyüme ve küçülme süreçleri

14 Sinir büyüme faktörü (Nerve growth factor= NGF) Beyin kökenli nörotrofik faktör (Brain-derived neurotrophic factor= BDNF) Nörotrofin-3 (NT-3) Nörotrofin-4/5 (NT-4/5) Nörotrofin-6 (NT-6) Değiştirici büyüme faktörü- 3 (Transforming growth factor- 3= TGF- 3) Temel fibroblast büyüme faktörü (Basic fibroblast growth factor=bfgf) Asidik fibroblast büyüme faktörü (afgf) Glia kökenli nörotrofik faktör (Glial-derived neurotrophic factor= GDNF) Siliar nörotrofik faktör (CNTF) Kolinerjik gelişme faktörü (Cholinergic development factor= CDF) Platelet kökenli nörotrofik faktör (Platelet-derived neurotrophic factor= PDNF) Insüline bağımlı büyüme faktörü (Insulin-dependent growth factor= IDGF) Epidermal büyüme faktörü (Epidermal growth factor= EGF) Proaptotik reseptörler (P75) Antiaptotik reseptörler (TrkA) Nörotrofik Faktörler Carvey, 1998: Stahl, 2000; Sah ve diğ., 2003

(Glial-derived neurotrophic factor= GDNF) Siliar nörotrofik faktör (CNTF) Kolinerjik gelişme faktörü (Cholinergic development factor= CDF) Platelet kökenli nörotrofik faktör (Platelet-derived

15 Nörotrofin reseptörleri Yaşamı sürdürme Hücre farklılaşması TRK sinyali P75

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